J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q974_LEIMA

TriTrypDb:

LmjF.26.1200 , LMJLV39_260017700 , LMJSD75_260016100

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 8
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q974

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q974

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.464
CLV_NRD_NRD_1	192	194	PF00675	0.740
CLV_NRD_NRD_1	254	256	PF00675	0.642
CLV_NRD_NRD_1	261	263	PF00675	0.595
CLV_NRD_NRD_1	338	340	PF00675	0.471
CLV_NRD_NRD_1	355	357	PF00675	0.620
CLV_NRD_NRD_1	485	487	PF00675	0.713
CLV_NRD_NRD_1	541	543	PF00675	0.648
CLV_NRD_NRD_1	56	58	PF00675	0.742
CLV_NRD_NRD_1	599	601	PF00675	0.617
CLV_NRD_NRD_1	7	9	PF00675	0.629
CLV_NRD_NRD_1	86	88	PF00675	0.645
CLV_NRD_NRD_1	89	91	PF00675	0.651
CLV_PCSK_FUR_1	259	263	PF00082	0.640
CLV_PCSK_FUR_1	84	88	PF00082	0.690
CLV_PCSK_KEX2_1	192	194	PF00082	0.739
CLV_PCSK_KEX2_1	250	252	PF00082	0.617
CLV_PCSK_KEX2_1	254	256	PF00082	0.619
CLV_PCSK_KEX2_1	261	263	PF00082	0.633
CLV_PCSK_KEX2_1	338	340	PF00082	0.469
CLV_PCSK_KEX2_1	357	359	PF00082	0.625
CLV_PCSK_KEX2_1	435	437	PF00082	0.772
CLV_PCSK_KEX2_1	474	476	PF00082	0.692
CLV_PCSK_KEX2_1	484	486	PF00082	0.750
CLV_PCSK_KEX2_1	541	543	PF00082	0.644
CLV_PCSK_KEX2_1	56	58	PF00082	0.742
CLV_PCSK_KEX2_1	598	600	PF00082	0.624
CLV_PCSK_KEX2_1	7	9	PF00082	0.621
CLV_PCSK_KEX2_1	86	88	PF00082	0.654
CLV_PCSK_KEX2_1	89	91	PF00082	0.658
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.649
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.650
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.478
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.625
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.772
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.692
CLV_PCSK_PC7_1	3	9	PF00082	0.726
CLV_PCSK_PC7_1	537	543	PF00082	0.715
CLV_PCSK_SKI1_1	106	110	PF00082	0.613
CLV_PCSK_SKI1_1	247	251	PF00082	0.657
CLV_PCSK_SKI1_1	262	266	PF00082	0.691
CLV_PCSK_SKI1_1	296	300	PF00082	0.483
CLV_PCSK_SKI1_1	362	366	PF00082	0.629
CLV_PCSK_SKI1_1	454	458	PF00082	0.630
CLV_PCSK_SKI1_1	463	467	PF00082	0.606
CLV_PCSK_SKI1_1	554	558	PF00082	0.736
CLV_PCSK_SKI1_1	56	60	PF00082	0.741
CLV_PCSK_SKI1_1	600	604	PF00082	0.637
CLV_PCSK_SKI1_1	8	12	PF00082	0.617
CLV_PCSK_SKI1_1	97	101	PF00082	0.656
DEG_APCC_DBOX_1	105	113	PF00400	0.484
DEG_APCC_DBOX_1	599	607	PF00400	0.428
DEG_APCC_DBOX_1	7	15	PF00400	0.543
DEG_SPOP_SBC_1	45	49	PF00917	0.583
DEG_SPOP_SBC_1	64	68	PF00917	0.536
DOC_CKS1_1	182	187	PF01111	0.500
DOC_CKS1_1	225	230	PF01111	0.510
