Putative aldo/keto reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldo/keto reductase, putative

Species:

Leishmania major

UniProt:

Q4Q973_LEIMA

TriTrypDb:

LmjF.26.1210 , LMJLV39_260017800 , LMJSD75_260016200

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q973

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q973

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	7	2
GO:0004033	aldo-keto reductase (NADP) activity	5	2
GO:0008106	alcohol dehydrogenase (NADP+) activity	6	2
GO:0016491	oxidoreductase activity	2	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.224
CLV_PCSK_SKI1_1	161	165	PF00082	0.272
CLV_PCSK_SKI1_1	273	277	PF00082	0.403
CLV_PCSK_SKI1_1	378	382	PF00082	0.510
CLV_PCSK_SKI1_1	40	44	PF00082	0.262
DEG_APCC_DBOX_1	72	80	PF00400	0.431
DEG_Nend_UBRbox_3	1	3	PF02207	0.606
DOC_CYCLIN_RxL_1	375	384	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	230	233	PF00134	0.313
DOC_MAPK_gen_1	254	261	PF00069	0.470
DOC_MAPK_gen_1	273	283	PF00069	0.483
DOC_MAPK_gen_1	390	398	PF00069	0.426
DOC_MAPK_MEF2A_6	73	82	PF00069	0.418
DOC_PP2B_LxvP_1	230	233	PF13499	0.430
DOC_PP4_FxxP_1	18	21	PF00568	0.439
DOC_USP7_MATH_1	188	192	PF00917	0.712
DOC_USP7_MATH_1	215	219	PF00917	0.694
DOC_USP7_MATH_1	223	227	PF00917	0.606
DOC_USP7_MATH_1	308	312	PF00917	0.515
DOC_USP7_MATH_1	34	38	PF00917	0.503
DOC_USP7_MATH_1	8	12	PF00917	0.536
DOC_USP7_MATH_1	83	87	PF00917	0.539
DOC_USP7_UBL2_3	81	85	PF12436	0.418
DOC_WW_Pin1_4	211	216	PF00397	0.594
DOC_WW_Pin1_4	262	267	PF00397	0.323
DOC_WW_Pin1_4	302	307	PF00397	0.669
LIG_14-3-3_CanoR_1	378	388	PF00244	0.508
LIG_BIR_III_4	126	130	PF00653	0.512
LIG_BRCT_BRCA1_1	14	18	PF00533	0.407
LIG_eIF4E_1	108	114	PF01652	0.411
LIG_eIF4E_1	56	62	PF01652	0.470
LIG_FHA_1	25	31	PF00498	0.432
LIG_Integrin_RGD_1	31	33	PF01839	0.274
LIG_LIR_Apic_2	15	21	PF02991	0.393
LIG_LIR_Gen_1	348	357	PF02991	0.487
LIG_LIR_Gen_1	75	84	PF02991	0.434
LIG_LIR_Nem_3	348	353	PF02991	0.409
LIG_LIR_Nem_3	75	80	PF02991	0.434
LIG_MYND_1	229	233	PF01753	0.304
LIG_PCNA_PIPBox_1	385	394	PF02747	0.429
LIG_SH2_CRK	152	156	PF00017	0.472
LIG_SH2_CRK	264	268	PF00017	0.331
LIG_SH2_CRK	327	331	PF00017	0.415
LIG_SH2_STAP1	108	112	PF00017	0.394
LIG_SH2_STAT5	152	155	PF00017	0.472
LIG_SH2_STAT5	252	255	PF00017	0.364
LIG_SH2_STAT5	287	290	PF00017	0.497
LIG_SH2_STAT5	327	330	PF00017	0.404
LIG_SH2_STAT5	349	352	PF00017	0.515
LIG_SH3_3	11	17	PF00018	0.433
LIG_SH3_3	226	232	PF00018	0.406
LIG_SH3_3	294	300	PF00018	0.618
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.321
LIG_TYR_ITIM	150	155	PF00017	0.472
LIG_UBA3_1	140	149	PF00899	0.472
LIG_UBA3_1	97	103	PF00899	0.498
MOD_CDK_SPxxK_3	262	269	PF00069	0.409
MOD_CK1_1	210	216	PF00069	0.710
MOD_CK1_1	224	230	PF00069	0.433
MOD_CK1_1	289	295	PF00069	0.606
MOD_CK1_1	86	92	PF00069	0.489
MOD_CK2_1	174	180	PF00069	0.645
MOD_CK2_1	213	219	PF00069	0.598
MOD_CK2_1	85	91	PF00069	0.455
MOD_GlcNHglycan	126	130	PF01048	0.238
MOD_GlcNHglycan	210	213	PF01048	0.701
MOD_GlcNHglycan	223	226	PF01048	0.464
MOD_GlcNHglycan	291	294	PF01048	0.610
MOD_GlcNHglycan	36	39	PF01048	0.322
MOD_GlcNHglycan	68	71	PF01048	0.224
MOD_GSK3_1	207	214	PF00069	0.720
MOD_GSK3_1	326	333	PF00069	0.414
MOD_GSK3_1	8	15	PF00069	0.377
MOD_LATS_1	284	290	PF00433	0.380
MOD_N-GLC_1	289	294	PF02516	0.512
