C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q993_LEIMA

TriTrypDb:

LmjF.26.1010 , LMJLV39_260015700 , LMJSD75_260014100

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q993

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q993

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.657
CLV_NRD_NRD_1	282	284	PF00675	0.670
CLV_PCSK_KEX2_1	217	219	PF00082	0.692
CLV_PCSK_KEX2_1	282	284	PF00082	0.672
CLV_PCSK_KEX2_1	5	7	PF00082	0.687
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.692
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.776
CLV_PCSK_SKI1_1	129	133	PF00082	0.520
CLV_PCSK_SKI1_1	161	165	PF00082	0.635
CLV_PCSK_SKI1_1	217	221	PF00082	0.678
DEG_APCC_DBOX_1	26	34	PF00400	0.597
DEG_SCF_FBW7_1	374	381	PF00400	0.705
DEG_SPOP_SBC_1	378	382	PF00917	0.803
DOC_CYCLIN_RxL_1	129	140	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.752
DOC_MAPK_gen_1	217	225	PF00069	0.553
DOC_MAPK_gen_1	5	11	PF00069	0.656
DOC_MAPK_MEF2A_6	5	13	PF00069	0.683
DOC_PP1_RVXF_1	132	139	PF00149	0.575
DOC_PP1_RVXF_1	192	198	PF00149	0.614
DOC_PP2B_LxvP_1	11	14	PF13499	0.657
DOC_USP7_MATH_1	361	365	PF00917	0.646
DOC_USP7_MATH_1	396	400	PF00917	0.718
DOC_WW_Pin1_4	122	127	PF00397	0.683
DOC_WW_Pin1_4	328	333	PF00397	0.653
DOC_WW_Pin1_4	334	339	PF00397	0.574
DOC_WW_Pin1_4	374	379	PF00397	0.684
DOC_WW_Pin1_4	383	388	PF00397	0.679
LIG_14-3-3_CanoR_1	129	138	PF00244	0.593
LIG_14-3-3_CanoR_1	344	348	PF00244	0.562
LIG_14-3-3_CanoR_1	6	12	PF00244	0.717
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BRCT_BRCA1_1	221	225	PF00533	0.542
LIG_FHA_1	130	136	PF00498	0.534
LIG_FHA_1	14	20	PF00498	0.537
LIG_FHA_1	286	292	PF00498	0.772
LIG_FHA_1	337	343	PF00498	0.650
LIG_FHA_1	384	390	PF00498	0.678
LIG_FHA_1	57	63	PF00498	0.513
LIG_FHA_2	29	35	PF00498	0.681
LIG_FHA_2	344	350	PF00498	0.564
LIG_FHA_2	366	372	PF00498	0.660
LIG_LIR_Gen_1	85	94	PF02991	0.464
LIG_LIR_Nem_3	222	228	PF02991	0.523
LIG_LIR_Nem_3	25	29	PF02991	0.575
LIG_LIR_Nem_3	85	89	PF02991	0.452
LIG_MLH1_MIPbox_1	221	225	PF16413	0.543
LIG_PAM2_1	334	346	PF00658	0.689
LIG_Pex14_1	240	244	PF04695	0.587
LIG_Pex14_1	82	86	PF04695	0.428
LIG_PTB_Apo_2	391	398	PF02174	0.796
LIG_REV1ctd_RIR_1	222	231	PF16727	0.555
LIG_REV1ctd_RIR_1	241	249	PF16727	0.418
LIG_SH2_CRK	86	90	PF00017	0.515
LIG_SH2_NCK_1	108	112	PF00017	0.567
LIG_SH2_NCK_1	86	90	PF00017	0.443
LIG_SH2_STAP1	108	112	PF00017	0.498
LIG_SH2_STAT3	262	265	PF00017	0.672
LIG_SH2_STAT3	350	353	PF00017	0.593
LIG_SH2_STAT3	93	96	PF00017	0.613
LIG_SH2_STAT5	248	251	PF00017	0.650
LIG_SH2_STAT5	29	32	PF00017	0.585
LIG_SH2_STAT5	350	353	PF00017	0.593
LIG_SH2_STAT5	93	96	PF00017	0.520
