Axonemal_dynein_light_chain_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

axonemal dynein light chain, putative

Species:

Leishmania major

UniProt:

Q4Q982_LEIMA

TriTrypDb:

LmjF.26.1120 , LMJLV39_260016900 , LMJSD75_260015300

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q982

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q982

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.647
CLV_C14_Caspase3-7	246	250	PF00656	0.675
CLV_MEL_PAP_1	89	95	PF00089	0.651
CLV_NRD_NRD_1	290	292	PF00675	0.322
CLV_NRD_NRD_1	31	33	PF00675	0.583
CLV_NRD_NRD_1	311	313	PF00675	0.320
CLV_NRD_NRD_1	380	382	PF00675	0.315
CLV_NRD_NRD_1	405	407	PF00675	0.315
CLV_NRD_NRD_1	431	433	PF00675	0.345
CLV_PCSK_KEX2_1	290	292	PF00082	0.322
CLV_PCSK_KEX2_1	311	313	PF00082	0.320
CLV_PCSK_KEX2_1	404	406	PF00082	0.315
CLV_PCSK_KEX2_1	422	424	PF00082	0.315
CLV_PCSK_KEX2_1	443	445	PF00082	0.395
CLV_PCSK_KEX2_1	454	456	PF00082	0.457
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.315
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.395
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.457
CLV_PCSK_SKI1_1	341	345	PF00082	0.333
CLV_PCSK_SKI1_1	350	354	PF00082	0.315
DEG_SCF_FBW7_1	259	264	PF00400	0.646
DOC_CYCLIN_RxL_1	347	356	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.594
DOC_PP2B_LxvP_1	259	262	PF13499	0.552
DOC_PP4_FxxP_1	41	44	PF00568	0.603
DOC_USP7_MATH_1	104	108	PF00917	0.709
DOC_USP7_MATH_1	113	117	PF00917	0.633
DOC_USP7_MATH_1	196	200	PF00917	0.614
DOC_USP7_MATH_1	210	214	PF00917	0.564
DOC_USP7_MATH_1	314	318	PF00917	0.294
DOC_WW_Pin1_4	115	120	PF00397	0.787
DOC_WW_Pin1_4	139	144	PF00397	0.572
DOC_WW_Pin1_4	147	152	PF00397	0.580
DOC_WW_Pin1_4	257	262	PF00397	0.701
DOC_WW_Pin1_4	265	270	PF00397	0.568
DOC_WW_Pin1_4	282	287	PF00397	0.543
LIG_14-3-3_CanoR_1	280	286	PF00244	0.556
LIG_14-3-3_CanoR_1	341	346	PF00244	0.347
LIG_14-3-3_CanoR_1	381	388	PF00244	0.327
LIG_14-3-3_CanoR_1	409	417	PF00244	0.268
LIG_Actin_RPEL_3	352	371	PF02755	0.395
LIG_APCC_ABBAyCdc20_2	328	334	PF00400	0.315
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BIR_III_1	1	5	PF00653	0.562
LIG_BIR_III_3	1	5	PF00653	0.562
LIG_Clathr_ClatBox_1	230	234	PF01394	0.625
LIG_FHA_1	104	110	PF00498	0.679
LIG_FHA_1	143	149	PF00498	0.609
LIG_FHA_1	18	24	PF00498	0.498
LIG_FHA_1	202	208	PF00498	0.662
LIG_FHA_1	258	264	PF00498	0.733
LIG_FHA_1	265	271	PF00498	0.590
LIG_FHA_1	283	289	PF00498	0.325
LIG_FHA_1	365	371	PF00498	0.318
LIG_FHA_2	382	388	PF00498	0.315
LIG_FHA_2	395	401	PF00498	0.315
LIG_LIR_Apic_2	39	44	PF02991	0.602
LIG_LIR_Gen_1	366	375	PF02991	0.315
LIG_LIR_Gen_1	8	18	PF02991	0.510
LIG_LIR_Nem_3	15	21	PF02991	0.504
LIG_LIR_Nem_3	366	371	PF02991	0.315
LIG_LIR_Nem_3	8	13	PF02991	0.516
LIG_PCNA_yPIPBox_3	328	340	PF02747	0.395
LIG_Pex14_1	413	417	PF04695	0.315
LIG_Rb_LxCxE_1	344	360	PF01857	0.334
LIG_SH2_CRK	18	22	PF00017	0.506
LIG_SH2_CRK	368	372	PF00017	0.315
LIG_SH2_CRK	417	421	PF00017	0.315
LIG_SH2_STAP1	368	372	PF00017	0.315
LIG_SH2_STAP1	441	445	PF00017	0.315
LIG_SH2_STAP1	47	51	PF00017	0.500
LIG_SH2_STAT5	185	188	PF00017	0.625
LIG_SH2_STAT5	391	394	PF00017	0.320
