Aldo_ket_red domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q991_LEIMA

TriTrypDb:

LmjF.26.1030 , LMJLV39_260015900 , LMJSD75_260014300

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q991

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q991

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.473
CLV_NRD_NRD_1	312	314	PF00675	0.428
CLV_NRD_NRD_1	48	50	PF00675	0.668
CLV_NRD_NRD_1	578	580	PF00675	0.422
CLV_NRD_NRD_1	75	77	PF00675	0.619
CLV_PCSK_FUR_1	576	580	PF00082	0.422
CLV_PCSK_KEX2_1	312	314	PF00082	0.428
CLV_PCSK_KEX2_1	48	50	PF00082	0.647
CLV_PCSK_KEX2_1	578	580	PF00082	0.440
CLV_PCSK_PC7_1	308	314	PF00082	0.455
CLV_PCSK_PC7_1	44	50	PF00082	0.663
CLV_PCSK_SKI1_1	106	110	PF00082	0.657
CLV_PCSK_SKI1_1	126	130	PF00082	0.388
CLV_PCSK_SKI1_1	376	380	PF00082	0.535
CLV_PCSK_SKI1_1	48	52	PF00082	0.642
CLV_PCSK_SKI1_1	521	525	PF00082	0.396
CLV_PCSK_SKI1_1	557	561	PF00082	0.441
CLV_PCSK_SKI1_1	579	583	PF00082	0.429
CLV_PCSK_SKI1_1	775	779	PF00082	0.600
DEG_APCC_DBOX_1	307	315	PF00400	0.459
DEG_APCC_DBOX_1	47	55	PF00400	0.677
DEG_APCC_DBOX_1	520	528	PF00400	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.696
DOC_CKS1_1	414	419	PF01111	0.651
DOC_CKS1_1	572	577	PF01111	0.532
DOC_CYCLIN_RxL_1	472	480	PF00134	0.423
DOC_MAPK_MEF2A_6	339	347	PF00069	0.359
DOC_PP1_RVXF_1	643	650	PF00149	0.368
DOC_PP2B_LxvP_1	393	396	PF13499	0.515
DOC_PP2B_LxvP_1	487	490	PF13499	0.466
DOC_PP2B_LxvP_1	681	684	PF13499	0.418
DOC_USP7_MATH_1	108	112	PF00917	0.448
DOC_USP7_MATH_1	137	141	PF00917	0.565
DOC_USP7_MATH_1	196	200	PF00917	0.382
DOC_USP7_MATH_1	288	292	PF00917	0.593
DOC_USP7_MATH_1	690	694	PF00917	0.452
DOC_USP7_MATH_1	91	95	PF00917	0.690
DOC_USP7_UBL2_3	593	597	PF12436	0.424
DOC_USP7_UBL2_3	721	725	PF12436	0.638
DOC_WW_Pin1_4	31	36	PF00397	0.721
DOC_WW_Pin1_4	320	325	PF00397	0.411
DOC_WW_Pin1_4	387	392	PF00397	0.377
DOC_WW_Pin1_4	413	418	PF00397	0.654
DOC_WW_Pin1_4	457	462	PF00397	0.549
DOC_WW_Pin1_4	482	487	PF00397	0.375
DOC_WW_Pin1_4	571	576	PF00397	0.540
DOC_WW_Pin1_4	630	635	PF00397	0.392
DOC_WW_Pin1_4	700	705	PF00397	0.480
LIG_14-3-3_CanoR_1	148	152	PF00244	0.433
LIG_14-3-3_CanoR_1	160	164	PF00244	0.389
LIG_14-3-3_CanoR_1	168	174	PF00244	0.222
LIG_14-3-3_CanoR_1	316	324	PF00244	0.431
LIG_APCC_ABBA_1	370	375	PF00400	0.417
LIG_BRCT_BRCA1_1	160	164	PF00533	0.412
LIG_BRCT_BRCA1_1	663	667	PF00533	0.394
LIG_Clathr_ClatBox_1	730	734	PF01394	0.691
LIG_deltaCOP1_diTrp_1	165	169	PF00928	0.558
LIG_deltaCOP1_diTrp_1	325	331	PF00928	0.411
LIG_eIF4E_1	652	658	PF01652	0.464
LIG_eIF4E_1	708	714	PF01652	0.691
LIG_FHA_1	266	272	PF00498	0.543
LIG_FHA_1	421	427	PF00498	0.527
LIG_FHA_1	53	59	PF00498	0.717
LIG_FHA_1	69	75	PF00498	0.730
LIG_FHA_1	762	768	PF00498	0.612
LIG_FHA_2	160	166	PF00498	0.407
LIG_FHA_2	259	265	PF00498	0.582
LIG_FHA_2	336	342	PF00498	0.385
LIG_FHA_2	351	357	PF00498	0.343
LIG_FHA_2	515	521	PF00498	0.410
LIG_GBD_Chelix_1	224	232	PF00786	0.528
