RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q977_LEIMA

TriTrypDb:

LmjF.26.1170 , LMJLV39_260017400 , LMJSD75_260015800

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q977

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q977

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.748
CLV_C14_Caspase3-7	413	417	PF00656	0.530
CLV_NRD_NRD_1	229	231	PF00675	0.713
CLV_NRD_NRD_1	401	403	PF00675	0.556
CLV_NRD_NRD_1	428	430	PF00675	0.472
CLV_NRD_NRD_1	456	458	PF00675	0.534
CLV_NRD_NRD_1	463	465	PF00675	0.563
CLV_NRD_NRD_1	498	500	PF00675	0.856
CLV_PCSK_FUR_1	399	403	PF00082	0.555
CLV_PCSK_KEX2_1	231	233	PF00082	0.726
CLV_PCSK_KEX2_1	399	401	PF00082	0.557
CLV_PCSK_KEX2_1	428	430	PF00082	0.472
CLV_PCSK_KEX2_1	456	458	PF00082	0.523
CLV_PCSK_KEX2_1	498	500	PF00082	0.856
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.726
CLV_PCSK_SKI1_1	393	397	PF00082	0.568
CLV_PCSK_SKI1_1	402	406	PF00082	0.506
DEG_APCC_DBOX_1	401	409	PF00400	0.555
DEG_APCC_DBOX_1	94	102	PF00400	0.570
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DEG_SPOP_SBC_1	141	145	PF00917	0.802
DEG_SPOP_SBC_1	281	285	PF00917	0.688
DEG_SPOP_SBC_1	437	441	PF00917	0.547
DOC_ANK_TNKS_1	271	278	PF00023	0.727
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.567
DOC_MAPK_gen_1	399	408	PF00069	0.564
DOC_MAPK_gen_1	423	432	PF00069	0.623
DOC_MAPK_MEF2A_6	195	202	PF00069	0.586
DOC_MAPK_MEF2A_6	399	408	PF00069	0.542
DOC_PP2B_LxvP_1	23	26	PF13499	0.703
DOC_PP2B_LxvP_1	292	295	PF13499	0.719
DOC_PP2B_LxvP_1	406	409	PF13499	0.586
DOC_PP2B_LxvP_1	492	495	PF13499	0.741
DOC_USP7_MATH_1	110	114	PF00917	0.687
DOC_USP7_MATH_1	141	145	PF00917	0.798
DOC_USP7_MATH_1	206	210	PF00917	0.643
DOC_USP7_MATH_1	281	285	PF00917	0.667
DOC_USP7_MATH_1	318	322	PF00917	0.835
DOC_USP7_MATH_1	417	421	PF00917	0.565
DOC_USP7_MATH_1	43	47	PF00917	0.756
DOC_USP7_MATH_1	437	441	PF00917	0.411
DOC_USP7_UBL2_3	461	465	PF12436	0.542
DOC_WW_Pin1_4	108	113	PF00397	0.669
DOC_WW_Pin1_4	122	127	PF00397	0.548
DOC_WW_Pin1_4	262	267	PF00397	0.752
DOC_WW_Pin1_4	29	34	PF00397	0.722
DOC_WW_Pin1_4	314	319	PF00397	0.719
DOC_WW_Pin1_4	55	60	PF00397	0.781
DOC_WW_Pin1_4	99	104	PF00397	0.732
LIG_14-3-3_CanoR_1	199	203	PF00244	0.711
LIG_14-3-3_CanoR_1	358	364	PF00244	0.514
LIG_14-3-3_CanoR_1	393	398	PF00244	0.623
LIG_14-3-3_CanoR_1	435	445	PF00244	0.607
