PKD_channel domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polycystin cation channel, putative

Species:

Leishmania major

UniProt:

Q4Q995_LEIMA

TriTrypDb:

LmjF.26.0990 , LMJLV39_260015500 , LMJSD75_260013900

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	9
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q995

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q995

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005216	monoatomic ion channel activity	4	9
GO:0005217	intracellular ligand-gated monoatomic ion channel activity	6	2
GO:0005261	monoatomic cation channel activity	5	9
GO:0005262	calcium channel activity	6	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	9
GO:0015075	monoatomic ion transmembrane transporter activity	3	9
GO:0015085	calcium ion transmembrane transporter activity	6	2
GO:0015267	channel activity	4	9
GO:0015276	ligand-gated monoatomic ion channel activity	5	2
GO:0015278	calcium-release channel activity	7	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	9
GO:0022803	passive transmembrane transporter activity	3	9
GO:0022834	ligand-gated channel activity	6	2
GO:0022836	gated channel activity	5	2
GO:0022857	transmembrane transporter activity	2	9
GO:0022890	inorganic cation transmembrane transporter activity	4	9
GO:0046873	metal ion transmembrane transporter activity	5	2
GO:0072345	NAADP-sensitive calcium-release channel activity	8	2
GO:0099094	ligand-gated monoatomic cation channel activity	6	2
GO:0099604	ligand-gated calcium channel activity	7	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.364
CLV_MEL_PAP_1	164	170	PF00089	0.650
CLV_NRD_NRD_1	192	194	PF00675	0.648
CLV_NRD_NRD_1	232	234	PF00675	0.647
CLV_NRD_NRD_1	524	526	PF00675	0.590
CLV_NRD_NRD_1	55	57	PF00675	0.644
CLV_NRD_NRD_1	560	562	PF00675	0.626
CLV_PCSK_FUR_1	190	194	PF00082	0.689
CLV_PCSK_KEX2_1	192	194	PF00082	0.648
CLV_PCSK_KEX2_1	232	234	PF00082	0.616
CLV_PCSK_KEX2_1	329	331	PF00082	0.676
CLV_PCSK_KEX2_1	524	526	PF00082	0.629
CLV_PCSK_KEX2_1	55	57	PF00082	0.604
CLV_PCSK_KEX2_1	560	562	PF00082	0.626
CLV_PCSK_KEX2_1	579	581	PF00082	0.329
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.676
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.550
CLV_PCSK_SKI1_1	177	181	PF00082	0.627
CLV_PCSK_SKI1_1	182	186	PF00082	0.509
CLV_PCSK_SKI1_1	198	202	PF00082	0.514
CLV_PCSK_SKI1_1	263	267	PF00082	0.445
CLV_PCSK_SKI1_1	29	33	PF00082	0.506
CLV_PCSK_SKI1_1	570	574	PF00082	0.572
CLV_PCSK_SKI1_1	579	583	PF00082	0.491
CLV_PCSK_SKI1_1	82	86	PF00082	0.600
CLV_Separin_Metazoa	571	575	PF03568	0.777
DEG_APCC_DBOX_1	176	184	PF00400	0.423
DEG_SPOP_SBC_1	482	486	PF00917	0.680
DOC_ANK_TNKS_1	166	173	PF00023	0.431
DOC_CYCLIN_RxL_1	79	89	PF00134	0.427
DOC_MAPK_MEF2A_6	177	185	PF00069	0.390
DOC_MAPK_MEF2A_6	218	227	PF00069	0.452
DOC_MAPK_MEF2A_6	354	361	PF00069	0.358
DOC_PP1_RVXF_1	180	186	PF00149	0.315
DOC_USP7_MATH_1	147	151	PF00917	0.374
DOC_USP7_MATH_1	477	481	PF00917	0.601
DOC_USP7_MATH_1	500	504	PF00917	0.736
DOC_USP7_MATH_1	553	557	PF00917	0.801
DOC_USP7_MATH_1	66	70	PF00917	0.273
DOC_USP7_MATH_1	78	82	PF00917	0.424
DOC_WW_Pin1_4	129	134	PF00397	0.444
DOC_WW_Pin1_4	149	154	PF00397	0.277
