Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9A3_LEIMA

TriTrypDb:

LmjF.26.0910 , LMJLV39_260014700 , LMJSD75_260013100

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q9A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9A3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001653	peptide receptor activity	3	11
GO:0038023	signaling receptor activity	2	11
GO:0060089	molecular transducer activity	1	11
GO:0140625	opioid growth factor receptor activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.551
CLV_C14_Caspase3-7	290	294	PF00656	0.743
CLV_C14_Caspase3-7	395	399	PF00656	0.493
CLV_C14_Caspase3-7	59	63	PF00656	0.607
CLV_NRD_NRD_1	208	210	PF00675	0.566
CLV_NRD_NRD_1	26	28	PF00675	0.518
CLV_PCSK_KEX2_1	208	210	PF00082	0.566
CLV_PCSK_KEX2_1	26	28	PF00082	0.750
CLV_PCSK_KEX2_1	389	391	PF00082	0.500
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.441
CLV_PCSK_SKI1_1	209	213	PF00082	0.483
CLV_PCSK_SKI1_1	248	252	PF00082	0.584
CLV_PCSK_SKI1_1	260	264	PF00082	0.494
CLV_PCSK_SKI1_1	331	335	PF00082	0.355
CLV_PCSK_SKI1_1	357	361	PF00082	0.349
DEG_APCC_DBOX_1	259	267	PF00400	0.596
DEG_Nend_UBRbox_2	1	3	PF02207	0.633
DEG_SPOP_SBC_1	57	61	PF00917	0.581
DOC_CYCLIN_RxL_1	206	215	PF00134	0.389
DOC_CYCLIN_RxL_1	328	335	PF00134	0.346
DOC_CYCLIN_yClb1_LxF_4	128	134	PF00134	0.300
DOC_CYCLIN_yCln2_LP_2	104	107	PF00134	0.434
DOC_MAPK_DCC_7	357	367	PF00069	0.365
DOC_MAPK_gen_1	328	338	PF00069	0.386
DOC_MAPK_MEF2A_6	135	144	PF00069	0.369
DOC_MAPK_MEF2A_6	331	338	PF00069	0.320
DOC_PP1_RVXF_1	133	139	PF00149	0.365
DOC_PP1_RVXF_1	342	349	PF00149	0.396
DOC_PP1_RVXF_1	355	361	PF00149	0.320
DOC_PP2B_LxvP_1	104	107	PF13499	0.434
DOC_PP4_FxxP_1	360	363	PF00568	0.465
DOC_USP7_MATH_1	160	164	PF00917	0.733
DOC_USP7_MATH_1	192	196	PF00917	0.588
DOC_USP7_MATH_2	78	84	PF00917	0.519
DOC_USP7_UBL2_3	384	388	PF12436	0.485
DOC_WW_Pin1_4	188	193	PF00397	0.543
DOC_WW_Pin1_4	74	79	PF00397	0.765
DOC_WW_Pin1_4	82	87	PF00397	0.635
DOC_WW_Pin1_4	90	95	PF00397	0.522
LIG_14-3-3_CanoR_1	227	233	PF00244	0.413
LIG_14-3-3_CanoR_1	328	334	PF00244	0.321
LIG_14-3-3_CanoR_1	41	47	PF00244	0.438
LIG_Actin_WH2_2	326	342	PF00022	0.445
LIG_BRCT_BRCA1_1	317	321	PF00533	0.427
LIG_BRCT_BRCA1_1	35	39	PF00533	0.378
LIG_eIF4E_1	230	236	PF01652	0.455
LIG_FHA_1	274	280	PF00498	0.519
LIG_FHA_1	48	54	PF00498	0.643
LIG_FHA_2	13	19	PF00498	0.647
LIG_FHA_2	393	399	PF00498	0.544
LIG_FHA_2	75	81	PF00498	0.610
LIG_GBD_Chelix_1	341	349	PF00786	0.361
LIG_LIR_Gen_1	132	141	PF02991	0.427
LIG_LIR_Gen_1	200	211	PF02991	0.530
LIG_LIR_Gen_1	231	239	PF02991	0.341
LIG_LIR_Gen_1	259	269	PF02991	0.526
LIG_LIR_Gen_1	315	322	PF02991	0.434
LIG_LIR_Gen_1	335	346	PF02991	0.333
LIG_LIR_Gen_1	51	58	PF02991	0.550
LIG_LIR_Nem_3	132	136	PF02991	0.460
LIG_LIR_Nem_3	200	206	PF02991	0.462
LIG_LIR_Nem_3	226	232	PF02991	0.399
LIG_LIR_Nem_3	259	264	PF02991	0.397
LIG_LIR_Nem_3	315	319	PF02991	0.535
LIG_LIR_Nem_3	335	341	PF02991	0.287
LIG_LIR_Nem_3	352	358	PF02991	0.380
LIG_LIR_Nem_3	51	57	PF02991	0.687
LIG_MYND_1	143	147	PF01753	0.437
LIG_NRBOX	201	207	PF00104	0.512
LIG_NRBOX	329	335	PF00104	0.303
LIG_Pex14_1	257	261	PF04695	0.376
LIG_REV1ctd_RIR_1	236	246	PF16727	0.515
LIG_SH2_CRK	230	234	PF00017	0.393
LIG_SH2_CRK	355	359	PF00017	0.372
LIG_SH2_PTP2	232	235	PF00017	0.447