DOC_CYCLIN_RxL_1	356	369	PF00134	0.445
DOC_MAPK_DCC_7	514	523	PF00069	0.483
DOC_MAPK_MEF2A_6	445	453	PF00069	0.496
DOC_MAPK_MEF2A_6	514	523	PF00069	0.502
DOC_PP1_RVXF_1	525	531	PF00149	0.485
DOC_PP2B_LxvP_1	287	290	PF13499	0.377
DOC_PP4_FxxP_1	221	224	PF00568	0.530
DOC_SPAK_OSR1_1	3	7	PF12202	0.490
DOC_USP7_MATH_1	104	108	PF00917	0.428
DOC_USP7_MATH_1	174	178	PF00917	0.414
DOC_USP7_MATH_1	200	204	PF00917	0.559
DOC_USP7_MATH_1	41	45	PF00917	0.536
DOC_USP7_MATH_1	424	428	PF00917	0.509
DOC_USP7_MATH_1	46	50	PF00917	0.548
DOC_USP7_MATH_1	487	491	PF00917	0.555
DOC_USP7_MATH_1	620	624	PF00917	0.522
DOC_USP7_MATH_1	69	73	PF00917	0.497
DOC_USP7_MATH_1	93	97	PF00917	0.516
DOC_USP7_UBL2_3	257	261	PF12436	0.476
DOC_USP7_UBL2_3	265	269	PF12436	0.506
DOC_USP7_UBL2_3	527	531	PF12436	0.477
DOC_USP7_UBL2_3	618	622	PF12436	0.466
DOC_WW_Pin1_4	123	128	PF00397	0.351
DOC_WW_Pin1_4	181	186	PF00397	0.496
DOC_WW_Pin1_4	224	229	PF00397	0.510
DOC_WW_Pin1_4	291	296	PF00397	0.250
DOC_WW_Pin1_4	313	318	PF00397	0.362
DOC_WW_Pin1_4	332	337	PF00397	0.356
DOC_WW_Pin1_4	500	505	PF00397	0.569
LIG_14-3-3_CanoR_1	210	215	PF00244	0.570
LIG_14-3-3_CanoR_1	331	336	PF00244	0.364
LIG_14-3-3_CanoR_1	542	548	PF00244	0.452
LIG_14-3-3_CanoR_1	552	557	PF00244	0.436
LIG_APCC_ABBA_1	235	240	PF00400	0.512
LIG_APCC_ABBA_1	307	312	PF00400	0.280
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BIR_III_2	292	296	PF00653	0.250
LIG_BRCT_BRCA1_1	516	520	PF00533	0.453
LIG_BRCT_BRCA1_1	70	74	PF00533	0.555
LIG_FHA_1	273	279	PF00498	0.479
LIG_FHA_1	302	308	PF00498	0.197
LIG_FHA_1	345	351	PF00498	0.443
LIG_FHA_1	448	454	PF00498	0.515
LIG_FHA_1	578	584	PF00498	0.445
LIG_FHA_1	607	613	PF00498	0.479
LIG_FHA_2	251	257	PF00498	0.516
LIG_FHA_2	391	397	PF00498	0.426
LIG_FHA_2	553	559	PF00498	0.466
LIG_FHA_2	76	82	PF00498	0.430
LIG_HP1_1	127	131	PF01393	0.406
LIG_LIR_Apic_2	145	151	PF02991	0.439
LIG_LIR_Gen_1	176	187	PF02991	0.512
LIG_LIR_Gen_1	517	528	PF02991	0.520
LIG_LIR_Gen_1	71	82	PF02991	0.485
LIG_LIR_Nem_3	176	182	PF02991	0.496
LIG_LIR_Nem_3	184	190	PF02991	0.469
LIG_LIR_Nem_3	213	217	PF02991	0.477
LIG_LIR_Nem_3	280	286	PF02991	0.281
LIG_LIR_Nem_3	327	333	PF02991	0.271
LIG_LIR_Nem_3	472	476	PF02991	0.378
LIG_LIR_Nem_3	517	523	PF02991	0.522
LIG_LIR_Nem_3	608	613	PF02991	0.434
LIG_LIR_Nem_3	71	77	PF02991	0.517
LIG_PCNA_PIPBox_1	172	181	PF02747	0.446
LIG_Pex14_1	157	161	PF04695	0.328
LIG_Pex14_2	378	382	PF04695	0.465
LIG_Pex14_2	70	74	PF04695	0.388
LIG_Rb_pABgroove_1	581	589	PF01858	0.503
LIG_SH2_CRK	167	171	PF00017	0.409
LIG_SH2_CRK	179	183	PF00017	0.438
