FYR C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ISWI complex protein

Species:

Leishmania major

UniProt:

Q4Q9A7_LEIMA

TriTrypDb:

LmjF.26.0870 , LMJLV39_260014300 , LMJSD75_260012700

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031010	ISWI-type complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0070603	SWI/SNF superfamily-type complex	3	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1904949	ATPase complex	3	2
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q9A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	445	449	PF00656	0.709
CLV_C14_Caspase3-7	450	454	PF00656	0.714
CLV_C14_Caspase3-7	651	655	PF00656	0.710
CLV_C14_Caspase3-7	726	730	PF00656	0.607
CLV_C14_Caspase3-7	765	769	PF00656	0.632
CLV_C14_Caspase3-7	88	92	PF00656	0.436
CLV_C14_Caspase3-7	97	101	PF00656	0.397
CLV_NRD_NRD_1	108	110	PF00675	0.472
CLV_NRD_NRD_1	215	217	PF00675	0.601
CLV_NRD_NRD_1	242	244	PF00675	0.627
CLV_NRD_NRD_1	288	290	PF00675	0.636
CLV_NRD_NRD_1	291	293	PF00675	0.615
CLV_NRD_NRD_1	325	327	PF00675	0.627
CLV_NRD_NRD_1	412	414	PF00675	0.616
CLV_NRD_NRD_1	417	419	PF00675	0.639
CLV_NRD_NRD_1	461	463	PF00675	0.633
CLV_NRD_NRD_1	465	467	PF00675	0.622
CLV_NRD_NRD_1	498	500	PF00675	0.605
CLV_NRD_NRD_1	610	612	PF00675	0.622
CLV_NRD_NRD_1	733	735	PF00675	0.635
CLV_PCSK_FUR_1	289	293	PF00082	0.648
CLV_PCSK_FUR_1	465	469	PF00082	0.632
CLV_PCSK_FUR_1	496	500	PF00082	0.588
CLV_PCSK_KEX2_1	215	217	PF00082	0.601
CLV_PCSK_KEX2_1	241	243	PF00082	0.643
CLV_PCSK_KEX2_1	286	288	PF00082	0.642
CLV_PCSK_KEX2_1	291	293	PF00082	0.615
CLV_PCSK_KEX2_1	323	325	PF00082	0.628
CLV_PCSK_KEX2_1	416	418	PF00082	0.640
CLV_PCSK_KEX2_1	465	467	PF00082	0.633
CLV_PCSK_KEX2_1	498	500	PF00082	0.601
CLV_PCSK_KEX2_1	600	602	PF00082	0.597
CLV_PCSK_KEX2_1	609	611	PF00082	0.613
CLV_PCSK_KEX2_1	702	704	PF00082	0.476
CLV_PCSK_KEX2_1	738	740	PF00082	0.657
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.643
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.642
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.628
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.630
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.597
CLV_PCSK_PC1ET2_1	702	704	PF00082	0.476
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.778
CLV_PCSK_PC7_1	238	244	PF00082	0.650
CLV_PCSK_PC7_1	287	293	PF00082	0.649
CLV_PCSK_PC7_1	413	419	PF00082	0.633
CLV_PCSK_PC7_1	734	740	PF00082	0.651
CLV_PCSK_SKI1_1	102	106	PF00082	0.457
CLV_PCSK_SKI1_1	109	113	PF00082	0.366
CLV_PCSK_SKI1_1	35	39	PF00082	0.402
CLV_PCSK_SKI1_1	715	719	PF00082	0.597
CLV_PCSK_SKI1_1	77	81	PF00082	0.472
DEG_APCC_DBOX_1	714	722	PF00400	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.372
DEG_SCF_FBW7_1	219	226	PF00400	0.644
DEG_SPOP_SBC_1	11	15	PF00917	0.538
DEG_SPOP_SBC_1	171	175	PF00917	0.394
DEG_SPOP_SBC_1	192	196	PF00917	0.551
DEG_SPOP_SBC_1	37	41	PF00917	0.473
