Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q979_LEIMA

TriTrypDb:

LmjF.26.1150 , LMJLV39_260017200 , LMJSD75_260015600

Length:

769

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q979

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q979

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.604
CLV_C14_Caspase3-7	191	195	PF00656	0.586
CLV_C14_Caspase3-7	598	602	PF00656	0.548
CLV_C14_Caspase3-7	685	689	PF00656	0.576
CLV_C14_Caspase3-7	697	701	PF00656	0.612
CLV_C14_Caspase3-7	715	719	PF00656	0.455
CLV_NRD_NRD_1	267	269	PF00675	0.651
CLV_NRD_NRD_1	308	310	PF00675	0.726
CLV_NRD_NRD_1	4	6	PF00675	0.655
CLV_NRD_NRD_1	442	444	PF00675	0.564
CLV_NRD_NRD_1	49	51	PF00675	0.557
CLV_NRD_NRD_1	501	503	PF00675	0.557
CLV_NRD_NRD_1	582	584	PF00675	0.687
CLV_NRD_NRD_1	585	587	PF00675	0.626
CLV_NRD_NRD_1	759	761	PF00675	0.654
CLV_PCSK_FUR_1	582	586	PF00082	0.651
CLV_PCSK_KEX2_1	266	268	PF00082	0.663
CLV_PCSK_KEX2_1	3	5	PF00082	0.654
CLV_PCSK_KEX2_1	308	310	PF00082	0.726
CLV_PCSK_KEX2_1	442	444	PF00082	0.564
CLV_PCSK_KEX2_1	49	51	PF00082	0.557
CLV_PCSK_KEX2_1	501	503	PF00082	0.557
CLV_PCSK_KEX2_1	582	584	PF00082	0.669
CLV_PCSK_KEX2_1	585	587	PF00082	0.608
CLV_PCSK_KEX2_1	759	761	PF00082	0.654
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.663
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.761
CLV_PCSK_SKI1_1	103	107	PF00082	0.482
CLV_PCSK_SKI1_1	308	312	PF00082	0.649
CLV_PCSK_SKI1_1	341	345	PF00082	0.546
CLV_PCSK_SKI1_1	542	546	PF00082	0.548
CLV_PCSK_SKI1_1	574	578	PF00082	0.618
CLV_PCSK_SKI1_1	73	77	PF00082	0.404
CLV_PCSK_SKI1_1	737	741	PF00082	0.353
CLV_PCSK_SKI1_1	760	764	PF00082	0.552
DEG_APCC_DBOX_1	102	110	PF00400	0.467
DEG_SPOP_SBC_1	367	371	PF00917	0.342
DEG_SPOP_SBC_1	534	538	PF00917	0.619
DEG_SPOP_SBC_1	566	570	PF00917	0.606
DEG_SPOP_SBC_1	625	629	PF00917	0.720
DOC_CYCLIN_RxL_1	107	115	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	748	754	PF00134	0.464
DOC_PP1_RVXF_1	637	643	PF00149	0.530
DOC_PP1_RVXF_1	718	725	PF00149	0.393
DOC_PP4_FxxP_1	223	226	PF00568	0.536
DOC_PP4_MxPP_1	321	324	PF00568	0.666
DOC_SPAK_OSR1_1	222	226	PF12202	0.543
DOC_USP7_MATH_1	132	136	PF00917	0.579
DOC_USP7_MATH_1	17	21	PF00917	0.587
DOC_USP7_MATH_1	253	257	PF00917	0.644
DOC_USP7_MATH_1	351	355	PF00917	0.479
DOC_USP7_MATH_1	406	410	PF00917	0.668
DOC_USP7_MATH_1	449	453	PF00917	0.608
DOC_USP7_MATH_1	534	538	PF00917	0.736
DOC_USP7_MATH_1	619	623	PF00917	0.756
DOC_USP7_MATH_1	753	757	PF00917	0.471
DOC_USP7_MATH_1	758	762	PF00917	0.541
DOC_WW_Pin1_4	236	241	PF00397	0.578
DOC_WW_Pin1_4	24	29	PF00397	0.580
DOC_WW_Pin1_4	457	462	PF00397	0.635
DOC_WW_Pin1_4	626	631	PF00397	0.675
DOC_WW_Pin1_4	63	68	PF00397	0.406
LIG_14-3-3_CanoR_1	396	406	PF00244	0.633
LIG_14-3-3_CanoR_1	484	489	PF00244	0.543
LIG_14-3-3_CanoR_1	49	54	PF00244	0.711
LIG_14-3-3_CanoR_1	502	508	PF00244	0.360
LIG_14-3-3_CanoR_1	565	575	PF00244	0.677
LIG_14-3-3_CanoR_1	583	589	PF00244	0.715
LIG_14-3-3_CanoR_1	639	648	PF00244	0.570