LIG_SH2_CRK	284	288	PF00017	0.291
LIG_SH2_CRK	330	334	PF00017	0.262
LIG_SH2_CRK	473	477	PF00017	0.434
LIG_SH2_CRK	568	572	PF00017	0.498
LIG_SH2_CRK	613	617	PF00017	0.503
LIG_SH2_NCK_1	167	171	PF00017	0.425
LIG_SH2_NCK_1	179	183	PF00017	0.454
LIG_SH2_NCK_1	238	242	PF00017	0.514
LIG_SH2_NCK_1	420	424	PF00017	0.511
LIG_SH2_NCK_1	568	572	PF00017	0.448
LIG_SH2_SRC	238	241	PF00017	0.513
LIG_SH2_STAP1	179	183	PF00017	0.482
LIG_SH2_STAP1	420	424	PF00017	0.496
LIG_SH2_STAT3	587	590	PF00017	0.487
LIG_SH2_STAT3	635	638	PF00017	0.459
LIG_SH2_STAT5	188	191	PF00017	0.527
LIG_SH2_STAT5	392	395	PF00017	0.513
LIG_SH2_STAT5	416	419	PF00017	0.402
LIG_SH2_STAT5	479	482	PF00017	0.396
LIG_SH2_STAT5	529	532	PF00017	0.518
LIG_SH2_STAT5	547	550	PF00017	0.518
LIG_SH2_STAT5	568	571	PF00017	0.414
LIG_SH3_3	121	127	PF00018	0.450
LIG_SH3_3	179	185	PF00018	0.477
LIG_SH3_3	513	519	PF00018	0.531
LIG_SH3_3	586	592	PF00018	0.492
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.277
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.475
LIG_SUMO_SIM_par_1	129	134	PF11976	0.288
LIG_TRAF2_1	393	396	PF00917	0.452
LIG_TRAF2_1	570	573	PF00917	0.431
LIG_WRC_WIRS_1	379	384	PF05994	0.457
MOD_CDC14_SPxK_1	335	338	PF00782	0.294
MOD_CDC14_SPxK_1	503	506	PF00782	0.527
MOD_CDK_SPK_2	291	296	PF00069	0.268
MOD_CDK_SPxK_1	332	338	PF00069	0.294
MOD_CDK_SPxK_1	500	506	PF00069	0.529
MOD_CDK_SPxxK_3	332	339	PF00069	0.294
MOD_CK1_1	142	148	PF00069	0.589
MOD_CK1_1	177	183	PF00069	0.515
MOD_CK1_1	2	8	PF00069	0.562
MOD_CK1_1	201	207	PF00069	0.546
MOD_CK1_1	380	386	PF00069	0.488
MOD_CK1_1	44	50	PF00069	0.520
MOD_CK1_1	68	74	PF00069	0.514
MOD_CK2_1	390	396	PF00069	0.421
MOD_CK2_1	567	573	PF00069	0.427
MOD_CK2_1	628	634	PF00069	0.468
MOD_CK2_1	75	81	PF00069	0.434
MOD_GlcNHglycan	141	144	PF01048	0.433
MOD_GlcNHglycan	200	203	PF01048	0.730
MOD_GlcNHglycan	204	207	PF01048	0.717
MOD_GlcNHglycan	22	25	PF01048	0.736
MOD_GlcNHglycan	266	269	PF01048	0.724
MOD_GlcNHglycan	27	30	PF01048	0.724
MOD_GlcNHglycan	41	44	PF01048	0.609
MOD_GlcNHglycan	436	439	PF01048	0.768
MOD_GlcNHglycan	487	490	PF01048	0.755
MOD_GlcNHglycan	67	70	PF01048	0.765
MOD_GSK3_1	142	149	PF00069	0.577
MOD_GSK3_1	173	180	PF00069	0.480
MOD_GSK3_1	198	205	PF00069	0.561
MOD_GSK3_1	35	42	PF00069	0.462
MOD_GSK3_1	44	51	PF00069	0.501
MOD_GSK3_1	510	517	PF00069	0.528
MOD_GSK3_1	552	559	PF00069	0.445
MOD_GSK3_1	59	66	PF00069	0.498
MOD_LATS_1	512	518	PF00433	0.455
MOD_N-GLC_1	620	625	PF02516	0.718
MOD_NEK2_1	378	383	PF00069	0.427
MOD_NEK2_1	574	579	PF00069	0.406
MOD_NEK2_1	59	64	PF00069	0.464
MOD_NEK2_1	606	611	PF00069	0.444
