Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q976_LEIMA

TriTrypDb:

LmjF.26.1180 , LMJLV39_260017500 , LMJSD75_260015900

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q976

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q976

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.620
CLV_C14_Caspase3-7	241	245	PF00656	0.572
CLV_NRD_NRD_1	143	145	PF00675	0.555
CLV_NRD_NRD_1	195	197	PF00675	0.660
CLV_NRD_NRD_1	432	434	PF00675	0.541
CLV_NRD_NRD_1	596	598	PF00675	0.668
CLV_PCSK_KEX2_1	130	132	PF00082	0.684
CLV_PCSK_KEX2_1	142	144	PF00082	0.516
CLV_PCSK_KEX2_1	432	434	PF00082	0.541
CLV_PCSK_KEX2_1	595	597	PF00082	0.698
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.629
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.507
CLV_PCSK_SKI1_1	376	380	PF00082	0.398
CLV_PCSK_SKI1_1	597	601	PF00082	0.553
DEG_SCF_FBW7_2	40	45	PF00400	0.604
DEG_SPOP_SBC_1	90	94	PF00917	0.506
DEG_SPOP_SBC_1	96	100	PF00917	0.508
DOC_ANK_TNKS_1	464	471	PF00023	0.584
DOC_MAPK_FxFP_2	230	233	PF00069	0.464
DOC_MAPK_HePTP_8	522	534	PF00069	0.430
DOC_MAPK_MEF2A_6	296	303	PF00069	0.457
DOC_MAPK_MEF2A_6	525	534	PF00069	0.434
DOC_MAPK_MEF2A_6	77	84	PF00069	0.560
DOC_MAPK_NFAT4_5	77	85	PF00069	0.442
DOC_PP1_RVXF_1	71	77	PF00149	0.512
DOC_PP2B_LxvP_1	652	655	PF13499	0.660
DOC_PP2B_PxIxI_1	343	349	PF00149	0.476
DOC_PP4_FxxP_1	230	233	PF00568	0.464
DOC_PP4_FxxP_1	466	469	PF00568	0.596
DOC_SPAK_OSR1_1	465	469	PF12202	0.613
DOC_USP7_MATH_1	12	16	PF00917	0.741
DOC_USP7_MATH_1	162	166	PF00917	0.653
DOC_USP7_MATH_1	173	177	PF00917	0.543
DOC_USP7_MATH_1	184	188	PF00917	0.513
DOC_USP7_MATH_1	192	196	PF00917	0.719
DOC_USP7_MATH_1	237	241	PF00917	0.478
DOC_USP7_MATH_1	245	249	PF00917	0.719
DOC_USP7_MATH_1	334	338	PF00917	0.631
DOC_USP7_MATH_1	380	384	PF00917	0.469
DOC_USP7_MATH_1	409	413	PF00917	0.709
DOC_USP7_MATH_1	469	473	PF00917	0.528
DOC_USP7_MATH_1	575	579	PF00917	0.730
DOC_USP7_MATH_1	89	93	PF00917	0.498
DOC_USP7_MATH_1	96	100	PF00917	0.497
DOC_WW_Pin1_4	136	141	PF00397	0.681
DOC_WW_Pin1_4	326	331	PF00397	0.572
DOC_WW_Pin1_4	38	43	PF00397	0.616
DOC_WW_Pin1_4	92	97	PF00397	0.528
LIG_14-3-3_CanoR_1	196	204	PF00244	0.673
LIG_14-3-3_CanoR_1	319	327	PF00244	0.416
LIG_14-3-3_CanoR_1	345	353	PF00244	0.528
LIG_14-3-3_CanoR_1	413	421	PF00244	0.456
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BIR_III_4	69	73	PF00653	0.356
