RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q988_LEIMA

TriTrypDb:

LmjF.26.1060 , LMJLV39_260016200 , LMJSD75_260014600

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q988

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q988

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.600
CLV_C14_Caspase3-7	312	316	PF00656	0.689
CLV_NRD_NRD_1	221	223	PF00675	0.681
CLV_PCSK_KEX2_1	221	223	PF00082	0.681
CLV_PCSK_SKI1_1	133	137	PF00082	0.719
CLV_PCSK_SKI1_1	63	67	PF00082	0.307
DEG_SCF_FBW7_2	286	293	PF00400	0.805
DOC_CKS1_1	287	292	PF01111	0.732
DOC_USP7_MATH_1	117	121	PF00917	0.532
DOC_USP7_MATH_1	275	279	PF00917	0.754
DOC_USP7_MATH_1	296	300	PF00917	0.741
DOC_USP7_MATH_1	311	315	PF00917	0.611
DOC_USP7_MATH_1	48	52	PF00917	0.423
DOC_USP7_MATH_1	58	62	PF00917	0.485
DOC_USP7_MATH_1	84	88	PF00917	0.499
DOC_WW_Pin1_4	189	194	PF00397	0.702
DOC_WW_Pin1_4	286	291	PF00397	0.731
DOC_WW_Pin1_4	3	8	PF00397	0.574
LIG_14-3-3_CanoR_1	30	38	PF00244	0.454
LIG_BIR_III_2	262	266	PF00653	0.560
LIG_BIR_III_4	257	261	PF00653	0.546
LIG_BRCT_BRCA1_1	131	135	PF00533	0.714
LIG_BRCT_BRCA1_1	68	72	PF00533	0.499
LIG_FHA_1	100	106	PF00498	0.524
LIG_FHA_1	171	177	PF00498	0.591
LIG_FHA_1	186	192	PF00498	0.604
LIG_FHA_1	19	25	PF00498	0.548
LIG_FHA_2	163	169	PF00498	0.573
LIG_FHA_2	301	307	PF00498	0.710
LIG_FHA_2	4	10	PF00498	0.721
LIG_LIR_Apic_2	79	83	PF02991	0.517
LIG_LIR_Gen_1	203	209	PF02991	0.537
LIG_LIR_Nem_3	246	252	PF02991	0.594
LIG_LIR_Nem_3	4	8	PF02991	0.603
LIG_LIR_Nem_3	51	56	PF02991	0.520
LIG_LIR_Nem_3	60	65	PF02991	0.513
LIG_PDZ_Class_3	325	330	PF00595	0.767
LIG_PROFILIN_1	264	270	PF00235	0.553
LIG_SH2_CRK	80	84	PF00017	0.517
LIG_SH2_STAP1	205	209	PF00017	0.598
LIG_SH2_STAT3	32	35	PF00017	0.460
LIG_SH2_STAT5	252	255	PF00017	0.594
LIG_SH2_STAT5	32	35	PF00017	0.460
LIG_SH2_STAT5	91	94	PF00017	0.553
LIG_SH3_1	261	267	PF00018	0.723
LIG_SH3_3	261	267	PF00018	0.765
LIG_SH3_3	52	58	PF00018	0.555
LIG_SUMO_SIM_par_1	112	118	PF11976	0.642
LIG_WRC_WIRS_1	2	7	PF05994	0.653
MOD_CK1_1	118	124	PF00069	0.656
MOD_CK1_1	160	166	PF00069	0.696
MOD_CK1_1	171	177	PF00069	0.681
MOD_CK1_1	278	284	PF00069	0.729
MOD_CK2_1	162	168	PF00069	0.699
MOD_CK2_1	300	306	PF00069	0.721
MOD_CK2_1	48	54	PF00069	0.438
MOD_GlcNHglycan	117	120	PF01048	0.685
MOD_GlcNHglycan	121	124	PF01048	0.642
MOD_GlcNHglycan	159	162	PF01048	0.714
MOD_GlcNHglycan	193	196	PF01048	0.750
MOD_GlcNHglycan	272	275	PF01048	0.704
MOD_GlcNHglycan	46	49	PF01048	0.562
MOD_GlcNHglycan	67	71	PF01048	0.314
MOD_GlcNHglycan	74	77	PF01048	0.321
MOD_GSK3_1	115	122	PF00069	0.650
MOD_GSK3_1	157	164	PF00069	0.673
MOD_GSK3_1	185	192	PF00069	0.714
MOD_GSK3_1	296	303	PF00069	0.720
MOD_GSK3_1	44	51	PF00069	0.544
MOD_GSK3_1	72	79	PF00069	0.499
MOD_N-GLC_1	171	176	PF02516	0.728
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	115	120	PF00069	0.624
MOD_NEK2_1	136	141	PF00069	0.698
MOD_NEK2_1	72	77	PF00069	0.516
MOD_PIKK_1	136	142	PF00454	0.779
MOD_PIKK_1	31	37	PF00454	0.450
MOD_PKA_2	136	142	PF00069	0.693
MOD_PKA_2	157	163	PF00069	0.723
MOD_Plk_1	84	90	PF00069	0.542
MOD_Plk_4	300	306	PF00069	0.554
MOD_ProDKin_1	189	195	PF00069	0.702
MOD_ProDKin_1	286	292	PF00069	0.733
MOD_ProDKin_1	3	9	PF00069	0.576
MOD_SUMO_for_1	49	52	PF00179	0.555
MOD_SUMO_rev_2	206	214	PF00179	0.675
TRG_ENDOCYTIC_2	205	208	PF00928	0.555
TRG_ENDOCYTIC_2	56	59	PF00928	0.527
TRG_ENDOCYTIC_2	62	65	PF00928	0.505
TRG_ER_diArg_1	220	222	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I9	Leptomonas seymouri	57%	99%
A0A3Q8ICS1	Leishmania donovani	92%	100%
A0A422NSU1	Trypanosoma rangeli	41%	100%
A4HEW2	Leishmania braziliensis	82%	90%
A4I235	Leishmania infantum	92%	100%
E9AY85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%