LIG_LIR_Apic_2	412	417	PF02991	0.661
LIG_LIR_Apic_2	630	634	PF02991	0.540
LIG_LIR_Gen_1	240	250	PF02991	0.375
LIG_LIR_Gen_1	328	336	PF02991	0.388
LIG_LIR_Gen_1	497	506	PF02991	0.489
LIG_LIR_Gen_1	696	707	PF02991	0.567
LIG_LIR_Nem_3	240	245	PF02991	0.342
LIG_LIR_Nem_3	328	334	PF02991	0.390
LIG_LIR_Nem_3	440	446	PF02991	0.522
LIG_LIR_Nem_3	497	502	PF02991	0.500
LIG_LIR_Nem_3	566	571	PF02991	0.425
LIG_LIR_Nem_3	696	702	PF02991	0.526
LIG_LYPXL_yS_3	401	404	PF13949	0.522
LIG_MLH1_MIPbox_1	663	667	PF16413	0.394
LIG_MYND_1	391	395	PF01753	0.439
LIG_MYND_3	540	544	PF01753	0.475
LIG_NRBOX	23	29	PF00104	0.507
LIG_Pex14_1	326	330	PF04695	0.407
LIG_Pex14_1	568	572	PF04695	0.421
LIG_Pex14_1	595	599	PF04695	0.384
LIG_Pex14_2	559	563	PF04695	0.386
LIG_Pex14_2	564	568	PF04695	0.392
LIG_PTB_Apo_2	330	337	PF02174	0.393
LIG_PTB_Apo_2	558	565	PF02174	0.385
LIG_PTB_Phospho_1	330	336	PF10480	0.393
LIG_Rb_pABgroove_1	349	357	PF01858	0.476
LIG_SH2_CRK	414	418	PF00017	0.649
LIG_SH2_CRK	572	576	PF00017	0.412
LIG_SH2_CRK	699	703	PF00017	0.577
LIG_SH2_GRB2like	499	502	PF00017	0.402
LIG_SH2_GRB2like	699	702	PF00017	0.493
LIG_SH2_NCK_1	699	703	PF00017	0.580
LIG_SH2_PTP2	631	634	PF00017	0.459
LIG_SH2_SRC	699	702	PF00017	0.519
LIG_SH2_STAP1	599	603	PF00017	0.418
LIG_SH2_STAT5	156	159	PF00017	0.403
LIG_SH2_STAT5	373	376	PF00017	0.383
LIG_SH2_STAT5	552	555	PF00017	0.406
LIG_SH2_STAT5	631	634	PF00017	0.459
LIG_SH2_STAT5	666	669	PF00017	0.390
LIG_SH2_STAT5	729	732	PF00017	0.643
LIG_SH3_1	399	405	PF00018	0.497
LIG_SH3_1	415	421	PF00018	0.499
LIG_SH3_1	732	738	PF00018	0.595
LIG_SH3_3	32	38	PF00018	0.711
LIG_SH3_3	385	391	PF00018	0.477
LIG_SH3_3	392	398	PF00018	0.332
LIG_SH3_3	399	405	PF00018	0.453
LIG_SH3_3	415	421	PF00018	0.499
LIG_SH3_3	443	449	PF00018	0.382
LIG_SH3_3	64	70	PF00018	0.569
LIG_SH3_3	699	705	PF00018	0.459
LIG_SH3_3	732	738	PF00018	0.575
LIG_SUMO_SIM_anti_2	341	347	PF11976	0.350
LIG_SUMO_SIM_par_1	344	349	PF11976	0.366
LIG_SUMO_SIM_par_1	685	693	PF11976	0.439
LIG_TRAF2_1	684	687	PF00917	0.503
LIG_TRAF2_1	78	81	PF00917	0.650
LIG_TRFH_1	708	712	PF08558	0.564
LIG_TYR_ITIM	383	388	PF00017	0.381
LIG_TYR_ITIM	482	487	PF00017	0.418
LIG_TYR_ITIM	697	702	PF00017	0.553
LIG_UBA3_1	275	283	PF00899	0.665
LIG_UBA3_1	370	379	PF00899	0.411
LIG_UBA3_1	709	718	PF00899	0.639
MOD_CDK_SPK_2	571	576	PF00069	0.543
MOD_CDK_SPxK_1	413	419	PF00069	0.655
MOD_CDK_SPxxK_3	571	578	PF00069	0.544
MOD_CK1_1	286	292	PF00069	0.505
MOD_CK1_1	36	42	PF00069	0.711
MOD_CK1_1	56	62	PF00069	0.724
MOD_CK1_1	63	69	PF00069	0.712
MOD_CK1_1	693	699	PF00069	0.507
MOD_CK1_1	75	81	PF00069	0.490
MOD_CK2_1	159	165	PF00069	0.417
MOD_CK2_1	258	264	PF00069	0.576
MOD_CK2_1	335	341	PF00069	0.392
MOD_CK2_1	482	488	PF00069	0.379
MOD_CK2_1	514	520	PF00069	0.389
MOD_CK2_1	749	755	PF00069	0.712
MOD_CK2_1	75	81	PF00069	0.665
MOD_GlcNHglycan	110	113	PF01048	0.444
MOD_GlcNHglycan	122	125	PF01048	0.474
MOD_GlcNHglycan	14	17	PF01048	0.714
MOD_GlcNHglycan	238	242	PF01048	0.448
