RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania major

UniProt:

Q4Q980_LEIMA

TriTrypDb:

LmjF.26.1140 , LMJLV39_260017100 , LMJSD75_260015500

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q980

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q980

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0009895	negative regulation of catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016553	base conversion or substitution editing	6	2
GO:0016554	cytidine to uridine editing	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031330	negative regulation of cellular catabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0043489	RNA stabilization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048255	mRNA stabilization	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1902369	negative regulation of RNA catabolic process	7	2
GO:1902373	negative regulation of mRNA catabolic process	7	2
GO:1903311	regulation of mRNA metabolic process	6	2
GO:1903312	negative regulation of mRNA metabolic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.357
CLV_NRD_NRD_1	225	227	PF00675	0.351
CLV_NRD_NRD_1	286	288	PF00675	0.436
CLV_NRD_NRD_1	297	299	PF00675	0.369
CLV_NRD_NRD_1	306	308	PF00675	0.391
CLV_NRD_NRD_1	363	365	PF00675	0.345
CLV_NRD_NRD_1	61	63	PF00675	0.655
CLV_PCSK_KEX2_1	192	194	PF00082	0.357
CLV_PCSK_KEX2_1	225	227	PF00082	0.351
CLV_PCSK_KEX2_1	286	288	PF00082	0.449
CLV_PCSK_KEX2_1	297	299	PF00082	0.291
CLV_PCSK_KEX2_1	306	308	PF00082	0.391
CLV_PCSK_KEX2_1	492	494	PF00082	0.453
CLV_PCSK_KEX2_1	61	63	PF00082	0.629
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.453
CLV_PCSK_SKI1_1	163	167	PF00082	0.530
CLV_PCSK_SKI1_1	217	221	PF00082	0.369
CLV_PCSK_SKI1_1	260	264	PF00082	0.379
CLV_PCSK_SKI1_1	281	285	PF00082	0.386
CLV_PCSK_SKI1_1	298	302	PF00082	0.354
CLV_PCSK_SKI1_1	411	415	PF00082	0.652
CLV_PCSK_SKI1_1	495	499	PF00082	0.413
CLV_Separin_Metazoa	222	226	PF03568	0.367
DEG_APCC_DBOX_1	297	305	PF00400	0.343
DEG_APCC_DBOX_1	419	427	PF00400	0.403
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DEG_SPOP_SBC_1	39	43	PF00917	0.712
DOC_CKS1_1	211	216	PF01111	0.390
DOC_CYCLIN_RxL_1	257	268	PF00134	0.494
DOC_MAPK_gen_1	364	371	PF00069	0.351
DOC_MAPK_HePTP_8	467	479	PF00069	0.464
DOC_MAPK_MEF2A_6	364	373	PF00069	0.367
DOC_MAPK_MEF2A_6	470	479	PF00069	0.510
DOC_PP2B_LxvP_1	109	112	PF13499	0.556
DOC_PP4_FxxP_1	315	318	PF00568	0.358
DOC_PP4_MxPP_1	332	335	PF00568	0.493
DOC_USP7_MATH_1	24	28	PF00917	0.684
DOC_USP7_MATH_1	336	340	PF00917	0.512
DOC_USP7_MATH_1	34	38	PF00917	0.760
DOC_USP7_MATH_1	460	464	PF00917	0.392
DOC_USP7_MATH_1	50	54	PF00917	0.587
DOC_USP7_UBL2_3	525	529	PF12436	0.516
DOC_WW_Pin1_4	176	181	PF00397	0.451
