JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q965_LEIMA

TriTrypDb:

LmjF.26.1290 , LMJLV39_260018600 , LMJSD75_260017000

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q965

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q965

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	2
GO:0051213	dioxygenase activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	502	504	PF00675	0.459
CLV_NRD_NRD_1	540	542	PF00675	0.417
CLV_NRD_NRD_1	84	86	PF00675	0.714
CLV_PCSK_KEX2_1	486	488	PF00082	0.482
CLV_PCSK_KEX2_1	542	544	PF00082	0.416
CLV_PCSK_KEX2_1	83	85	PF00082	0.713
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.482
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.306
CLV_PCSK_SKI1_1	113	117	PF00082	0.393
CLV_PCSK_SKI1_1	14	18	PF00082	0.466
CLV_PCSK_SKI1_1	140	144	PF00082	0.362
CLV_PCSK_SKI1_1	199	203	PF00082	0.281
CLV_PCSK_SKI1_1	378	382	PF00082	0.266
DEG_APCC_DBOX_1	272	280	PF00400	0.281
DEG_APCC_DBOX_1	502	510	PF00400	0.360
DEG_Nend_UBRbox_1	1	4	PF02207	0.508
DOC_ANK_TNKS_1	54	61	PF00023	0.549
DOC_CKS1_1	306	311	PF01111	0.287
DOC_CYCLIN_yCln2_LP_2	385	388	PF00134	0.281
DOC_MAPK_DCC_7	289	297	PF00069	0.287
DOC_MAPK_DCC_7	30	39	PF00069	0.503
DOC_MAPK_DCC_7	503	511	PF00069	0.393
DOC_MAPK_gen_1	197	205	PF00069	0.290
DOC_MAPK_gen_1	378	386	PF00069	0.281
DOC_MAPK_gen_1	503	511	PF00069	0.393
DOC_MAPK_MEF2A_6	197	205	PF00069	0.331
DOC_MAPK_MEF2A_6	30	39	PF00069	0.503
DOC_MAPK_MEF2A_6	504	513	PF00069	0.341
DOC_PP2B_LxvP_1	245	248	PF13499	0.200
DOC_PP2B_LxvP_1	385	388	PF13499	0.281
DOC_PP2B_LxvP_1	519	522	PF13499	0.266
DOC_PP4_FxxP_1	32	35	PF00568	0.503
DOC_PP4_FxxP_1	356	359	PF00568	0.314
DOC_PP4_FxxP_1	573	576	PF00568	0.281
DOC_USP7_MATH_1	153	157	PF00917	0.362
DOC_USP7_MATH_1	187	191	PF00917	0.382
DOC_USP7_MATH_1	21	25	PF00917	0.541
DOC_USP7_MATH_1	360	364	PF00917	0.281
DOC_USP7_MATH_1	476	480	PF00917	0.322
DOC_USP7_MATH_1	550	554	PF00917	0.406
DOC_WW_Pin1_4	203	208	PF00397	0.266
DOC_WW_Pin1_4	243	248	PF00397	0.287
DOC_WW_Pin1_4	283	288	PF00397	0.411
DOC_WW_Pin1_4	305	310	PF00397	0.426
DOC_WW_Pin1_4	472	477	PF00397	0.285
DOC_WW_Pin1_4	552	557	PF00397	0.309
LIG_14-3-3_CanoR_1	14	19	PF00244	0.528
LIG_14-3-3_CanoR_1	197	202	PF00244	0.327
LIG_14-3-3_CanoR_1	2	7	PF00244	0.667
LIG_14-3-3_CanoR_1	216	220	PF00244	0.316
LIG_14-3-3_CanoR_1	273	277	PF00244	0.330
LIG_14-3-3_CanoR_1	471	476	PF00244	0.286
LIG_BIR_III_4	453	457	PF00653	0.411
LIG_BRCT_BRCA1_1	423	427	PF00533	0.411
LIG_deltaCOP1_diTrp_1	128	136	PF00928	0.278
LIG_deltaCOP1_diTrp_1	421	427	PF00928	0.331
LIG_FHA_1	1	7	PF00498	0.718
LIG_FHA_1	146	152	PF00498	0.200
LIG_FHA_1	198	204	PF00498	0.311
LIG_FHA_1	219	225	PF00498	0.424
