Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q987_LEIMA

TriTrypDb:

LmjF.26.1070 , LMJLV39_260016300 , LMJSD75_260014700

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q987

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q987

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.567
CLV_C14_Caspase3-7	423	427	PF00656	0.612
CLV_MEL_PAP_1	201	207	PF00089	0.529
CLV_NRD_NRD_1	260	262	PF00675	0.485
CLV_NRD_NRD_1	339	341	PF00675	0.503
CLV_NRD_NRD_1	447	449	PF00675	0.594
CLV_NRD_NRD_1	458	460	PF00675	0.465
CLV_NRD_NRD_1	490	492	PF00675	0.403
CLV_NRD_NRD_1	495	497	PF00675	0.535
CLV_PCSK_KEX2_1	260	262	PF00082	0.499
CLV_PCSK_KEX2_1	339	341	PF00082	0.503
CLV_PCSK_KEX2_1	447	449	PF00082	0.594
CLV_PCSK_KEX2_1	458	460	PF00082	0.465
CLV_PCSK_KEX2_1	490	492	PF00082	0.448
CLV_PCSK_KEX2_1	495	497	PF00082	0.535
CLV_PCSK_PC7_1	491	497	PF00082	0.520
CLV_PCSK_SKI1_1	153	157	PF00082	0.635
CLV_PCSK_SKI1_1	447	451	PF00082	0.608
CLV_PCSK_SKI1_1	71	75	PF00082	0.542
DEG_APCC_DBOX_1	105	113	PF00400	0.660
DOC_CYCLIN_RxL_1	68	78	PF00134	0.570
DOC_MAPK_MEF2A_6	304	312	PF00069	0.452
DOC_MAPK_MEF2A_6	313	320	PF00069	0.450
DOC_PP1_RVXF_1	193	199	PF00149	0.472
DOC_PP4_FxxP_1	113	116	PF00568	0.584
DOC_PP4_FxxP_1	38	41	PF00568	0.564
DOC_PP4_FxxP_1	509	512	PF00568	0.520
DOC_USP7_MATH_1	116	120	PF00917	0.721
DOC_USP7_MATH_1	16	20	PF00917	0.733
DOC_USP7_MATH_1	167	171	PF00917	0.605
DOC_USP7_MATH_1	208	212	PF00917	0.615
DOC_USP7_MATH_1	324	328	PF00917	0.607
DOC_USP7_MATH_1	371	375	PF00917	0.628
DOC_USP7_MATH_1	424	428	PF00917	0.666
DOC_USP7_MATH_1	60	64	PF00917	0.706
DOC_USP7_MATH_1	88	92	PF00917	0.740
DOC_USP7_UBL2_3	17	21	PF12436	0.569
DOC_WW_Pin1_4	11	16	PF00397	0.691
DOC_WW_Pin1_4	114	119	PF00397	0.609
DOC_WW_Pin1_4	134	139	PF00397	0.565
DOC_WW_Pin1_4	168	173	PF00397	0.591
DOC_WW_Pin1_4	3	8	PF00397	0.644
DOC_WW_Pin1_4	37	42	PF00397	0.704
DOC_WW_Pin1_4	375	380	PF00397	0.673
LIG_14-3-3_CanoR_1	260	268	PF00244	0.494
LIG_14-3-3_CanoR_1	313	319	PF00244	0.484
LIG_14-3-3_CanoR_1	339	346	PF00244	0.481
LIG_14-3-3_CanoR_1	372	381	PF00244	0.618
LIG_14-3-3_CanoR_1	428	436	PF00244	0.669
LIG_14-3-3_CanoR_1	447	453	PF00244	0.706
LIG_14-3-3_CanoR_1	495	503	PF00244	0.621
LIG_14-3-3_CanoR_1	98	108	PF00244	0.615
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_BIR_III_2	376	380	PF00653	0.653
