Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q961_LEIMA

TriTrypDb:

LmjF.26.1330 , LMJLV39_260019000 , LMJSD75_260017400

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q961

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q961

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	266	268	PF00675	0.633
CLV_PCSK_KEX2_1	266	268	PF00082	0.578
CLV_PCSK_SKI1_1	173	177	PF00082	0.519
CLV_PCSK_SKI1_1	202	206	PF00082	0.497
CLV_PCSK_SKI1_1	303	307	PF00082	0.545
DEG_APCC_DBOX_1	201	209	PF00400	0.495
DEG_APCC_DBOX_1	302	310	PF00400	0.432
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DOC_CKS1_1	178	183	PF01111	0.580
DOC_MAPK_gen_1	199	209	PF00069	0.426
DOC_MAPK_gen_1	235	244	PF00069	0.456
DOC_MAPK_gen_1	371	380	PF00069	0.593
DOC_MAPK_MEF2A_6	202	209	PF00069	0.431
DOC_MAPK_MEF2A_6	235	244	PF00069	0.456
DOC_MAPK_NFAT4_5	202	210	PF00069	0.434
DOC_PP2B_LxvP_1	130	133	PF13499	0.607
DOC_PP4_FxxP_1	178	181	PF00568	0.589
DOC_USP7_MATH_1	283	287	PF00917	0.712
DOC_USP7_MATH_1	327	331	PF00917	0.717
DOC_WW_Pin1_4	106	111	PF00397	0.604
DOC_WW_Pin1_4	177	182	PF00397	0.611
DOC_WW_Pin1_4	221	226	PF00397	0.692
DOC_WW_Pin1_4	320	325	PF00397	0.794
DOC_WW_Pin1_4	359	364	PF00397	0.547
LIG_14-3-3_CanoR_1	173	182	PF00244	0.550
LIG_14-3-3_CanoR_1	33	41	PF00244	0.509
LIG_14-3-3_CanoR_1	8	14	PF00244	0.531
LIG_Actin_WH2_2	56	71	PF00022	0.614
LIG_BIR_III_2	61	65	PF00653	0.544
LIG_BRCT_BRCA1_1	34	38	PF00533	0.479
LIG_BRCT_BRCA1_1	360	364	PF00533	0.593
LIG_CSL_BTD_1	29	32	PF09270	0.555
LIG_FHA_1	178	184	PF00498	0.587
LIG_FHA_1	196	202	PF00498	0.528
LIG_FHA_2	107	113	PF00498	0.542
LIG_FHA_2	232	238	PF00498	0.591
LIG_FHA_2	254	260	PF00498	0.592
LIG_FHA_2	287	293	PF00498	0.613
LIG_FHA_2	56	62	PF00498	0.665
LIG_Integrin_RGD_1	267	269	PF01839	0.581
LIG_LIR_Apic_2	147	153	PF02991	0.594
LIG_LIR_Apic_2	176	181	PF02991	0.585
LIG_LIR_Gen_1	35	43	PF02991	0.573
LIG_LIR_Gen_1	58	68	PF02991	0.520
LIG_LIR_Nem_3	35	41	PF02991	0.506
LIG_LIR_Nem_3	361	367	PF02991	0.561
LIG_LIR_Nem_3	58	63	PF02991	0.534
LIG_MLH1_MIPbox_1	34	38	PF16413	0.479
LIG_NRBOX	113	119	PF00104	0.561
LIG_NRBOX	204	210	PF00104	0.497
LIG_Pex14_1	34	38	PF04695	0.499
LIG_Pex14_2	212	216	PF04695	0.523
LIG_SH2_CRK	210	214	PF00017	0.482
LIG_SH2_NCK_1	150	154	PF00017	0.518
LIG_SH2_STAT5	174	177	PF00017	0.503
LIG_SH3_1	222	228	PF00018	0.635
LIG_SH3_3	180	186	PF00018	0.619
LIG_SH3_3	222	228	PF00018	0.713