LIG_BRCT_BRCA1_1	209	213	PF00533	0.737
LIG_BRCT_BRCA1_1	53	57	PF00533	0.651
LIG_BRCT_BRCA1_1	607	611	PF00533	0.418
LIG_CaM_NSCaTE_8	148	155	PF13499	0.586
LIG_FHA_1	248	254	PF00498	0.671
LIG_FHA_1	321	327	PF00498	0.486
LIG_FHA_1	352	358	PF00498	0.459
LIG_FHA_1	426	432	PF00498	0.556
LIG_FHA_1	495	501	PF00498	0.539
LIG_FHA_1	513	519	PF00498	0.382
LIG_FHA_2	333	339	PF00498	0.646
LIG_GBD_Chelix_1	549	557	PF00786	0.381
LIG_LIR_Apic_2	134	140	PF02991	0.627
LIG_LIR_Gen_1	35	43	PF02991	0.626
LIG_LIR_Gen_1	542	553	PF02991	0.430
LIG_LIR_Gen_1	659	667	PF02991	0.592
LIG_LIR_Nem_3	176	182	PF02991	0.513
LIG_LIR_Nem_3	35	40	PF02991	0.613
LIG_LIR_Nem_3	367	372	PF02991	0.369
LIG_LIR_Nem_3	542	548	PF02991	0.416
LIG_LIR_Nem_3	659	665	PF02991	0.685
LIG_LYPXL_S_1	226	230	PF13949	0.467
LIG_MYND_1	224	228	PF01753	0.516
LIG_NRBOX	552	558	PF00104	0.376
LIG_PALB2_WD40_1	144	152	PF16756	0.604
LIG_Pex14_2	57	61	PF04695	0.631
LIG_PTB_Apo_2	626	633	PF02174	0.539
LIG_RPA_C_Fungi	408	420	PF08784	0.603
LIG_SH2_CRK	137	141	PF00017	0.663
LIG_SH2_CRK	179	183	PF00017	0.594
LIG_SH2_CRK	372	376	PF00017	0.350
LIG_SH2_CRK	545	549	PF00017	0.418
LIG_SH2_NCK_1	396	400	PF00017	0.627
LIG_SH2_NCK_1	88	92	PF00017	0.529
LIG_SH2_SRC	372	375	PF00017	0.456
LIG_SH2_SRC	533	536	PF00017	0.468
LIG_SH2_STAP1	115	119	PF00017	0.511
LIG_SH2_STAP1	545	549	PF00017	0.366
LIG_SH2_STAT3	256	259	PF00017	0.660
LIG_SH2_STAT5	151	154	PF00017	0.557
LIG_SH2_STAT5	238	241	PF00017	0.542
LIG_SH2_STAT5	256	259	PF00017	0.582
LIG_SH2_STAT5	533	536	PF00017	0.468
LIG_SH2_STAT5	664	667	PF00017	0.700
LIG_SH3_3	209	215	PF00018	0.631
LIG_SH3_3	383	389	PF00018	0.476
LIG_SH3_3	555	561	PF00018	0.399
LIG_SH3_3	571	577	PF00018	0.536
LIG_SH3_3	628	634	PF00018	0.545
LIG_SUMO_SIM_anti_2	484	491	PF11976	0.373
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.430
LIG_SUMO_SIM_par_1	97	106	PF11976	0.557
LIG_TRAF2_1	16	19	PF00917	0.676
LIG_TRAF2_1	283	286	PF00917	0.751
LIG_TRAF2_1	580	583	PF00917	0.660
LIG_TYR_ITIM	543	548	PF00017	0.415
MOD_CDC14_SPxK_1	139	142	PF00782	0.616
MOD_CDK_SPxK_1	136	142	PF00069	0.614
MOD_CDK_SPxxK_3	136	143	PF00069	0.608
MOD_CK1_1	167	173	PF00069	0.686
MOD_CK1_1	200	206	PF00069	0.728
MOD_CK1_1	208	214	PF00069	0.676
MOD_CK1_1	337	343	PF00069	0.648
MOD_CK1_1	523	529	PF00069	0.400
MOD_CK1_1	92	98	PF00069	0.555