LIG_BRCT_BRCA1_1	178	182	PF00533	0.586
LIG_BRCT_BRCA1_1	201	205	PF00533	0.611
LIG_BRCT_BRCA1_1	210	214	PF00533	0.514
LIG_BRCT_BRCA1_1	262	266	PF00533	0.345
LIG_BRCT_BRCA1_1	90	94	PF00533	0.627
LIG_deltaCOP1_diTrp_1	231	240	PF00928	0.479
LIG_FHA_1	339	345	PF00498	0.564
LIG_FHA_1	346	352	PF00498	0.448
LIG_FHA_1	448	454	PF00498	0.652
LIG_FHA_1	84	90	PF00498	0.594
LIG_FHA_2	154	160	PF00498	0.637
LIG_FHA_2	236	242	PF00498	0.482
LIG_FHA_2	351	357	PF00498	0.498
LIG_FHA_2	47	53	PF00498	0.567
LIG_FHA_2	63	69	PF00498	0.608
LIG_GBD_Chelix_1	480	488	PF00786	0.440
LIG_LIR_Apic_2	111	116	PF02991	0.579
LIG_LIR_Apic_2	36	41	PF02991	0.568
LIG_LIR_Apic_2	507	512	PF02991	0.522
LIG_LIR_Gen_1	402	412	PF02991	0.550
LIG_LIR_Nem_3	179	185	PF02991	0.584
LIG_LIR_Nem_3	402	408	PF02991	0.531
LIG_SH2_CRK	84	88	PF00017	0.554
LIG_SH2_NCK_1	352	356	PF00017	0.500
LIG_SH2_NCK_1	84	88	PF00017	0.554
LIG_SH2_STAT3	185	188	PF00017	0.637
LIG_SH2_STAT3	298	301	PF00017	0.524
LIG_SH2_STAT5	270	273	PF00017	0.480
LIG_SH2_STAT5	352	355	PF00017	0.424
LIG_SH2_STAT5	483	486	PF00017	0.486
LIG_SH2_STAT5	76	79	PF00017	0.545
LIG_SH3_3	12	18	PF00018	0.692
LIG_SH3_3	160	166	PF00018	0.555
LIG_SH3_3	38	44	PF00018	0.740
LIG_SH3_3	500	506	PF00018	0.670
LIG_SH3_3	54	60	PF00018	0.562
LIG_SH3_4	17	24	PF00018	0.571
LIG_TRAF2_1	65	68	PF00917	0.639
LIG_WRC_WIRS_1	35	40	PF05994	0.570
LIG_WW_3	58	62	PF00397	0.627
MOD_CDC14_SPxK_1	14	17	PF00782	0.653
MOD_CDK_SPxK_1	11	17	PF00069	0.664
MOD_CDK_SPxxK_3	3	10	PF00069	0.558
MOD_CK1_1	121	127	PF00069	0.653
MOD_CK1_1	145	151	PF00069	0.644
MOD_CK1_1	154	160	PF00069	0.700
MOD_CK1_1	171	177	PF00069	0.484
MOD_CK1_1	206	212	PF00069	0.605
MOD_CK1_1	33	39	PF00069	0.678
MOD_CK1_1	375	381	PF00069	0.535
MOD_CK1_1	40	46	PF00069	0.687
MOD_CK1_1	6	12	PF00069	0.656
MOD_CK1_1	63	69	PF00069	0.753
MOD_CK2_1	114	120	PF00069	0.632
MOD_CK2_1	153	159	PF00069	0.636
MOD_CK2_1	180	186	PF00069	0.583
MOD_CK2_1	235	241	PF00069	0.513
MOD_CK2_1	350	356	PF00069	0.495
MOD_CK2_1	470	476	PF00069	0.471
MOD_CK2_1	62	68	PF00069	0.762
MOD_GlcNHglycan	120	123	PF01048	0.712
MOD_GlcNHglycan	127	130	PF01048	0.697
MOD_GlcNHglycan	145	148	PF01048	0.554
MOD_GlcNHglycan	18	21	PF01048	0.714
MOD_GlcNHglycan	201	204	PF01048	0.615
MOD_GlcNHglycan	206	209	PF01048	0.537
MOD_GlcNHglycan	247	250	PF01048	0.646
MOD_GlcNHglycan	252	255	PF01048	0.712