DEG_SPOP_SBC_1	58	62	PF00917	0.527
DOC_CYCLIN_yCln2_LP_2	555	561	PF00134	0.600
DOC_MAPK_gen_1	398	408	PF00069	0.608
DOC_MAPK_RevD_3	587	601	PF00069	0.570
DOC_PP2B_LxvP_1	126	129	PF13499	0.419
DOC_PP2B_LxvP_1	156	159	PF13499	0.458
DOC_PP2B_LxvP_1	371	374	PF13499	0.672
DOC_PP2B_LxvP_1	555	558	PF13499	0.547
DOC_PP4_FxxP_1	21	24	PF00568	0.610
DOC_SPAK_OSR1_1	706	710	PF12202	0.511
DOC_USP7_MATH_1	129	133	PF00917	0.444
DOC_USP7_MATH_1	170	174	PF00917	0.494
DOC_USP7_MATH_1	206	210	PF00917	0.549
DOC_USP7_MATH_1	223	227	PF00917	0.659
DOC_USP7_MATH_1	233	237	PF00917	0.632
DOC_USP7_MATH_1	258	262	PF00917	0.595
DOC_USP7_MATH_1	374	378	PF00917	0.400
DOC_USP7_MATH_1	447	451	PF00917	0.712
DOC_USP7_MATH_1	46	50	PF00917	0.450
DOC_USP7_MATH_1	483	487	PF00917	0.711
DOC_USP7_MATH_1	510	514	PF00917	0.583
DOC_USP7_MATH_1	63	67	PF00917	0.386
DOC_USP7_MATH_1	803	807	PF00917	0.610
DOC_USP7_MATH_2	230	236	PF00917	0.699
DOC_USP7_UBL2_3	224	228	PF12436	0.662
DOC_USP7_UBL2_3	463	467	PF12436	0.612
DOC_WW_Pin1_4	202	207	PF00397	0.702
DOC_WW_Pin1_4	217	222	PF00397	0.637
DOC_WW_Pin1_4	242	247	PF00397	0.640
DOC_WW_Pin1_4	254	259	PF00397	0.609
DOC_WW_Pin1_4	299	304	PF00397	0.798
DOC_WW_Pin1_4	357	362	PF00397	0.521
DOC_WW_Pin1_4	529	534	PF00397	0.617
DOC_WW_Pin1_4	669	674	PF00397	0.615
DOC_WW_Pin1_4	776	781	PF00397	0.666
LIG_14-3-3_CanoR_1	242	246	PF00244	0.676
LIG_14-3-3_CanoR_1	249	253	PF00244	0.644
LIG_14-3-3_CanoR_1	324	333	PF00244	0.573
LIG_14-3-3_CanoR_1	35	44	PF00244	0.442
LIG_14-3-3_CanoR_1	556	562	PF00244	0.664
LIG_Actin_WH2_2	134	151	PF00022	0.401
LIG_APCC_ABBAyCdc20_2	23	29	PF00400	0.388
LIG_BIR_III_2	255	259	PF00653	0.614
LIG_BIR_III_2	797	801	PF00653	0.542
LIG_BIR_III_4	446	450	PF00653	0.551
LIG_BRCT_BRCA1_1	513	517	PF00533	0.590
LIG_DCNL_PONY_1	1	4	PF03556	0.438
LIG_FHA_1	173	179	PF00498	0.475
LIG_FHA_1	193	199	PF00498	0.515
LIG_FHA_1	260	266	PF00498	0.683
LIG_FHA_1	519	525	PF00498	0.663
LIG_FHA_1	549	555	PF00498	0.494
LIG_FHA_1	566	572	PF00498	0.388
LIG_FHA_1	59	65	PF00498	0.630
LIG_FHA_1	71	77	PF00498	0.354
LIG_FHA_1	82	88	PF00498	0.360
LIG_FHA_2	558	564	PF00498	0.581
LIG_FHA_2	714	720	PF00498	0.584
LIG_FHA_2	748	754	PF00498	0.831
LIG_FHA_2	760	766	PF00498	0.579
LIG_FHA_2	86	92	PF00498	0.392
LIG_FHA_2	95	101	PF00498	0.413
LIG_FXI_DFP_1	116	120	PF00024	0.397
LIG_Integrin_RGD_1	525	527	PF01839	0.558
LIG_LIR_Apic_2	52	58	PF02991	0.514
LIG_LIR_Apic_2	547	553	PF02991	0.552
LIG_LIR_Gen_1	714	721	PF02991	0.508
LIG_LIR_Nem_3	381	387	PF02991	0.428
LIG_LIR_Nem_3	551	555	PF02991	0.734
LIG_LIR_Nem_3	714	720	PF02991	0.533
LIG_LRP6_Inhibitor_1	136	142	PF00058	0.399
LIG_LYPXL_yS_3	552	555	PF13949	0.564
LIG_MYND_1	369	373	PF01753	0.543
LIG_MYND_1	553	557	PF01753	0.556
LIG_Pex14_1	575	579	PF04695	0.546
LIG_SH2_CRK	55	59	PF00017	0.546
LIG_SH2_CRK	550	554	PF00017	0.717
LIG_SH2_STAT3	201	204	PF00017	0.541
LIG_SH2_STAT5	31	34	PF00017	0.352
