Mcp5_PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meiotic cell cortex C-terminal pleckstrin homology, putative

Species:

Leishmania major

UniProt:

Q4Q999_LEIMA

TriTrypDb:

LmjF.26.0950 , LMJLV39_260015100 , LMJSD75_260013500

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005938	cell cortex	3	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q999

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q999

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	6
GO:0032065	maintenance of protein location in cell cortex	4	6
GO:0032507	maintenance of protein location in cell	3	6
GO:0045185	maintenance of protein location	3	6
GO:0051179	localization	1	6
GO:0051235	maintenance of location	2	6
GO:0051651	maintenance of location in cell	2	6

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005543	phospholipid binding	3	6
GO:0008289	lipid binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.525
CLV_NRD_NRD_1	153	155	PF00675	0.593
CLV_NRD_NRD_1	198	200	PF00675	0.745
CLV_NRD_NRD_1	214	216	PF00675	0.579
CLV_NRD_NRD_1	332	334	PF00675	0.682
CLV_NRD_NRD_1	354	356	PF00675	0.672
CLV_NRD_NRD_1	380	382	PF00675	0.557
CLV_NRD_NRD_1	51	53	PF00675	0.819
CLV_NRD_NRD_1	530	532	PF00675	0.232
CLV_NRD_NRD_1	7	9	PF00675	0.669
CLV_PCSK_FUR_1	151	155	PF00082	0.599
CLV_PCSK_FUR_1	465	469	PF00082	0.262
CLV_PCSK_KEX2_1	153	155	PF00082	0.646
CLV_PCSK_KEX2_1	198	200	PF00082	0.745
CLV_PCSK_KEX2_1	214	216	PF00082	0.579
CLV_PCSK_KEX2_1	299	301	PF00082	0.694
CLV_PCSK_KEX2_1	332	334	PF00082	0.682
CLV_PCSK_KEX2_1	354	356	PF00082	0.672
CLV_PCSK_KEX2_1	380	382	PF00082	0.557
CLV_PCSK_KEX2_1	467	469	PF00082	0.302
CLV_PCSK_KEX2_1	50	52	PF00082	0.815
CLV_PCSK_KEX2_1	530	532	PF00082	0.224
CLV_PCSK_KEX2_1	6	8	PF00082	0.663
CLV_PCSK_KEX2_1	72	74	PF00082	0.670
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.669
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.262
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.670
CLV_PCSK_PC7_1	376	382	PF00082	0.574
CLV_PCSK_SKI1_1	126	130	PF00082	0.567
DEG_SCF_FBW7_1	76	83	PF00400	0.665
DEG_SCF_TRCP1_1	11	16	PF00400	0.645
DEG_SPOP_SBC_1	276	280	PF00917	0.668
DEG_SPOP_SBC_1	283	287	PF00917	0.616
DEG_SPOP_SBC_1	612	616	PF00917	0.686
DEG_SPOP_SBC_1	84	88	PF00917	0.646
DOC_CKS1_1	174	179	PF01111	0.607
DOC_CKS1_1	526	531	PF01111	0.341
DOC_CKS1_1	77	82	PF01111	0.681
DOC_CYCLIN_RxL_1	120	133	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	514	520	PF00134	0.362
DOC_PP2B_LxvP_1	178	181	PF13499	0.705
DOC_PP2B_LxvP_1	347	350	PF13499	0.624
DOC_PP2B_LxvP_1	514	517	PF13499	0.337
