RNA pseudouridylate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania major

UniProt:

Q4Q978_LEIMA

TriTrypDb:

LmjF.26.1160 , LMJLV39_260017300 , LMJSD75_260015700

Length:

977

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q978

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q978

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	2
GO:0001522	pseudouridine synthesis	6	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009451	RNA modification	5	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016072	rRNA metabolic process	7	2
GO:0031118	rRNA pseudouridine synthesis	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0009982	pseudouridine synthase activity	4	8
GO:0016853	isomerase activity	2	8
GO:0016866	intramolecular transferase activity	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.691
CLV_C14_Caspase3-7	441	445	PF00656	0.814
CLV_NRD_NRD_1	129	131	PF00675	0.620
CLV_NRD_NRD_1	177	179	PF00675	0.665
CLV_NRD_NRD_1	182	184	PF00675	0.616
CLV_NRD_NRD_1	313	315	PF00675	0.521
CLV_NRD_NRD_1	390	392	PF00675	0.492
CLV_NRD_NRD_1	397	399	PF00675	0.565
CLV_NRD_NRD_1	414	416	PF00675	0.628
CLV_NRD_NRD_1	5	7	PF00675	0.639
CLV_NRD_NRD_1	66	68	PF00675	0.406
CLV_NRD_NRD_1	773	775	PF00675	0.823
CLV_NRD_NRD_1	87	89	PF00675	0.446
CLV_PCSK_KEX2_1	129	131	PF00082	0.649
CLV_PCSK_KEX2_1	133	135	PF00082	0.683
CLV_PCSK_KEX2_1	177	179	PF00082	0.662
CLV_PCSK_KEX2_1	182	184	PF00082	0.614
CLV_PCSK_KEX2_1	271	273	PF00082	0.384
CLV_PCSK_KEX2_1	313	315	PF00082	0.521
CLV_PCSK_KEX2_1	390	392	PF00082	0.443
CLV_PCSK_KEX2_1	413	415	PF00082	0.609
CLV_PCSK_KEX2_1	5	7	PF00082	0.639
CLV_PCSK_KEX2_1	66	68	PF00082	0.406
CLV_PCSK_KEX2_1	773	775	PF00082	0.766
CLV_PCSK_KEX2_1	795	797	PF00082	0.693
CLV_PCSK_KEX2_1	87	89	PF00082	0.468
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.568
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.444
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.690
CLV_PCSK_PC7_1	129	135	PF00082	0.695
CLV_PCSK_PC7_1	178	184	PF00082	0.654
CLV_PCSK_PC7_1	83	89	PF00082	0.474
CLV_PCSK_SKI1_1	119	123	PF00082	0.522
CLV_PCSK_SKI1_1	129	133	PF00082	0.635
CLV_PCSK_SKI1_1	51	55	PF00082	0.608
CLV_PCSK_SKI1_1	778	782	PF00082	0.726
CLV_PCSK_SKI1_1	792	796	PF00082	0.677
CLV_PCSK_SKI1_1	87	91	PF00082	0.389
CLV_PCSK_SKI1_1	891	895	PF00082	0.601
CLV_Separin_Metazoa	410	414	PF03568	0.583
DEG_APCC_DBOX_1	651	659	PF00400	0.535
DEG_ODPH_VHL_1	268	279	PF01847	0.506
DEG_SCF_FBW7_2	430	435	PF00400	0.753