MOD_CK2_1	12	18	PF00069	0.709
MOD_CK2_1	332	338	PF00069	0.648
MOD_CK2_1	523	529	PF00069	0.384
MOD_CK2_1	97	103	PF00069	0.496
MOD_GlcNHglycan	1	4	PF01048	0.659
MOD_GlcNHglycan	166	169	PF01048	0.677
MOD_GlcNHglycan	171	174	PF01048	0.715
MOD_GlcNHglycan	207	210	PF01048	0.694
MOD_GlcNHglycan	241	244	PF01048	0.567
MOD_GlcNHglycan	366	369	PF01048	0.487
MOD_GlcNHglycan	399	402	PF01048	0.646
MOD_GlcNHglycan	407	410	PF01048	0.704
MOD_GlcNHglycan	415	418	PF01048	0.399
MOD_GlcNHglycan	448	451	PF01048	0.699
MOD_GlcNHglycan	471	474	PF01048	0.547
MOD_GlcNHglycan	561	564	PF01048	0.504
MOD_GlcNHglycan	622	625	PF01048	0.621
MOD_GSK3_1	122	129	PF00069	0.609
MOD_GSK3_1	163	170	PF00069	0.592
MOD_GSK3_1	200	207	PF00069	0.739
MOD_GSK3_1	232	239	PF00069	0.499
MOD_GSK3_1	243	250	PF00069	0.476
MOD_GSK3_1	313	320	PF00069	0.462
MOD_GSK3_1	333	340	PF00069	0.599
MOD_GSK3_1	397	404	PF00069	0.692
MOD_GSK3_1	405	412	PF00069	0.657
MOD_GSK3_1	90	97	PF00069	0.529
MOD_N-GLC_1	13	18	PF02516	0.782
MOD_N-GLC_1	446	451	PF02516	0.505
MOD_NEK2_1	204	209	PF00069	0.669
MOD_NEK2_1	317	322	PF00069	0.417
MOD_NEK2_1	650	655	PF00069	0.532
MOD_OFUCOSY	377	384	PF10250	0.452
MOD_PIKK_1	425	431	PF00454	0.538
MOD_PK_1	520	526	PF00069	0.486
MOD_PKA_2	575	581	PF00069	0.660
MOD_Plk_1	337	343	PF00069	0.684
MOD_Plk_1	658	664	PF00069	0.687
MOD_Plk_2-3	260	266	PF00069	0.576
MOD_Plk_4	208	214	PF00069	0.642
MOD_Plk_4	514	520	PF00069	0.480
MOD_Plk_4	544	550	PF00069	0.436
MOD_ProDKin_1	136	142	PF00069	0.680
MOD_ProDKin_1	326	332	PF00069	0.588
MOD_ProDKin_1	38	44	PF00069	0.613
MOD_ProDKin_1	92	98	PF00069	0.533
TRG_DiLeu_BaEn_1	78	83	PF01217	0.489
TRG_ENDOCYTIC_2	179	182	PF00928	0.553
TRG_ENDOCYTIC_2	227	230	PF00928	0.455
TRG_ENDOCYTIC_2	545	548	PF00928	0.418
TRG_ENDOCYTIC_2	664	667	PF00928	0.691
TRG_ER_diArg_1	143	145	PF00400	0.549
TRG_ER_diArg_1	431	433	PF00400	0.529
TRG_ER_diArg_1	595	597	PF00400	0.749
TRG_NLS_Bipartite_1	130	146	PF00514	0.545
TRG_NLS_MonoExtN_4	140	146	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I055	Leptomonas seymouri	48%	98%
A0A1X0NTQ8	Trypanosomatidae	24%	100%
A0A3Q8IH11	Leishmania donovani	92%	100%
A0A422N6S6	Trypanosoma rangeli	28%	100%
A4HEX3	Leishmania braziliensis	75%	100%
A4I247	Leishmania infantum	92%	100%
C9ZRV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AY97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%