Peptidase_M28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q990_LEIMA

TriTrypDb:

LmjF.26.1040 , LMJLV39_260016000 , LMJSD75_260014400

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q990

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q990

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	11
GO:0010646	regulation of cell communication	4	11
GO:0023051	regulation of signaling	3	11
GO:0048583	regulation of response to stimulus	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.211
CLV_C14_Caspase3-7	394	398	PF00656	0.410
CLV_NRD_NRD_1	154	156	PF00675	0.649
CLV_NRD_NRD_1	168	170	PF00675	0.590
CLV_NRD_NRD_1	240	242	PF00675	0.472
CLV_NRD_NRD_1	389	391	PF00675	0.573
CLV_PCSK_KEX2_1	154	156	PF00082	0.649
CLV_PCSK_KEX2_1	168	170	PF00082	0.590
CLV_PCSK_KEX2_1	240	242	PF00082	0.472
CLV_PCSK_KEX2_1	320	322	PF00082	0.538
CLV_PCSK_KEX2_1	389	391	PF00082	0.580
CLV_PCSK_KEX2_1	403	405	PF00082	0.488
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.538
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.572
CLV_PCSK_SKI1_1	142	146	PF00082	0.501
CLV_PCSK_SKI1_1	154	158	PF00082	0.608
CLV_PCSK_SKI1_1	159	163	PF00082	0.581
CLV_PCSK_SKI1_1	240	244	PF00082	0.538
CLV_PCSK_SKI1_1	289	293	PF00082	0.512
CLV_PCSK_SKI1_1	33	37	PF00082	0.568
CLV_PCSK_SKI1_1	52	56	PF00082	0.585
CLV_PCSK_SKI1_1	99	103	PF00082	0.596
CLV_Separin_Metazoa	143	147	PF03568	0.247
CLV_Separin_Metazoa	59	63	PF03568	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SCF_FBW7_1	493	499	PF00400	0.423
DEG_SPOP_SBC_1	271	275	PF00917	0.338
DOC_ANK_TNKS_1	38	45	PF00023	0.370
DOC_CKS1_1	493	498	PF01111	0.426
DOC_CYCLIN_RxL_1	139	149	PF00134	0.249
DOC_CYCLIN_yCln2_LP_2	297	300	PF00134	0.278
DOC_MAPK_gen_1	154	162	PF00069	0.409
DOC_MAPK_gen_1	99	108	PF00069	0.348
DOC_MAPK_MEF2A_6	155	164	PF00069	0.275
DOC_MAPK_MEF2A_6	3	11	PF00069	0.488
DOC_MAPK_MEF2A_6	305	314	PF00069	0.239
DOC_MAPK_MEF2A_6	336	344	PF00069	0.274
DOC_MAPK_MEF2A_6	99	108	PF00069	0.401
DOC_MAPK_RevD_3	308	321	PF00069	0.306
DOC_PP1_RVXF_1	31	38	PF00149	0.355
DOC_PP2B_LxvP_1	297	300	PF13499	0.324
DOC_PP2B_LxvP_1	92	95	PF13499	0.361
DOC_USP7_MATH_1	362	366	PF00917	0.306
DOC_USP7_MATH_1	418	422	PF00917	0.439
DOC_USP7_MATH_1	443	447	PF00917	0.336
DOC_USP7_MATH_1	65	69	PF00917	0.426
DOC_WW_Pin1_4	217	222	PF00397	0.365
DOC_WW_Pin1_4	242	247	PF00397	0.369
DOC_WW_Pin1_4	446	451	PF00397	0.316
DOC_WW_Pin1_4	492	497	PF00397	0.431
LIG_14-3-3_CanoR_1	146	151	PF00244	0.382
LIG_14-3-3_CanoR_1	154	162	PF00244	0.414
LIG_14-3-3_CanoR_1	240	246	PF00244	0.338
LIG_14-3-3_CanoR_1	33	38	PF00244	0.335