DEG_SPOP_SBC_1	162	166	PF00917	0.642
DEG_SPOP_SBC_1	454	458	PF00917	0.715
DEG_SPOP_SBC_1	827	831	PF00917	0.773
DOC_ANK_TNKS_1	838	845	PF00023	0.555
DOC_CKS1_1	506	511	PF01111	0.745
DOC_CKS1_1	640	645	PF01111	0.557
DOC_CKS1_1	678	683	PF01111	0.588
DOC_CYCLIN_RxL_1	125	135	PF00134	0.619
DOC_CYCLIN_RxL_1	81	91	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	523	529	PF00134	0.690
DOC_MAPK_gen_1	271	279	PF00069	0.514
DOC_MAPK_gen_1	371	381	PF00069	0.452
DOC_MAPK_gen_1	5	13	PF00069	0.535
DOC_MAPK_gen_1	729	737	PF00069	0.642
DOC_MAPK_MEF2A_6	211	220	PF00069	0.437
DOC_PP2B_LxvP_1	521	524	PF13499	0.660
DOC_PP2B_LxvP_1	924	927	PF13499	0.539
DOC_PP4_FxxP_1	609	612	PF00568	0.635
DOC_PP4_FxxP_1	967	970	PF00568	0.571
DOC_USP7_MATH_1	189	193	PF00917	0.652
DOC_USP7_MATH_1	418	422	PF00917	0.647
DOC_USP7_MATH_1	53	57	PF00917	0.620
DOC_USP7_MATH_1	544	548	PF00917	0.594
DOC_USP7_MATH_1	593	597	PF00917	0.629
DOC_USP7_MATH_1	626	630	PF00917	0.754
DOC_USP7_MATH_1	631	635	PF00917	0.749
DOC_USP7_MATH_1	696	700	PF00917	0.642
DOC_USP7_MATH_1	769	773	PF00917	0.718
DOC_USP7_MATH_1	825	829	PF00917	0.695
DOC_USP7_MATH_1	929	933	PF00917	0.648
DOC_USP7_UBL2_3	791	795	PF12436	0.705
DOC_WW_Pin1_4	135	140	PF00397	0.607
DOC_WW_Pin1_4	183	188	PF00397	0.641
DOC_WW_Pin1_4	20	25	PF00397	0.492
DOC_WW_Pin1_4	291	296	PF00397	0.573
DOC_WW_Pin1_4	428	433	PF00397	0.793
DOC_WW_Pin1_4	45	50	PF00397	0.579
DOC_WW_Pin1_4	455	460	PF00397	0.666
DOC_WW_Pin1_4	505	510	PF00397	0.789
DOC_WW_Pin1_4	513	518	PF00397	0.752
DOC_WW_Pin1_4	594	599	PF00397	0.704
DOC_WW_Pin1_4	639	644	PF00397	0.558
DOC_WW_Pin1_4	677	682	PF00397	0.732
DOC_WW_Pin1_4	767	772	PF00397	0.761
DOC_WW_Pin1_4	905	910	PF00397	0.676
DOC_WW_Pin1_4	922	927	PF00397	0.498
DOC_WW_Pin1_4	931	936	PF00397	0.617
DOC_WW_Pin1_4	98	103	PF00397	0.509
LIG_14-3-3_CanoR_1	313	319	PF00244	0.628
LIG_14-3-3_CanoR_1	436	441	PF00244	0.566
LIG_14-3-3_CanoR_1	548	556	PF00244	0.618
LIG_14-3-3_CanoR_1	652	662	PF00244	0.460
LIG_14-3-3_CanoR_1	748	754	PF00244	0.608
LIG_14-3-3_CanoR_1	778	783	PF00244	0.725
LIG_14-3-3_CanoR_1	796	801	PF00244	0.622
LIG_APCC_ABBA_1	90	95	PF00400	0.377
LIG_APCC_ABBAyCdc20_2	732	738	PF00400	0.665
LIG_FHA_1	259	265	PF00498	0.371
LIG_FHA_1	288	294	PF00498	0.426
LIG_FHA_1	30	36	PF00498	0.469
LIG_FHA_1	374	380	PF00498	0.452
LIG_FHA_1	406	412	PF00498	0.543
LIG_FHA_1	487	493	PF00498	0.713
LIG_FHA_1	583	589	PF00498	0.645
LIG_FHA_1	60	66	PF00498	0.582
LIG_FHA_1	643	649	PF00498	0.612
