Leucine rich repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q972_LEIMA

TriTrypDb:

LmjF.26.1220 , LMJLV39_260017900 , LMJSD75_260016300

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4Q972

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q972

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0036158	outer dynein arm assembly	7	10
GO:0036159	inner dynein arm assembly	7	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0044877	protein-containing complex binding	2	10
GO:0070840	dynein complex binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.501
CLV_C14_Caspase3-7	204	208	PF00656	0.371
CLV_C14_Caspase3-7	237	241	PF00656	0.572
CLV_C14_Caspase3-7	526	530	PF00656	0.731
CLV_C14_Caspase3-7	553	557	PF00656	0.745
CLV_MEL_PAP_1	128	134	PF00089	0.483
CLV_NRD_NRD_1	267	269	PF00675	0.580
CLV_NRD_NRD_1	339	341	PF00675	0.589
CLV_NRD_NRD_1	431	433	PF00675	0.345
CLV_NRD_NRD_1	455	457	PF00675	0.357
CLV_NRD_NRD_1	492	494	PF00675	0.458
CLV_PCSK_FUR_1	337	341	PF00082	0.485
CLV_PCSK_FUR_1	438	442	PF00082	0.441
CLV_PCSK_KEX2_1	267	269	PF00082	0.749
CLV_PCSK_KEX2_1	297	299	PF00082	0.522
CLV_PCSK_KEX2_1	339	341	PF00082	0.589
CLV_PCSK_KEX2_1	433	435	PF00082	0.472
CLV_PCSK_KEX2_1	440	442	PF00082	0.491
CLV_PCSK_KEX2_1	455	457	PF00082	0.272
CLV_PCSK_KEX2_1	486	488	PF00082	0.413
CLV_PCSK_KEX2_1	492	494	PF00082	0.447
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.542
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.472
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.451
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.522
CLV_PCSK_SKI1_1	174	178	PF00082	0.389
CLV_PCSK_SKI1_1	433	437	PF00082	0.409
CLV_PCSK_SKI1_1	440	444	PF00082	0.399
CLV_PCSK_SKI1_1	448	452	PF00082	0.353
CLV_PCSK_SKI1_1	456	460	PF00082	0.298
DEG_ODPH_VHL_1	72	85	PF01847	0.390
DEG_SIAH_1	106	114	PF03145	0.511
DEG_SPOP_SBC_1	555	559	PF00917	0.593
DOC_CDC14_PxL_1	408	416	PF14671	0.385
DOC_CYCLIN_RxL_1	434	447	PF00134	0.502
DOC_MAPK_gen_1	202	211	PF00069	0.492
DOC_MAPK_gen_1	297	304	PF00069	0.439
DOC_MAPK_gen_1	337	346	PF00069	0.595
DOC_MAPK_gen_1	410	419	PF00069	0.358
DOC_MAPK_gen_1	438	445	PF00069	0.452
DOC_PP1_RVXF_1	82	88	PF00149	0.334
DOC_SPAK_OSR1_1	131	135	PF12202	0.494
DOC_USP7_MATH_1	176	180	PF00917	0.472
DOC_USP7_MATH_1	247	251	PF00917	0.747
DOC_USP7_MATH_1	25	29	PF00917	0.701
DOC_USP7_MATH_1	359	363	PF00917	0.429
DOC_USP7_MATH_1	536	540	PF00917	0.717
DOC_USP7_MATH_1	555	559	PF00917	0.666
DOC_USP7_MATH_1	591	595	PF00917	0.701
DOC_USP7_MATH_1	600	604	PF00917	0.623
DOC_USP7_MATH_1	626	630	PF00917	0.715
DOC_USP7_MATH_1	648	652	PF00917	0.776
DOC_WW_Pin1_4	149	154	PF00397	0.680
DOC_WW_Pin1_4	240	245	PF00397	0.629
DOC_WW_Pin1_4	250	255	PF00397	0.653
DOC_WW_Pin1_4	269	274	PF00397	0.528
DOC_WW_Pin1_4	289	294	PF00397	0.459
DOC_WW_Pin1_4	318	323	PF00397	0.498
LIG_14-3-3_CanoR_1	131	135	PF00244	0.494
LIG_14-3-3_CanoR_1	298	303	PF00244	0.529
LIG_14-3-3_CanoR_1	306	316	PF00244	0.427
LIG_14-3-3_CanoR_1	339	345	PF00244	0.781
LIG_14-3-3_CanoR_1	357	366	PF00244	0.280
