J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4Q9A0_LEIMA

TriTrypDb:

LmjF.26.0940 , LMJLV39_260015000 , LMJSD75_260013400

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q9A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9A0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0007006	mitochondrial membrane organization	5	2
GO:0007007	inner mitochondrial membrane organization	6	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0042407	cristae formation	7	2
GO:0061024	membrane organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.616
CLV_C14_Caspase3-7	22	26	PF00656	0.607
CLV_C14_Caspase3-7	85	89	PF00656	0.355
CLV_NRD_NRD_1	122	124	PF00675	0.521
CLV_NRD_NRD_1	453	455	PF00675	0.406
CLV_NRD_NRD_1	53	55	PF00675	0.361
CLV_NRD_NRD_1	649	651	PF00675	0.272
CLV_NRD_NRD_1	683	685	PF00675	0.410
CLV_NRD_NRD_1	817	819	PF00675	0.317
CLV_PCSK_KEX2_1	122	124	PF00082	0.517
CLV_PCSK_KEX2_1	53	55	PF00082	0.362
CLV_PCSK_KEX2_1	731	733	PF00082	0.395
CLV_PCSK_KEX2_1	819	821	PF00082	0.279
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.330
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.360
CLV_PCSK_SKI1_1	112	116	PF00082	0.476
CLV_PCSK_SKI1_1	128	132	PF00082	0.416
CLV_PCSK_SKI1_1	356	360	PF00082	0.444
CLV_PCSK_SKI1_1	509	513	PF00082	0.521
CLV_PCSK_SKI1_1	53	57	PF00082	0.300
CLV_PCSK_SKI1_1	728	732	PF00082	0.330
CLV_PCSK_SKI1_1	8	12	PF00082	0.456
DEG_APCC_DBOX_1	476	484	PF00400	0.314
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DOC_CKS1_1	242	247	PF01111	0.614
DOC_CKS1_1	803	808	PF01111	0.410
DOC_CYCLIN_yCln2_LP_2	620	626	PF00134	0.500
DOC_MAPK_DCC_7	598	608	PF00069	0.530
DOC_MAPK_DCC_7	762	770	PF00069	0.210
DOC_MAPK_FxFP_2	162	165	PF00069	0.551
DOC_MAPK_gen_1	508	514	PF00069	0.482
DOC_MAPK_gen_1	53	59	PF00069	0.301
DOC_MAPK_gen_1	553	561	PF00069	0.441
DOC_MAPK_gen_1	596	605	PF00069	0.488
DOC_MAPK_gen_1	663	671	PF00069	0.410
DOC_MAPK_gen_1	681	691	PF00069	0.410
DOC_MAPK_gen_1	818	825	PF00069	0.291
DOC_MAPK_HePTP_8	593	605	PF00069	0.402
DOC_MAPK_MEF2A_6	365	374	PF00069	0.459
DOC_MAPK_MEF2A_6	596	605	PF00069	0.417
DOC_MAPK_MEF2A_6	762	770	PF00069	0.355
DOC_PP1_RVXF_1	810	817	PF00149	0.346
DOC_PP2B_LxvP_1	367	370	PF13499	0.483
DOC_PP2B_LxvP_1	620	623	PF13499	0.434
DOC_PP2B_LxvP_1	785	788	PF13499	0.279
DOC_PP4_FxxP_1	162	165	PF00568	0.573
DOC_PP4_FxxP_1	608	611	PF00568	0.442
DOC_PP4_FxxP_1	798	801	PF00568	0.279
DOC_USP7_MATH_1	165	169	PF00917	0.683
DOC_USP7_MATH_1	186	190	PF00917	0.821
DOC_USP7_MATH_1	209	213	PF00917	0.717
DOC_USP7_MATH_1	228	232	PF00917	0.696
DOC_USP7_MATH_1	258	262	PF00917	0.683
DOC_USP7_MATH_1	32	36	PF00917	0.502
DOC_USP7_MATH_1	538	542	PF00917	0.436
DOC_USP7_MATH_1	611	615	PF00917	0.536
DOC_USP7_MATH_1	744	748	PF00917	0.352
DOC_USP7_MATH_1	756	760	PF00917	0.257
