J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q967_LEIMA

TriTrypDb:

LmjF.26.1270 , LMJLV39_260018400 , LMJSD75_260016800

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q967

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q967

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.548
CLV_C14_Caspase3-7	310	314	PF00656	0.563
CLV_C14_Caspase3-7	60	64	PF00656	0.609
CLV_NRD_NRD_1	119	121	PF00675	0.708
CLV_NRD_NRD_1	190	192	PF00675	0.567
CLV_NRD_NRD_1	337	339	PF00675	0.576
CLV_NRD_NRD_1	399	401	PF00675	0.437
CLV_NRD_NRD_1	460	462	PF00675	0.386
CLV_NRD_NRD_1	576	578	PF00675	0.771
CLV_NRD_NRD_1	609	611	PF00675	0.720
CLV_NRD_NRD_1	67	69	PF00675	0.623
CLV_NRD_NRD_1	734	736	PF00675	0.612
CLV_NRD_NRD_1	760	762	PF00675	0.529
CLV_NRD_NRD_1	801	803	PF00675	0.500
CLV_PCSK_FUR_1	337	341	PF00082	0.693
CLV_PCSK_FUR_1	801	805	PF00082	0.497
CLV_PCSK_KEX2_1	190	192	PF00082	0.571
CLV_PCSK_KEX2_1	209	211	PF00082	0.450
CLV_PCSK_KEX2_1	325	327	PF00082	0.626
CLV_PCSK_KEX2_1	337	339	PF00082	0.576
CLV_PCSK_KEX2_1	399	401	PF00082	0.321
CLV_PCSK_KEX2_1	460	462	PF00082	0.342
CLV_PCSK_KEX2_1	575	577	PF00082	0.775
CLV_PCSK_KEX2_1	609	611	PF00082	0.741
CLV_PCSK_KEX2_1	67	69	PF00082	0.582
CLV_PCSK_KEX2_1	801	803	PF00082	0.495
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.506
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.661
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.658
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.329
CLV_PCSK_PC1ET2_1	803	805	PF00082	0.577
CLV_PCSK_PC7_1	333	339	PF00082	0.582
CLV_PCSK_SKI1_1	240	244	PF00082	0.541
CLV_PCSK_SKI1_1	296	300	PF00082	0.591
CLV_PCSK_SKI1_1	325	329	PF00082	0.633
CLV_PCSK_SKI1_1	339	343	PF00082	0.695
CLV_PCSK_SKI1_1	501	505	PF00082	0.633
CLV_PCSK_SKI1_1	577	581	PF00082	0.707
CLV_PCSK_SKI1_1	703	707	PF00082	0.634
CLV_PCSK_SKI1_1	735	739	PF00082	0.474
CLV_PCSK_SKI1_1	814	818	PF00082	0.637
CLV_Separin_Metazoa	507	511	PF03568	0.675
DEG_SPOP_SBC_1	583	587	PF00917	0.760
DEG_SPOP_SBC_1	598	602	PF00917	0.453
DEG_SPOP_SBC_1	663	667	PF00917	0.732
DEG_SPOP_SBC_1	843	847	PF00917	0.627
DOC_ANK_TNKS_1	252	259	PF00023	0.481
DOC_ANK_TNKS_1	752	759	PF00023	0.404
DOC_CKS1_1	554	559	PF01111	0.781
DOC_CYCLIN_RxL_1	700	708	PF00134	0.625
DOC_MAPK_gen_1	209	216	PF00069	0.531
DOC_MAPK_gen_1	315	323	PF00069	0.575