LIG_14-3-3_CanoR_1	456	463	PF00244	0.632
LIG_AP2alpha_2	92	94	PF02296	0.672
LIG_BIR_III_2	416	420	PF00653	0.505
LIG_FHA_1	256	262	PF00498	0.566
LIG_FHA_1	36	42	PF00498	0.778
LIG_FHA_1	392	398	PF00498	0.625
LIG_FHA_1	440	446	PF00498	0.529
LIG_FHA_2	387	393	PF00498	0.403
LIG_FHA_2	42	48	PF00498	0.600
LIG_KLC1_Yacidic_2	215	220	PF13176	0.541
LIG_LIR_Gen_1	349	357	PF02991	0.640
LIG_LIR_Nem_3	213	217	PF02991	0.538
LIG_LIR_Nem_3	349	355	PF02991	0.648
LIG_Pex14_2	77	81	PF04695	0.658
LIG_SH2_SRC	172	175	PF00017	0.555
LIG_SH2_SRC	218	221	PF00017	0.656
LIG_SH2_STAP1	352	356	PF00017	0.523
LIG_SH2_STAT5	163	166	PF00017	0.570
LIG_SH2_STAT5	218	221	PF00017	0.656
LIG_SH3_1	24	30	PF00018	0.693
LIG_SH3_3	150	156	PF00018	0.498
LIG_SH3_3	173	179	PF00018	0.464
LIG_SH3_3	24	30	PF00018	0.722
LIG_SH3_3	272	278	PF00018	0.794
LIG_SH3_3	56	62	PF00018	0.670
LIG_SH3_3	90	96	PF00018	0.674
LIG_SH3_3	97	103	PF00018	0.709
LIG_SUMO_SIM_anti_2	335	342	PF11976	0.685
LIG_SUMO_SIM_anti_2	97	102	PF11976	0.733
LIG_SUMO_SIM_par_1	295	302	PF11976	0.660
LIG_TRFH_1	21	25	PF08558	0.672
LIG_UBA3_1	405	412	PF00899	0.634
MOD_CDK_SPK_2	55	60	PF00069	0.721
MOD_CK1_1	102	108	PF00069	0.640
MOD_CK1_1	125	131	PF00069	0.632
MOD_CK1_1	137	143	PF00069	0.781
MOD_CK1_1	210	216	PF00069	0.735
MOD_CK1_1	225	231	PF00069	0.535
MOD_CK1_1	265	271	PF00069	0.792
MOD_CK1_1	317	323	PF00069	0.806
MOD_CK1_1	32	38	PF00069	0.709
MOD_CK1_1	386	392	PF00069	0.622
MOD_CK1_1	439	445	PF00069	0.627
MOD_CK1_1	46	52	PF00069	0.590
MOD_CK1_1	55	61	PF00069	0.699
MOD_CK1_1	68	74	PF00069	0.656
MOD_CK1_1	88	94	PF00069	0.465
MOD_CK2_1	102	108	PF00069	0.810
MOD_CK2_1	141	147	PF00069	0.790
MOD_CK2_1	230	236	PF00069	0.593
MOD_CK2_1	285	291	PF00069	0.811
MOD_CK2_1	386	392	PF00069	0.556
MOD_CK2_1	408	414	PF00069	0.652
MOD_CK2_1	41	47	PF00069	0.601
MOD_CK2_1	464	470	PF00069	0.529
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.720
MOD_GlcNHglycan	112	115	PF01048	0.688
MOD_GlcNHglycan	127	130	PF01048	0.784
MOD_GlcNHglycan	133	137	PF01048	0.714
MOD_GlcNHglycan	186	189	PF01048	0.577
MOD_GlcNHglycan	209	212	PF01048	0.668
MOD_GlcNHglycan	224	227	PF01048	0.563
MOD_GlcNHglycan	267	270	PF01048	0.729
MOD_GlcNHglycan	287	290	PF01048	0.735
MOD_GlcNHglycan	291	295	PF01048	0.732
MOD_GlcNHglycan	324	327	PF01048	0.770
MOD_GlcNHglycan	419	422	PF01048	0.518
