AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9A1_LEIMA

TriTrypDb:

LmjF.26.0930 , LMJLV39_260014900 , LMJSD75_260013300

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q9A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9A1

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0032200	telomere organization	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003678	DNA helicase activity	3	1
GO:0003824	catalytic activity	1	1
GO:0004386	helicase activity	2	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017076	purine nucleotide binding	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.757
CLV_MEL_PAP_1	101	107	PF00089	0.592
CLV_NRD_NRD_1	165	167	PF00675	0.473
CLV_NRD_NRD_1	217	219	PF00675	0.456
CLV_NRD_NRD_1	229	231	PF00675	0.469
CLV_NRD_NRD_1	27	29	PF00675	0.598
CLV_NRD_NRD_1	486	488	PF00675	0.650
CLV_NRD_NRD_1	509	511	PF00675	0.553
CLV_PCSK_KEX2_1	165	167	PF00082	0.473
CLV_PCSK_KEX2_1	229	231	PF00082	0.519
CLV_PCSK_KEX2_1	27	29	PF00082	0.598
CLV_PCSK_KEX2_1	384	386	PF00082	0.570
CLV_PCSK_KEX2_1	488	490	PF00082	0.641
CLV_PCSK_KEX2_1	509	511	PF00082	0.553
CLV_PCSK_KEX2_1	667	669	PF00082	0.534
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.570
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.641
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.534
CLV_PCSK_SKI1_1	229	233	PF00082	0.457
CLV_PCSK_SKI1_1	362	366	PF00082	0.757
CLV_PCSK_SKI1_1	381	385	PF00082	0.423
CLV_PCSK_SKI1_1	78	82	PF00082	0.541
DEG_MDM2_SWIB_1	581	589	PF02201	0.434
DEG_Nend_Nbox_1	1	3	PF02207	0.693
DEG_SPOP_SBC_1	397	401	PF00917	0.614
DOC_CKS1_1	171	176	PF01111	0.575
DOC_CYCLIN_RxL_1	654	662	PF00134	0.502
DOC_MAPK_gen_1	229	236	PF00069	0.542
DOC_MAPK_gen_1	487	495	PF00069	0.599
DOC_MAPK_gen_1	611	620	PF00069	0.665
DOC_MAPK_gen_1	74	81	PF00069	0.479
DOC_MAPK_MEF2A_6	611	620	PF00069	0.527
DOC_MAPK_MEF2A_6	655	663	PF00069	0.487
DOC_PP1_RVXF_1	622	629	PF00149	0.538
DOC_PP1_RVXF_1	76	82	PF00149	0.553
DOC_PP2B_LxvP_1	240	243	PF13499	0.560
DOC_USP7_MATH_1	271	275	PF00917	0.687
DOC_USP7_MATH_1	303	307	PF00917	0.697
DOC_USP7_MATH_1	354	358	PF00917	0.699
DOC_USP7_MATH_1	577	581	PF00917	0.525
DOC_USP7_MATH_1	80	84	PF00917	0.429
DOC_USP7_UBL2_3	246	250	PF12436	0.512
DOC_USP7_UBL2_3	555	559	PF12436	0.664
DOC_WW_Pin1_4	170	175	PF00397	0.493
LIG_14-3-3_CanoR_1	229	237	PF00244	0.477
LIG_14-3-3_CanoR_1	260	265	PF00244	0.730
LIG_14-3-3_CanoR_1	533	541	PF00244	0.554
LIG_14-3-3_CanoR_1	635	642	PF00244	0.523
LIG_APCC_ABBA_1	607	612	PF00400	0.567
LIG_BRCT_BRCA1_1	258	262	PF00533	0.718
LIG_BRCT_BRCA1_1	354	358	PF00533	0.703
LIG_BRCT_BRCA1_1	447	451	PF00533	0.595
LIG_Clathr_ClatBox_1	157	161	PF01394	0.482
LIG_Clathr_ClatBox_1	201	205	PF01394	0.564
LIG_deltaCOP1_diTrp_1	205	211	PF00928	0.393