LIG_FHA_1	75	81	PF00498	0.332
LIG_FHA_1	779	785	PF00498	0.585
LIG_FHA_1	827	833	PF00498	0.679
LIG_FHA_1	876	882	PF00498	0.591
LIG_FHA_1	919	925	PF00498	0.565
LIG_FHA_2	40	46	PF00498	0.548
LIG_FHA_2	495	501	PF00498	0.604
LIG_FHA_2	7	13	PF00498	0.602
LIG_FHA_2	809	815	PF00498	0.609
LIG_FHA_2	838	844	PF00498	0.553
LIG_LIR_Apic_2	157	163	PF02991	0.703
LIG_LIR_Apic_2	18	24	PF02991	0.531
LIG_LIR_Gen_1	203	214	PF02991	0.464
LIG_LIR_Gen_1	73	80	PF02991	0.446
LIG_LIR_Gen_1	733	742	PF02991	0.660
LIG_LIR_Nem_3	203	209	PF02991	0.453
LIG_LIR_Nem_3	300	305	PF02991	0.482
LIG_LIR_Nem_3	73	79	PF02991	0.395
LIG_LIR_Nem_3	733	737	PF02991	0.682
LIG_NRBOX	259	265	PF00104	0.489
LIG_NRBOX	603	609	PF00104	0.637
LIG_NRP_CendR_1	976	977	PF00754	0.614
LIG_SH2_CRK	160	164	PF00017	0.707
LIG_SH2_CRK	206	210	PF00017	0.463
LIG_SH2_CRK	236	240	PF00017	0.377
LIG_SH2_CRK	257	261	PF00017	0.437
LIG_SH2_CRK	305	309	PF00017	0.496
LIG_SH2_GRB2like	256	259	PF00017	0.507
LIG_SH2_NCK_1	160	164	PF00017	0.707
LIG_SH2_NCK_1	305	309	PF00017	0.513
LIG_SH2_NCK_1	860	864	PF00017	0.584
LIG_SH2_SRC	305	308	PF00017	0.560
LIG_SH2_STAP1	105	109	PF00017	0.347
LIG_SH2_STAP1	302	306	PF00017	0.544
LIG_SH2_STAP1	72	76	PF00017	0.459
LIG_SH2_STAP1	93	97	PF00017	0.474
LIG_SH2_STAT3	115	118	PF00017	0.501
LIG_SH2_STAT3	41	44	PF00017	0.475
LIG_SH2_STAT3	474	477	PF00017	0.529
LIG_SH2_STAT5	115	118	PF00017	0.501
LIG_SH2_STAT5	160	163	PF00017	0.709
LIG_SH2_STAT5	266	269	PF00017	0.425
LIG_SH2_STAT5	342	345	PF00017	0.664
LIG_SH2_STAT5	41	44	PF00017	0.440
LIG_SH2_STAT5	480	483	PF00017	0.475
LIG_SH2_STAT5	545	548	PF00017	0.635
LIG_SH2_STAT5	644	647	PF00017	0.572
LIG_SH2_STAT5	749	752	PF00017	0.615
LIG_SH3_1	305	311	PF00018	0.535
LIG_SH3_1	33	39	PF00018	0.512
LIG_SH3_2	308	313	PF14604	0.597
LIG_SH3_3	238	244	PF00018	0.511
LIG_SH3_3	264	270	PF00018	0.366
LIG_SH3_3	276	282	PF00018	0.418
LIG_SH3_3	305	311	PF00018	0.567
LIG_SH3_3	315	321	PF00018	0.615
LIG_SH3_3	33	39	PF00018	0.475
LIG_SH3_3	362	368	PF00018	0.580
LIG_SH3_3	43	49	PF00018	0.533
LIG_SH3_3	449	455	PF00018	0.749
LIG_SH3_3	456	462	PF00018	0.678
LIG_SH3_3	514	520	PF00018	0.736
LIG_SH3_3	583	589	PF00018	0.706
LIG_SH3_3	664	670	PF00018	0.453
LIG_SH3_3	675	681	PF00018	0.630
LIG_SH3_3	682	688	PF00018	0.653
LIG_SH3_3	923	929	PF00018	0.639
LIG_Sin3_3	223	230	PF02671	0.464
LIG_SUMO_SIM_anti_2	376	383	PF11976	0.424
LIG_SUMO_SIM_par_1	780	785	PF11976	0.560
LIG_TRAF2_1	42	45	PF00917	0.555
LIG_TRAF2_1	817	820	PF00917	0.581
LIG_TRFH_1	266	270	PF08558	0.363