LIG_FHA_1	306	312	PF00498	0.344
LIG_FHA_1	516	522	PF00498	0.383
LIG_FHA_1	560	566	PF00498	0.418
LIG_FHA_2	104	110	PF00498	0.287
LIG_FHA_2	15	21	PF00498	0.469
LIG_FHA_2	299	305	PF00498	0.331
LIG_FHA_2	45	51	PF00498	0.520
LIG_FHA_2	84	90	PF00498	0.764
LIG_FXI_DFP_1	440	444	PF00024	0.411
LIG_Integrin_isoDGR_2	208	210	PF01839	0.266
LIG_LIR_Apic_2	570	576	PF02991	0.280
LIG_LIR_Gen_1	323	333	PF02991	0.296
LIG_LIR_Gen_1	371	380	PF02991	0.268
LIG_LIR_Gen_1	382	388	PF02991	0.271
LIG_LIR_Nem_3	128	133	PF02991	0.339
LIG_LIR_Nem_3	323	328	PF02991	0.269
LIG_LIR_Nem_3	371	377	PF02991	0.268
LIG_LIR_Nem_3	382	386	PF02991	0.271
LIG_LIR_Nem_3	424	430	PF02991	0.371
LIG_LIR_Nem_3	583	587	PF02991	0.396
LIG_NRBOX	278	284	PF00104	0.281
LIG_NRBOX	62	68	PF00104	0.577
LIG_PDZ_Class_2	583	588	PF00595	0.412
LIG_Pex14_1	389	393	PF04695	0.281
LIG_Pex14_1	423	427	PF04695	0.411
LIG_Pex14_2	110	114	PF04695	0.281
LIG_SH2_CRK	280	284	PF00017	0.330
LIG_SH2_CRK	313	317	PF00017	0.411
LIG_SH2_CRK	374	378	PF00017	0.266
LIG_SH2_NCK_1	219	223	PF00017	0.411
LIG_SH2_PTP2	512	515	PF00017	0.300
LIG_SH2_SRC	512	515	PF00017	0.300
LIG_SH2_SRC	520	523	PF00017	0.234
LIG_SH2_STAP1	219	223	PF00017	0.403
LIG_SH2_STAP1	569	573	PF00017	0.271
LIG_SH2_STAT3	51	54	PF00017	0.550
LIG_SH2_STAT5	141	144	PF00017	0.300
LIG_SH2_STAT5	325	328	PF00017	0.364
LIG_SH2_STAT5	512	515	PF00017	0.278
LIG_SH2_STAT5	520	523	PF00017	0.251
LIG_SH3_3	192	198	PF00018	0.411
LIG_SH3_3	271	277	PF00018	0.287
LIG_SH3_3	288	294	PF00018	0.236
LIG_SH3_3	381	387	PF00018	0.307
LIG_SH3_3	389	395	PF00018	0.277
LIG_SH3_3	502	508	PF00018	0.331
LIG_SH3_3	554	560	PF00018	0.294
LIG_SUMO_SIM_anti_2	577	583	PF11976	0.381
LIG_SUMO_SIM_par_1	14	20	PF11976	0.599
LIG_SUMO_SIM_par_1	200	206	PF11976	0.268
LIG_SUMO_SIM_par_1	577	583	PF11976	0.375
LIG_TRAF2_1	106	109	PF00917	0.506
LIG_TRAF2_1	158	161	PF00917	0.391
LIG_TRAF2_1	225	228	PF00917	0.286
LIG_TRAF2_1	497	500	PF00917	0.331
LIG_TRFH_1	383	387	PF08558	0.281
LIG_TYR_ITIM	311	316	PF00017	0.352
LIG_WW_2	557	560	PF00397	0.325
MOD_CDC14_SPxK_1	286	289	PF00782	0.287
MOD_CDK_SPxK_1	283	289	PF00069	0.287
MOD_CDK_SPxxK_3	203	210	PF00069	0.266
MOD_CK1_1	246	252	PF00069	0.424
MOD_CK1_1	361	367	PF00069	0.298
MOD_CK1_1	4	10	PF00069	0.713
MOD_CK1_1	479	485	PF00069	0.311
MOD_CK1_1	574	580	PF00069	0.481
MOD_CK2_1	103	109	PF00069	0.258
MOD_CK2_1	14	20	PF00069	0.488
MOD_CK2_1	153	159	PF00069	0.408
MOD_CK2_1	187	193	PF00069	0.439
MOD_CK2_1	478	484	PF00069	0.306
MOD_CK2_1	486	492	PF00069	0.272
MOD_CK2_1	83	89	PF00069	0.699
MOD_Cter_Amidation	501	504	PF01082	0.397
MOD_GlcNHglycan	24	27	PF01048	0.494
MOD_GlcNHglycan	481	484	PF01048	0.438
MOD_GlcNHglycan	546	549	PF01048	0.460
