Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q985_LEIMA

TriTrypDb:

LmjF.26.1090 , LMJLV39_260016600 , LMJSD75_260015000

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q985

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q985

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.489
CLV_C14_Caspase3-7	93	97	PF00656	0.688
CLV_NRD_NRD_1	88	90	PF00675	0.770
CLV_PCSK_KEX2_1	88	90	PF00082	0.770
CLV_PCSK_SKI1_1	16	20	PF00082	0.663
CLV_PCSK_SKI1_1	269	273	PF00082	0.425
CLV_PCSK_SKI1_1	28	32	PF00082	0.692
CLV_PCSK_SKI1_1	403	407	PF00082	0.444
DEG_SPOP_SBC_1	194	198	PF00917	0.643
DOC_CDC14_PxL_1	243	251	PF14671	0.450
DOC_CKS1_1	220	225	PF01111	0.602
DOC_CKS1_1	45	50	PF01111	0.790
DOC_CYCLIN_RxL_1	13	21	PF00134	0.656
DOC_CYCLIN_RxL_1	207	218	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	158	164	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.671
DOC_PP1_RVXF_1	208	215	PF00149	0.529
DOC_PP2B_LxvP_1	183	186	PF13499	0.690
DOC_PP2B_LxvP_1	313	316	PF13499	0.525
DOC_PP4_FxxP_1	31	34	PF00568	0.700
DOC_USP7_MATH_1	133	137	PF00917	0.549
DOC_USP7_MATH_1	178	182	PF00917	0.713
DOC_USP7_MATH_1	194	198	PF00917	0.641
DOC_USP7_MATH_1	342	346	PF00917	0.499
DOC_USP7_MATH_1	363	367	PF00917	0.373
DOC_USP7_MATH_1	420	424	PF00917	0.553
DOC_USP7_MATH_1	56	60	PF00917	0.702
DOC_WW_Pin1_4	111	116	PF00397	0.649
DOC_WW_Pin1_4	196	201	PF00397	0.605
DOC_WW_Pin1_4	219	224	PF00397	0.605
DOC_WW_Pin1_4	280	285	PF00397	0.601
DOC_WW_Pin1_4	290	295	PF00397	0.385
DOC_WW_Pin1_4	44	49	PF00397	0.759
LIG_14-3-3_CanoR_1	138	143	PF00244	0.519
LIG_14-3-3_CanoR_1	210	215	PF00244	0.467
LIG_14-3-3_CanoR_1	298	307	PF00244	0.522
LIG_14-3-3_CanoR_1	61	71	PF00244	0.685
LIG_14-3-3_CanoR_1	72	82	PF00244	0.655
LIG_Actin_WH2_2	372	388	PF00022	0.388
LIG_APCC_ABBA_1	297	302	PF00400	0.422
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_eIF4E_1	356	362	PF01652	0.474
LIG_EVH1_1	31	35	PF00568	0.492
LIG_FHA_1	152	158	PF00498	0.386
LIG_FHA_1	308	314	PF00498	0.527
LIG_FHA_1	334	340	PF00498	0.522
LIG_FHA_1	374	380	PF00498	0.503
LIG_FHA_2	220	226	PF00498	0.592
LIG_FHA_2	246	252	PF00498	0.679
LIG_FHA_2	342	348	PF00498	0.442
LIG_FHA_2	45	51	PF00498	0.749
LIG_FXI_DFP_1	300	304	PF00024	0.455
LIG_GBD_Chelix_1	413	421	PF00786	0.533
LIG_HP1_1	371	375	PF01393	0.438
LIG_LIR_Apic_2	199	205	PF02991	0.568
LIG_LIR_Apic_2	29	34	PF02991	0.628
LIG_LIR_Gen_1	136	147	PF02991	0.558
LIG_LIR_Gen_1	416	422	PF02991	0.541
LIG_LIR_Nem_3	136	142	PF02991	0.563
LIG_LIR_Nem_3	312	317	PF02991	0.540
LIG_LIR_Nem_3	416	421	PF02991	0.531
LIG_LIR_Nem_3	68	74	PF02991	0.597
LIG_NRBOX	14	20	PF00104	0.660
LIG_NRBOX	287	293	PF00104	0.425
LIG_NRBOX	356	362	PF00104	0.474
LIG_Pex14_1	139	143	PF04695	0.551
LIG_Pex14_2	303	307	PF04695	0.393
LIG_PTAP_UEV_1	152	157	PF05743	0.495