LIG_SH2_STAT5	550	553	PF00017	0.589
LIG_SH2_STAT5	71	74	PF00017	0.443
LIG_SH2_STAT5	711	714	PF00017	0.561
LIG_SH2_STAT5	98	101	PF00017	0.429
LIG_SH3_1	734	740	PF00018	0.639
LIG_SH3_3	22	28	PF00018	0.492
LIG_SH3_3	347	353	PF00018	0.584
LIG_SH3_3	366	372	PF00018	0.399
LIG_SH3_3	403	409	PF00018	0.614
LIG_SH3_3	527	533	PF00018	0.722
LIG_SH3_3	535	541	PF00018	0.804
LIG_SH3_3	580	586	PF00018	0.520
LIG_SH3_3	667	673	PF00018	0.652
LIG_SH3_3	678	684	PF00018	0.578
LIG_SH3_3	734	740	PF00018	0.670
LIG_SH3_4	463	470	PF00018	0.674
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.565
LIG_SUMO_SIM_anti_2	716	722	PF11976	0.558
LIG_SUMO_SIM_par_1	344	349	PF11976	0.596
LIG_SUMO_SIM_par_1	557	563	PF11976	0.586
LIG_SUMO_SIM_par_1	688	693	PF11976	0.543
LIG_TRAF2_1	544	547	PF00917	0.598
LIG_TRAF2_1	780	783	PF00917	0.641
MOD_CDK_SPK_2	219	224	PF00069	0.650
MOD_CDK_SPxxK_3	217	224	PF00069	0.701
MOD_CDK_SPxxK_3	242	249	PF00069	0.609
MOD_CK1_1	103	109	PF00069	0.392
MOD_CK1_1	181	187	PF00069	0.501
MOD_CK1_1	196	202	PF00069	0.589
MOD_CK1_1	236	242	PF00069	0.758
MOD_CK1_1	329	335	PF00069	0.659
MOD_CK1_1	357	363	PF00069	0.614
MOD_CK1_1	49	55	PF00069	0.436
MOD_CK1_1	513	519	PF00069	0.647
MOD_CK1_1	664	670	PF00069	0.663
MOD_CK1_1	672	678	PF00069	0.729
MOD_CK1_1	713	719	PF00069	0.504
MOD_CK1_1	776	782	PF00069	0.703
MOD_CK2_1	513	519	PF00069	0.660
MOD_CK2_1	557	563	PF00069	0.586
MOD_CK2_1	63	69	PF00069	0.424
MOD_CK2_1	747	753	PF00069	0.791
MOD_CK2_1	776	782	PF00069	0.709
MOD_Cter_Amidation	700	703	PF01082	0.464
MOD_Cter_Amidation	732	735	PF01082	0.704
MOD_GlcNHglycan	102	105	PF01048	0.424
MOD_GlcNHglycan	225	228	PF01048	0.627
MOD_GlcNHglycan	235	238	PF01048	0.681
MOD_GlcNHglycan	356	359	PF01048	0.590
MOD_GlcNHglycan	448	452	PF01048	0.759
MOD_GlcNHglycan	484	488	PF01048	0.681
MOD_GlcNHglycan	61	64	PF01048	0.516
MOD_GlcNHglycan	663	666	PF01048	0.663
MOD_GlcNHglycan	667	670	PF01048	0.695
MOD_GlcNHglycan	725	728	PF01048	0.591
MOD_GlcNHglycan	774	778	PF01048	0.714
MOD_GSK3_1	177	184	PF00069	0.485
MOD_GSK3_1	192	199	PF00069	0.604
MOD_GSK3_1	2	9	PF00069	0.396
MOD_GSK3_1	200	207	PF00069	0.588
MOD_GSK3_1	215	222	PF00069	0.595
MOD_GSK3_1	232	239	PF00069	0.654
MOD_GSK3_1	244	251	PF00069	0.601
MOD_GSK3_1	254	261	PF00069	0.571
MOD_GSK3_1	270	277	PF00069	0.544
MOD_GSK3_1	325	332	PF00069	0.708
MOD_GSK3_1	374	381	PF00069	0.464
MOD_GSK3_1	437	444	PF00069	0.658
MOD_GSK3_1	525	532	PF00069	0.561
MOD_GSK3_1	59	66	PF00069	0.450
MOD_GSK3_1	661	668	PF00069	0.815
MOD_GSK3_1	669	676	PF00069	0.577
MOD_GSK3_1	690	697	PF00069	0.533
MOD_GSK3_1	709	716	PF00069	0.493
MOD_GSK3_1	799	806	PF00069	0.603
MOD_GSK3_1	81	88	PF00069	0.392
MOD_GSK3_1	94	101	PF00069	0.562
MOD_N-GLC_1	2	7	PF02516	0.438
MOD_N-GLC_1	29	34	PF02516	0.310
MOD_N-GLC_1	722	727	PF02516	0.555
MOD_NEK2_1	178	183	PF00069	0.507
MOD_NEK2_1	197	202	PF00069	0.490
MOD_NEK2_1	2	7	PF00069	0.438