DOC_WW_Pin1_4	199	204	PF00397	0.433
DOC_WW_Pin1_4	289	294	PF00397	0.771
DOC_WW_Pin1_4	435	440	PF00397	0.355
DOC_WW_Pin1_4	529	534	PF00397	0.665
DOC_WW_Pin1_4	549	554	PF00397	0.810
DOC_WW_Pin1_4	565	570	PF00397	0.804
LIG_14-3-3_CanoR_1	167	175	PF00244	0.392
LIG_14-3-3_CanoR_1	182	188	PF00244	0.248
LIG_14-3-3_CanoR_1	198	203	PF00244	0.355
LIG_14-3-3_CanoR_1	226	231	PF00244	0.431
LIG_14-3-3_CanoR_1	35	39	PF00244	0.415
LIG_14-3-3_CterR_2	587	590	PF00244	0.738
LIG_Actin_WH2_2	168	184	PF00022	0.407
LIG_BRCT_BRCA1_1	39	43	PF00533	0.396
LIG_BRCT_BRCA1_1	92	96	PF00533	0.494
LIG_deltaCOP1_diTrp_1	302	307	PF00928	0.588
LIG_EH1_1	352	360	PF00400	0.437
LIG_EVH1_2	101	105	PF00568	0.395
LIG_FHA_1	101	107	PF00498	0.349
LIG_FHA_1	123	129	PF00498	0.403
LIG_FHA_1	138	144	PF00498	0.418
LIG_FHA_1	203	209	PF00498	0.402
LIG_FHA_1	220	226	PF00498	0.435
LIG_FHA_1	319	325	PF00498	0.366
LIG_FHA_1	339	345	PF00498	0.323
LIG_FHA_1	414	420	PF00498	0.290
LIG_FHA_2	57	63	PF00498	0.365
LIG_GBD_Chelix_1	7	15	PF00786	0.274
LIG_LIR_Apic_2	545	549	PF02991	0.662
LIG_LIR_Gen_1	117	126	PF02991	0.397
LIG_LIR_Gen_1	204	214	PF02991	0.358
LIG_LIR_Gen_1	318	326	PF02991	0.437
LIG_LIR_Gen_1	430	439	PF02991	0.296
LIG_LIR_Gen_1	453	462	PF02991	0.337
LIG_LIR_Gen_1	93	104	PF02991	0.436
LIG_LIR_Nem_3	103	108	PF02991	0.335
LIG_LIR_Nem_3	117	121	PF02991	0.347
LIG_LIR_Nem_3	204	209	PF02991	0.364
LIG_LIR_Nem_3	318	322	PF02991	0.435
LIG_LIR_Nem_3	351	356	PF02991	0.420
LIG_LIR_Nem_3	453	457	PF02991	0.337
LIG_LIR_Nem_3	51	57	PF02991	0.443
LIG_LIR_Nem_3	93	99	PF02991	0.420
LIG_NRBOX	12	18	PF00104	0.394
LIG_PDZ_Class_2	585	590	PF00595	0.689
LIG_Pex14_1	506	510	PF04695	0.794
LIG_Pex14_2	446	450	PF04695	0.337
LIG_Pex14_2	454	458	PF04695	0.337
LIG_RPA_C_Fungi	187	199	PF08784	0.575
LIG_SH2_CRK	118	122	PF00017	0.557
LIG_SH2_CRK	23	27	PF00017	0.423
LIG_SH2_CRK	275	279	PF00017	0.719
LIG_SH2_CRK	75	79	PF00017	0.382
LIG_SH2_GRB2like	88	91	PF00017	0.613
LIG_SH2_NCK_1	36	40	PF00017	0.539
LIG_SH2_NCK_1	546	550	PF00017	0.589
LIG_SH2_NCK_1	75	79	PF00017	0.426
LIG_SH2_PTP2	366	369	PF00017	0.362
LIG_SH2_STAP1	126	130	PF00017	0.567
LIG_SH2_STAP1	474	478	PF00017	0.431
LIG_SH2_STAT5	310	313	PF00017	0.400
LIG_SH2_STAT5	36	39	PF00017	0.535
LIG_SH2_STAT5	366	369	PF00017	0.362
LIG_SH2_STAT5	408	411	PF00017	0.337
LIG_SH2_STAT5	41	44	PF00017	0.515
LIG_SH2_STAT5	52	55	PF00017	0.533
LIG_SH2_STAT5	88	91	PF00017	0.476
LIG_SH3_3	130	136	PF00018	0.469
LIG_SH3_3	563	569	PF00018	0.760
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.539
LIG_SUMO_SIM_anti_2	312	318	PF11976	0.405
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.485
LIG_SUMO_SIM_anti_2	337	344	PF11976	0.394
LIG_SUMO_SIM_anti_2	416	422	PF11976	0.321
LIG_SUMO_SIM_par_1	247	253	PF11976	0.390
LIG_TRAF2_1	279	282	PF00917	0.731
LIG_TRAF2_1	335	338	PF00917	0.437
LIG_TRAF2_1	509	512	PF00917	0.660
LIG_WRC_WIRS_1	316	321	PF05994	0.394
LIG_WRC_WIRS_1	350	355	PF05994	0.437
LIG_WRC_WIRS_1	429	434	PF05994	0.337
LIG_WRC_WIRS_1	451	456	PF05994	0.337
MOD_CDK_SPK_2	565	570	PF00069	0.785
MOD_CK1_1	228	234	PF00069	0.465
MOD_CK1_1	318	324	PF00069	0.394
MOD_CK1_1	411	417	PF00069	0.334
MOD_CK1_1	480	486	PF00069	0.589
