MRH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucosidase II beta subunit-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q994_LEIMA

TriTrypDb:

LmjF.26.1000 , LMJLV39_260015600 , LMJSD75_260014000

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0017177	glucosidase II complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4Q994

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q994

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	10
GO:0009100	glycoprotein metabolic process	4	8
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:1901135	carbohydrate derivative metabolic process	3	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0016310	phosphorylation	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	143	149	PF00089	0.527
CLV_NRD_NRD_1	139	141	PF00675	0.668
CLV_NRD_NRD_1	192	194	PF00675	0.626
CLV_NRD_NRD_1	35	37	PF00675	0.610
CLV_NRD_NRD_1	8	10	PF00675	0.551
CLV_PCSK_KEX2_1	139	141	PF00082	0.447
CLV_PCSK_KEX2_1	7	9	PF00082	0.601
CLV_PCSK_SKI1_1	209	213	PF00082	0.611
CLV_PCSK_SKI1_1	313	317	PF00082	0.566
CLV_PCSK_SKI1_1	326	330	PF00082	0.534
DOC_AGCK_PIF_1	235	240	PF00069	0.385
DOC_CKS1_1	329	334	PF01111	0.328
DOC_CYCLIN_RxL_1	206	216	PF00134	0.535
DOC_PP4_FxxP_1	329	332	PF00568	0.315
DOC_USP7_MATH_1	12	16	PF00917	0.546
DOC_USP7_MATH_1	187	191	PF00917	0.529
DOC_USP7_MATH_1	88	92	PF00917	0.655
DOC_USP7_UBL2_3	112	116	PF12436	0.441
DOC_WW_Pin1_4	211	216	PF00397	0.440
DOC_WW_Pin1_4	328	333	PF00397	0.314
LIG_14-3-3_CanoR_1	140	146	PF00244	0.623
LIG_14-3-3_CanoR_1	153	159	PF00244	0.455
LIG_Clathr_ClatBox_1	314	318	PF01394	0.367
LIG_FHA_1	217	223	PF00498	0.328
LIG_FHA_1	237	243	PF00498	0.183
LIG_FHA_1	270	276	PF00498	0.312
LIG_FHA_1	282	288	PF00498	0.312
LIG_FHA_1	70	76	PF00498	0.649
LIG_FHA_2	216	222	PF00498	0.360
LIG_FHA_2	314	320	PF00498	0.344
LIG_LIR_Gen_1	176	184	PF02991	0.391
LIG_LIR_Gen_1	20	31	PF02991	0.546
LIG_LIR_Gen_1	237	248	PF02991	0.361
LIG_LIR_Gen_1	45	53	PF02991	0.624
LIG_LIR_Nem_3	176	181	PF02991	0.424
LIG_LIR_Nem_3	20	26	PF02991	0.545
LIG_LIR_Nem_3	232	238	PF02991	0.366
LIG_LIR_Nem_3	239	243	PF02991	0.342
LIG_LIR_Nem_3	45	51	PF02991	0.666
LIG_MYND_3	30	34	PF01753	0.538
LIG_Pex14_2	231	235	PF04695	0.385
LIG_SH2_CRK	23	27	PF00017	0.541
LIG_SH2_CRK	240	244	PF00017	0.415
LIG_SH2_CRK	325	329	PF00017	0.298
LIG_SH2_GRB2like	288	291	PF00017	0.385
LIG_SH2_SRC	240	243	PF00017	0.218
LIG_SH2_SRC	288	291	PF00017	0.395
LIG_SH2_STAP1	23	27	PF00017	0.541
LIG_SH2_STAP1	238	242	PF00017	0.312
LIG_SH2_STAP1	273	277	PF00017	0.345
LIG_SH2_STAP1	63	67	PF00017	0.715
LIG_SH2_STAT5	108	111	PF00017	0.526
LIG_SH2_STAT5	158	161	PF00017	0.626
LIG_SH2_STAT5	238	241	PF00017	0.330
LIG_SH3_3	304	310	PF00018	0.360
LIG_SH3_3	314	320	PF00018	0.220
LIG_TRAF2_1	316	319	PF00917	0.385
LIG_UBA3_1	180	189	PF00899	0.494
LIG_UBA3_1	222	228	PF00899	0.301
LIG_UBA3_1	261	266	PF00899	0.218
LIG_WRC_WIRS_1	175	180	PF05994	0.420
MOD_CK1_1	213	219	PF00069	0.451
MOD_CK1_1	65	71	PF00069	0.655
MOD_CK2_1	12	18	PF00069	0.566
MOD_CK2_1	264	270	PF00069	0.395
MOD_CK2_1	313	319	PF00069	0.318
MOD_GlcNHglycan	104	108	PF01048	0.521
MOD_GlcNHglycan	148	151	PF01048	0.398
MOD_GlcNHglycan	161	165	PF01048	0.538
MOD_GlcNHglycan	2	5	PF01048	0.607
MOD_GSK3_1	141	148	PF00069	0.601
MOD_GSK3_1	211	218	PF00069	0.592
MOD_GSK3_1	65	72	PF00069	0.627
MOD_NEK2_1	244	249	PF00069	0.306
MOD_NEK2_1	253	258	PF00069	0.363
MOD_NEK2_1	264	269	PF00069	0.335
MOD_PIKK_1	281	287	PF00454	0.361
MOD_PKA_1	139	145	PF00069	0.387
MOD_PKA_2	102	108	PF00069	0.375
MOD_PKA_2	139	145	PF00069	0.644
MOD_PKA_2	152	158	PF00069	0.465
MOD_PKA_2	88	94	PF00069	0.602
MOD_Plk_1	229	235	PF00069	0.394
MOD_Plk_1	236	242	PF00069	0.383
MOD_Plk_1	269	275	PF00069	0.315
MOD_Plk_1	281	287	PF00069	0.315
MOD_Plk_2-3	229	235	PF00069	0.330
MOD_Plk_4	244	250	PF00069	0.392
MOD_Plk_4	271	277	PF00069	0.258
MOD_ProDKin_1	211	217	PF00069	0.434
MOD_ProDKin_1	328	334	PF00069	0.314
MOD_SUMO_rev_2	104	113	PF00179	0.528
MOD_SUMO_rev_2	199	204	PF00179	0.473
TRG_AP2beta_CARGO_1	176	185	PF09066	0.390
TRG_ENDOCYTIC_2	23	26	PF00928	0.539
TRG_ENDOCYTIC_2	240	243	PF00928	0.415
TRG_ENDOCYTIC_2	325	328	PF00928	0.315
TRG_ER_diArg_1	138	140	PF00400	0.480
TRG_ER_diArg_1	6	9	PF00400	0.609
TRG_NLS_MonoExtC_3	193	199	PF00514	0.553
TRG_NLS_MonoExtN_4	193	198	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	224	229	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ILH9	Bodo saltans	30%	70%
A0A1X0NSB3	Trypanosomatidae	41%	70%
A0A3Q8IDT4	Leishmania donovani	86%	100%
A0A3R7L6D4	Trypanosoma rangeli	38%	70%
A4HEV5	Leishmania braziliensis	52%	68%
A4I229	Leishmania infantum	86%	100%
C9ZRX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	70%
E9AY78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5DQZ5	Trypanosoma cruzi	35%	70%