DOC_WW_Pin1_4	20	25	PF00397	0.709
DOC_WW_Pin1_4	210	215	PF00397	0.403
DOC_WW_Pin1_4	330	335	PF00397	0.381
DOC_WW_Pin1_4	349	354	PF00397	0.363
DOC_WW_Pin1_4	65	70	PF00397	0.688
DOC_WW_Pin1_4	96	101	PF00397	0.590
LIG_14-3-3_CanoR_1	17	25	PF00244	0.715
LIG_14-3-3_CanoR_1	192	196	PF00244	0.358
LIG_14-3-3_CanoR_1	217	222	PF00244	0.364
LIG_14-3-3_CanoR_1	380	387	PF00244	0.334
LIG_14-3-3_CanoR_1	495	500	PF00244	0.551
LIG_14-3-3_CanoR_1	61	71	PF00244	0.657
LIG_Actin_RPEL_3	219	238	PF02755	0.365
LIG_Clathr_ClatBox_1	368	372	PF01394	0.448
LIG_FHA_1	111	117	PF00498	0.472
LIG_FHA_1	165	171	PF00498	0.420
LIG_FHA_1	218	224	PF00498	0.370
LIG_FHA_1	240	246	PF00498	0.344
LIG_FHA_1	291	297	PF00498	0.392
LIG_FHA_1	303	309	PF00498	0.434
LIG_FHA_1	33	39	PF00498	0.760
LIG_FHA_1	343	349	PF00498	0.405
LIG_FHA_1	439	445	PF00498	0.432
LIG_FHA_1	467	473	PF00498	0.449
LIG_FHA_2	143	149	PF00498	0.632
LIG_FHA_2	164	170	PF00498	0.526
LIG_FHA_2	326	332	PF00498	0.362
LIG_FHA_2	350	356	PF00498	0.381
LIG_FHA_2	381	387	PF00498	0.496
LIG_FHA_2	79	85	PF00498	0.718
LIG_LIR_Apic_2	205	209	PF02991	0.499
LIG_LIR_Apic_2	314	318	PF02991	0.365
LIG_LIR_Apic_2	56	60	PF02991	0.556
LIG_LIR_Gen_1	22	33	PF02991	0.682
LIG_LIR_Gen_1	401	408	PF02991	0.447
LIG_LIR_Nem_3	22	28	PF02991	0.678
LIG_LIR_Nem_3	401	406	PF02991	0.428
LIG_LIR_Nem_3	68	73	PF02991	0.630
LIG_LYPXL_yS_3	70	73	PF13949	0.635
LIG_NRBOX	504	510	PF00104	0.363
LIG_NRBOX	519	525	PF00104	0.355
LIG_SH2_CRK	212	216	PF00017	0.476
LIG_SH2_CRK	25	29	PF00017	0.668
LIG_SH2_CRK	403	407	PF00017	0.402
LIG_SH2_CRK	57	61	PF00017	0.715
LIG_SH2_NCK_1	267	271	PF00017	0.404
LIG_SH2_NCK_1	403	407	PF00017	0.421
LIG_SH2_STAP1	197	201	PF00017	0.336
LIG_SH2_STAP1	25	29	PF00017	0.668
LIG_SH2_STAT5	212	215	PF00017	0.411
LIG_SH2_STAT5	239	242	PF00017	0.328
LIG_SH2_STAT5	327	330	PF00017	0.349
LIG_SH2_STAT5	458	461	PF00017	0.365
LIG_SH3_3	228	234	PF00018	0.487
LIG_SH3_3	68	74	PF00018	0.640
LIG_SH3_3	80	86	PF00018	0.755
LIG_SUMO_SIM_anti_2	166	174	PF11976	0.517
LIG_SUMO_SIM_anti_2	220	225	PF11976	0.375
LIG_SUMO_SIM_par_1	217	222	PF11976	0.380
LIG_SUMO_SIM_par_1	394	401	PF11976	0.430
LIG_TRAF2_1	352	355	PF00917	0.511
LIG_TYR_ITSM	21	28	PF00017	0.657
LIG_TYR_ITSM	399	406	PF00017	0.453
MOD_CDK_SPxxK_3	210	217	PF00069	0.407
MOD_CK1_1	20	26	PF00069	0.711
MOD_CK1_1	37	43	PF00069	0.599
MOD_CK1_1	398	404	PF00069	0.484
MOD_CK1_1	463	469	PF00069	0.401
MOD_CK1_1	53	59	PF00069	0.611
MOD_CK1_1	65	71	PF00069	0.685
MOD_CK1_1	99	105	PF00069	0.639
MOD_CK2_1	142	148	PF00069	0.428
MOD_CK2_1	151	157	PF00069	0.563
MOD_CK2_1	163	169	PF00069	0.521
MOD_CK2_1	349	355	PF00069	0.383
MOD_CK2_1	380	386	PF00069	0.512
MOD_CK2_1	78	84	PF00069	0.754
MOD_Cter_Amidation	490	493	PF01082	0.486
MOD_GlcNHglycan	101	104	PF01048	0.612