DOC_USP7_UBL2_3	681	685	PF12436	0.306
DOC_WW_Pin1_4	241	246	PF00397	0.736
DOC_WW_Pin1_4	253	258	PF00397	0.787
DOC_WW_Pin1_4	41	46	PF00397	0.410
DOC_WW_Pin1_4	532	537	PF00397	0.494
DOC_WW_Pin1_4	567	572	PF00397	0.526
DOC_WW_Pin1_4	607	612	PF00397	0.430
DOC_WW_Pin1_4	707	712	PF00397	0.324
DOC_WW_Pin1_4	713	718	PF00397	0.412
DOC_WW_Pin1_4	802	807	PF00397	0.410
LIG_14-3-3_CanoR_1	342	351	PF00244	0.613
LIG_14-3-3_CanoR_1	361	365	PF00244	0.450
LIG_14-3-3_CanoR_1	371	377	PF00244	0.514
LIG_14-3-3_CanoR_1	383	391	PF00244	0.559
LIG_14-3-3_CanoR_1	454	462	PF00244	0.451
LIG_14-3-3_CanoR_1	477	481	PF00244	0.553
LIG_14-3-3_CanoR_1	527	533	PF00244	0.465
LIG_14-3-3_CanoR_1	598	604	PF00244	0.482
LIG_14-3-3_CanoR_1	644	652	PF00244	0.376
LIG_14-3-3_CanoR_1	757	762	PF00244	0.383
LIG_Actin_WH2_2	113	130	PF00022	0.321
LIG_Actin_WH2_2	726	743	PF00022	0.210
LIG_APCC_ABBA_1	823	828	PF00400	0.410
LIG_BIR_III_4	103	107	PF00653	0.443
LIG_BRCT_BRCA1_1	356	360	PF00533	0.501
LIG_BRCT_BRCA1_1	372	376	PF00533	0.376
LIG_BRCT_BRCA1_1	580	584	PF00533	0.592
LIG_EH1_1	626	634	PF00400	0.523
LIG_FHA_1	156	162	PF00498	0.588
LIG_FHA_1	457	463	PF00498	0.470
LIG_FHA_1	482	488	PF00498	0.604
LIG_FHA_1	540	546	PF00498	0.445
LIG_FHA_1	560	566	PF00498	0.461
LIG_FHA_1	803	809	PF00498	0.484
LIG_FHA_2	195	201	PF00498	0.559
LIG_FHA_2	282	288	PF00498	0.617
LIG_FHA_2	391	397	PF00498	0.545
LIG_FHA_2	46	52	PF00498	0.410
LIG_HCF-1_HBM_1	472	475	PF13415	0.427
LIG_LIR_Apic_2	163	167	PF02991	0.588
LIG_LIR_Apic_2	546	551	PF02991	0.487
LIG_LIR_Gen_1	35	45	PF02991	0.344
LIG_LIR_Gen_1	492	502	PF02991	0.338
LIG_LIR_Gen_1	581	592	PF02991	0.464
LIG_LIR_Gen_1	699	709	PF02991	0.410
LIG_LIR_Gen_1	81	91	PF02991	0.278
LIG_LIR_Nem_3	35	41	PF02991	0.347
LIG_LIR_Nem_3	362	367	PF02991	0.551
LIG_LIR_Nem_3	492	497	PF02991	0.378
LIG_LIR_Nem_3	581	587	PF02991	0.472
LIG_LIR_Nem_3	631	637	PF02991	0.497
LIG_LIR_Nem_3	699	705	PF02991	0.410
LIG_LIR_Nem_3	81	86	PF02991	0.278
LIG_LIR_Nem_3	88	93	PF02991	0.277
LIG_PCNA_yPIPBox_3	342	354	PF02747	0.524
LIG_PCNA_yPIPBox_3	661	675	PF02747	0.410
LIG_PDZ_Class_2	838	843	PF00595	0.349
LIG_Pex14_1	721	725	PF04695	0.210
LIG_Pex14_2	360	364	PF04695	0.436
LIG_PTB_Apo_2	689	696	PF02174	0.279
LIG_PTB_Apo_2	77	84	PF02174	0.275
LIG_PTB_Phospho_1	689	695	PF10480	0.279
LIG_REV1ctd_RIR_1	574	584	PF16727	0.530
LIG_SH2_CRK	38	42	PF00017	0.334
LIG_SH2_CRK	525	529	PF00017	0.409
LIG_SH2_PTP2	90	93	PF00017	0.391
LIG_SH2_SRC	549	552	PF00017	0.402
LIG_SH2_STAP1	405	409	PF00017	0.429
LIG_SH2_STAT3	646	649	PF00017	0.413
LIG_SH2_STAT5	129	132	PF00017	0.396
LIG_SH2_STAT5	475	478	PF00017	0.517
LIG_SH2_STAT5	501	504	PF00017	0.473
LIG_SH2_STAT5	549	552	PF00017	0.503
LIG_SH2_STAT5	646	649	PF00017	0.355
LIG_SH2_STAT5	804	807	PF00017	0.357
LIG_SH2_STAT5	90	93	PF00017	0.322