LIG_14-3-3_CanoR_1	413	418	PF00244	0.406
LIG_14-3-3_CanoR_1	455	463	PF00244	0.561
LIG_14-3-3_CanoR_1	535	544	PF00244	0.648
LIG_14-3-3_CanoR_1	549	555	PF00244	0.730
LIG_14-3-3_CanoR_1	624	631	PF00244	0.815
LIG_14-3-3_CanoR_1	638	646	PF00244	0.588
LIG_Actin_WH2_2	404	420	PF00022	0.355
LIG_AP2alpha_2	112	114	PF02296	0.639
LIG_APCC_ABBA_1	77	82	PF00400	0.405
LIG_APCC_ABBAyCdc20_2	440	446	PF00400	0.442
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BRCT_BRCA1_1	211	215	PF00533	0.405
LIG_Clathr_ClatBox_1	405	409	PF01394	0.387
LIG_Clathr_ClatBox_1	442	446	PF01394	0.348
LIG_eIF4E_1	188	194	PF01652	0.423
LIG_FHA_1	299	305	PF00498	0.415
LIG_FHA_1	308	314	PF00498	0.368
LIG_FHA_1	37	43	PF00498	0.424
LIG_FHA_1	499	505	PF00498	0.588
LIG_FHA_1	539	545	PF00498	0.737
LIG_FHA_1	7	13	PF00498	0.726
LIG_FHA_2	521	527	PF00498	0.665
LIG_FHA_2	558	564	PF00498	0.670
LIG_FHA_2	73	79	PF00498	0.511
LIG_LIR_Gen_1	175	184	PF02991	0.360
LIG_LIR_Gen_1	201	211	PF02991	0.381
LIG_LIR_Gen_1	312	322	PF02991	0.418
LIG_LIR_Gen_1	78	88	PF02991	0.347
LIG_LIR_Nem_3	175	180	PF02991	0.369
LIG_LIR_Nem_3	201	206	PF02991	0.397
LIG_LIR_Nem_3	312	317	PF02991	0.404
LIG_LIR_Nem_3	489	494	PF02991	0.500
LIG_LIR_Nem_3	75	80	PF02991	0.365
LIG_LYPXL_S_1	180	184	PF13949	0.349
LIG_LYPXL_yS_3	181	184	PF13949	0.348
LIG_PTB_Apo_2	188	195	PF02174	0.486
LIG_PTB_Apo_2	63	70	PF02174	0.444
LIG_PTB_Phospho_1	63	69	PF10480	0.439
LIG_SH2_CRK	102	106	PF00017	0.591
LIG_SH2_CRK	385	389	PF00017	0.396
LIG_SH2_CRK	53	57	PF00017	0.385
LIG_SH2_CRK	69	73	PF00017	0.359
LIG_SH2_GRB2like	511	514	PF00017	0.505
LIG_SH2_NCK_1	69	73	PF00017	0.459
LIG_SH2_SRC	511	514	PF00017	0.554
LIG_SH2_STAP1	226	230	PF00017	0.543
LIG_SH2_STAP1	69	73	PF00017	0.435
LIG_SH2_STAT5	102	105	PF00017	0.585
LIG_SH2_STAT5	188	191	PF00017	0.426
LIG_SH2_STAT5	511	514	PF00017	0.637
LIG_SH2_STAT5	63	66	PF00017	0.360
LIG_SH2_STAT5	80	83	PF00017	0.348
LIG_SH3_3	102	108	PF00018	0.565
LIG_SH3_3	287	293	PF00018	0.554
LIG_SH3_3	346	352	PF00018	0.721
LIG_SH3_3	501	507	PF00018	0.454
LIG_SH3_5	507	511	PF00018	0.644
LIG_SUMO_SIM_anti_2	284	292	PF11976	0.585
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.465
LIG_SUMO_SIM_anti_2	402	409	PF11976	0.328
LIG_SUMO_SIM_par_1	389	394	PF11976	0.331
LIG_SUMO_SIM_par_1	402	409	PF11976	0.422
LIG_TRAF2_1	475	478	PF00917	0.594
LIG_TYR_ITIM	383	388	PF00017	0.391
LIG_WW_3	618	622	PF00397	0.603
MOD_CK1_1	23	29	PF00069	0.631
MOD_CK1_1	243	249	PF00069	0.600
MOD_CK1_1	250	256	PF00069	0.558
MOD_CK1_1	540	546	PF00069	0.718
MOD_CK1_1	557	563	PF00069	0.684
MOD_CK2_1	198	204	PF00069	0.570
MOD_CK2_1	557	563	PF00069	0.665
MOD_CK2_1	610	616	PF00069	0.791
MOD_CK2_1	72	78	PF00069	0.404
MOD_GlcNHglycan	211	214	PF01048	0.419
MOD_GlcNHglycan	227	230	PF01048	0.339
MOD_GlcNHglycan	245	248	PF01048	0.635
MOD_GlcNHglycan	249	252	PF01048	0.717
MOD_GlcNHglycan	27	30	PF01048	0.630
MOD_GlcNHglycan	276	279	PF01048	0.654
MOD_GlcNHglycan	419	422	PF01048	0.384
MOD_GlcNHglycan	575	578	PF01048	0.793
MOD_GlcNHglycan	580	584	PF01048	0.755