MOD_GlcNHglycan	293	296	PF01048	0.562
MOD_GlcNHglycan	588	591	PF01048	0.474
MOD_GlcNHglycan	692	695	PF01048	0.516
MOD_GlcNHglycan	758	761	PF01048	0.719
MOD_GlcNHglycan	93	96	PF01048	0.676
MOD_GSK3_1	147	154	PF00069	0.411
MOD_GSK3_1	177	184	PF00069	0.397
MOD_GSK3_1	282	289	PF00069	0.543
MOD_GSK3_1	29	36	PF00069	0.641
MOD_GSK3_1	50	57	PF00069	0.578
MOD_GSK3_1	59	66	PF00069	0.705
MOD_GSK3_1	68	75	PF00069	0.659
MOD_GSK3_1	717	724	PF00069	0.647
MOD_N-GLC_1	450	455	PF02516	0.351
MOD_N-GLC_1	466	471	PF02516	0.370
MOD_N-GLC_1	700	705	PF02516	0.481
MOD_N-GLC_1	91	96	PF02516	0.715
MOD_NEK2_1	158	163	PF00069	0.484
MOD_NEK2_1	182	187	PF00069	0.516
MOD_NEK2_1	237	242	PF00069	0.460
MOD_NEK2_1	301	306	PF00069	0.515
MOD_NEK2_1	450	455	PF00069	0.383
MOD_NEK2_1	477	482	PF00069	0.377
MOD_NEK2_1	547	552	PF00069	0.376
MOD_NEK2_1	58	63	PF00069	0.575
MOD_NEK2_1	661	666	PF00069	0.391
MOD_NEK2_2	183	188	PF00069	0.406
MOD_NEK2_2	288	293	PF00069	0.602
MOD_NEK2_2	350	355	PF00069	0.403
MOD_PIKK_1	301	307	PF00454	0.502
MOD_PIKK_1	450	456	PF00454	0.390
MOD_PKA_2	12	18	PF00069	0.664
MOD_PKA_2	137	143	PF00069	0.522
MOD_PKA_2	147	153	PF00069	0.417
MOD_PKA_2	159	165	PF00069	0.394
MOD_PKA_2	296	302	PF00069	0.454
MOD_PKA_2	315	321	PF00069	0.228
MOD_PKA_2	75	81	PF00069	0.555
MOD_Plk_1	158	164	PF00069	0.455
MOD_Plk_1	258	264	PF00069	0.600
MOD_Plk_1	301	307	PF00069	0.502
MOD_Plk_1	466	472	PF00069	0.488
MOD_Plk_1	519	525	PF00069	0.497
MOD_Plk_2-3	159	165	PF00069	0.436
MOD_Plk_4	159	165	PF00069	0.434
MOD_Plk_4	350	356	PF00069	0.414
MOD_Plk_4	547	553	PF00069	0.377
MOD_ProDKin_1	31	37	PF00069	0.721
MOD_ProDKin_1	320	326	PF00069	0.411
MOD_ProDKin_1	387	393	PF00069	0.376
MOD_ProDKin_1	413	419	PF00069	0.655
MOD_ProDKin_1	457	463	PF00069	0.557
MOD_ProDKin_1	482	488	PF00069	0.379
MOD_ProDKin_1	571	577	PF00069	0.535
MOD_ProDKin_1	630	636	PF00069	0.386
MOD_ProDKin_1	700	706	PF00069	0.492
MOD_SUMO_rev_2	505	511	PF00179	0.409
MOD_SUMO_rev_2	522	532	PF00179	0.421
MOD_SUMO_rev_2	711	720	PF00179	0.608
TRG_DiLeu_BaEn_1	488	493	PF01217	0.425
TRG_DiLeu_BaEn_4	686	692	PF01217	0.512
TRG_ENDOCYTIC_2	229	232	PF00928	0.393
TRG_ENDOCYTIC_2	385	388	PF00928	0.375
TRG_ENDOCYTIC_2	401	404	PF00928	0.522
TRG_ENDOCYTIC_2	427	430	PF00928	0.394
TRG_ENDOCYTIC_2	484	487	PF00928	0.418
TRG_ENDOCYTIC_2	499	502	PF00928	0.335
TRG_ENDOCYTIC_2	599	602	PF00928	0.381
TRG_ENDOCYTIC_2	699	702	PF00928	0.567
TRG_ER_diArg_1	271	274	PF00400	0.546
TRG_ER_diArg_1	311	313	PF00400	0.414
TRG_ER_diArg_1	47	49	PF00400	0.635
TRG_ER_diArg_1	577	579	PF00400	0.435
TRG_ER_diArg_1	607	610	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK7	Leptomonas seymouri	78%	100%
A0A0S4JUK7	Bodo saltans	63%	100%
A0A1X0NTZ9	Trypanosomatidae	71%	100%
A0A3Q8IH01	Leishmania donovani	97%	100%
A4HEV9	Leishmania braziliensis	89%	100%
C9ZRX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AY82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BUF5	Trypanosoma cruzi	74%	100%