LIG_SH2_CRK	112	116	PF00017	0.705
LIG_SH2_CRK	118	122	PF00017	0.579
LIG_SH2_CRK	71	75	PF00017	0.608
LIG_SH2_GRB2like	356	359	PF00017	0.549
LIG_SH2_STAT3	229	232	PF00017	0.532
LIG_SH2_STAT5	130	133	PF00017	0.468
LIG_SH2_STAT5	148	151	PF00017	0.360
LIG_SH2_STAT5	356	359	PF00017	0.561
LIG_SH3_1	150	156	PF00018	0.511
LIG_SH3_2	35	40	PF14604	0.604
LIG_SH3_3	150	156	PF00018	0.472
LIG_SH3_3	29	35	PF00018	0.667
LIG_SH3_3	45	51	PF00018	0.780
LIG_SUMO_SIM_par_1	269	275	PF11976	0.392
LIG_SUMO_SIM_par_1	370	376	PF11976	0.386
LIG_UBA3_1	287	295	PF00899	0.548
MOD_CDK_SPK_2	290	295	PF00069	0.473
MOD_CK1_1	181	187	PF00069	0.765
MOD_CK1_1	196	202	PF00069	0.582
MOD_CK1_1	345	351	PF00069	0.545
MOD_CK1_1	65	71	PF00069	0.658
MOD_CK2_1	219	225	PF00069	0.602
MOD_CK2_1	280	286	PF00069	0.552
MOD_CK2_1	341	347	PF00069	0.439
MOD_GlcNHglycan	183	186	PF01048	0.725
MOD_GlcNHglycan	347	350	PF01048	0.421
MOD_GlcNHglycan	56	59	PF01048	0.690
MOD_GlcNHglycan	64	67	PF01048	0.621
MOD_GlcNHglycan	75	78	PF01048	0.461
MOD_GlcNHglycan	99	104	PF01048	0.772
MOD_GSK3_1	129	136	PF00069	0.515
MOD_GSK3_1	177	184	PF00069	0.731
MOD_GSK3_1	341	348	PF00069	0.469
MOD_GSK3_1	50	57	PF00069	0.682
MOD_GSK3_1	91	98	PF00069	0.679
MOD_N-GLC_1	10	15	PF02516	0.670
MOD_N-GLC_1	181	186	PF02516	0.530
MOD_N-GLC_1	342	347	PF02516	0.548
MOD_NEK2_1	126	131	PF00069	0.504
MOD_NEK2_1	18	23	PF00069	0.654
MOD_NEK2_1	237	242	PF00069	0.525
MOD_NEK2_1	341	346	PF00069	0.518
MOD_NEK2_1	351	356	PF00069	0.436
MOD_NEK2_1	421	426	PF00069	0.579
MOD_NEK2_1	73	78	PF00069	0.666
MOD_NEK2_2	333	338	PF00069	0.467
MOD_PIKK_1	262	268	PF00454	0.658
MOD_PIKK_1	421	427	PF00454	0.580
MOD_PIKK_1	91	97	PF00454	0.686
MOD_Plk_1	10	16	PF00069	0.671
MOD_Plk_1	126	132	PF00069	0.582
MOD_Plk_1	342	348	PF00069	0.542
MOD_Plk_4	126	132	PF00069	0.500
MOD_Plk_4	138	144	PF00069	0.333
MOD_Plk_4	210	216	PF00069	0.461
MOD_Plk_4	321	327	PF00069	0.459
MOD_Plk_4	352	358	PF00069	0.483
MOD_ProDKin_1	111	117	PF00069	0.635
MOD_ProDKin_1	196	202	PF00069	0.590
MOD_ProDKin_1	219	225	PF00069	0.603
MOD_ProDKin_1	280	286	PF00069	0.599
MOD_ProDKin_1	290	296	PF00069	0.378
MOD_ProDKin_1	44	50	PF00069	0.757
MOD_SUMO_rev_2	219	228	PF00179	0.574
TRG_DiLeu_BaEn_1	347	352	PF01217	0.450
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.492
TRG_ENDOCYTIC_2	418	421	PF00928	0.536
TRG_ENDOCYTIC_2	71	74	PF00928	0.604
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7E4	Leptomonas seymouri	42%	91%
A0A1X0NTZ3	Trypanosomatidae	31%	100%
A0A3Q8ICX1	Leishmania donovani	91%	100%
A0A3R7L6E6	Trypanosoma rangeli	30%	100%
A4HEW5	Leishmania braziliensis	74%	86%
A4I238	Leishmania infantum	91%	100%
C9ZRW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AY88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%