MOD_NEK2_1	628	633	PF00069	0.458
MOD_PIKK_1	380	386	PF00454	0.388
MOD_PKA_1	250	256	PF00069	0.423
MOD_PKA_1	434	440	PF00069	0.584
MOD_PKA_1	485	491	PF00069	0.523
MOD_PKA_2	2	8	PF00069	0.632
MOD_PKA_2	250	256	PF00069	0.423
MOD_PKA_2	324	330	PF00069	0.362
MOD_PKA_2	485	491	PF00069	0.574
MOD_PKB_1	137	145	PF00069	0.655
MOD_PKB_1	208	216	PF00069	0.479
MOD_Plk_1	620	626	PF00069	0.518
MOD_Plk_1	93	99	PF00069	0.538
MOD_Plk_4	174	180	PF00069	0.509
MOD_Plk_4	239	245	PF00069	0.501
MOD_Plk_4	50	56	PF00069	0.478
MOD_Plk_4	606	612	PF00069	0.439
MOD_ProDKin_1	123	129	PF00069	0.351
MOD_ProDKin_1	181	187	PF00069	0.498
MOD_ProDKin_1	224	230	PF00069	0.510
MOD_ProDKin_1	291	297	PF00069	0.250
MOD_ProDKin_1	313	319	PF00069	0.362
MOD_ProDKin_1	332	338	PF00069	0.356
MOD_ProDKin_1	500	506	PF00069	0.571
MOD_SUMO_rev_2	427	437	PF00179	0.547
TRG_DiLeu_BaEn_4	395	401	PF01217	0.512
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.511
TRG_ENDOCYTIC_2	153	156	PF00928	0.394
TRG_ENDOCYTIC_2	167	170	PF00928	0.343
TRG_ENDOCYTIC_2	179	182	PF00928	0.437
TRG_ENDOCYTIC_2	187	190	PF00928	0.305
TRG_ENDOCYTIC_2	283	286	PF00928	0.272
TRG_ENDOCYTIC_2	330	333	PF00928	0.262
TRG_ENDOCYTIC_2	473	476	PF00928	0.403
TRG_ENDOCYTIC_2	479	482	PF00928	0.439
TRG_ENDOCYTIC_2	568	571	PF00928	0.414
TRG_ER_diArg_1	137	140	PF00400	0.620
TRG_ER_diArg_1	192	194	PF00400	0.539
TRG_ER_diArg_1	207	210	PF00400	0.485
TRG_ER_diArg_1	400	403	PF00400	0.384
TRG_ER_diArg_1	451	454	PF00400	0.428
TRG_ER_diArg_1	484	486	PF00400	0.565
TRG_ER_diArg_1	540	542	PF00400	0.451
TRG_ER_diArg_1	55	57	PF00400	0.548
TRG_ER_diArg_1	551	554	PF00400	0.492
TRG_ER_diArg_1	598	600	PF00400	0.436
TRG_ER_diArg_1	6	8	PF00400	0.548
TRG_ER_diArg_1	84	87	PF00400	0.459
TRG_ER_FFAT_2	176	184	PF00635	0.370
TRG_NES_CRM1_1	601	615	PF08389	0.458
TRG_NLS_Bipartite_1	250	266	PF00514	0.477
TRG_NLS_MonoCore_2	337	342	PF00514	0.336
TRG_NLS_MonoExtC_3	260	265	PF00514	0.540
TRG_NLS_MonoExtC_3	337	343	PF00514	0.339
TRG_NLS_MonoExtN_4	259	266	PF00514	0.534
TRG_NLS_MonoExtN_4	336	342	PF00514	0.326
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL2	Leptomonas seymouri	64%	100%
A0A0S4JWY5	Bodo saltans	35%	100%
A0A1X0NS91	Trypanosomatidae	43%	100%
A0A3Q8ICT2	Leishmania donovani	91%	99%
A0A422N6M1	Trypanosoma rangeli	45%	100%
A4HEX5	Leishmania braziliensis	79%	97%
A4I249	Leishmania infantum	91%	99%
C9ZRU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	83%
C9ZRV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AY99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BUD6	Trypanosoma cruzi	45%	100%