DOC_MAPK_gen_1	408	418	PF00069	0.432
DOC_MAPK_gen_1	535	543	PF00069	0.567
DOC_MAPK_gen_1	91	101	PF00069	0.705
DOC_MAPK_MEF2A_6	209	216	PF00069	0.464
DOC_MAPK_MEF2A_6	516	525	PF00069	0.586
DOC_MAPK_MEF2A_6	535	543	PF00069	0.580
DOC_MAPK_RevD_3	721	736	PF00069	0.637
DOC_MAPK_RevD_3	789	804	PF00069	0.615
DOC_PP1_RVXF_1	259	266	PF00149	0.489
DOC_PP4_FxxP_1	580	583	PF00568	0.587
DOC_PP4_FxxP_1	701	704	PF00568	0.592
DOC_PP4_FxxP_1	726	729	PF00568	0.525
DOC_USP7_MATH_1	104	108	PF00917	0.627
DOC_USP7_MATH_1	115	119	PF00917	0.701
DOC_USP7_MATH_1	289	293	PF00917	0.639
DOC_USP7_MATH_1	4	8	PF00917	0.753
DOC_USP7_MATH_1	519	523	PF00917	0.585
DOC_USP7_MATH_1	562	566	PF00917	0.763
DOC_USP7_MATH_1	571	575	PF00917	0.764
DOC_USP7_MATH_1	583	587	PF00917	0.662
DOC_USP7_MATH_1	598	602	PF00917	0.561
DOC_USP7_MATH_1	615	619	PF00917	0.750
DOC_USP7_MATH_1	627	631	PF00917	0.696
DOC_USP7_MATH_1	663	667	PF00917	0.720
DOC_USP7_MATH_1	839	843	PF00917	0.561
DOC_USP7_MATH_1	844	848	PF00917	0.601
DOC_USP7_MATH_2	650	656	PF00917	0.528
DOC_USP7_UBL2_3	117	121	PF12436	0.710
DOC_USP7_UBL2_3	342	346	PF12436	0.631
DOC_USP7_UBL2_3	364	368	PF12436	0.696
DOC_USP7_UBL2_3	408	412	PF12436	0.328
DOC_WW_Pin1_4	132	137	PF00397	0.638
DOC_WW_Pin1_4	204	209	PF00397	0.540
DOC_WW_Pin1_4	270	275	PF00397	0.406
DOC_WW_Pin1_4	431	436	PF00397	0.482
DOC_WW_Pin1_4	483	488	PF00397	0.559
DOC_WW_Pin1_4	553	558	PF00397	0.679
DOC_WW_Pin1_4	560	565	PF00397	0.675
DOC_WW_Pin1_4	664	669	PF00397	0.599
LIG_14-3-3_CanoR_1	149	154	PF00244	0.660
LIG_14-3-3_CanoR_1	308	312	PF00244	0.621
LIG_14-3-3_CanoR_1	340	347	PF00244	0.610
LIG_14-3-3_CanoR_1	350	355	PF00244	0.488
LIG_14-3-3_CanoR_1	399	407	PF00244	0.309
LIG_14-3-3_CanoR_1	577	583	PF00244	0.709
LIG_14-3-3_CanoR_1	753	759	PF00244	0.616
LIG_14-3-3_CanoR_1	825	833	PF00244	0.507
LIG_Actin_WH2_2	175	192	PF00022	0.664
LIG_Actin_WH2_2	227	242	PF00022	0.522
LIG_Actin_WH2_2	314	331	PF00022	0.655
LIG_AP_GAE_1	34	40	PF02883	0.732
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BIR_III_4	229	233	PF00653	0.542
LIG_BRCT_BRCA1_1	352	356	PF00533	0.569
LIG_BRCT_BRCA1_1	665	669	PF00533	0.696
LIG_BRCT_BRCA1_1	681	685	PF00533	0.450
LIG_DLG_GKlike_1	149	156	PF00625	0.675
LIG_DLG_GKlike_1	350	358	PF00625	0.657
LIG_eIF4E_1	727	733	PF01652	0.600
LIG_FHA_1	402	408	PF00498	0.432