MOD_GlcNHglycan	601	605	PF01048	0.715
MOD_GSK3_1	1	8	PF00069	0.696
MOD_GSK3_1	11	18	PF00069	0.640
MOD_GSK3_1	176	183	PF00069	0.461
MOD_GSK3_1	20	27	PF00069	0.568
MOD_GSK3_1	239	246	PF00069	0.756
MOD_GSK3_1	250	257	PF00069	0.699
MOD_GSK3_1	274	281	PF00069	0.688
MOD_GSK3_1	285	292	PF00069	0.544
MOD_GSK3_1	413	420	PF00069	0.373
MOD_GSK3_1	520	527	PF00069	0.582
MOD_GSK3_1	536	543	PF00069	0.685
MOD_GSK3_1	545	552	PF00069	0.708
MOD_GSK3_1	554	561	PF00069	0.629
MOD_GSK3_1	575	582	PF00069	0.655
MOD_GSK3_1	68	75	PF00069	0.501
MOD_LATS_1	547	553	PF00433	0.620
MOD_N-GLC_1	20	25	PF02516	0.772
MOD_N-GLC_1	209	214	PF02516	0.339
MOD_N-GLC_1	31	36	PF02516	0.631
MOD_N-GLC_1	591	596	PF02516	0.779
MOD_NEK2_1	193	198	PF00069	0.512
MOD_NEK2_1	24	29	PF00069	0.644
MOD_NEK2_1	256	261	PF00069	0.622
MOD_NEK2_1	391	396	PF00069	0.326
MOD_NEK2_1	417	422	PF00069	0.353
MOD_NEK2_1	424	429	PF00069	0.386
MOD_NEK2_1	610	615	PF00069	0.687
MOD_NEK2_2	176	181	PF00069	0.473
MOD_NEK2_2	359	364	PF00069	0.431
MOD_PIKK_1	100	106	PF00454	0.516
MOD_PIKK_1	610	616	PF00454	0.790
MOD_PIKK_1	626	632	PF00454	0.811
MOD_PKA_1	339	345	PF00069	0.610
MOD_PKA_2	130	136	PF00069	0.765
MOD_PKA_2	307	313	PF00069	0.435
MOD_PKA_2	339	345	PF00069	0.658
MOD_PKA_2	537	543	PF00069	0.748
MOD_PKA_2	545	551	PF00069	0.638
MOD_PKA_2	6	12	PF00069	0.587
MOD_PKB_1	337	345	PF00069	0.505
MOD_PKB_1	432	440	PF00069	0.481
MOD_Plk_1	159	165	PF00069	0.648
MOD_Plk_1	198	204	PF00069	0.450
MOD_Plk_1	20	26	PF00069	0.721
MOD_Plk_1	285	291	PF00069	0.560
MOD_Plk_4	176	182	PF00069	0.365
MOD_Plk_4	285	291	PF00069	0.744
MOD_Plk_4	91	97	PF00069	0.388
MOD_ProDKin_1	149	155	PF00069	0.677
MOD_ProDKin_1	240	246	PF00069	0.629
MOD_ProDKin_1	250	256	PF00069	0.651
MOD_ProDKin_1	269	275	PF00069	0.526
MOD_ProDKin_1	289	295	PF00069	0.449
MOD_ProDKin_1	318	324	PF00069	0.504
MOD_SUMO_rev_2	478	488	PF00179	0.507
MOD_SUMO_rev_2	613	620	PF00179	0.627
MOD_SUMO_rev_2	78	86	PF00179	0.353
TRG_DiLeu_BaEn_1	402	407	PF01217	0.343
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.541
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.443
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.561
TRG_ENDOCYTIC_2	102	105	PF00928	0.585
TRG_ENDOCYTIC_2	181	184	PF00928	0.348
TRG_ENDOCYTIC_2	385	388	PF00928	0.395
TRG_ENDOCYTIC_2	69	72	PF00928	0.427
TRG_ENDOCYTIC_2	80	83	PF00928	0.292
TRG_ER_diArg_1	337	340	PF00400	0.569
TRG_ER_diArg_1	431	434	PF00400	0.468
TRG_ER_diArg_1	455	457	PF00400	0.357
TRG_ER_diArg_1	491	493	PF00400	0.457
TRG_NLS_MonoExtN_4	429	436	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	441	446	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C5	Leptomonas seymouri	54%	100%
A0A0S4JQS0	Bodo saltans	37%	100%
A0A3Q8IFU8	Leishmania donovani	90%	100%
A0A422N6Q2	Trypanosoma rangeli	35%	100%
A4HEX7	Leishmania braziliensis	74%	100%
A4I251	Leishmania infantum	90%	100%
C9ZRV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AYA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DQX0	Trypanosoma cruzi	39%	90%