LIG_SH3_1	154	160	PF00018	0.636
LIG_SH3_1	318	324	PF00018	0.739
LIG_SH3_3	120	126	PF00018	0.598
LIG_SH3_3	145	151	PF00018	0.641
LIG_SH3_3	154	160	PF00018	0.586
LIG_SH3_3	318	324	PF00018	0.704
LIG_SH3_3	332	338	PF00018	0.704
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.761
LIG_SUMO_SIM_par_1	331	337	PF11976	0.702
LIG_UBA3_1	365	373	PF00899	0.716
MOD_CDK_SPxxK_3	122	129	PF00069	0.674
MOD_CK1_1	28	34	PF00069	0.593
MOD_CK1_1	328	334	PF00069	0.679
MOD_CK1_1	399	405	PF00069	0.758
MOD_CK1_1	75	81	PF00069	0.503
MOD_CK2_1	309	315	PF00069	0.642
MOD_CK2_1	316	322	PF00069	0.760
MOD_CK2_1	377	383	PF00069	0.801
MOD_GlcNHglycan	142	145	PF01048	0.558
MOD_GlcNHglycan	311	314	PF01048	0.613
MOD_GlcNHglycan	318	321	PF01048	0.712
MOD_GlcNHglycan	34	38	PF01048	0.726
MOD_GlcNHglycan	353	356	PF01048	0.727
MOD_GlcNHglycan	72	75	PF01048	0.487
MOD_GlcNHglycan	77	80	PF01048	0.443
MOD_GSK3_1	256	263	PF00069	0.749
MOD_GSK3_1	361	368	PF00069	0.632
MOD_GSK3_1	374	381	PF00069	0.656
MOD_GSK3_1	396	403	PF00069	0.698
MOD_GSK3_1	68	75	PF00069	0.543
MOD_N-GLC_1	397	402	PF02516	0.707
MOD_NEK2_1	115	120	PF00069	0.563
MOD_NEK2_1	243	248	PF00069	0.601
MOD_NEK2_1	365	370	PF00069	0.646
MOD_NEK2_1	397	402	PF00069	0.697
MOD_NEK2_1	62	67	PF00069	0.489
MOD_NEK2_1	70	75	PF00069	0.486
MOD_NEK2_2	343	348	PF00069	0.562
MOD_OFUCOSY	174	180	PF10250	0.693
MOD_PIKK_1	115	121	PF00454	0.604
MOD_PIKK_1	149	155	PF00454	0.645
MOD_PIKK_1	397	403	PF00454	0.767
MOD_PIKK_1	68	74	PF00454	0.565
MOD_PKA_2	343	349	PF00069	0.580
MOD_PKA_2	351	357	PF00069	0.611
MOD_Plk_1	361	367	PF00069	0.647
MOD_Plk_4	219	225	PF00069	0.504
MOD_Plk_4	243	249	PF00069	0.619
MOD_Plk_4	331	337	PF00069	0.728
MOD_Plk_4	361	367	PF00069	0.647
MOD_Plk_4	62	68	PF00069	0.514
MOD_Plk_4	77	83	PF00069	0.539
MOD_ProDKin_1	122	128	PF00069	0.674
MOD_ProDKin_1	328	334	PF00069	0.646
MOD_ProDKin_1	374	380	PF00069	0.686
MOD_ProDKin_1	383	389	PF00069	0.675
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.569
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.671
TRG_ENDOCYTIC_2	175	178	PF00928	0.608
TRG_ENDOCYTIC_2	86	89	PF00928	0.446
TRG_ER_diArg_1	191	194	PF00400	0.580
TRG_ER_diArg_1	282	284	PF00400	0.688
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL9	Leptomonas seymouri	84%	100%
A0A0S4II62	Bodo saltans	51%	100%
A0A1X0NSZ7	Trypanosomatidae	63%	100%
A0A3Q8IDL6	Leishmania donovani	99%	100%
A0A3R7NVU2	Trypanosoma rangeli	60%	100%
A4HEV6	Leishmania braziliensis	95%	100%
A4I230	Leishmania infantum	99%	100%
C9ZRX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	93%
E9AY79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%