MOD_GlcNHglycan	19	22	PF01048	0.631
MOD_GlcNHglycan	393	396	PF01048	0.461
MOD_GlcNHglycan	408	411	PF01048	0.657
MOD_GlcNHglycan	65	68	PF01048	0.677
MOD_GlcNHglycan	74	77	PF01048	0.668
MOD_GSK3_1	107	114	PF00069	0.534
MOD_GSK3_1	121	128	PF00069	0.390
MOD_GSK3_1	16	23	PF00069	0.679
MOD_GSK3_1	239	246	PF00069	0.346
MOD_GSK3_1	33	40	PF00069	0.564
MOD_GSK3_1	391	398	PF00069	0.467
MOD_GSK3_1	49	56	PF00069	0.630
MOD_GSK3_1	90	97	PF00069	0.750
MOD_LATS_1	15	21	PF00433	0.727
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	191	196	PF00069	0.354
MOD_NEK2_1	238	243	PF00069	0.327
MOD_NEK2_1	258	263	PF00069	0.209
MOD_NEK2_1	282	287	PF00069	0.389
MOD_NEK2_1	38	43	PF00069	0.703
MOD_NEK2_1	391	396	PF00069	0.467
MOD_NEK2_2	197	202	PF00069	0.359
MOD_NEK2_2	395	400	PF00069	0.335
MOD_PIKK_1	357	363	PF00454	0.439
MOD_PKA_1	225	231	PF00069	0.507
MOD_PKA_2	16	22	PF00069	0.636
MOD_PKA_2	191	197	PF00069	0.352
MOD_PKA_2	225	231	PF00069	0.507
MOD_PKA_2	342	348	PF00069	0.404
MOD_PKA_2	404	410	PF00069	0.572
MOD_PKB_1	493	501	PF00069	0.418
MOD_Plk_1	258	264	PF00069	0.420
MOD_Plk_1	78	84	PF00069	0.651
MOD_Plk_4	24	30	PF00069	0.731
MOD_Plk_4	258	264	PF00069	0.430
MOD_Plk_4	316	322	PF00069	0.346
MOD_Plk_4	34	40	PF00069	0.632
MOD_Plk_4	463	469	PF00069	0.427
MOD_Plk_4	519	525	PF00069	0.478
MOD_Plk_4	78	84	PF00069	0.711
MOD_Plk_4	90	96	PF00069	0.654
MOD_ProDKin_1	176	182	PF00069	0.447
MOD_ProDKin_1	20	26	PF00069	0.712
MOD_ProDKin_1	210	216	PF00069	0.399
MOD_ProDKin_1	330	336	PF00069	0.384
MOD_ProDKin_1	349	355	PF00069	0.358
MOD_ProDKin_1	65	71	PF00069	0.686
MOD_ProDKin_1	96	102	PF00069	0.588
MOD_SUMO_rev_2	156	165	PF00179	0.387
TRG_DiLeu_BaEn_1	169	174	PF01217	0.397
TRG_DiLeu_BaEn_1	259	264	PF01217	0.512
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.472
TRG_ENDOCYTIC_2	212	215	PF00928	0.437
TRG_ENDOCYTIC_2	25	28	PF00928	0.755
TRG_ENDOCYTIC_2	267	270	PF00928	0.402
TRG_ENDOCYTIC_2	403	406	PF00928	0.396
TRG_ENDOCYTIC_2	70	73	PF00928	0.788
TRG_ER_diArg_1	191	193	PF00400	0.358
TRG_ER_diArg_1	224	226	PF00400	0.360
TRG_ER_diArg_1	296	298	PF00400	0.372
TRG_ER_diArg_1	306	308	PF00400	0.391
TRG_ER_diArg_1	493	496	PF00400	0.455
TRG_ER_diArg_1	60	62	PF00400	0.656
TRG_NES_CRM1_1	361	375	PF08389	0.459
TRG_NLS_MonoExtC_3	491	496	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGU4	Leptomonas seymouri	78%	94%
A0A0S4JSB1	Bodo saltans	57%	100%
A0A1X0NS86	Trypanosomatidae	68%	100%
A0A3Q8IDM7	Leishmania donovani	96%	100%
A0A422N6M4	Trypanosoma rangeli	63%	100%
A4HEW9	Leishmania braziliensis	88%	100%
A4I243	Leishmania infantum	96%	100%
C9ZRW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	99%
E9AY93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B995	Trypanosoma cruzi	65%	100%