MOD_NEK2_1	1	6	PF00069	0.672
MOD_NEK2_1	330	335	PF00069	0.435
MOD_NEK2_1	373	378	PF00069	0.449
MOD_NEK2_1	49	54	PF00069	0.418
MOD_PIKK_1	408	414	PF00454	0.488
MOD_Plk_4	188	194	PF00069	0.671
MOD_Plk_4	326	332	PF00069	0.413
MOD_Plk_4	8	14	PF00069	0.365
MOD_ProDKin_1	211	217	PF00069	0.592
MOD_ProDKin_1	262	268	PF00069	0.322
MOD_ProDKin_1	302	308	PF00069	0.663
TRG_DiLeu_BaEn_1	315	320	PF01217	0.314
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.371
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.492
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.486
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.431
TRG_ENDOCYTIC_2	152	155	PF00928	0.472
TRG_ENDOCYTIC_2	264	267	PF00928	0.334
TRG_ENDOCYTIC_2	327	330	PF00928	0.399
TRG_ENDOCYTIC_2	47	50	PF00928	0.512
TRG_NES_CRM1_1	95	110	PF08389	0.438
TRG_NLS_MonoExtC_3	101	107	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	57%	100%
A0A0N0P8F4	Leptomonas seymouri	28%	100%
A0A0N1I9Z1	Leptomonas seymouri	27%	100%
A0A0S4J7K9	Bodo saltans	25%	100%
A0A1X0NIH1	Trypanosomatidae	39%	100%
A0A3Q8IFG1	Leishmania donovani	27%	100%
A0A3S7WZZ0	Leishmania donovani	92%	73%
A0A3S7X124	Leishmania donovani	26%	100%
A0A422N9R4	Trypanosoma rangeli	41%	100%
A0QL30	Mycobacterium avium (strain 104)	27%	100%
A0QV09	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	100%
A1KMW6	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	29%	100%
A1T726	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	29%	100%
A1UEC5	Mycobacterium sp. (strain KMS)	27%	100%
A3PXS9	Mycobacterium sp. (strain JLS)	27%	100%
A4HEX6	Leishmania braziliensis	76%	99%
A4HG21	Leishmania braziliensis	26%	100%
A4HJJ7	Leishmania braziliensis	29%	100%
A4I250	Leishmania infantum	92%	73%
A4I342	Leishmania infantum	26%	100%
A4I6Z4	Leishmania infantum	27%	100%
A4TE41	Mycolicibacterium gilvum (strain PYR-GCK)	27%	100%
A5U6Y1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	29%	100%
B8ZS00	Mycobacterium leprae (strain Br4923)	26%	100%
B9VRJ2	Papaver somniferum	25%	100%
C9ZJL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A735	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ACW1	Leishmania major	27%	100%
E9AYA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AZF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B215	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O34678	Bacillus subtilis (strain 168)	27%	100%
O69462	Mycobacterium leprae (strain TN)	26%	100%
P14065	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P22045	Leishmania major	26%	87%
P38115	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P9WQA4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WQA5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q0GYU4	Hypocrea jecorina	26%	100%
Q12458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q1BAN7	Mycobacterium sp. (strain MCS)	27%	100%
Q28FD1	Xenopus tropicalis	27%	100%
Q3ZFI7	Hypocrea jecorina	26%	100%
Q6AZW2	Danio rerio	24%	100%
Q6GMC7	Xenopus laevis	25%	100%
Q73SC5	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	28%	100%
Q7TXI6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	100%
Q9M338	Arabidopsis thaliana	26%	100%
Q9SQ69	Papaver somniferum	24%	100%
Q9SQ70	Papaver somniferum	25%	100%
V5B6J8	Trypanosoma cruzi	25%	100%
V5BR74	Trypanosoma cruzi	41%	100%