LIG_deltaCOP1_diTrp_1	566	575	PF00928	0.580
LIG_deltaCOP1_diTrp_1	627	631	PF00928	0.526
LIG_EH1_1	390	398	PF00400	0.589
LIG_FHA_1	153	159	PF00498	0.510
LIG_FHA_1	455	461	PF00498	0.526
LIG_FHA_1	512	518	PF00498	0.480
LIG_FHA_1	57	63	PF00498	0.423
LIG_FHA_1	599	605	PF00498	0.613
LIG_FHA_1	654	660	PF00498	0.482
LIG_FHA_2	275	281	PF00498	0.802
LIG_FHA_2	320	326	PF00498	0.756
LIG_FHA_2	561	567	PF00498	0.533
LIG_Integrin_isoDGR_2	507	509	PF01839	0.571
LIG_LIR_Apic_2	185	190	PF02991	0.444
LIG_LIR_Apic_2	427	432	PF02991	0.614
LIG_LIR_Gen_1	205	213	PF02991	0.410
LIG_LIR_Gen_1	535	545	PF02991	0.507
LIG_LIR_Nem_3	133	138	PF02991	0.323
LIG_LIR_Nem_3	173	178	PF02991	0.394
LIG_LIR_Nem_3	185	189	PF02991	0.425
LIG_LIR_Nem_3	205	210	PF02991	0.399
LIG_LIR_Nem_3	25	29	PF02991	0.377
LIG_LIR_Nem_3	5	10	PF02991	0.644
LIG_LIR_Nem_3	526	530	PF02991	0.526
LIG_LIR_Nem_3	535	541	PF02991	0.504
LIG_LIR_Nem_3	648	654	PF02991	0.511
LIG_LYPXL_S_1	471	475	PF13949	0.577
LIG_LYPXL_yS_3	472	475	PF13949	0.539
LIG_NRBOX	516	522	PF00104	0.569
LIG_PCNA_PIPBox_1	3	12	PF02747	0.710
LIG_PCNA_yPIPBox_3	3	15	PF02747	0.711
LIG_Pex14_1	207	211	PF04695	0.377
LIG_Pex14_2	131	135	PF04695	0.376
LIG_Pex14_2	22	26	PF04695	0.631
LIG_Pex14_2	581	585	PF04695	0.423
LIG_SH2_CRK	237	241	PF00017	0.565
LIG_SH2_CRK	380	384	PF00017	0.732
LIG_SH2_CRK	429	433	PF00017	0.688
LIG_SH2_CRK	553	557	PF00017	0.515
LIG_SH2_NCK_1	181	185	PF00017	0.472
LIG_SH2_STAT3	200	203	PF00017	0.414
LIG_SH2_STAT3	477	480	PF00017	0.580
LIG_SH2_STAT5	200	203	PF00017	0.414
LIG_SH2_STAT5	95	98	PF00017	0.488
LIG_SH3_1	168	174	PF00018	0.555
LIG_SH3_2	483	488	PF14604	0.651
LIG_SH3_3	168	174	PF00018	0.547
LIG_SH3_3	187	193	PF00018	0.321
LIG_SH3_3	206	212	PF00018	0.417
LIG_SH3_3	309	315	PF00018	0.751
LIG_SH3_3	326	332	PF00018	0.782
LIG_SH3_3	365	371	PF00018	0.594
LIG_SH3_3	455	461	PF00018	0.586
LIG_SH3_3	467	473	PF00018	0.557
LIG_SH3_3	480	486	PF00018	0.525
LIG_SH3_3	542	548	PF00018	0.523
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.386
LIG_SUMO_SIM_anti_2	340	352	PF11976	0.749
LIG_SUMO_SIM_anti_2	603	608	PF11976	0.592
LIG_SUMO_SIM_par_1	142	147	PF11976	0.407
LIG_SUMO_SIM_par_1	154	159	PF11976	0.428
LIG_SUMO_SIM_par_1	600	605	PF11976	0.625
LIG_TRAF2_1	111	114	PF00917	0.564
LIG_TYR_ITIM	378	383	PF00017	0.745
LIG_TYR_ITIM	551	556	PF00017	0.486
MOD_CK1_1	134	140	PF00069	0.410
MOD_CK1_1	263	269	PF00069	0.694
MOD_CK1_1	274	280	PF00069	0.785
MOD_CK1_1	338	344	PF00069	0.696
MOD_CK1_1	36	42	PF00069	0.439
MOD_CK1_1	400	406	PF00069	0.637
MOD_CK2_1	103	109	PF00069	0.633
MOD_CK2_1	249	255	PF00069	0.663
MOD_CK2_1	264	270	PF00069	0.417
MOD_CK2_1	274	280	PF00069	0.689
MOD_CK2_1	560	566	PF00069	0.475
MOD_CK2_1	577	583	PF00069	0.510
MOD_CMANNOS	628	631	PF00535	0.528