LIG_TYR_ITIM	204	209	PF00017	0.454
LIG_WW_2	687	690	PF00397	0.584
MOD_CDC14_SPxK_1	48	51	PF00782	0.611
MOD_CDC14_SPxK_1	770	773	PF00782	0.704
MOD_CDK_SPxK_1	45	51	PF00069	0.590
MOD_CDK_SPxK_1	767	773	PF00069	0.699
MOD_CDK_SPxxK_3	20	27	PF00069	0.535
MOD_CDK_SPxxK_3	291	298	PF00069	0.492
MOD_CDK_SPxxK_3	767	774	PF00069	0.764
MOD_CK1_1	135	141	PF00069	0.630
MOD_CK1_1	158	164	PF00069	0.773
MOD_CK1_1	259	265	PF00069	0.425
MOD_CK1_1	286	292	PF00069	0.420
MOD_CK1_1	336	342	PF00069	0.651
MOD_CK1_1	495	501	PF00069	0.731
MOD_CK1_1	512	518	PF00069	0.571
MOD_CK1_1	828	834	PF00069	0.582
MOD_CK1_1	904	910	PF00069	0.702
MOD_CK2_1	189	195	PF00069	0.663
MOD_CK2_1	259	265	PF00069	0.425
MOD_CK2_1	291	297	PF00069	0.442
MOD_CK2_1	39	45	PF00069	0.535
MOD_CK2_1	469	475	PF00069	0.629
MOD_CK2_1	494	500	PF00069	0.657
MOD_CK2_1	6	12	PF00069	0.616
MOD_CK2_1	814	820	PF00069	0.584
MOD_CK2_1	837	843	PF00069	0.555
MOD_CK2_1	930	936	PF00069	0.663
MOD_Cter_Amidation	85	88	PF01082	0.461
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.647
MOD_GlcNHglycan	134	137	PF01048	0.626
MOD_GlcNHglycan	150	153	PF01048	0.643
MOD_GlcNHglycan	169	172	PF01048	0.581
MOD_GlcNHglycan	335	338	PF01048	0.649
MOD_GlcNHglycan	348	352	PF01048	0.537
MOD_GlcNHglycan	376	379	PF01048	0.445
MOD_GlcNHglycan	494	497	PF01048	0.608
MOD_GlcNHglycan	55	58	PF01048	0.589
MOD_GlcNHglycan	551	554	PF01048	0.559
MOD_GlcNHglycan	571	574	PF01048	0.683
MOD_GlcNHglycan	590	593	PF01048	0.803
MOD_GlcNHglycan	627	631	PF01048	0.741
MOD_GlcNHglycan	671	674	PF01048	0.673
MOD_GlcNHglycan	718	722	PF01048	0.647
MOD_GlcNHglycan	878	881	PF01048	0.584
MOD_GlcNHglycan	939	942	PF01048	0.709
MOD_GSK3_1	144	151	PF00069	0.645
MOD_GSK3_1	154	161	PF00069	0.695
MOD_GSK3_1	162	169	PF00069	0.599
MOD_GSK3_1	242	249	PF00069	0.470
MOD_GSK3_1	283	290	PF00069	0.412
MOD_GSK3_1	329	336	PF00069	0.709
MOD_GSK3_1	343	350	PF00069	0.507
MOD_GSK3_1	436	443	PF00069	0.771
MOD_GSK3_1	454	461	PF00069	0.642
MOD_GSK3_1	505	512	PF00069	0.670
MOD_GSK3_1	51	58	PF00069	0.648
MOD_GSK3_1	544	551	PF00069	0.609
MOD_GSK3_1	565	572	PF00069	0.670
MOD_GSK3_1	694	701	PF00069	0.769
MOD_GSK3_1	705	712	PF00069	0.639
MOD_GSK3_1	796	803	PF00069	0.683
MOD_GSK3_1	901	908	PF00069	0.697
MOD_GSK3_1	918	925	PF00069	0.536
MOD_N-GLC_1	922	927	PF02516	0.572
MOD_N-GLC_1	945	950	PF02516	0.652
MOD_NEK2_1	132	137	PF00069	0.563
MOD_NEK2_1	148	153	PF00069	0.604
MOD_NEK2_1	155	160	PF00069	0.580
MOD_NEK2_1	283	288	PF00069	0.406
MOD_NEK2_1	29	34	PF00069	0.526