MOD_NEK2_1	265	270	PF00069	0.601
MOD_NEK2_1	362	367	PF00069	0.612
MOD_NEK2_1	38	43	PF00069	0.514
MOD_NEK2_1	571	576	PF00069	0.496
MOD_NEK2_1	59	64	PF00069	0.613
MOD_NEK2_1	690	695	PF00069	0.551
MOD_NEK2_1	72	77	PF00069	0.331
MOD_NEK2_1	721	726	PF00069	0.499
MOD_NEK2_1	85	90	PF00069	0.375
MOD_PIKK_1	200	206	PF00454	0.796
MOD_PIKK_1	210	216	PF00454	0.529
MOD_PIKK_1	270	276	PF00454	0.600
MOD_PIKK_1	38	44	PF00454	0.517
MOD_PIKK_1	690	696	PF00454	0.535
MOD_PK_1	476	482	PF00069	0.554
MOD_PKA_1	215	221	PF00069	0.598
MOD_PKA_1	241	247	PF00069	0.620
MOD_PKA_1	287	293	PF00069	0.649
MOD_PKA_1	324	330	PF00069	0.608
MOD_PKA_1	417	423	PF00069	0.707
MOD_PKA_1	702	708	PF00069	0.480
MOD_PKA_2	215	221	PF00069	0.611
MOD_PKA_2	237	243	PF00069	0.655
MOD_PKA_2	248	254	PF00069	0.600
MOD_PKA_2	287	293	PF00069	0.649
MOD_PKA_2	324	330	PF00069	0.608
MOD_PKA_2	417	423	PF00069	0.707
MOD_PKA_2	500	506	PF00069	0.601
MOD_PKA_2	658	664	PF00069	0.616
MOD_PKA_2	702	708	PF00069	0.480
MOD_PKA_2	760	766	PF00069	0.565
MOD_PKB_1	324	332	PF00069	0.703
MOD_Plk_1	2	8	PF00069	0.439
MOD_Plk_1	29	35	PF00069	0.313
MOD_Plk_1	434	440	PF00069	0.612
MOD_Plk_1	483	489	PF00069	0.623
MOD_Plk_1	690	696	PF00069	0.535
MOD_Plk_1	713	719	PF00069	0.532
MOD_Plk_1	94	100	PF00069	0.464
MOD_Plk_2-3	29	35	PF00069	0.450
MOD_Plk_4	193	199	PF00069	0.624
MOD_Plk_4	346	352	PF00069	0.620
MOD_Plk_4	6	12	PF00069	0.429
MOD_Plk_4	682	688	PF00069	0.550
MOD_Plk_4	784	790	PF00069	0.625
MOD_ProDKin_1	202	208	PF00069	0.706
MOD_ProDKin_1	217	223	PF00069	0.633
MOD_ProDKin_1	242	248	PF00069	0.641
MOD_ProDKin_1	254	260	PF00069	0.609
MOD_ProDKin_1	299	305	PF00069	0.797
MOD_ProDKin_1	357	363	PF00069	0.512
MOD_ProDKin_1	529	535	PF00069	0.620
MOD_ProDKin_1	669	675	PF00069	0.614
MOD_ProDKin_1	776	782	PF00069	0.666
MOD_SUMO_rev_2	472	478	PF00179	0.649
MOD_SUMO_rev_2	625	630	PF00179	0.685
MOD_SUMO_rev_2	765	772	PF00179	0.563
MOD_SUMO_rev_2	95	104	PF00179	0.507
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.490
TRG_ENDOCYTIC_2	552	555	PF00928	0.602
TRG_ER_diArg_1	287	289	PF00400	0.656
TRG_ER_diArg_1	291	293	PF00400	0.618
TRG_ER_diArg_1	324	326	PF00400	0.634
TRG_ER_diArg_1	415	418	PF00400	0.638
TRG_ER_diArg_1	464	466	PF00400	0.626
TRG_ER_diArg_1	496	499	PF00400	0.588
TRG_ER_diArg_1	609	611	PF00400	0.613
TRG_NLS_MonoCore_2	322	327	PF00514	0.626
TRG_NLS_MonoCore_2	412	417	PF00514	0.593
TRG_NLS_MonoCore_2	461	466	PF00514	0.620
TRG_NLS_MonoExtC_3	412	417	PF00514	0.606
TRG_NLS_MonoExtC_3	461	466	PF00514	0.615
TRG_NLS_MonoExtN_4	238	245	PF00514	0.606
TRG_NLS_MonoExtN_4	320	327	PF00514	0.555
TRG_NLS_MonoExtN_4	463	470	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK0	Leptomonas seymouri	41%	100%
A0A3Q8IC42	Leishmania donovani	89%	100%
A4HEU2	Leishmania braziliensis	67%	100%
A4I217	Leishmania infantum	89%	100%
E9AY65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%