NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 74, putative

Species:

Leishmania major

UniProt:

Q4Q969_LEIMA

TriTrypDb:

LmjF.26.1250 , LMJLV39_260018200 , LMJSD75_260016600

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	4
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q969

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q969

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.441
CLV_C14_Caspase3-7	317	321	PF00656	0.420
CLV_C14_Caspase3-7	631	635	PF00656	0.696
CLV_NRD_NRD_1	105	107	PF00675	0.364
CLV_NRD_NRD_1	27	29	PF00675	0.462
CLV_NRD_NRD_1	524	526	PF00675	0.551
CLV_NRD_NRD_1	539	541	PF00675	0.410
CLV_NRD_NRD_1	546	548	PF00675	0.493
CLV_NRD_NRD_1	616	618	PF00675	0.664
CLV_NRD_NRD_1	673	675	PF00675	0.508
CLV_PCSK_FUR_1	613	617	PF00082	0.723
CLV_PCSK_KEX2_1	27	29	PF00082	0.476
CLV_PCSK_KEX2_1	31	33	PF00082	0.462
CLV_PCSK_KEX2_1	458	460	PF00082	0.513
CLV_PCSK_KEX2_1	524	526	PF00082	0.557
CLV_PCSK_KEX2_1	539	541	PF00082	0.410
CLV_PCSK_KEX2_1	546	548	PF00082	0.493
CLV_PCSK_KEX2_1	615	617	PF00082	0.676
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.492
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.485
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.731
CLV_PCSK_PC7_1	27	33	PF00082	0.515
CLV_PCSK_SKI1_1	107	111	PF00082	0.327
CLV_PCSK_SKI1_1	115	119	PF00082	0.478
CLV_PCSK_SKI1_1	265	269	PF00082	0.487
CLV_PCSK_SKI1_1	303	307	PF00082	0.354
CLV_PCSK_SKI1_1	539	543	PF00082	0.516
CLV_PCSK_SKI1_1	54	58	PF00082	0.316
CLV_PCSK_SKI1_1	637	641	PF00082	0.696
CLV_PCSK_SKI1_1	648	652	PF00082	0.543
DEG_APCC_DBOX_1	601	609	PF00400	0.672
DEG_APCC_KENBOX_2	470	474	PF00400	0.573
DEG_Nend_UBRbox_3	1	3	PF02207	0.392
DOC_CYCLIN_RxL_1	262	271	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	263	269	PF00134	0.390
DOC_MAPK_gen_1	674	684	PF00069	0.516
DOC_USP7_MATH_1	16	20	PF00917	0.455
DOC_USP7_MATH_1	205	209	PF00917	0.361
DOC_USP7_MATH_1	340	344	PF00917	0.516
DOC_USP7_MATH_1	516	520	PF00917	0.618
DOC_USP7_MATH_1	541	545	PF00917	0.494
DOC_USP7_MATH_1	624	628	PF00917	0.688
DOC_USP7_MATH_1	642	646	PF00917	0.699
DOC_USP7_UBL2_3	306	310	PF12436	0.354
DOC_WW_Pin1_4	150	155	PF00397	0.481
DOC_WW_Pin1_4	99	104	PF00397	0.362
LIG_14-3-3_CanoR_1	235	245	PF00244	0.507
LIG_14-3-3_CanoR_1	371	376	PF00244	0.392
LIG_14-3-3_CanoR_1	540	550	PF00244	0.589
LIG_BRCT_BRCA1_1	83	87	PF00533	0.413
LIG_FHA_1	120	126	PF00498	0.502
LIG_FHA_1	246	252	PF00498	0.409
LIG_FHA_1	300	306	PF00498	0.377
LIG_FHA_1	378	384	PF00498	0.399
LIG_FHA_1	386	392	PF00498	0.478
LIG_FHA_1	9	15	PF00498	0.358
LIG_FHA_2	315	321	PF00498	0.354
LIG_FHA_2	388	394	PF00498	0.480
LIG_FHA_2	533	539	PF00498	0.577
LIG_FHA_2	649	655	PF00498	0.593
LIG_FHA_2	681	687	PF00498	0.532
LIG_LIR_Gen_1	137	148	PF02991	0.458
LIG_LIR_Gen_1	314	323	PF02991	0.363
LIG_LIR_Gen_1	374	383	PF02991	0.424