MOD_NEK2_1	549	554	PF00069	0.566
MOD_NEK2_1	60	65	PF00069	0.552
MOD_NEK2_1	653	658	PF00069	0.568
MOD_NEK2_1	74	79	PF00069	0.362
MOD_NEK2_1	826	831	PF00069	0.679
MOD_NEK2_1	918	923	PF00069	0.676
MOD_NEK2_2	749	754	PF00069	0.583
MOD_PIKK_1	124	130	PF00454	0.627
MOD_PIKK_1	336	342	PF00454	0.542
MOD_PK_1	314	320	PF00069	0.527
MOD_PK_1	391	397	PF00069	0.520
MOD_PKA_2	725	731	PF00069	0.664
MOD_PKB_1	483	491	PF00069	0.660
MOD_PKB_1	563	571	PF00069	0.536
MOD_Plk_1	486	492	PF00069	0.538
MOD_Plk_1	697	703	PF00069	0.558
MOD_Plk_1	72	78	PF00069	0.380
MOD_Plk_2-3	814	820	PF00069	0.584
MOD_Plk_4	259	265	PF00069	0.425
MOD_Plk_4	283	289	PF00069	0.406
MOD_Plk_4	391	397	PF00069	0.503
MOD_ProDKin_1	135	141	PF00069	0.611
MOD_ProDKin_1	183	189	PF00069	0.640
MOD_ProDKin_1	20	26	PF00069	0.495
MOD_ProDKin_1	291	297	PF00069	0.565
MOD_ProDKin_1	428	434	PF00069	0.792
MOD_ProDKin_1	45	51	PF00069	0.585
MOD_ProDKin_1	455	461	PF00069	0.661
MOD_ProDKin_1	505	511	PF00069	0.785
MOD_ProDKin_1	513	519	PF00069	0.749
MOD_ProDKin_1	594	600	PF00069	0.701
MOD_ProDKin_1	639	645	PF00069	0.556
MOD_ProDKin_1	677	683	PF00069	0.733
MOD_ProDKin_1	767	773	PF00069	0.762
MOD_ProDKin_1	905	911	PF00069	0.676
MOD_ProDKin_1	922	928	PF00069	0.501
MOD_ProDKin_1	931	937	PF00069	0.619
MOD_ProDKin_1	98	104	PF00069	0.501
TRG_AP2beta_CARGO_1	73	83	PF09066	0.453
TRG_DiLeu_BaEn_4	635	641	PF01217	0.632
TRG_DiLeu_BaEn_4	821	827	PF01217	0.566
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.624
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.434
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.479
TRG_ENDOCYTIC_2	206	209	PF00928	0.459
TRG_ENDOCYTIC_2	236	239	PF00928	0.374
TRG_ENDOCYTIC_2	257	260	PF00928	0.438
TRG_ER_diArg_1	129	131	PF00400	0.611
TRG_ER_diArg_1	312	314	PF00400	0.509
TRG_ER_diArg_1	390	392	PF00400	0.466
TRG_ER_diArg_1	412	415	PF00400	0.658
TRG_ER_diArg_1	483	486	PF00400	0.581
TRG_ER_diArg_1	5	8	PF00400	0.635
TRG_ER_diArg_1	562	565	PF00400	0.626
TRG_ER_diArg_1	65	67	PF00400	0.445
TRG_ER_diArg_1	87	89	PF00400	0.468
TRG_ER_diArg_1	975	977	PF00400	0.512
TRG_NLS_MonoExtN_4	792	799	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	956	961	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN9	Leptomonas seymouri	43%	100%
A0A3Q8IC63	Leishmania donovani	88%	100%
A0A3R7NDN7	Trypanosoma rangeli	33%	100%
A4HEX1	Leishmania braziliensis	69%	100%
A4I245	Leishmania infantum	87%	100%
E9AY95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%