MOD_GlcNHglycan	262	265	PF01048	0.362
MOD_GlcNHglycan	422	425	PF01048	0.644
MOD_GlcNHglycan	428	431	PF01048	0.837
MOD_GlcNHglycan	90	93	PF01048	0.623
MOD_GSK3_1	114	121	PF00069	0.668
MOD_GSK3_1	167	174	PF00069	0.627
MOD_GSK3_1	176	183	PF00069	0.489
MOD_GSK3_1	199	206	PF00069	0.610
MOD_GSK3_1	232	239	PF00069	0.472
MOD_GSK3_1	256	263	PF00069	0.513
MOD_GSK3_1	30	37	PF00069	0.656
MOD_GSK3_1	320	327	PF00069	0.570
MOD_GSK3_1	338	345	PF00069	0.461
MOD_GSK3_1	350	357	PF00069	0.388
MOD_GSK3_1	371	378	PF00069	0.539
MOD_GSK3_1	416	423	PF00069	0.630
MOD_GSK3_1	42	49	PF00069	0.674
MOD_GSK3_1	424	431	PF00069	0.601
MOD_GSK3_1	490	497	PF00069	0.587
MOD_GSK3_1	59	66	PF00069	0.676
MOD_LATS_1	28	34	PF00433	0.624
MOD_LATS_1	445	451	PF00433	0.615
MOD_N-GLC_1	175	180	PF02516	0.494
MOD_NEK2_1	125	130	PF00069	0.723
MOD_NEK2_1	320	325	PF00069	0.698
MOD_NEK2_1	354	359	PF00069	0.510
MOD_NEK2_1	401	406	PF00069	0.426
MOD_NEK2_1	420	425	PF00069	0.583
MOD_NEK2_1	83	88	PF00069	0.752
MOD_NEK2_2	108	113	PF00069	0.592
MOD_PIKK_1	270	276	PF00454	0.427
MOD_PIKK_1	30	36	PF00454	0.683
MOD_PIKK_1	99	105	PF00454	0.551
MOD_PKA_1	260	266	PF00069	0.472
MOD_PKA_1	447	453	PF00069	0.509
MOD_PKA_1	490	496	PF00069	0.528
MOD_PKA_2	203	209	PF00069	0.600
MOD_PKA_2	260	266	PF00069	0.502
MOD_PKA_2	338	344	PF00069	0.523
MOD_PKA_2	371	377	PF00069	0.642
MOD_PKA_2	447	453	PF00069	0.594
MOD_PKA_2	470	476	PF00069	0.565
MOD_PKA_2	490	496	PF00069	0.371
MOD_PKA_2	60	66	PF00069	0.695
MOD_PKA_2	97	103	PF00069	0.654
MOD_Plk_1	416	422	PF00069	0.641
MOD_Plk_1	69	75	PF00069	0.474
MOD_Plk_4	108	114	PF00069	0.597
MOD_Plk_4	401	407	PF00069	0.435
MOD_Plk_4	448	454	PF00069	0.568
MOD_ProDKin_1	11	17	PF00069	0.690
MOD_ProDKin_1	114	120	PF00069	0.609
MOD_ProDKin_1	134	140	PF00069	0.567
MOD_ProDKin_1	168	174	PF00069	0.589
MOD_ProDKin_1	3	9	PF00069	0.644
MOD_ProDKin_1	37	43	PF00069	0.703
MOD_ProDKin_1	375	381	PF00069	0.674
TRG_DiLeu_BaEn_1	136	141	PF01217	0.584
TRG_DiLeu_BaEn_2	394	400	PF01217	0.441
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.620
TRG_ENDOCYTIC_2	84	87	PF00928	0.555
TRG_ER_diArg_1	490	492	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P648	Leptomonas seymouri	33%	100%
A0A3S7WZS1	Leishmania donovani	89%	91%
A4HEW3	Leishmania braziliensis	67%	92%
A4I236	Leishmania infantum	89%	91%
E9AY86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	91%