LIG_SH2_STAP1	121	125	PF00017	0.545
LIG_SH2_STAP1	203	207	PF00017	0.428
LIG_SH2_STAP1	230	234	PF00017	0.367
LIG_SH2_STAT3	121	124	PF00017	0.553
LIG_SH2_STAT5	232	235	PF00017	0.369
LIG_SH3_3	216	222	PF00018	0.380
LIG_SH3_3	307	313	PF00018	0.640
LIG_SH3_3	371	377	PF00018	0.511
LIG_SH3_3	67	73	PF00018	0.757
LIG_SUMO_SIM_anti_2	213	221	PF11976	0.572
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.290
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.263
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.558
LIG_SUMO_SIM_par_1	363	368	PF11976	0.311
LIG_TRAF2_1	256	259	PF00917	0.557
LIG_TYR_ITIM	228	233	PF00017	0.324
LIG_WRC_WIRS_1	316	321	PF05994	0.481
LIG_WW_1	313	316	PF00397	0.578
MOD_CDK_SPxxK_3	84	91	PF00069	0.490
MOD_CK1_1	195	201	PF00069	0.454
MOD_CK1_1	382	388	PF00069	0.436
MOD_CK1_1	87	93	PF00069	0.538
MOD_CK2_1	12	18	PF00069	0.612
MOD_CK2_1	180	186	PF00069	0.603
MOD_CK2_1	188	194	PF00069	0.536
MOD_CK2_1	195	201	PF00069	0.422
MOD_CK2_1	74	80	PF00069	0.767
MOD_GlcNHglycan	164	167	PF01048	0.657
MOD_GlcNHglycan	170	173	PF01048	0.697
MOD_GlcNHglycan	181	185	PF01048	0.680
MOD_GlcNHglycan	197	200	PF01048	0.433
MOD_GlcNHglycan	323	326	PF01048	0.480
MOD_GlcNHglycan	70	73	PF01048	0.725
MOD_GlcNHglycan	82	85	PF01048	0.679
MOD_GSK3_1	158	165	PF00069	0.585
MOD_GSK3_1	168	175	PF00069	0.691
MOD_GSK3_1	188	195	PF00069	0.533
MOD_GSK3_1	269	276	PF00069	0.587
MOD_GSK3_1	378	385	PF00069	0.531
MOD_GSK3_1	392	399	PF00069	0.381
MOD_GSK3_1	57	64	PF00069	0.637
MOD_GSK3_1	68	75	PF00069	0.633
MOD_GSK3_1	80	87	PF00069	0.654
MOD_N-GLC_1	168	173	PF02516	0.575
MOD_NEK2_1	100	105	PF00069	0.329
MOD_NEK2_1	125	130	PF00069	0.548
MOD_NEK2_1	321	326	PF00069	0.497
MOD_PIKK_1	274	280	PF00454	0.497
MOD_PIKK_1	44	50	PF00454	0.579
MOD_PKA_2	25	31	PF00069	0.686
MOD_PKA_2	267	273	PF00069	0.419
MOD_PKA_2	392	398	PF00069	0.496
MOD_Plk_1	351	357	PF00069	0.430
MOD_Plk_1	365	371	PF00069	0.347
MOD_Plk_4	100	106	PF00069	0.428
MOD_Plk_4	228	234	PF00069	0.385
MOD_Plk_4	365	371	PF00069	0.404
MOD_Plk_4	93	99	PF00069	0.453
MOD_ProDKin_1	188	194	PF00069	0.536
MOD_ProDKin_1	74	80	PF00069	0.768
MOD_ProDKin_1	82	88	PF00069	0.628
MOD_ProDKin_1	90	96	PF00069	0.512
TRG_DiLeu_BaEn_1	201	206	PF01217	0.433
TRG_DiLeu_BaEn_1	246	251	PF01217	0.607
TRG_DiLeu_BaEn_1	259	264	PF01217	0.572
TRG_DiLeu_BaEn_4	246	252	PF01217	0.470
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.360
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.396
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.354
TRG_ENDOCYTIC_2	203	206	PF00928	0.467
TRG_ENDOCYTIC_2	230	233	PF00928	0.394
TRG_ENDOCYTIC_2	261	264	PF00928	0.377
TRG_ENDOCYTIC_2	316	319	PF00928	0.502
TRG_ENDOCYTIC_2	355	358	PF00928	0.368
TRG_ENDOCYTIC_2	40	43	PF00928	0.470
TRG_ER_diArg_1	207	209	PF00400	0.561
TRG_NES_CRM1_1	335	347	PF08389	0.382
TRG_NLS_MonoExtN_4	386	392	PF00514	0.398
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ78	Leptomonas seymouri	52%	100%
A0A1X0NT07	Trypanosomatidae	35%	100%
A0A3Q8IFS6	Leishmania donovani	91%	100%
A0A422MXD1	Trypanosoma rangeli	37%	100%
A4HEU6	Leishmania braziliensis	73%	100%
A4I220	Leishmania infantum	91%	100%
C9ZRY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AY69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5BUN4	Trypanosoma cruzi	32%	100%