MOD_Cter_Amidation	507	510	PF01082	0.544
MOD_GlcNHglycan	305	308	PF01048	0.664
MOD_GlcNHglycan	343	346	PF01048	0.666
MOD_GlcNHglycan	400	403	PF01048	0.645
MOD_GlcNHglycan	556	559	PF01048	0.562
MOD_GlcNHglycan	82	85	PF01048	0.440
MOD_GSK3_1	126	133	PF00069	0.553
MOD_GSK3_1	152	159	PF00069	0.393
MOD_GSK3_1	256	263	PF00069	0.627
MOD_GSK3_1	272	279	PF00069	0.781
MOD_GSK3_1	334	341	PF00069	0.712
MOD_GSK3_1	354	361	PF00069	0.682
MOD_GSK3_1	396	403	PF00069	0.616
MOD_GSK3_1	528	535	PF00069	0.554
MOD_GSK3_1	584	591	PF00069	0.425
MOD_GSK3_1	672	679	PF00069	0.727
MOD_N-GLC_1	533	538	PF02516	0.604
MOD_N-GLC_1	598	603	PF02516	0.642
MOD_NEK2_1	126	131	PF00069	0.477
MOD_NEK2_1	2	7	PF00069	0.631
MOD_NEK2_1	217	222	PF00069	0.554
MOD_NEK2_1	262	267	PF00069	0.692
MOD_NEK2_1	339	344	PF00069	0.754
MOD_NEK2_1	358	363	PF00069	0.653
MOD_NEK2_1	396	401	PF00069	0.512
MOD_NEK2_1	407	412	PF00069	0.520
MOD_NEK2_2	577	582	PF00069	0.526
MOD_NEK2_2	588	593	PF00069	0.516
MOD_PIKK_1	109	115	PF00454	0.545
MOD_PIKK_1	34	40	PF00454	0.455
MOD_PKA_1	229	235	PF00069	0.497
MOD_PKA_2	103	109	PF00069	0.617
MOD_PKA_2	217	223	PF00069	0.476
MOD_PKA_2	229	235	PF00069	0.468
MOD_PKA_2	532	538	PF00069	0.580
MOD_PKA_2	634	640	PF00069	0.541
MOD_Plk_1	127	133	PF00069	0.485
MOD_Plk_1	598	604	PF00069	0.619
MOD_Plk_2-3	249	255	PF00069	0.649
MOD_Plk_2-3	409	415	PF00069	0.643
MOD_Plk_2-3	454	460	PF00069	0.652
MOD_Plk_4	152	158	PF00069	0.407
MOD_Plk_4	212	218	PF00069	0.488
MOD_Plk_4	354	360	PF00069	0.720
MOD_Plk_4	577	583	PF00069	0.448
MOD_ProDKin_1	170	176	PF00069	0.484
TRG_DiLeu_BaEn_2	386	392	PF01217	0.620
TRG_DiLeu_BaEn_4	226	232	PF01217	0.348
TRG_ENDOCYTIC_2	237	240	PF00928	0.490
TRG_ENDOCYTIC_2	380	383	PF00928	0.737
TRG_ENDOCYTIC_2	468	471	PF00928	0.553
TRG_ENDOCYTIC_2	472	475	PF00928	0.532
TRG_ENDOCYTIC_2	553	556	PF00928	0.497
TRG_ER_diArg_1	165	168	PF00400	0.433
TRG_ER_diArg_1	228	230	PF00400	0.544
TRG_ER_diArg_1	26	28	PF00400	0.620
TRG_ER_diArg_1	461	464	PF00400	0.555
TRG_ER_diArg_1	486	489	PF00400	0.609
TRG_ER_diArg_1	509	511	PF00400	0.571
TRG_ER_diArg_1	654	657	PF00400	0.475
TRG_NES_CRM1_1	114	128	PF08389	0.564
TRG_NES_CRM1_1	244	255	PF08389	0.550
TRG_NES_CRM1_1	409	424	PF08389	0.544
TRG_NLS_MonoExtN_4	486	491	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F1	Leptomonas seymouri	68%	99%
A0A0S4IRV6	Bodo saltans	42%	99%
A0A1X0NSL8	Trypanosomatidae	52%	94%
A0A3S7WZQ1	Leishmania donovani	96%	100%
A0A422MXA7	Trypanosoma rangeli	53%	95%
A4HEU8	Leishmania braziliensis	88%	100%
A4I222	Leishmania infantum	97%	100%
C9ZRY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AY71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q57VU6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	52%	99%
V5DR06	Trypanosoma cruzi	52%	95%