J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q974_LEIMA

TriTrypDb:

LmjF.26.1200 , LMJLV39_260017700 , LMJSD75_260016100

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 8
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

Q4Q974

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q974

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.464
CLV_NRD_NRD_1	192	194	PF00675	0.740
CLV_NRD_NRD_1	254	256	PF00675	0.642
CLV_NRD_NRD_1	261	263	PF00675	0.595
CLV_NRD_NRD_1	338	340	PF00675	0.471
CLV_NRD_NRD_1	355	357	PF00675	0.620
CLV_NRD_NRD_1	485	487	PF00675	0.713
CLV_NRD_NRD_1	541	543	PF00675	0.648
CLV_NRD_NRD_1	56	58	PF00675	0.742
CLV_NRD_NRD_1	599	601	PF00675	0.617

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL2	Leptomonas seymouri	64%	100%
A0A0S4JWY5	Bodo saltans	35%	100%
A0A1X0NS91	Trypanosomatidae	43%	100%
A0A3Q8ICT2	Leishmania donovani	91%	99%
A0A422N6M1	Trypanosoma rangeli	45%	100%
A4HEX5	Leishmania braziliensis	79%	97%
A4I249	Leishmania infantum	91%	99%
C9ZRU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	83%
C9ZRV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AY99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%

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