LIG_14-3-3_CanoR_1	713	717	PF00244	0.528
LIG_14-3-3_CanoR_1	737	743	PF00244	0.416
LIG_14-3-3_CanoR_1	759	763	PF00244	0.668
LIG_14-3-3_CanoR_1	8	14	PF00244	0.491
LIG_Actin_WH2_2	468	486	PF00022	0.673
LIG_BIR_III_4	700	704	PF00653	0.607
LIG_deltaCOP1_diTrp_1	665	675	PF00928	0.439
LIG_EH1_1	330	338	PF00400	0.349
LIG_eIF4E_1	219	225	PF01652	0.355
LIG_eIF4E_1	41	47	PF01652	0.561
LIG_FHA_1	242	248	PF00498	0.790
LIG_FHA_1	484	490	PF00498	0.506
LIG_FHA_1	571	577	PF00498	0.593
LIG_FHA_1	635	641	PF00498	0.546
LIG_FHA_1	738	744	PF00498	0.357
LIG_FHA_2	136	142	PF00498	0.494
LIG_FHA_2	340	346	PF00498	0.424
LIG_FHA_2	504	510	PF00498	0.551
LIG_FHA_2	567	573	PF00498	0.602
LIG_FHA_2	585	591	PF00498	0.663
LIG_FHA_2	64	70	PF00498	0.439
LIG_FHA_2	660	666	PF00498	0.711
LIG_FHA_2	713	719	PF00498	0.472
LIG_Integrin_RGD_1	658	660	PF01839	0.623
LIG_LIR_Gen_1	641	648	PF02991	0.467
LIG_LIR_Gen_1	66	75	PF02991	0.455
LIG_LIR_Gen_1	732	743	PF02991	0.408
LIG_LIR_Nem_3	328	334	PF02991	0.375
LIG_LIR_Nem_3	359	364	PF02991	0.403
LIG_LIR_Nem_3	641	645	PF02991	0.475
LIG_LIR_Nem_3	66	71	PF02991	0.454
LIG_LIR_Nem_3	732	738	PF02991	0.409
LIG_NRBOX	208	214	PF00104	0.505
LIG_PDZ_Class_1	764	769	PF00595	0.617
LIG_Pex14_1	113	117	PF04695	0.424
LIG_SH2_CRK	361	365	PF00017	0.405
LIG_SH2_CRK	735	739	PF00017	0.371
LIG_SH2_STAP1	735	739	PF00017	0.394
LIG_SH2_STAT5	731	734	PF00017	0.534
LIG_SH3_3	320	326	PF00018	0.533
LIG_SH3_3	343	349	PF00018	0.479
LIG_SH3_3	608	614	PF00018	0.702
LIG_Sin3_3	93	100	PF02671	0.454
LIG_SUMO_SIM_par_1	332	338	PF11976	0.415
LIG_SUMO_SIM_par_1	342	347	PF11976	0.434
LIG_SUMO_SIM_par_1	363	372	PF11976	0.405
LIG_SUMO_SIM_par_1	555	560	PF11976	0.562
LIG_TRAF2_1	326	329	PF00917	0.575
LIG_TRAF2_1	405	408	PF00917	0.566
LIG_TRAF2_1	663	666	PF00917	0.558
LIG_UBA3_1	553	561	PF00899	0.603
LIG_WRC_WIRS_1	13	18	PF05994	0.515
LIG_WW_2	323	326	PF00397	0.513
MOD_CDK_SPxxK_3	459	466	PF00069	0.513
MOD_CDK_SPxxK_3	63	70	PF00069	0.401
MOD_CK1_1	12	18	PF00069	0.532
MOD_CK1_1	135	141	PF00069	0.502
MOD_CK1_1	254	260	PF00069	0.687
MOD_CK1_1	366	372	PF00069	0.544
MOD_CK1_1	375	381	PF00069	0.411
MOD_CK1_1	452	458	PF00069	0.681
MOD_CK1_1	52	58	PF00069	0.686
MOD_CK1_1	570	576	PF00069	0.672
MOD_CK1_1	632	638	PF00069	0.618
MOD_CK2_1	173	179	PF00069	0.501
MOD_CK2_1	366	372	PF00069	0.467
MOD_CK2_1	459	465	PF00069	0.569
MOD_CK2_1	507	513	PF00069	0.480
MOD_CK2_1	566	572	PF00069	0.752
MOD_CK2_1	584	590	PF00069	0.681
MOD_CK2_1	63	69	PF00069	0.457
MOD_CK2_1	659	665	PF00069	0.562
MOD_Cter_Amidation	47	50	PF01082	0.606
MOD_GlcNHglycan	114	117	PF01048	0.472
MOD_GlcNHglycan	134	137	PF01048	0.445
MOD_GlcNHglycan	248	252	PF01048	0.672
MOD_GlcNHglycan	290	293	PF01048	0.724
MOD_GlcNHglycan	353	356	PF01048	0.582
MOD_GlcNHglycan	399	402	PF01048	0.609
MOD_GlcNHglycan	408	411	PF01048	0.600
MOD_GlcNHglycan	437	440	PF01048	0.532
MOD_GlcNHglycan	451	454	PF01048	0.553
MOD_GlcNHglycan	5	8	PF01048	0.578
MOD_GlcNHglycan	55	58	PF01048	0.709
MOD_GlcNHglycan	605	608	PF01048	0.709
