Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q963_LEIMA

TriTrypDb:

LmjF.26.1310 , LMJLV39_260018800 , LMJSD75_260017200

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q963

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q963

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.350
CLV_NRD_NRD_1	14	16	PF00675	0.449
CLV_NRD_NRD_1	306	308	PF00675	0.443
CLV_NRD_NRD_1	321	323	PF00675	0.303
CLV_NRD_NRD_1	54	56	PF00675	0.480
CLV_NRD_NRD_1	99	101	PF00675	0.449
CLV_PCSK_KEX2_1	110	112	PF00082	0.396
CLV_PCSK_KEX2_1	306	308	PF00082	0.468
CLV_PCSK_KEX2_1	321	323	PF00082	0.303
CLV_PCSK_SKI1_1	10	14	PF00082	0.481
CLV_PCSK_SKI1_1	170	174	PF00082	0.404
CLV_PCSK_SKI1_1	191	195	PF00082	0.403
CLV_PCSK_SKI1_1	243	247	PF00082	0.274
DEG_APCC_DBOX_1	227	235	PF00400	0.353
DEG_Nend_Nbox_1	1	3	PF02207	0.704
DOC_CYCLIN_RxL_1	237	247	PF00134	0.338
DOC_CYCLIN_RxL_1	32	43	PF00134	0.612
DOC_CYCLIN_RxL_1	4	14	PF00134	0.709
DOC_MAPK_gen_1	304	313	PF00069	0.598
DOC_MAPK_MEF2A_6	146	155	PF00069	0.678
DOC_MAPK_MEF2A_6	306	315	PF00069	0.711
DOC_MAPK_MEF2A_6	327	336	PF00069	0.301
DOC_MAPK_NFAT4_5	327	335	PF00069	0.326
DOC_PP1_RVXF_1	196	203	PF00149	0.478
DOC_PP1_RVXF_1	241	247	PF00149	0.287
DOC_PP2B_LxvP_1	239	242	PF13499	0.401
DOC_PP2B_LxvP_1	67	70	PF13499	0.709
DOC_USP7_UBL2_3	97	101	PF12436	0.631
DOC_WW_Pin1_4	3	8	PF00397	0.699
LIG_14-3-3_CanoR_1	181	189	PF00244	0.634
LIG_Actin_WH2_2	216	234	PF00022	0.488
LIG_BIR_III_2	298	302	PF00653	0.633
LIG_eIF4E_1	251	257	PF01652	0.345
LIG_FHA_1	182	188	PF00498	0.649
LIG_FHA_1	3	9	PF00498	0.693
LIG_FHA_1	324	330	PF00498	0.416
LIG_FHA_2	315	321	PF00498	0.598
LIG_LIR_Nem_3	194	200	PF02991	0.551
LIG_LIR_Nem_3	24	30	PF02991	0.540
LIG_LIR_Nem_3	272	278	PF02991	0.554
LIG_LIR_Nem_3	31	36	PF02991	0.557
LIG_NRBOX	328	334	PF00104	0.312
LIG_PCNA_PIPBox_1	20	29	PF02747	0.555
LIG_SH2_CRK	197	201	PF00017	0.460
LIG_SH2_CRK	33	37	PF00017	0.672
LIG_SH2_GRB2like	163	166	PF00017	0.516
LIG_SH2_STAP1	183	187	PF00017	0.713
LIG_SH2_STAT3	183	186	PF00017	0.662
LIG_SH2_STAT5	183	186	PF00017	0.691
LIG_SH2_STAT5	2	5	PF00017	0.667
LIG_SH2_STAT5	201	204	PF00017	0.165
LIG_SH2_STAT5	216	219	PF00017	0.395
LIG_SH3_3	150	156	PF00018	0.726
LIG_SH3_3	220	226	PF00018	0.445
LIG_SH3_3	260	266	PF00018	0.573
LIG_SUMO_SIM_par_1	331	337	PF11976	0.326
LIG_TYR_ITIM	195	200	PF00017	0.643
LIG_UBA3_1	172	176	PF00899	0.648
LIG_UBA3_1	8	16	PF00899	0.710
MOD_CDK_SPxxK_3	3	10	PF00069	0.703
MOD_CK1_1	72	78	PF00069	0.685
MOD_CK1_1	80	86	PF00069	0.613
MOD_CK2_1	18	24	PF00069	0.619
MOD_CK2_1	314	320	PF00069	0.648
MOD_GlcNHglycan	146	149	PF01048	0.515
MOD_GlcNHglycan	246	249	PF01048	0.397
MOD_GlcNHglycan	283	286	PF01048	0.407
MOD_GlcNHglycan	71	74	PF01048	0.452
MOD_GlcNHglycan	81	85	PF01048	0.379
MOD_GSK3_1	187	194	PF00069	0.593
MOD_GSK3_1	72	79	PF00069	0.661
MOD_NEK2_1	182	187	PF00069	0.603
MOD_NEK2_1	244	249	PF00069	0.298
MOD_NEK2_1	256	261	PF00069	0.466
MOD_PIKK_1	175	181	PF00454	0.630
MOD_PIKK_1	182	188	PF00454	0.614
MOD_PKA_2	187	193	PF00069	0.600
MOD_Plk_1	135	141	PF00069	0.608
MOD_Plk_2-3	18	24	PF00069	0.629
MOD_Plk_4	18	24	PF00069	0.619
MOD_Plk_4	191	197	PF00069	0.555
MOD_Plk_4	207	213	PF00069	0.253
MOD_ProDKin_1	3	9	PF00069	0.699
TRG_AP2beta_CARGO_1	24	34	PF09066	0.554
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.416
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.701
TRG_ENDOCYTIC_2	197	200	PF00928	0.537
TRG_ENDOCYTIC_2	201	204	PF00928	0.272
TRG_ENDOCYTIC_2	216	219	PF00928	0.415
TRG_ENDOCYTIC_2	251	254	PF00928	0.389
TRG_ENDOCYTIC_2	33	36	PF00928	0.643
TRG_ER_diArg_1	110	112	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V8	Leptomonas seymouri	72%	96%
A0A0S4KIA3	Bodo saltans	32%	100%
A0A1X0NS63	Trypanosomatidae	46%	93%
A0A3R7M7G1	Trypanosoma rangeli	51%	100%
A0A3S7WZZ7	Leishmania donovani	96%	100%
A4HEY6	Leishmania braziliensis	89%	100%
A4I260	Leishmania infantum	97%	100%
C9ZRU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AYB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B9S2	Trypanosoma cruzi	49%	99%