DOC_PP2B_LxvP_1	553	556	PF13499	0.454
DOC_USP7_MATH_1	130	134	PF00917	0.786
DOC_USP7_MATH_1	135	139	PF00917	0.715
DOC_USP7_MATH_1	181	185	PF00917	0.739
DOC_USP7_MATH_1	229	233	PF00917	0.777
DOC_USP7_MATH_1	248	252	PF00917	0.764
DOC_USP7_MATH_1	25	29	PF00917	0.686
DOC_USP7_MATH_1	276	280	PF00917	0.685
DOC_USP7_MATH_1	283	287	PF00917	0.641
DOC_USP7_MATH_1	432	436	PF00917	0.632
DOC_USP7_MATH_1	489	493	PF00917	0.331
DOC_USP7_MATH_1	569	573	PF00917	0.717
DOC_USP7_MATH_1	612	616	PF00917	0.663
DOC_USP7_MATH_1	80	84	PF00917	0.692
DOC_USP7_UBL2_3	78	82	PF12436	0.677
DOC_WW_Pin1_4	108	113	PF00397	0.695
DOC_WW_Pin1_4	140	145	PF00397	0.681
DOC_WW_Pin1_4	167	172	PF00397	0.652
DOC_WW_Pin1_4	173	178	PF00397	0.607
DOC_WW_Pin1_4	206	211	PF00397	0.805
DOC_WW_Pin1_4	253	258	PF00397	0.690
DOC_WW_Pin1_4	270	275	PF00397	0.681
DOC_WW_Pin1_4	279	284	PF00397	0.698
DOC_WW_Pin1_4	304	309	PF00397	0.776
DOC_WW_Pin1_4	485	490	PF00397	0.273
DOC_WW_Pin1_4	505	510	PF00397	0.349
DOC_WW_Pin1_4	525	530	PF00397	0.341
DOC_WW_Pin1_4	586	591	PF00397	0.672
DOC_WW_Pin1_4	65	70	PF00397	0.673
DOC_WW_Pin1_4	76	81	PF00397	0.623
LIG_14-3-3_CanoR_1	136	142	PF00244	0.607
LIG_14-3-3_CanoR_1	159	165	PF00244	0.728
LIG_14-3-3_CanoR_1	187	196	PF00244	0.662
LIG_14-3-3_CanoR_1	203	207	PF00244	0.724
LIG_14-3-3_CanoR_1	277	283	PF00244	0.772
LIG_14-3-3_CanoR_1	284	289	PF00244	0.746
LIG_14-3-3_CanoR_1	316	322	PF00244	0.751
LIG_14-3-3_CanoR_1	327	335	PF00244	0.616
LIG_14-3-3_CanoR_1	417	425	PF00244	0.709
LIG_14-3-3_CanoR_1	530	536	PF00244	0.375
LIG_14-3-3_CanoR_1	568	574	PF00244	0.676
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_deltaCOP1_diTrp_1	458	463	PF00928	0.412
LIG_EH_1	376	380	PF12763	0.629
LIG_EVH1_2	395	399	PF00568	0.611
LIG_FHA_1	87	93	PF00498	0.719
LIG_FHA_2	207	213	PF00498	0.699
LIG_FHA_2	233	239	PF00498	0.673
LIG_FHA_2	318	324	PF00498	0.602
LIG_FHA_2	434	440	PF00498	0.619
LIG_LIR_Apic_2	16	20	PF02991	0.634
LIG_LIR_Apic_2	558	563	PF02991	0.588
LIG_LIR_Gen_1	24	33	PF02991	0.564
LIG_LIR_Gen_1	383	391	PF02991	0.602
LIG_LIR_Gen_1	544	555	PF02991	0.412
LIG_LIR_Nem_3	11	17	PF02991	0.642
LIG_LIR_Nem_3	24	29	PF02991	0.582
LIG_LIR_Nem_3	383	387	PF02991	0.599
LIG_LIR_Nem_3	544	550	PF02991	0.412
LIG_LIR_Nem_3	586	591	PF02991	0.716
LIG_Pex14_1	584	588	PF04695	0.673
LIG_PTB_Apo_2	387	394	PF02174	0.606
LIG_PTB_Phospho_1	387	393	PF10480	0.603
LIG_REV1ctd_RIR_1	518	527	PF16727	0.412
LIG_SH2_CRK	17	21	PF00017	0.636
LIG_SH2_CRK	547	551	PF00017	0.412
LIG_SH2_CRK	560	564	PF00017	0.509
LIG_SH2_CRK	588	592	PF00017	0.676