MOD_GlcNHglycan	470	473	PF01048	0.655
MOD_GlcNHglycan	54	57	PF01048	0.726
MOD_GlcNHglycan	65	68	PF01048	0.651
MOD_GlcNHglycan	70	73	PF01048	0.571
MOD_GSK3_1	118	125	PF00069	0.588
MOD_GSK3_1	137	144	PF00069	0.783
MOD_GSK3_1	206	213	PF00069	0.642
MOD_GSK3_1	25	32	PF00069	0.713
MOD_GSK3_1	281	288	PF00069	0.821
MOD_GSK3_1	314	321	PF00069	0.802
MOD_GSK3_1	37	44	PF00069	0.706
MOD_GSK3_1	433	440	PF00069	0.631
MOD_GSK3_1	45	52	PF00069	0.667
MOD_GSK3_1	464	471	PF00069	0.547
MOD_N-GLC_1	141	146	PF02516	0.565
MOD_N-GLC_1	68	73	PF02516	0.691
MOD_NEK2_1	134	139	PF00069	0.808
MOD_NEK2_1	198	203	PF00069	0.708
MOD_NEK2_1	356	361	PF00069	0.515
MOD_NEK2_1	36	41	PF00069	0.817
MOD_NEK2_1	377	382	PF00069	0.520
MOD_NEK2_1	391	396	PF00069	0.518
MOD_NEK2_1	438	443	PF00069	0.564
MOD_NEK2_1	63	68	PF00069	0.792
MOD_NEK2_1	77	82	PF00069	0.591
MOD_PIKK_1	267	273	PF00454	0.781
MOD_PIKK_1	283	289	PF00454	0.739
MOD_PIKK_1	311	317	PF00454	0.742
MOD_PIKK_1	346	352	PF00454	0.597
MOD_PIKK_1	377	383	PF00454	0.524
MOD_PIKK_1	440	446	PF00454	0.520
MOD_PKA_1	230	236	PF00069	0.593
MOD_PKA_1	456	462	PF00069	0.607
MOD_PKA_1	464	470	PF00069	0.548
MOD_PKA_2	198	204	PF00069	0.635
MOD_PKA_2	321	327	PF00069	0.647
MOD_PKA_2	357	363	PF00069	0.518
MOD_PKA_2	456	462	PF00069	0.560
MOD_PKA_2	94	100	PF00069	0.662
MOD_Plk_1	256	262	PF00069	0.607
MOD_Plk_1	391	397	PF00069	0.624
MOD_Plk_4	198	204	PF00069	0.691
MOD_ProDKin_1	108	114	PF00069	0.669
MOD_ProDKin_1	122	128	PF00069	0.548
MOD_ProDKin_1	262	268	PF00069	0.750
MOD_ProDKin_1	29	35	PF00069	0.724
MOD_ProDKin_1	314	320	PF00069	0.719
MOD_ProDKin_1	55	61	PF00069	0.731
MOD_ProDKin_1	99	105	PF00069	0.731
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.567
TRG_ENDOCYTIC_2	352	355	PF00928	0.538
TRG_ER_diArg_1	21	24	PF00400	0.578
TRG_ER_diArg_1	229	232	PF00400	0.754
TRG_ER_diArg_1	399	402	PF00400	0.552
TRG_ER_diArg_1	427	429	PF00400	0.464
TRG_ER_diArg_1	455	457	PF00400	0.521
TRG_NES_CRM1_1	422	433	PF08389	0.627
TRG_NLS_MonoExtC_3	229	234	PF00514	0.726
TRG_NLS_MonoExtN_4	230	235	PF00514	0.725
TRG_Pf-PMV_PEXEL_1	428	433	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J9	Leptomonas seymouri	46%	96%
A0A3S7WZT2	Leishmania donovani	89%	99%
A4HEX2	Leishmania braziliensis	67%	100%
A4I246	Leishmania infantum	89%	99%
E9AY96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%