LIG_FHA_1	732	738	PF00498	0.627
LIG_FHA_1	821	827	PF00498	0.690
LIG_FHA_2	21	27	PF00498	0.663
LIG_FHA_2	308	314	PF00498	0.529
LIG_FHA_2	41	47	PF00498	0.440
LIG_FHA_2	484	490	PF00498	0.543
LIG_FHA_2	815	821	PF00498	0.595
LIG_FHA_2	91	97	PF00498	0.750
LIG_GBD_Chelix_1	775	783	PF00786	0.584
LIG_IBAR_NPY_1	391	393	PF08397	0.449
LIG_LIR_Apic_2	698	704	PF02991	0.592
LIG_LIR_Gen_1	215	225	PF02991	0.451
LIG_LIR_Gen_1	34	44	PF02991	0.686
LIG_LIR_Gen_1	449	458	PF02991	0.334
LIG_LIR_Gen_1	675	685	PF02991	0.585
LIG_LIR_Gen_1	742	750	PF02991	0.472
LIG_LIR_Gen_1	771	779	PF02991	0.570
LIG_LIR_Nem_3	215	220	PF02991	0.454
LIG_LIR_Nem_3	264	268	PF02991	0.451
LIG_LIR_Nem_3	285	290	PF02991	0.559
LIG_LIR_Nem_3	34	40	PF02991	0.722
LIG_LIR_Nem_3	449	455	PF02991	0.334
LIG_LIR_Nem_3	476	482	PF02991	0.647
LIG_LIR_Nem_3	498	503	PF02991	0.697
LIG_LIR_Nem_3	675	681	PF02991	0.596
LIG_LIR_Nem_3	690	695	PF02991	0.561
LIG_LIR_Nem_3	742	748	PF02991	0.477
LIG_LIR_Nem_3	771	775	PF02991	0.551
LIG_PCNA_yPIPBox_3	228	240	PF02747	0.442
LIG_PCNA_yPIPBox_3	784	795	PF02747	0.603
LIG_Pex14_1	213	217	PF04695	0.471
LIG_Pex14_2	681	685	PF04695	0.555
LIG_PTB_Apo_2	281	288	PF02174	0.477
LIG_PTB_Apo_2	766	773	PF02174	0.589
LIG_PTB_Phospho_1	281	287	PF10480	0.477
LIG_PTB_Phospho_1	766	772	PF10480	0.587
LIG_SH2_CRK	201	205	PF00017	0.659
LIG_SH2_CRK	287	291	PF00017	0.590
LIG_SH2_CRK	411	415	PF00017	0.328
LIG_SH2_CRK	452	456	PF00017	0.328
LIG_SH2_CRK	772	776	PF00017	0.584
LIG_SH2_GRB2like	767	770	PF00017	0.568
LIG_SH2_STAP1	772	776	PF00017	0.620
LIG_SH2_STAP1	806	810	PF00017	0.479
LIG_SH2_STAT3	785	788	PF00017	0.468
LIG_SH2_STAT3	835	838	PF00017	0.543
LIG_SH2_STAT5	188	191	PF00017	0.521
LIG_SH2_STAT5	592	595	PF00017	0.749
LIG_SH2_STAT5	71	74	PF00017	0.601
LIG_SH2_STAT5	713	716	PF00017	0.530
LIG_SH2_STAT5	767	770	PF00017	0.463
LIG_SH2_STAT5	785	788	PF00017	0.427
LIG_SH2_STAT5	810	813	PF00017	0.490
LIG_SH2_STAT5	835	838	PF00017	0.543
LIG_SH3_3	268	274	PF00018	0.454
LIG_SH3_3	414	420	PF00018	0.328
LIG_SH3_3	429	435	PF00018	0.359
LIG_SH3_3	551	557	PF00018	0.732
LIG_SH3_3	667	673	PF00018	0.677
LIG_TRAF2_1	434	437	PF00917	0.363
LIG_TRFH_1	669	673	PF08558	0.636
LIG_TYR_ITIM	266	271	PF00017	0.405
LIG_TYR_ITSM	283	290	PF00017	0.586
MOD_CDK_SPK_2	204	209	PF00069	0.540
MOD_CDK_SPxK_1	204	210	PF00069	0.537
