Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CMGC/SRPK protein kinase, putative

Species:

Leishmania major

UniProt:

Q4Q996_LEIMA

TriTrypDb:

LmjF.26.0980 , LMJLV39_260015400 , LMJSD75_260013800

Length:

1311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q996

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0035556	intracellular signal transduction	3	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004707	MAP kinase activity	5	2
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1027	1031	PF00656	0.438
CLV_C14_Caspase3-7	1094	1098	PF00656	0.365
CLV_C14_Caspase3-7	426	430	PF00656	0.659
CLV_NRD_NRD_1	1169	1171	PF00675	0.432
CLV_NRD_NRD_1	1250	1252	PF00675	0.414
CLV_NRD_NRD_1	618	620	PF00675	0.676
CLV_NRD_NRD_1	641	643	PF00675	0.621
CLV_NRD_NRD_1	804	806	PF00675	0.579
CLV_NRD_NRD_1	95	97	PF00675	0.552
CLV_NRD_NRD_1	986	988	PF00675	0.438

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZR2	Leishmania donovani	90%	99%
A4HEV3	Leishmania braziliensis	71%	93%
A4I227	Leishmania infantum	90%	94%
E9AY76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%

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