LIG_SH3_3	239	245	PF00018	0.668
LIG_SH3_3	24	30	PF00018	0.528
LIG_SH3_3	294	300	PF00018	0.518
LIG_SH3_3	516	522	PF00018	0.599
LIG_SH3_3	568	574	PF00018	0.525
LIG_SH3_3	694	700	PF00018	0.279
LIG_SH3_3	705	711	PF00018	0.279
LIG_SH3_3	800	806	PF00018	0.373
LIG_SH3_3	829	835	PF00018	0.279
LIG_SH3_CIN85_PxpxPR_1	334	339	PF14604	0.594
LIG_Sin3_3	248	255	PF02671	0.538
LIG_Sin3_3	561	568	PF02671	0.426
LIG_SUMO_SIM_anti_2	672	678	PF11976	0.410
LIG_SUMO_SIM_par_1	129	134	PF11976	0.502
LIG_SUMO_SIM_par_1	672	678	PF11976	0.210
LIG_SUMO_SIM_par_1	766	771	PF11976	0.304
LIG_TRAF2_1	300	303	PF00917	0.561
LIG_TRAF2_1	680	683	PF00917	0.410
LIG_UBA3_1	605	612	PF00899	0.465
LIG_WRPW_2	634	637	PF00400	0.447
LIG_WW_1	522	525	PF00397	0.555
MOD_CDK_SPK_2	41	46	PF00069	0.355
MOD_CDK_SPK_2	607	612	PF00069	0.446
MOD_CK1_1	147	153	PF00069	0.528
MOD_CK1_1	155	161	PF00069	0.534
MOD_CK1_1	173	179	PF00069	0.655
MOD_CK1_1	227	233	PF00069	0.628
MOD_CK1_1	321	327	PF00069	0.609
MOD_CK1_1	390	396	PF00069	0.541
MOD_CK1_1	760	766	PF00069	0.403
MOD_CK1_1	783	789	PF00069	0.357
MOD_CK2_1	175	181	PF00069	0.631
MOD_CK2_1	194	200	PF00069	0.812
MOD_CK2_1	210	216	PF00069	0.592
MOD_CK2_1	262	268	PF00069	0.710
MOD_CK2_1	281	287	PF00069	0.545
MOD_CK2_1	390	396	PF00069	0.512
MOD_CK2_1	466	472	PF00069	0.438
MOD_CK2_1	745	751	PF00069	0.234
MOD_Cter_Amidation	506	509	PF01082	0.446
MOD_GlcNHglycan	146	149	PF01048	0.579
MOD_GlcNHglycan	177	180	PF01048	0.768
MOD_GlcNHglycan	187	191	PF01048	0.607
MOD_GlcNHglycan	20	24	PF01048	0.659
MOD_GlcNHglycan	226	229	PF01048	0.682
MOD_GlcNHglycan	253	256	PF01048	0.784
MOD_GlcNHglycan	274	277	PF01048	0.690
MOD_GlcNHglycan	319	323	PF01048	0.602
MOD_GlcNHglycan	325	328	PF01048	0.651
MOD_GlcNHglycan	33	37	PF01048	0.489
MOD_GlcNHglycan	441	444	PF01048	0.630
MOD_GlcNHglycan	456	459	PF01048	0.394
MOD_GlcNHglycan	580	583	PF01048	0.658
MOD_GlcNHglycan	620	623	PF01048	0.454
MOD_GlcNHglycan	717	720	PF01048	0.435
MOD_GlcNHglycan	782	785	PF01048	0.410
MOD_GSK3_1	146	153	PF00069	0.569
MOD_GSK3_1	170	177	PF00069	0.726
MOD_GSK3_1	19	26	PF00069	0.709
MOD_GSK3_1	224	231	PF00069	0.705
MOD_GSK3_1	237	244	PF00069	0.631
MOD_GSK3_1	258	265	PF00069	0.666
MOD_GSK3_1	28	35	PF00069	0.635
MOD_GSK3_1	356	363	PF00069	0.496
MOD_GSK3_1	375	382	PF00069	0.350
MOD_GSK3_1	385	392	PF00069	0.482
MOD_GSK3_1	401	408	PF00069	0.281
MOD_GSK3_1	41	48	PF00069	0.349
MOD_GSK3_1	450	457	PF00069	0.413
MOD_GSK3_1	528	535	PF00069	0.416
MOD_GSK3_1	607	614	PF00069	0.507
MOD_GSK3_1	618	625	PF00069	0.486
MOD_GSK3_1	67	74	PF00069	0.375
MOD_GSK3_1	740	747	PF00069	0.457
MOD_GSK3_1	756	763	PF00069	0.150
MOD_GSK3_1	766	773	PF00069	0.424
MOD_N-GLC_1	532	537	PF02516	0.484
MOD_N-GLC_1	713	718	PF02516	0.306
MOD_NEK2_1	139	144	PF00069	0.479
MOD_NEK2_1	146	151	PF00069	0.500
MOD_NEK2_1	224	229	PF00069	0.626