LIG_14-3-3_CanoR_1	390	400	PF00244	0.438
LIG_14-3-3_CanoR_1	478	487	PF00244	0.365
LIG_14-3-3_CterR_2	545	549	PF00244	0.637
LIG_APCC_ABBA_1	501	506	PF00400	0.339
LIG_APCC_ABBA_1	544	549	PF00400	0.634
LIG_BRCT_BRCA1_1	119	123	PF00533	0.394
LIG_BRCT_BRCA1_1	514	518	PF00533	0.334
LIG_eIF4E_1	256	262	PF01652	0.289
LIG_FHA_1	155	161	PF00498	0.412
LIG_FHA_1	165	171	PF00498	0.470
LIG_FHA_1	272	278	PF00498	0.310
LIG_FHA_1	373	379	PF00498	0.355
LIG_FHA_1	493	499	PF00498	0.369
LIG_FHA_1	505	511	PF00498	0.341
LIG_FHA_1	539	545	PF00498	0.592
LIG_FHA_1	73	79	PF00498	0.277
LIG_FHA_2	111	117	PF00498	0.323
LIG_FHA_2	279	285	PF00498	0.361
LIG_FHA_2	301	307	PF00498	0.245
LIG_FHA_2	392	398	PF00498	0.387
LIG_FHA_2	487	493	PF00498	0.419
LIG_GBD_Chelix_1	234	242	PF00786	0.506
LIG_LIR_Gen_1	211	222	PF02991	0.258
LIG_LIR_Gen_1	309	319	PF02991	0.267
LIG_LIR_Gen_1	489	498	PF02991	0.422
LIG_LIR_Nem_3	211	217	PF02991	0.258
LIG_LIR_Nem_3	237	242	PF02991	0.258
LIG_LIR_Nem_3	286	291	PF02991	0.258
LIG_LIR_Nem_3	309	314	PF02991	0.267
LIG_LIR_Nem_3	349	354	PF02991	0.248
LIG_LIR_Nem_3	382	388	PF02991	0.393
LIG_LIR_Nem_3	489	493	PF02991	0.411
LIG_LIR_Nem_3	499	504	PF02991	0.351
LIG_LIR_Nem_3	68	74	PF02991	0.391
LIG_MLH1_MIPbox_1	119	123	PF16413	0.402
LIG_NRBOX	143	149	PF00104	0.417
LIG_NRBOX	526	532	PF00104	0.435
LIG_PCNA_PIPBox_1	207	216	PF02747	0.361
LIG_SH2_PTP2	535	538	PF00017	0.446
LIG_SH2_SRC	311	314	PF00017	0.338
LIG_SH2_SRC	535	538	PF00017	0.446
LIG_SH2_STAP1	354	358	PF00017	0.247
LIG_SH2_STAP1	461	465	PF00017	0.302
LIG_SH2_STAP1	504	508	PF00017	0.295
LIG_SH2_STAP1	74	78	PF00017	0.360
LIG_SH2_STAT3	247	250	PF00017	0.361
LIG_SH2_STAT5	133	136	PF00017	0.287
LIG_SH2_STAT5	188	191	PF00017	0.381
LIG_SH2_STAT5	311	314	PF00017	0.338
LIG_SH2_STAT5	435	438	PF00017	0.376
LIG_SH2_STAT5	516	519	PF00017	0.472
LIG_SH2_STAT5	535	538	PF00017	0.309
LIG_SH2_STAT5	74	77	PF00017	0.293
LIG_SH3_3	186	192	PF00018	0.402
LIG_SUMO_SIM_par_1	104	114	PF11976	0.387
LIG_SUMO_SIM_par_1	8	14	PF11976	0.532
LIG_TRAF2_1	248	251	PF00917	0.361
LIG_TRAF2_1	489	492	PF00917	0.423
LIG_TRAF2_1	503	506	PF00917	0.351
LIG_UBA3_1	337	343	PF00899	0.306
LIG_WRC_WIRS_1	118	123	PF05994	0.401
LIG_WW_3	298	302	PF00397	0.278
MOD_CDK_SPxxK_3	217	224	PF00069	0.361
MOD_CDK_SPxxK_3	242	249	PF00069	0.361
MOD_CK1_1	220	226	PF00069	0.309
MOD_CK1_1	275	281	PF00069	0.361
MOD_CK1_1	346	352	PF00069	0.310
MOD_CK1_1	446	452	PF00069	0.316
MOD_CK1_1	483	489	PF00069	0.353
MOD_CK2_1	110	116	PF00069	0.327
MOD_CK2_1	278	284	PF00069	0.305
MOD_CK2_1	486	492	PF00069	0.364
MOD_GlcNHglycan	180	183	PF01048	0.572