LIG_LIR_Gen_1	389	398	PF02991	0.462
LIG_LIR_Gen_1	528	536	PF02991	0.451
LIG_LIR_Gen_1	553	561	PF02991	0.597
LIG_LIR_Nem_3	102	108	PF02991	0.348
LIG_LIR_Nem_3	137	143	PF02991	0.386
LIG_LIR_Nem_3	314	319	PF02991	0.354
LIG_LIR_Nem_3	326	331	PF02991	0.326
LIG_LIR_Nem_3	374	378	PF02991	0.413
LIG_LIR_Nem_3	389	395	PF02991	0.426
LIG_LIR_Nem_3	442	447	PF02991	0.497
LIG_LIR_Nem_3	528	532	PF02991	0.449
LIG_LIR_Nem_3	553	558	PF02991	0.541
LIG_Pex14_2	505	509	PF04695	0.490
LIG_PTB_Apo_2	426	433	PF02174	0.390
LIG_PTB_Apo_2	523	530	PF02174	0.531
LIG_PTB_Phospho_1	426	432	PF10480	0.383
LIG_PTB_Phospho_1	523	529	PF10480	0.583
LIG_REV1ctd_RIR_1	281	291	PF16727	0.411
LIG_RPA_C_Fungi	204	216	PF08784	0.389
LIG_RPA_C_Fungi	535	547	PF08784	0.499
LIG_SH2_CRK	529	533	PF00017	0.454
LIG_SH2_STAP1	259	263	PF00017	0.358
LIG_SH2_STAP1	529	533	PF00017	0.454
LIG_SH2_STAP1	550	554	PF00017	0.487
LIG_SH2_STAT5	282	285	PF00017	0.334
LIG_SH2_STAT5	447	450	PF00017	0.457
LIG_SH3_3	126	132	PF00018	0.369
LIG_SH3_3	435	441	PF00018	0.401
LIG_SUMO_SIM_anti_2	374	382	PF11976	0.413
LIG_SUMO_SIM_par_1	265	271	PF11976	0.378
LIG_TRAF2_1	238	241	PF00917	0.475
LIG_TRAF2_1	35	38	PF00917	0.626
MOD_CDK_SPxxK_3	99	106	PF00069	0.356
MOD_CK1_1	169	175	PF00069	0.419
MOD_CK1_1	222	228	PF00069	0.539
MOD_CK1_1	288	294	PF00069	0.429
MOD_CK1_1	299	305	PF00069	0.359
MOD_CK1_1	314	320	PF00069	0.392
MOD_CK1_1	343	349	PF00069	0.445
MOD_CK1_1	585	591	PF00069	0.706
MOD_CK1_1	611	617	PF00069	0.575
MOD_CK1_1	635	641	PF00069	0.630
MOD_CK2_1	16	22	PF00069	0.443
MOD_CK2_1	162	168	PF00069	0.391
MOD_CK2_1	371	377	PF00069	0.389
MOD_CK2_1	396	402	PF00069	0.426
MOD_CK2_1	532	538	PF00069	0.528
MOD_CK2_1	648	654	PF00069	0.613
MOD_CK2_1	674	680	PF00069	0.601
MOD_GlcNHglycan	122	125	PF01048	0.401
MOD_GlcNHglycan	148	151	PF01048	0.335
MOD_GlcNHglycan	173	176	PF01048	0.513
MOD_GlcNHglycan	190	193	PF01048	0.524
MOD_GlcNHglycan	221	224	PF01048	0.438
MOD_GlcNHglycan	225	228	PF01048	0.387
MOD_GlcNHglycan	240	244	PF01048	0.315
MOD_GlcNHglycan	252	255	PF01048	0.417
MOD_GlcNHglycan	298	301	PF01048	0.336
MOD_GlcNHglycan	33	36	PF01048	0.675
MOD_GlcNHglycan	344	348	PF01048	0.338
MOD_GlcNHglycan	493	496	PF01048	0.612
MOD_GlcNHglycan	543	546	PF01048	0.608
MOD_GlcNHglycan	585	588	PF01048	0.754
MOD_GlcNHglycan	610	613	PF01048	0.656
MOD_GlcNHglycan	626	629	PF01048	0.611
MOD_GlcNHglycan	634	637	PF01048	0.674
MOD_GlcNHglycan	644	647	PF01048	0.523
MOD_GlcNHglycan	654	658	PF01048	0.407
MOD_GlcNHglycan	96	99	PF01048	0.449
MOD_GSK3_1	1	8	PF00069	0.425
MOD_GSK3_1	115	122	PF00069	0.361
MOD_GSK3_1	12	19	PF00069	0.355
MOD_GSK3_1	146	153	PF00069	0.339
MOD_GSK3_1	162	169	PF00069	0.431
MOD_GSK3_1	219	226	PF00069	0.455
MOD_GSK3_1	288	295	PF00069	0.430
MOD_GSK3_1	311	318	PF00069	0.380
MOD_GSK3_1	326	333	PF00069	0.329
MOD_GSK3_1	491	498	PF00069	0.657
MOD_GSK3_1	607	614	PF00069	0.748
