2Fe-2S ferredoxin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2Fe-2S iron-sulfur cluster binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q989_LEIMA

TriTrypDb:

LmjF.26.1050 , LMJLV39_260016100 , LMJSD75_260014500

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q989

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q989

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0022900	electron transport chain	4	11
GO:0044237	cellular metabolic process	2	11
GO:0140647	P450-containing electron transport chain	5	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	11
GO:0009055	electron transfer activity	3	2
GO:0016491	oxidoreductase activity	2	2
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.530
CLV_NRD_NRD_1	33	35	PF00675	0.607
CLV_NRD_NRD_1	8	10	PF00675	0.628
CLV_PCSK_KEX2_1	134	136	PF00082	0.583
CLV_PCSK_KEX2_1	33	35	PF00082	0.607
CLV_PCSK_KEX2_1	8	10	PF00082	0.628
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.583
CLV_PCSK_SKI1_1	8	12	PF00082	0.656
DOC_MAPK_gen_1	144	154	PF00069	0.507
DOC_MAPK_gen_1	42	50	PF00069	0.457
DOC_MAPK_HePTP_8	131	145	PF00069	0.463
DOC_MAPK_MEF2A_6	42	50	PF00069	0.457
DOC_MAPK_RevD_3	20	34	PF00069	0.440
DOC_PP4_FxxP_1	104	107	PF00568	0.317
DOC_PP4_FxxP_1	50	53	PF00568	0.502
LIG_APCC_ABBA_1	101	106	PF00400	0.341
LIG_BRCT_BRCA1_1	31	35	PF00533	0.628
LIG_eIF4E_1	63	69	PF01652	0.317
LIG_FHA_1	12	18	PF00498	0.631
LIG_FHA_1	122	128	PF00498	0.317
LIG_FHA_1	5	11	PF00498	0.633
LIG_FHA_1	89	95	PF00498	0.298
LIG_FHA_2	106	112	PF00498	0.298
LIG_FHA_2	49	55	PF00498	0.446
LIG_FHA_2	65	71	PF00498	0.214
LIG_Integrin_isoDGR_2	3	5	PF01839	0.586
LIG_LIR_Apic_2	102	107	PF02991	0.318
LIG_LIR_Apic_2	47	53	PF02991	0.466
LIG_SH2_SRC	153	156	PF00017	0.550
LIG_SH2_STAT3	63	66	PF00017	0.298
LIG_SH2_STAT5	153	156	PF00017	0.550
LIG_SH2_STAT5	95	98	PF00017	0.298
LIG_SH3_3	140	146	PF00018	0.470
LIG_SUMO_SIM_par_1	44	49	PF11976	0.484
MOD_CK2_1	105	111	PF00069	0.298
MOD_GSK3_1	25	32	PF00069	0.616
MOD_GSK3_1	4	11	PF00069	0.470
MOD_GSK3_1	83	90	PF00069	0.312
MOD_NEK2_1	29	34	PF00069	0.690
MOD_NEK2_2	129	134	PF00069	0.396
MOD_NEK2_2	88	93	PF00069	0.298
MOD_OFUCOSY	87	92	PF10250	0.299
MOD_PKA_1	8	14	PF00069	0.587
MOD_PKA_2	146	152	PF00069	0.505
MOD_PKA_2	4	10	PF00069	0.548
MOD_Plk_1	48	54	PF00069	0.513
MOD_Plk_2-3	64	70	PF00069	0.317
MOD_Plk_4	12	18	PF00069	0.649
MOD_Plk_4	25	31	PF00069	0.693
MOD_Plk_4	64	70	PF00069	0.317
MOD_SUMO_rev_2	54	60	PF00179	0.371
TRG_DiLeu_BaEn_1	64	69	PF01217	0.317
TRG_ER_diArg_1	33	35	PF00400	0.671
TRG_ER_diArg_1	8	10	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	28%	100%
A0A0N1HYR7	Leptomonas seymouri	30%	100%
A0A0N1HZ74	Leptomonas seymouri	76%	93%
A0A0N1I5P4	Leptomonas seymouri	35%	100%
A0A0N1ILD8	Leptomonas seymouri	35%	95%
A0A0S4JS28	Bodo saltans	55%	100%
A0A1X0NSB1	Trypanosomatidae	59%	90%
A0A3R7MK78	Trypanosoma rangeli	36%	99%
A0A3R7NM96	Trypanosoma rangeli	64%	84%
A0A3S7WZQ5	Leishmania donovani	95%	93%
A0A3S7X4U4	Leishmania donovani	39%	89%
A4HEW1	Leishmania braziliensis	85%	86%
A4HJN3	Leishmania braziliensis	35%	100%
A4HJN9	Leishmania braziliensis	38%	91%
A4I234	Leishmania infantum	96%	93%
C9ZRX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	91%
E9AY84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	93%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	89%
P00257	Bos taurus	39%	87%
P13216	Gallus gallus	41%	100%
P24483	Rattus norvegicus	41%	86%
P29330	Ovis aries	40%	100%
P37193	Drosophila melanogaster	39%	94%
P46656	Mus musculus	40%	86%
Q05B51	Bos taurus	43%	87%
Q08C57	Danio rerio	40%	83%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	94%
Q1RJ69	Rickettsia bellii (strain RML369-C)	44%	100%
Q4Q610	Leishmania major	39%	89%
Q5FWQ0	Xenopus laevis	40%	84%
Q6P4F2	Homo sapiens	37%	87%
Q8S904	Arabidopsis thaliana	44%	82%
Q9AKC4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	44%	100%
Q9CPW2	Mus musculus	42%	93%
Q9M0V0	Arabidopsis thaliana	39%	82%
Q9ZDW6	Rickettsia prowazekii (strain Madrid E)	44%	100%