MOD_GlcNHglycan	621	624	PF01048	0.688
MOD_GlcNHglycan	63	66	PF01048	0.526
MOD_GlcNHglycan	631	634	PF01048	0.572
MOD_GlcNHglycan	649	652	PF01048	0.361
MOD_GlcNHglycan	755	758	PF01048	0.492
MOD_GlcNHglycan	79	82	PF01048	0.516
MOD_GSK3_1	11	18	PF00069	0.594
MOD_GSK3_1	232	239	PF00069	0.640
MOD_GSK3_1	247	254	PF00069	0.645
MOD_GSK3_1	363	370	PF00069	0.433
MOD_GSK3_1	374	381	PF00069	0.398
MOD_GSK3_1	449	456	PF00069	0.617
MOD_GSK3_1	49	56	PF00069	0.696
MOD_GSK3_1	503	510	PF00069	0.478
MOD_GSK3_1	566	573	PF00069	0.780
MOD_GSK3_1	625	632	PF00069	0.719
MOD_GSK3_1	634	641	PF00069	0.612
MOD_GSK3_1	73	80	PF00069	0.531
MOD_GSK3_1	82	89	PF00069	0.502
MOD_N-GLC_1	287	292	PF02516	0.628
MOD_N-GLC_1	603	608	PF02516	0.753
MOD_N-GLC_1	619	624	PF02516	0.601
MOD_NEK2_1	11	16	PF00069	0.647
MOD_NEK2_1	112	117	PF00069	0.486
MOD_NEK2_1	173	178	PF00069	0.451
MOD_NEK2_1	344	349	PF00069	0.486
MOD_NEK2_1	374	379	PF00069	0.421
MOD_NEK2_1	576	581	PF00069	0.632
MOD_NEK2_1	86	91	PF00069	0.686
MOD_NEK2_2	303	308	PF00069	0.620
MOD_NEK2_2	758	763	PF00069	0.505
MOD_OFUCOSY	39	44	PF10250	0.514
MOD_PIKK_1	17	23	PF00454	0.682
MOD_PIKK_1	267	273	PF00454	0.654
MOD_PIKK_1	576	582	PF00454	0.765
MOD_PK_1	484	490	PF00069	0.560
MOD_PKA_1	267	273	PF00069	0.654
MOD_PKA_1	3	9	PF00069	0.626
MOD_PKA_1	442	448	PF00069	0.632
MOD_PKA_1	49	55	PF00069	0.563
MOD_PKA_1	584	590	PF00069	0.735
MOD_PKA_2	267	273	PF00069	0.702
MOD_PKA_2	3	9	PF00069	0.670
MOD_PKA_2	442	448	PF00069	0.654
MOD_PKA_2	483	489	PF00069	0.500
MOD_PKA_2	49	55	PF00069	0.563
MOD_PKA_2	584	590	PF00069	0.717
MOD_PKA_2	638	644	PF00069	0.548
MOD_PKA_2	712	718	PF00069	0.480
MOD_PKA_2	758	764	PF00069	0.667
MOD_PKB_1	482	490	PF00069	0.573
MOD_Plk_1	273	279	PF00069	0.646
MOD_Plk_1	635	641	PF00069	0.485
MOD_Plk_4	225	231	PF00069	0.478
MOD_Plk_4	363	369	PF00069	0.433
MOD_Plk_4	484	490	PF00069	0.501
MOD_Plk_4	503	509	PF00069	0.488
MOD_Plk_4	712	718	PF00069	0.480
MOD_Plk_4	738	744	PF00069	0.452
MOD_ProDKin_1	236	242	PF00069	0.579
MOD_ProDKin_1	24	30	PF00069	0.580
MOD_ProDKin_1	457	463	PF00069	0.639
MOD_ProDKin_1	626	632	PF00069	0.674
MOD_ProDKin_1	63	69	PF00069	0.397
TRG_DiLeu_BaEn_1	208	213	PF01217	0.387
TRG_DiLeu_BaEn_3	157	163	PF01217	0.429
TRG_DiLeu_BaEn_4	154	160	PF01217	0.477
TRG_ENDOCYTIC_2	361	364	PF00928	0.401
TRG_ENDOCYTIC_2	735	738	PF00928	0.399
TRG_ER_diArg_1	2	5	PF00400	0.647
TRG_ER_diArg_1	307	309	PF00400	0.764
TRG_ER_diArg_1	441	443	PF00400	0.611
TRG_ER_diArg_1	482	485	PF00400	0.669
TRG_ER_diArg_1	49	51	PF00400	0.557
TRG_ER_diArg_1	501	503	PF00400	0.300
TRG_ER_diArg_1	581	583	PF00400	0.665
TRG_NES_CRM1_1	204	218	PF08389	0.422
TRG_NLS_MonoCore_2	582	587	PF00514	0.756
TRG_NLS_MonoExtN_4	581	588	PF00514	0.753
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC42	Leptomonas seymouri	39%	94%
A0A3Q8IDS0	Leishmania donovani	86%	98%
A4HEX0	Leishmania braziliensis	65%	92%
A4I244	Leishmania infantum	86%	98%
E9AY94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%