MOD_GSK3_1	624	631	PF00069	0.721
MOD_GSK3_1	653	660	PF00069	0.635
MOD_GSK3_1	81	88	PF00069	0.356
MOD_N-GLC_1	12	17	PF02516	0.367
MOD_N-GLC_1	314	319	PF02516	0.370
MOD_N-GLC_1	60	65	PF02516	0.311
MOD_NEK2_1	1	6	PF00069	0.403
MOD_NEK2_1	134	139	PF00069	0.394
MOD_NEK2_1	166	171	PF00069	0.497
MOD_NEK2_1	245	250	PF00069	0.346
MOD_NEK2_1	330	335	PF00069	0.457
MOD_NEK2_1	509	514	PF00069	0.509
MOD_NEK2_1	653	658	PF00069	0.655
MOD_NEK2_1	690	695	PF00069	0.625
MOD_NEK2_1	85	90	PF00069	0.351
MOD_PIKK_1	330	336	PF00454	0.380
MOD_PKA_1	31	37	PF00069	0.603
MOD_PKA_1	674	680	PF00069	0.601
MOD_PKA_2	31	37	PF00069	0.603
MOD_PKA_2	454	460	PF00069	0.466
MOD_PKA_2	462	468	PF00069	0.519
MOD_PKA_2	503	509	PF00069	0.660
MOD_PKA_2	583	589	PF00069	0.609
MOD_PKA_2	632	638	PF00069	0.771
MOD_Plk_1	292	298	PF00069	0.396
MOD_Plk_1	314	320	PF00069	0.361
MOD_Plk_1	326	332	PF00069	0.326
MOD_Plk_1	386	392	PF00069	0.459
MOD_Plk_1	393	399	PF00069	0.392
MOD_Plk_1	81	87	PF00069	0.433
MOD_Plk_2-3	162	168	PF00069	0.437
MOD_Plk_2-3	377	383	PF00069	0.392
MOD_Plk_2-3	387	393	PF00069	0.461
MOD_Plk_2-3	680	686	PF00069	0.536
MOD_Plk_4	162	168	PF00069	0.437
MOD_Plk_4	278	284	PF00069	0.324
MOD_Plk_4	292	298	PF00069	0.377
MOD_Plk_4	371	377	PF00069	0.366
MOD_Plk_4	387	393	PF00069	0.466
MOD_Plk_4	648	654	PF00069	0.605
MOD_ProDKin_1	150	156	PF00069	0.477
MOD_ProDKin_1	99	105	PF00069	0.363
MOD_SUMO_rev_2	381	388	PF00179	0.424
TRG_DiLeu_BaEn_1	241	246	PF01217	0.524
TRG_DiLeu_BaEn_1	528	533	PF01217	0.438
TRG_DiLeu_BaEn_2	161	167	PF01217	0.414
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.390
TRG_ENDOCYTIC_2	105	108	PF00928	0.476
TRG_ENDOCYTIC_2	140	143	PF00928	0.483
TRG_ENDOCYTIC_2	392	395	PF00928	0.449
TRG_ENDOCYTIC_2	432	435	PF00928	0.408
TRG_ENDOCYTIC_2	529	532	PF00928	0.463
TRG_ER_diArg_1	128	131	PF00400	0.356
TRG_NES_CRM1_1	92	104	PF08389	0.331
TRG_NLS_MonoExtC_3	27	32	PF00514	0.467
TRG_NLS_MonoExtC_3	614	619	PF00514	0.738
TRG_NLS_MonoExtC_3	673	678	PF00514	0.530
TRG_NLS_MonoExtN_4	27	32	PF00514	0.467
TRG_NLS_MonoExtN_4	613	619	PF00514	0.740
TRG_NLS_MonoExtN_4	674	679	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D9	Leptomonas seymouri	79%	100%
A0A0S4JNM6	Bodo saltans	52%	100%
A0A1X0NSW1	Trypanosomatidae	63%	100%
A0A3R7KNJ7	Trypanosoma rangeli	70%	100%
A0A3S7WZS4	Leishmania donovani	95%	99%
A4HEY0	Leishmania braziliensis	88%	99%
A4I254	Leishmania infantum	96%	100%
C9ZRU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AYA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
G0S902	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	100%
O74879	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q5RJG1	Mus musculus	33%	100%
Q66H99	Rattus norvegicus	33%	100%
Q6NVM6	Xenopus tropicalis	35%	100%
Q7T0Q5	Xenopus laevis	33%	100%
Q802W4	Danio rerio	33%	96%
Q9BSC4	Homo sapiens	32%	100%