MOD_NEK2_1	251	256	PF00069	0.536
MOD_NEK2_1	360	365	PF00069	0.410
MOD_NEK2_1	372	377	PF00069	0.461
MOD_NEK2_1	384	389	PF00069	0.571
MOD_NEK2_1	439	444	PF00069	0.497
MOD_NEK2_1	448	453	PF00069	0.376
MOD_NEK2_1	466	471	PF00069	0.297
MOD_NEK2_1	476	481	PF00069	0.374
MOD_NEK2_1	500	505	PF00069	0.429
MOD_NEK2_1	559	564	PF00069	0.395
MOD_NEK2_1	57	62	PF00069	0.337
MOD_NEK2_1	618	623	PF00069	0.433
MOD_NEK2_1	740	745	PF00069	0.210
MOD_NEK2_2	23	28	PF00069	0.538
MOD_NEK2_2	405	410	PF00069	0.475
MOD_NEK2_2	428	433	PF00069	0.510
MOD_PIKK_1	147	153	PF00454	0.624
MOD_PIKK_1	343	349	PF00454	0.518
MOD_PIKK_1	45	51	PF00454	0.350
MOD_PIKK_1	551	557	PF00454	0.462
MOD_PIKK_1	57	63	PF00454	0.322
MOD_PIKK_1	67	73	PF00454	0.376
MOD_PIKK_1	720	726	PF00454	0.410
MOD_PKA_1	454	460	PF00069	0.443
MOD_PKA_2	193	199	PF00069	0.628
MOD_PKA_2	360	366	PF00069	0.501
MOD_PKA_2	370	376	PF00069	0.525
MOD_PKA_2	476	482	PF00069	0.452
MOD_PKA_2	599	605	PF00069	0.518
MOD_PKA_2	740	746	PF00069	0.493
MOD_PKA_2	756	762	PF00069	0.243
MOD_PKA_2	780	786	PF00069	0.297
MOD_Plk_1	405	411	PF00069	0.553
MOD_Plk_1	448	454	PF00069	0.382
MOD_Plk_1	770	776	PF00069	0.279
MOD_Plk_2-3	401	407	PF00069	0.489
MOD_Plk_4	262	268	PF00069	0.537
MOD_Plk_4	434	440	PF00069	0.466
MOD_Plk_4	490	496	PF00069	0.477
MOD_Plk_4	588	594	PF00069	0.391
MOD_Plk_4	622	628	PF00069	0.499
MOD_Plk_4	791	797	PF00069	0.410
MOD_ProDKin_1	241	247	PF00069	0.735
MOD_ProDKin_1	253	259	PF00069	0.787
MOD_ProDKin_1	41	47	PF00069	0.410
MOD_ProDKin_1	532	538	PF00069	0.500
MOD_ProDKin_1	567	573	PF00069	0.529
MOD_ProDKin_1	607	613	PF00069	0.426
MOD_ProDKin_1	707	713	PF00069	0.324
MOD_ProDKin_1	802	808	PF00069	0.410
MOD_SUMO_for_1	680	683	PF00179	0.306
MOD_SUMO_rev_2	515	522	PF00179	0.550
TRG_DiLeu_BaEn_1	672	677	PF01217	0.410
TRG_ENDOCYTIC_2	38	41	PF00928	0.308
TRG_ENDOCYTIC_2	494	497	PF00928	0.427
TRG_ENDOCYTIC_2	525	528	PF00928	0.512
TRG_ENDOCYTIC_2	695	698	PF00928	0.279
TRG_ENDOCYTIC_2	90	93	PF00928	0.279
TRG_ER_diArg_1	121	123	PF00400	0.526
TRG_ER_diArg_1	308	311	PF00400	0.636
TRG_ER_diArg_1	52	54	PF00400	0.362
TRG_ER_diArg_1	598	601	PF00400	0.621
TRG_ER_diArg_1	663	666	PF00400	0.389
TRG_ER_diArg_1	738	741	PF00400	0.402
TRG_ER_diArg_1	817	820	PF00400	0.304
TRG_NES_CRM1_1	461	472	PF08389	0.463
TRG_NLS_MonoCore_2	817	822	PF00514	0.410
TRG_NLS_MonoExtN_4	818	823	PF00514	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P653	Leptomonas seymouri	61%	92%
A0A1X0NU14	Trypanosomatidae	31%	100%
A0A3S7WZV8	Leishmania donovani	93%	100%
A0A422MXE6	Trypanosoma rangeli	34%	100%
A4HEU9	Leishmania braziliensis	78%	100%
A4I223	Leishmania infantum	94%	100%
C9ZRY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AY72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B9C2	Trypanosoma cruzi	35%	100%