LIG_SH2_NCK_1	604	608	PF00017	0.644
LIG_SH2_PTP2	473	476	PF00017	0.412
LIG_SH2_SRC	393	396	PF00017	0.552
LIG_SH2_SRC	608	611	PF00017	0.696
LIG_SH2_SRC	9	12	PF00017	0.657
LIG_SH2_STAT3	298	301	PF00017	0.594
LIG_SH2_STAT3	367	370	PF00017	0.643
LIG_SH2_STAT5	367	370	PF00017	0.643
LIG_SH2_STAT5	373	376	PF00017	0.606
LIG_SH2_STAT5	393	396	PF00017	0.389
LIG_SH2_STAT5	473	476	PF00017	0.412
LIG_SH2_STAT5	9	12	PF00017	0.657
LIG_SH3_3	138	144	PF00018	0.677
LIG_SH3_3	189	195	PF00018	0.683
LIG_SH3_3	319	325	PF00018	0.711
LIG_SH3_3	332	338	PF00018	0.623
LIG_SH3_3	53	59	PF00018	0.721
LIG_SH3_3	74	80	PF00018	0.701
LIG_TRAF2_1	436	439	PF00917	0.731
LIG_TYR_ITIM	545	550	PF00017	0.412
MOD_CDC14_SPxK_1	256	259	PF00782	0.687
MOD_CDC14_SPxK_1	488	491	PF00782	0.262
MOD_CDK_SPK_2	279	284	PF00069	0.698
MOD_CDK_SPK_2	485	490	PF00069	0.273
MOD_CDK_SPK_2	525	530	PF00069	0.224
MOD_CDK_SPxK_1	253	259	PF00069	0.692
MOD_CDK_SPxK_1	485	491	PF00069	0.262
MOD_CDK_SPxK_1	525	531	PF00069	0.341
MOD_CDK_SPxK_1	76	82	PF00069	0.664
MOD_CDK_SPxxK_3	270	277	PF00069	0.675
MOD_CDK_SPxxK_3	309	316	PF00069	0.700
MOD_CDK_SPxxK_3	65	72	PF00069	0.669
MOD_CK1_1	101	107	PF00069	0.664
MOD_CK1_1	131	137	PF00069	0.678
MOD_CK1_1	140	146	PF00069	0.608
MOD_CK1_1	185	191	PF00069	0.640
MOD_CK1_1	204	210	PF00069	0.750
MOD_CK1_1	232	238	PF00069	0.710
MOD_CK1_1	251	257	PF00069	0.800
MOD_CK1_1	279	285	PF00069	0.764
MOD_CK1_1	312	318	PF00069	0.781
MOD_CK1_1	416	422	PF00069	0.607
MOD_CK1_1	502	508	PF00069	0.282
MOD_CK1_1	534	540	PF00069	0.381
MOD_CK1_1	586	592	PF00069	0.703
MOD_CK1_1	64	70	PF00069	0.796
MOD_CK1_1	83	89	PF00069	0.524
MOD_CK2_1	206	212	PF00069	0.766
MOD_CK2_1	232	238	PF00069	0.600
MOD_CK2_1	317	323	PF00069	0.709
MOD_CK2_1	432	438	PF00069	0.738
MOD_CK2_1	88	94	PF00069	0.646
MOD_GlcNHglycan	101	104	PF01048	0.602
MOD_GlcNHglycan	11	14	PF01048	0.654
MOD_GlcNHglycan	130	133	PF01048	0.723
MOD_GlcNHglycan	137	140	PF01048	0.649
MOD_GlcNHglycan	186	190	PF01048	0.735
MOD_GlcNHglycan	253	256	PF01048	0.640
MOD_GlcNHglycan	447	450	PF01048	0.390
MOD_GlcNHglycan	491	494	PF01048	0.503
MOD_GlcNHglycan	591	594	PF01048	0.625
MOD_GlcNHglycan	63	66	PF01048	0.791
MOD_GlcNHglycan	82	85	PF01048	0.531
MOD_GlcNHglycan	94	97	PF01048	0.645
MOD_GSK3_1	102	109	PF00069	0.667
MOD_GSK3_1	130	137	PF00069	0.711
MOD_GSK3_1	181	188	PF00069	0.690
MOD_GSK3_1	201	208	PF00069	0.799
MOD_GSK3_1	228	235	PF00069	0.634
MOD_GSK3_1	238	245	PF00069	0.675
MOD_GSK3_1	275	282	PF00069	0.822
MOD_GSK3_1	311	318	PF00069	0.735
MOD_GSK3_1	479	486	PF00069	0.412
MOD_GSK3_1	489	496	PF00069	0.306