MOD_GlcNHglycan	552	555	PF01048	0.441
MOD_GlcNHglycan	7	10	PF01048	0.768
MOD_GSK3_1	1	8	PF00069	0.736
MOD_GSK3_1	199	206	PF00069	0.347
MOD_GSK3_1	283	290	PF00069	0.287
MOD_GSK3_1	40	47	PF00069	0.502
MOD_GSK3_1	470	477	PF00069	0.486
MOD_LATS_1	76	82	PF00433	0.570
MOD_N-GLC_2	318	320	PF02516	0.266
MOD_NEK2_1	1	6	PF00069	0.677
MOD_NEK2_1	145	150	PF00069	0.348
MOD_NEK2_1	22	27	PF00069	0.495
MOD_NEK2_1	272	277	PF00069	0.348
MOD_NEK2_1	470	475	PF00069	0.299
MOD_NEK2_1	571	576	PF00069	0.300
MOD_NEK2_1	67	72	PF00069	0.528
MOD_NEK2_2	515	520	PF00069	0.411
MOD_PIKK_1	44	50	PF00454	0.472
MOD_PK_1	210	216	PF00069	0.302
MOD_PKA_1	486	492	PF00069	0.275
MOD_PKA_1	542	548	PF00069	0.200
MOD_PKA_1	83	89	PF00069	0.498
MOD_PKA_2	1	7	PF00069	0.726
MOD_PKA_2	215	221	PF00069	0.369
MOD_PKA_2	272	278	PF00069	0.300
MOD_PKA_2	470	476	PF00069	0.331
MOD_PKA_2	486	492	PF00069	0.173
MOD_PKA_2	542	548	PF00069	0.433
MOD_PKA_2	83	89	PF00069	0.619
MOD_Plk_1	145	151	PF00069	0.331
MOD_Plk_1	323	329	PF00069	0.386
MOD_Plk_1	569	575	PF00069	0.305
MOD_Plk_1	68	74	PF00069	0.580
MOD_Plk_1	88	94	PF00069	0.441
MOD_Plk_2-3	298	304	PF00069	0.411
MOD_Plk_2-3	408	414	PF00069	0.393
MOD_Plk_2-3	89	95	PF00069	0.739
MOD_Plk_4	14	20	PF00069	0.599
MOD_Plk_4	372	378	PF00069	0.430
MOD_Plk_4	408	414	PF00069	0.420
MOD_Plk_4	433	439	PF00069	0.474
MOD_Plk_4	515	521	PF00069	0.434
MOD_Plk_4	574	580	PF00069	0.482
MOD_Plk_4	62	68	PF00069	0.539
MOD_ProDKin_1	203	209	PF00069	0.266
MOD_ProDKin_1	243	249	PF00069	0.287
MOD_ProDKin_1	283	289	PF00069	0.411
MOD_ProDKin_1	305	311	PF00069	0.426
MOD_ProDKin_1	472	478	PF00069	0.285
MOD_ProDKin_1	552	558	PF00069	0.309
MOD_SUMO_for_1	395	398	PF00179	0.267
MOD_SUMO_for_1	485	488	PF00179	0.400
MOD_SUMO_rev_2	146	156	PF00179	0.323
TRG_DiLeu_BaEn_1	408	413	PF01217	0.287
TRG_DiLeu_BaEn_1	583	588	PF01217	0.412
TRG_DiLeu_BaEn_2	261	267	PF01217	0.200
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.331
TRG_ENDOCYTIC_2	280	283	PF00928	0.330
TRG_ENDOCYTIC_2	313	316	PF00928	0.281
TRG_ENDOCYTIC_2	325	328	PF00928	0.281
TRG_ENDOCYTIC_2	374	377	PF00928	0.269
TRG_ER_diArg_1	35	38	PF00400	0.356
TRG_ER_diArg_1	55	58	PF00400	0.325
TRG_ER_diArg_1	83	85	PF00400	0.635
TRG_NLS_MonoExtC_3	540	546	PF00514	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S7	Leptomonas seymouri	65%	100%
A0A0S4JXF9	Bodo saltans	30%	100%
A0A1X0NS77	Trypanosomatidae	42%	100%
A0A3Q8IP66	Leishmania donovani	92%	100%
A0A3R7K325	Trypanosoma rangeli	42%	100%
A4HEY4	Leishmania braziliensis	80%	100%
A4I258	Leishmania infantum	92%	100%
C9ZRU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AYA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
V5BED3	Trypanosoma cruzi	42%	100%