MOD_GlcNHglycan	200	203	PF01048	0.491
MOD_GlcNHglycan	225	228	PF01048	0.484
MOD_GlcNHglycan	229	232	PF01048	0.473
MOD_GlcNHglycan	345	348	PF01048	0.518
MOD_GlcNHglycan	482	485	PF01048	0.621
MOD_GlcNHglycan	67	70	PF01048	0.602
MOD_GSK3_1	117	124	PF00069	0.346
MOD_GSK3_1	160	167	PF00069	0.406
MOD_GSK3_1	174	181	PF00069	0.359
MOD_GSK3_1	194	201	PF00069	0.290
MOD_GSK3_1	213	220	PF00069	0.326
MOD_GSK3_1	223	230	PF00069	0.252
MOD_GSK3_1	271	278	PF00069	0.338
MOD_GSK3_1	479	486	PF00069	0.330
MOD_GSK3_1	492	499	PF00069	0.348
MOD_GSK3_1	78	85	PF00069	0.369
MOD_N-GLC_1	136	141	PF02516	0.625
MOD_N-GLC_1	175	180	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.561
MOD_NEK2_1	10	15	PF00069	0.440
MOD_NEK2_1	121	126	PF00069	0.369
MOD_NEK2_1	261	266	PF00069	0.264
MOD_NEK2_1	338	343	PF00069	0.341
MOD_NEK2_1	371	376	PF00069	0.341
MOD_NEK2_1	48	53	PF00069	0.347
MOD_NEK2_2	496	501	PF00069	0.393
MOD_PIKK_1	275	281	PF00454	0.320
MOD_PIKK_1	443	449	PF00454	0.343
MOD_PK_1	146	152	PF00069	0.427
MOD_PK_1	249	255	PF00069	0.306
MOD_PKA_1	154	160	PF00069	0.405
MOD_PKA_1	168	174	PF00069	0.350
MOD_PKA_1	240	246	PF00069	0.338
MOD_PKA_2	154	160	PF00069	0.413
MOD_PKA_2	168	174	PF00069	0.440
MOD_PKA_2	223	229	PF00069	0.369
MOD_PKA_2	240	246	PF00069	0.240
MOD_PKA_2	300	306	PF00069	0.278
MOD_PKA_2	477	483	PF00069	0.354
MOD_Plk_1	174	180	PF00069	0.357
MOD_Plk_1	504	510	PF00069	0.388
MOD_Plk_4	117	123	PF00069	0.406
MOD_Plk_4	256	262	PF00069	0.289
MOD_Plk_4	272	278	PF00069	0.361
MOD_Plk_4	424	430	PF00069	0.430
MOD_Plk_4	431	437	PF00069	0.341
MOD_Plk_4	512	518	PF00069	0.358
MOD_Plk_4	72	78	PF00069	0.290
MOD_ProDKin_1	217	223	PF00069	0.365
MOD_ProDKin_1	242	248	PF00069	0.369
MOD_ProDKin_1	446	452	PF00069	0.316
MOD_ProDKin_1	492	498	PF00069	0.426
TRG_DiLeu_BaEn_1	143	148	PF01217	0.413
TRG_DiLeu_LyEn_5	143	148	PF01217	0.413
TRG_ENDOCYTIC_2	311	314	PF00928	0.289
TRG_ENDOCYTIC_2	490	493	PF00928	0.385
TRG_ENDOCYTIC_2	535	538	PF00928	0.506
TRG_ER_diArg_1	168	170	PF00400	0.425
TRG_ER_diArg_1	239	241	PF00400	0.272
TRG_ER_diArg_1	388	390	PF00400	0.382
TRG_NES_CRM1_1	284	296	PF08389	0.299
TRG_NES_CRM1_1	309	322	PF08389	0.306
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P650	Leptomonas seymouri	61%	100%
A0A1X0NSR2	Trypanosomatidae	34%	86%
A0A3R7MV36	Trypanosoma rangeli	33%	91%
A0A3S7WZU9	Leishmania donovani	95%	100%
A4HEW0	Leishmania braziliensis	79%	100%
A4I233	Leishmania infantum	95%	100%
C9ZRX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
E9AY83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q5XIA1	Rattus norvegicus	24%	98%
V5BPU6	Trypanosoma cruzi	34%	91%