MOD_CK1_1	535	541	PF00069	0.750
MOD_CK2_1	332	338	PF00069	0.396
MOD_CK2_1	511	517	PF00069	0.715
MOD_CK2_1	544	550	PF00069	0.786
MOD_CK2_1	56	62	PF00069	0.518
MOD_CK2_1	565	571	PF00069	0.782
MOD_CK2_1	580	586	PF00069	0.453
MOD_GlcNHglycan	168	171	PF01048	0.509
MOD_GlcNHglycan	404	407	PF01048	0.465
MOD_GlcNHglycan	413	416	PF01048	0.394
MOD_GlcNHglycan	534	537	PF01048	0.787
MOD_GSK3_1	122	129	PF00069	0.491
MOD_GSK3_1	145	152	PF00069	0.670
MOD_GSK3_1	198	205	PF00069	0.556
MOD_GSK3_1	221	228	PF00069	0.443
MOD_GSK3_1	263	270	PF00069	0.419
MOD_GSK3_1	411	418	PF00069	0.349
MOD_GSK3_1	42	49	PF00069	0.560
MOD_GSK3_1	461	468	PF00069	0.442
MOD_GSK3_1	477	484	PF00069	0.506
MOD_GSK3_1	532	539	PF00069	0.739
MOD_GSK3_1	549	556	PF00069	0.742
MOD_GSK3_1	86	93	PF00069	0.553
MOD_N-GLC_1	138	143	PF02516	0.542
MOD_N-GLC_1	145	150	PF02516	0.540
MOD_N-GLC_1	332	337	PF02516	0.324
MOD_N-GLC_1	554	559	PF02516	0.664
MOD_N-GLC_1	89	94	PF02516	0.620
MOD_NEK2_1	137	142	PF00069	0.614
MOD_NEK2_1	183	188	PF00069	0.392
MOD_NEK2_1	3	8	PF00069	0.342
MOD_NEK2_1	349	354	PF00069	0.378
MOD_NEK2_1	372	377	PF00069	0.474
MOD_NEK2_1	419	424	PF00069	0.359
MOD_NEK2_1	428	433	PF00069	0.307
MOD_NEK2_1	450	455	PF00069	0.377
MOD_NEK2_1	86	91	PF00069	0.469
MOD_PIKK_1	472	478	PF00454	0.437
MOD_PK_1	226	232	PF00069	0.547
MOD_PKA_1	329	335	PF00069	0.580
MOD_PKA_2	166	172	PF00069	0.505
MOD_PKA_2	225	231	PF00069	0.535
MOD_PKA_2	329	335	PF00069	0.503
MOD_PKA_2	34	40	PF00069	0.528
MOD_PKA_2	498	504	PF00069	0.580
MOD_Plk_1	138	144	PF00069	0.594
MOD_Plk_1	263	269	PF00069	0.467
MOD_Plk_1	332	338	PF00069	0.324
MOD_Plk_2-3	511	517	PF00069	0.571
MOD_Plk_4	100	106	PF00069	0.523
MOD_Plk_4	263	269	PF00069	0.474
MOD_Plk_4	3	9	PF00069	0.385
MOD_Plk_4	338	344	PF00069	0.337
MOD_Plk_4	37	43	PF00069	0.484
MOD_Plk_4	377	383	PF00069	0.427
MOD_Plk_4	415	421	PF00069	0.372
MOD_Plk_4	428	434	PF00069	0.358
MOD_Plk_4	450	456	PF00069	0.355
MOD_Plk_4	465	471	PF00069	0.289
MOD_Plk_4	48	54	PF00069	0.563
MOD_Plk_4	66	72	PF00069	0.518
MOD_ProDKin_1	129	135	PF00069	0.559
MOD_ProDKin_1	149	155	PF00069	0.329
MOD_ProDKin_1	199	205	PF00069	0.539
MOD_ProDKin_1	289	295	PF00069	0.735
MOD_ProDKin_1	435	441	PF00069	0.437
MOD_ProDKin_1	529	535	PF00069	0.590
MOD_ProDKin_1	549	555	PF00069	0.797
MOD_ProDKin_1	565	571	PF00069	0.782
MOD_SUMO_rev_2	571	581	PF00179	0.723
TRG_DiLeu_BaEn_1	338	343	PF01217	0.437
TRG_DiLeu_LyEn_5	236	241	PF01217	0.539
TRG_ENDOCYTIC_2	118	121	PF00928	0.567
TRG_ENDOCYTIC_2	23	26	PF00928	0.409
TRG_ENDOCYTIC_2	275	278	PF00928	0.673
TRG_ENDOCYTIC_2	366	369	PF00928	0.362
TRG_ENDOCYTIC_2	510	513	PF00928	0.749
TRG_ENDOCYTIC_2	54	57	PF00928	0.545
TRG_ENDOCYTIC_2	74	77	PF00928	0.378
TRG_ER_diArg_1	190	193	PF00400	0.528
TRG_ER_diArg_1	257	260	PF00400	0.456
TRG_ER_diArg_1	524	527	PF00400	0.814
TRG_ER_diArg_1	54	56	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKU9	Leptomonas seymouri	57%	97%
A0A1X0NSA4	Trypanosomatidae	40%	100%
A0A3R7KKX3	Trypanosoma rangeli	38%	100%
A0A3S7WZS8	Leishmania donovani	92%	100%
A4I228	Leishmania infantum	92%	100%
C9ZRX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AY77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%