MOD_GSK3_1	499	506	PF00069	0.202
MOD_GSK3_1	579	586	PF00069	0.697
MOD_GSK3_1	61	68	PF00069	0.688
MOD_GSK3_1	76	83	PF00069	0.578
MOD_GSK3_1	84	91	PF00069	0.676
MOD_GSK3_1	9	16	PF00069	0.673
MOD_GSK3_1	92	99	PF00069	0.673
MOD_N-GLC_1	121	126	PF02516	0.690
MOD_N-GLC_1	596	601	PF02516	0.673
MOD_N-GLC_1	99	104	PF02516	0.685
MOD_NEK2_1	121	126	PF00069	0.713
MOD_NEK2_1	128	133	PF00069	0.680
MOD_NEK2_1	413	418	PF00069	0.636
MOD_NEK2_1	424	429	PF00069	0.509
MOD_NEK2_1	483	488	PF00069	0.412
MOD_NEK2_1	61	66	PF00069	0.689
MOD_NEK2_1	92	97	PF00069	0.691
MOD_NEK2_2	248	253	PF00069	0.695
MOD_PIKK_1	121	127	PF00454	0.704
MOD_PIKK_1	217	223	PF00454	0.603
MOD_PIKK_1	371	377	PF00454	0.653
MOD_PIKK_1	416	422	PF00454	0.690
MOD_PKA_2	135	141	PF00069	0.645
MOD_PKA_2	158	164	PF00069	0.664
MOD_PKA_2	182	188	PF00069	0.763
MOD_PKA_2	202	208	PF00069	0.728
MOD_PKA_2	276	282	PF00069	0.762
MOD_PKA_2	283	289	PF00069	0.751
MOD_PKA_2	315	321	PF00069	0.752
MOD_PKA_2	326	332	PF00069	0.612
MOD_PKA_2	416	422	PF00069	0.714
MOD_PKA_2	479	485	PF00069	0.387
MOD_PKA_2	567	573	PF00069	0.716
MOD_Plk_4	137	143	PF00069	0.721
MOD_Plk_4	160	166	PF00069	0.672
MOD_Plk_4	229	235	PF00069	0.790
MOD_Plk_4	317	323	PF00069	0.694
MOD_Plk_4	424	430	PF00069	0.474
MOD_Plk_4	479	485	PF00069	0.412
MOD_Plk_4	555	561	PF00069	0.450
MOD_Plk_4	88	94	PF00069	0.653
MOD_ProDKin_1	108	114	PF00069	0.709
MOD_ProDKin_1	140	146	PF00069	0.681
MOD_ProDKin_1	167	173	PF00069	0.653
MOD_ProDKin_1	206	212	PF00069	0.806
MOD_ProDKin_1	253	259	PF00069	0.692
MOD_ProDKin_1	270	276	PF00069	0.673
MOD_ProDKin_1	279	285	PF00069	0.696
MOD_ProDKin_1	304	310	PF00069	0.776
MOD_ProDKin_1	485	491	PF00069	0.273
MOD_ProDKin_1	505	511	PF00069	0.349
MOD_ProDKin_1	525	531	PF00069	0.341
MOD_ProDKin_1	586	592	PF00069	0.673
MOD_ProDKin_1	65	71	PF00069	0.672
MOD_ProDKin_1	76	82	PF00069	0.625
MOD_SUMO_rev_2	492	502	PF00179	0.412
TRG_DiLeu_BaEn_1	442	447	PF01217	0.540
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.576
TRG_ENDOCYTIC_2	26	29	PF00928	0.562
TRG_ENDOCYTIC_2	473	476	PF00928	0.485
TRG_ENDOCYTIC_2	547	550	PF00928	0.412
TRG_ENDOCYTIC_2	588	591	PF00928	0.675
TRG_ER_diArg_1	332	334	PF00400	0.682
TRG_ER_diArg_1	353	355	PF00400	0.679
TRG_ER_diArg_1	379	381	PF00400	0.572
TRG_ER_diArg_1	49	52	PF00400	0.794
TRG_ER_diArg_1	5	8	PF00400	0.657
TRG_ER_diArg_1	529	531	PF00400	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IP29	Leishmania donovani	90%	100%
A4HEV0	Leishmania braziliensis	57%	100%
A4I224	Leishmania infantum	89%	100%
E9AY73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%