LIG_SH2_STAT5	65	68	PF00017	0.567
LIG_SH3_2	110	115	PF14604	0.693
LIG_SH3_3	106	112	PF00018	0.635
LIG_SH3_3	145	151	PF00018	0.534
LIG_SH3_3	320	326	PF00018	0.345
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.319
LIG_TRAF2_1	232	235	PF00917	0.502
LIG_TYR_ITIM	16	21	PF00017	0.503
LIG_TYR_ITIM	304	309	PF00017	0.315
MOD_CK1_1	142	148	PF00069	0.624
MOD_CK1_1	199	205	PF00069	0.773
MOD_CK1_1	219	225	PF00069	0.691
MOD_CK1_1	264	270	PF00069	0.763
MOD_CK1_1	272	278	PF00069	0.514
MOD_CK1_1	94	100	PF00069	0.654
MOD_CK2_1	147	153	PF00069	0.713
MOD_CK2_1	159	165	PF00069	0.592
MOD_CK2_1	394	400	PF00069	0.345
MOD_CK2_1	5	11	PF00069	0.609
MOD_DYRK1A_RPxSP_1	115	119	PF00069	0.756
MOD_DYRK1A_RPxSP_1	147	151	PF00069	0.532
MOD_GlcNHglycan	101	104	PF01048	0.753
MOD_GlcNHglycan	106	109	PF01048	0.675
MOD_GlcNHglycan	128	131	PF01048	0.656
MOD_GlcNHglycan	136	139	PF01048	0.686
MOD_GlcNHglycan	201	204	PF01048	0.667
MOD_GlcNHglycan	218	221	PF01048	0.515
MOD_GlcNHglycan	244	248	PF01048	0.683
MOD_GlcNHglycan	263	266	PF01048	0.683
MOD_GlcNHglycan	316	319	PF01048	0.315
MOD_GlcNHglycan	373	376	PF01048	0.315
MOD_GlcNHglycan	74	77	PF01048	0.556
MOD_GlcNHglycan	94	97	PF01048	0.664
MOD_GSK3_1	115	122	PF00069	0.667
MOD_GSK3_1	197	204	PF00069	0.693
MOD_GSK3_1	239	246	PF00069	0.710
MOD_GSK3_1	257	264	PF00069	0.736
MOD_GSK3_1	265	272	PF00069	0.677
MOD_GSK3_1	278	285	PF00069	0.475
MOD_GSK3_1	394	401	PF00069	0.378
MOD_GSK3_1	91	98	PF00069	0.708
MOD_GSK3_1	99	106	PF00069	0.507
MOD_N-GLC_1	171	176	PF02516	0.587
MOD_NEK2_1	17	22	PF00069	0.487
MOD_NEK2_1	263	268	PF00069	0.617
MOD_NEK2_1	357	362	PF00069	0.291
MOD_NEK2_1	371	376	PF00069	0.391
MOD_PIKK_1	178	184	PF00454	0.562
MOD_PKA_1	381	387	PF00069	0.315
MOD_PKA_2	211	217	PF00069	0.768
MOD_PKA_2	314	320	PF00069	0.313
MOD_PKA_2	380	386	PF00069	0.326
MOD_PKA_2	408	414	PF00069	0.299
MOD_PKA_2	91	97	PF00069	0.671
MOD_PKA_2	99	105	PF00069	0.530
MOD_Plk_1	152	158	PF00069	0.607
MOD_Plk_1	57	63	PF00069	0.468
MOD_Plk_2-3	5	11	PF00069	0.609
MOD_Plk_4	12	18	PF00069	0.501
MOD_Plk_4	341	347	PF00069	0.425
MOD_ProDKin_1	115	121	PF00069	0.790
MOD_ProDKin_1	139	145	PF00069	0.574
MOD_ProDKin_1	147	153	PF00069	0.581
MOD_ProDKin_1	257	263	PF00069	0.699
MOD_ProDKin_1	265	271	PF00069	0.566
MOD_ProDKin_1	282	288	PF00069	0.539
MOD_SUMO_rev_2	245	255	PF00179	0.644
MOD_SUMO_rev_2	426	434	PF00179	0.315
MOD_SUMO_rev_2	451	456	PF00179	0.395
TRG_DiLeu_BaEn_1	349	354	PF01217	0.315
TRG_ENDOCYTIC_2	10	13	PF00928	0.514
TRG_ENDOCYTIC_2	18	21	PF00928	0.503
TRG_ENDOCYTIC_2	306	309	PF00928	0.315
TRG_ENDOCYTIC_2	368	371	PF00928	0.315
TRG_ENDOCYTIC_2	417	420	PF00928	0.315
TRG_ER_diArg_1	289	291	PF00400	0.322
TRG_ER_diArg_1	403	406	PF00400	0.315
TRG_ER_diLys_1	462	466	PF00400	0.635
TRG_NES_CRM1_1	11	27	PF08389	0.576
TRG_NES_CRM1_1	334	349	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	337	342	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P322	Leptomonas seymouri	46%	94%
A0A3S7WZS2	Leishmania donovani	92%	100%
A4HEW7	Leishmania braziliensis	73%	98%
A4I241	Leishmania infantum	93%	100%
E9AY91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%