LIG_SH3_3	354	360	PF00018	0.563
LIG_SH3_3	60	66	PF00018	0.549
LIG_SH3_3	88	94	PF00018	0.550
LIG_SUMO_SIM_anti_2	374	382	PF11976	0.521
LIG_SUMO_SIM_par_1	205	211	PF11976	0.437
LIG_SUMO_SIM_par_1	77	85	PF11976	0.564
LIG_TRAF2_1	234	237	PF00917	0.590
LIG_TYR_ITIM	208	213	PF00017	0.430
LIG_WRC_WIRS_1	209	214	PF05994	0.507
LIG_WW_3	219	223	PF00397	0.599
MOD_CDK_SPxK_1	320	326	PF00069	0.711
MOD_CK1_1	184	190	PF00069	0.613
MOD_CK1_1	211	217	PF00069	0.508
MOD_CK1_1	260	266	PF00069	0.650
MOD_CK1_1	286	292	PF00069	0.575
MOD_CK1_1	316	322	PF00069	0.627
MOD_CK2_1	106	112	PF00069	0.551
MOD_CK2_1	231	237	PF00069	0.542
MOD_CK2_1	253	259	PF00069	0.542
MOD_CK2_1	286	292	PF00069	0.619
MOD_GlcNHglycan	121	124	PF01048	0.604
MOD_GlcNHglycan	156	159	PF01048	0.691
MOD_GlcNHglycan	26	29	PF01048	0.548
MOD_GlcNHglycan	269	273	PF01048	0.735
MOD_GlcNHglycan	317	321	PF01048	0.720
MOD_GlcNHglycan	34	37	PF01048	0.494
MOD_GlcNHglycan	406	409	PF01048	0.542
MOD_GlcNHglycan	84	87	PF01048	0.600
MOD_GlcNHglycan	9	12	PF01048	0.508
MOD_GSK3_1	113	120	PF00069	0.527
MOD_GSK3_1	173	180	PF00069	0.539
MOD_GSK3_1	181	188	PF00069	0.567
MOD_GSK3_1	208	215	PF00069	0.499
MOD_GSK3_1	251	258	PF00069	0.571
MOD_GSK3_1	283	290	PF00069	0.731
MOD_GSK3_1	316	323	PF00069	0.630
MOD_GSK3_1	49	56	PF00069	0.676
MOD_N-GLC_1	251	256	PF02516	0.544
MOD_NEK2_1	117	122	PF00069	0.480
MOD_NEK2_1	125	130	PF00069	0.476
MOD_NEK2_1	18	23	PF00069	0.686
MOD_NEK2_1	194	199	PF00069	0.471
MOD_NEK2_1	208	213	PF00069	0.497
MOD_NEK2_1	67	72	PF00069	0.585
MOD_PK_1	134	140	PF00069	0.577
MOD_PKA_2	32	38	PF00069	0.453
MOD_PKA_2	327	333	PF00069	0.608
MOD_PKA_2	7	13	PF00069	0.543
MOD_Plk_4	113	119	PF00069	0.571
MOD_Plk_4	125	131	PF00069	0.448
MOD_Plk_4	208	214	PF00069	0.541
MOD_ProDKin_1	106	112	PF00069	0.600
MOD_ProDKin_1	177	183	PF00069	0.612
MOD_ProDKin_1	221	227	PF00069	0.694
MOD_ProDKin_1	320	326	PF00069	0.794
MOD_ProDKin_1	359	365	PF00069	0.542
MOD_SUMO_for_1	372	375	PF00179	0.514
TRG_DiLeu_BaEn_1	376	381	PF01217	0.517
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.532
TRG_ENDOCYTIC_2	210	213	PF00928	0.530
TRG_ER_diArg_1	325	328	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H2	Leptomonas seymouri	30%	95%
A0A3S7WZZ6	Leishmania donovani	88%	82%
A4HEY8	Leishmania braziliensis	64%	94%
A4I262	Leishmania infantum	89%	100%
E9AYB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%