MOD_CDK_SPxxK_3	431	438	PF00069	0.475
MOD_CDK_SPxxK_3	553	560	PF00069	0.777
MOD_CK1_1	111	117	PF00069	0.793
MOD_CK1_1	124	130	PF00069	0.624
MOD_CK1_1	174	180	PF00069	0.696
MOD_CK1_1	585	591	PF00069	0.646
MOD_CK1_1	655	661	PF00069	0.728
MOD_CK1_1	662	668	PF00069	0.716
MOD_CK1_1	7	13	PF00069	0.690
MOD_CK1_1	749	755	PF00069	0.577
MOD_CK1_1	842	848	PF00069	0.564
MOD_CK2_1	165	171	PF00069	0.766
MOD_CK2_1	431	437	PF00069	0.385
MOD_CK2_1	453	459	PF00069	0.321
MOD_CK2_1	483	489	PF00069	0.552
MOD_CK2_1	521	527	PF00069	0.579
MOD_CK2_1	627	633	PF00069	0.748
MOD_CK2_1	814	820	PF00069	0.636
MOD_DYRK1A_RPxSP_1	553	557	PF00069	0.742
MOD_GlcNHglycan	1	4	PF01048	0.738
MOD_GlcNHglycan	123	126	PF01048	0.714
MOD_GlcNHglycan	225	228	PF01048	0.461
MOD_GlcNHglycan	302	305	PF01048	0.557
MOD_GlcNHglycan	376	379	PF01048	0.682
MOD_GlcNHglycan	427	430	PF01048	0.428
MOD_GlcNHglycan	449	452	PF01048	0.449
MOD_GlcNHglycan	564	567	PF01048	0.717
MOD_GlcNHglycan	569	572	PF01048	0.692
MOD_GlcNHglycan	594	597	PF01048	0.673
MOD_GlcNHglycan	6	9	PF01048	0.720
MOD_GlcNHglycan	601	604	PF01048	0.608
MOD_GlcNHglycan	617	620	PF01048	0.756
MOD_GlcNHglycan	654	657	PF01048	0.657
MOD_GlcNHglycan	661	664	PF01048	0.704
MOD_GSK3_1	104	111	PF00069	0.629
MOD_GSK3_1	116	123	PF00069	0.662
MOD_GSK3_1	174	181	PF00069	0.713
MOD_GSK3_1	350	357	PF00069	0.527
MOD_GSK3_1	370	377	PF00069	0.443
MOD_GSK3_1	4	11	PF00069	0.676
MOD_GSK3_1	481	488	PF00069	0.691
MOD_GSK3_1	567	574	PF00069	0.707
MOD_GSK3_1	578	585	PF00069	0.682
MOD_GSK3_1	655	662	PF00069	0.727
MOD_GSK3_1	80	87	PF00069	0.633
MOD_GSK3_1	821	828	PF00069	0.614
MOD_GSK3_1	838	845	PF00069	0.571
MOD_N-GLC_1	18	23	PF02516	0.753
MOD_N-GLC_1	204	209	PF02516	0.540
MOD_NEK2_1	276	281	PF00069	0.487
MOD_NEK2_1	282	287	PF00069	0.459
MOD_NEK2_1	307	312	PF00069	0.568
MOD_NEK2_1	383	388	PF00069	0.684
MOD_NEK2_1	474	479	PF00069	0.518
MOD_NEK2_1	508	513	PF00069	0.657
MOD_NEK2_1	659	664	PF00069	0.746
MOD_NEK2_1	731	736	PF00069	0.642
MOD_NEK2_1	80	85	PF00069	0.726
MOD_PIKK_1	104	110	PF00454	0.641
MOD_PIKK_1	340	346	PF00454	0.726
MOD_PIKK_1	370	376	PF00454	0.654
MOD_PIKK_1	401	407	PF00454	0.366
MOD_PKA_1	120	126	PF00069	0.665
MOD_PKA_1	609	615	PF00069	0.700
MOD_PKA_2	307	313	PF00069	0.630
MOD_PKA_2	398	404	PF00069	0.437
MOD_PKA_2	40	46	PF00069	0.624
MOD_PKA_2	552	558	PF00069	0.724
MOD_PKA_2	598	604	PF00069	0.689
MOD_PKA_2	608	614	PF00069	0.672
MOD_PKA_2	752	758	PF00069	0.567
MOD_PKA_2	820	826	PF00069	0.668
MOD_PKA_2	90	96	PF00069	0.679
MOD_PKB_1	338	346	PF00069	0.600
MOD_Plk_1	749	755	PF00069	0.577
MOD_Plk_4	282	288	PF00069	0.475
MOD_Plk_4	490	496	PF00069	0.530
MOD_Plk_4	627	633	PF00069	0.748
MOD_ProDKin_1	132	138	PF00069	0.636
MOD_ProDKin_1	204	210	PF00069	0.537
MOD_ProDKin_1	270	276	PF00069	0.409
MOD_ProDKin_1	431	437	PF00069	0.482
MOD_ProDKin_1	483	489	PF00069	0.558
MOD_ProDKin_1	553	559	PF00069	0.682
MOD_ProDKin_1	560	566	PF00069	0.676
MOD_ProDKin_1	664	670	PF00069	0.596
MOD_SUMO_rev_2	434	439	PF00179	0.449
TRG_DiLeu_BaEn_4	27	33	PF01217	0.702
TRG_DiLeu_BaEn_4	35	41	PF01217	0.690
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.462
TRG_DiLeu_BaLyEn_6	701	706	PF01217	0.589
TRG_ENDOCYTIC_2	201	204	PF00928	0.532
TRG_ENDOCYTIC_2	217	220	PF00928	0.409
TRG_ENDOCYTIC_2	268	271	PF00928	0.407
TRG_ENDOCYTIC_2	287	290	PF00928	0.489
TRG_ENDOCYTIC_2	393	396	PF00928	0.328
TRG_ENDOCYTIC_2	411	414	PF00928	0.328
TRG_ENDOCYTIC_2	452	455	PF00928	0.328
TRG_ENDOCYTIC_2	678	681	PF00928	0.615
TRG_ENDOCYTIC_2	745	748	PF00928	0.478
TRG_ENDOCYTIC_2	767	770	PF00928	0.473
TRG_ENDOCYTIC_2	772	775	PF00928	0.581
TRG_ER_diArg_1	156	159	PF00400	0.585
TRG_ER_diArg_1	189	191	PF00400	0.579
TRG_ER_diArg_1	336	338	PF00400	0.588
TRG_ER_diArg_1	398	400	PF00400	0.437
TRG_ER_diArg_1	534	537	PF00400	0.585
TRG_ER_diArg_1	575	577	PF00400	0.777
TRG_ER_diArg_1	66	68	PF00400	0.642
TRG_ER_diArg_1	800	802	PF00400	0.486
TRG_NES_CRM1_1	349	363	PF08389	0.657
TRG_NES_CRM1_1	778	793	PF08389	0.572
TRG_NLS_Bipartite_1	325	343	PF00514	0.681
TRG_NLS_MonoExtC_3	337	342	PF00514	0.660
TRG_NLS_MonoExtN_4	337	343	PF00514	0.695
TRG_NLS_MonoExtN_4	801	806	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	761	766	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P0	Leptomonas seymouri	65%	93%
A0A0S4JSE4	Bodo saltans	34%	100%
A0A1X0NTP4	Trypanosomatidae	45%	95%
A0A3Q8ICY0	Leishmania donovani	92%	87%
A0A3S5IQK9	Trypanosoma rangeli	47%	100%
A4HEY2	Leishmania braziliensis	81%	98%
A4I256	Leishmania infantum	92%	100%
C9ZRU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AYA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DAC5	Trypanosoma cruzi	46%	100%