Putative DNA ligase k alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA ligase k alpha, putative

Species:

Leishmania major

UniProt:

Q4Q960_LEIMA

TriTrypDb:

LmjF.26.1340 , LMJLV39_260019100 , LMJSD75_260017500

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4Q960

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q960

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006259	DNA metabolic process	4	13
GO:0006281	DNA repair	5	13
GO:0006310	DNA recombination	5	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0006950	response to stress	2	13
GO:0006974	DNA damage response	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0033554	cellular response to stress	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0050896	response to stimulus	1	13
GO:0051716	cellular response to stimulus	2	13
GO:0071704	organic substance metabolic process	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0003909	DNA ligase activity	4	13
GO:0003910	DNA ligase (ATP) activity	5	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016874	ligase activity	2	13
GO:0016886	ligase activity, forming phosphoric ester bonds	3	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140097	catalytic activity, acting on DNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.444
CLV_C14_Caspase3-7	453	457	PF00656	0.483
CLV_NRD_NRD_1	152	154	PF00675	0.656
CLV_NRD_NRD_1	342	344	PF00675	0.562
CLV_NRD_NRD_1	443	445	PF00675	0.396
CLV_NRD_NRD_1	473	475	PF00675	0.312
CLV_NRD_NRD_1	584	586	PF00675	0.363
CLV_NRD_NRD_1	7	9	PF00675	0.527
CLV_NRD_NRD_1	91	93	PF00675	0.316
CLV_PCSK_KEX2_1	108	110	PF00082	0.316
CLV_PCSK_KEX2_1	27	29	PF00082	0.577
CLV_PCSK_KEX2_1	342	344	PF00082	0.469
CLV_PCSK_KEX2_1	443	445	PF00082	0.436
CLV_PCSK_KEX2_1	473	475	PF00082	0.312
CLV_PCSK_KEX2_1	499	501	PF00082	0.694
CLV_PCSK_KEX2_1	583	585	PF00082	0.292
CLV_PCSK_KEX2_1	7	9	PF00082	0.527
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.368
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.580
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.469
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.694
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.303
CLV_PCSK_SKI1_1	209	213	PF00082	0.387
CLV_PCSK_SKI1_1	24	28	PF00082	0.589
CLV_PCSK_SKI1_1	252	256	PF00082	0.429
CLV_PCSK_SKI1_1	276	280	PF00082	0.374
CLV_PCSK_SKI1_1	496	500	PF00082	0.688
CLV_PCSK_SKI1_1	555	559	PF00082	0.388
CLV_PCSK_SKI1_1	597	601	PF00082	0.311
DEG_APCC_DBOX_1	208	216	PF00400	0.343
DEG_Nend_UBRbox_1	1	4	PF02207	0.637
DEG_SCF_FBW7_1	574	579	PF00400	0.383
DOC_ANK_TNKS_1	620	627	PF00023	0.563
DOC_CKS1_1	377	382	PF01111	0.509
DOC_CYCLIN_RxL_1	273	282	PF00134	0.375
DOC_CYCLIN_yClb5_NLxxxL_5	209	215	PF00134	0.365
DOC_MAPK_gen_1	108	114	PF00069	0.361
DOC_MAPK_gen_1	39	48	PF00069	0.512
DOC_MAPK_RevD_3	461	474	PF00069	0.420
DOC_PP1_RVXF_1	250	257	PF00149	0.408
DOC_PP1_RVXF_1	90	97	PF00149	0.291
DOC_SPAK_OSR1_1	571	575	PF12202	0.383
DOC_USP7_MATH_1	135	139	PF00917	0.611
DOC_USP7_MATH_1	50	54	PF00917	0.572
DOC_USP7_MATH_1	502	506	PF00917	0.533
DOC_USP7_MATH_1	511	515	PF00917	0.663
DOC_USP7_MATH_1	75	79	PF00917	0.383
DOC_USP7_UBL2_3	122	126	PF12436	0.494
DOC_USP7_UBL2_3	217	221	PF12436	0.471
DOC_USP7_UBL2_3	306	310	PF12436	0.467
DOC_USP7_UBL2_3	340	344	PF12436	0.643
DOC_USP7_UBL2_3	591	595	PF12436	0.467
DOC_WW_Pin1_4	147	152	PF00397	0.699
DOC_WW_Pin1_4	232	237	PF00397	0.342
DOC_WW_Pin1_4	309	314	PF00397	0.685
DOC_WW_Pin1_4	376	381	PF00397	0.442
DOC_WW_Pin1_4	562	567	PF00397	0.333
DOC_WW_Pin1_4	572	577	PF00397	0.289
LIG_14-3-3_CanoR_1	177	183	PF00244	0.591
LIG_14-3-3_CanoR_1	421	431	PF00244	0.366
LIG_14-3-3_CanoR_1	464	468	PF00244	0.336
LIG_14-3-3_CanoR_1	527	532	PF00244	0.386
LIG_14-3-3_CanoR_1	571	575	PF00244	0.346
LIG_14-3-3_CanoR_1	585	591	PF00244	0.234
LIG_Actin_WH2_2	427	445	PF00022	0.468
LIG_BRCT_BRCA1_1	398	402	PF00533	0.539
LIG_FHA_1	206	212	PF00498	0.415
LIG_FHA_1	249	255	PF00498	0.462
LIG_FHA_1	282	288	PF00498	0.372
LIG_FHA_1	29	35	PF00498	0.733
LIG_FHA_1	315	321	PF00498	0.559
LIG_FHA_1	366	372	PF00498	0.522
LIG_FHA_1	377	383	PF00498	0.392
LIG_FHA_1	493	499	PF00498	0.705
LIG_FHA_2	260	266	PF00498	0.353
LIG_FHA_2	577	583	PF00498	0.305
LIG_LIR_Apic_2	374	380	PF02991	0.523
LIG_LIR_Gen_1	199	207	PF02991	0.441
LIG_LIR_Gen_1	327	338	PF02991	0.438
LIG_LIR_Gen_1	539	548	PF02991	0.390
LIG_LIR_Gen_1	560	566	PF02991	0.383
LIG_LIR_Gen_1	600	611	PF02991	0.295
LIG_LIR_Nem_3	199	205	PF02991	0.461
LIG_LIR_Nem_3	327	333	PF02991	0.423
LIG_LIR_Nem_3	413	419	PF02991	0.354
LIG_LIR_Nem_3	435	440	PF02991	0.395
LIG_LIR_Nem_3	466	470	PF02991	0.347
LIG_LIR_Nem_3	539	545	PF02991	0.372
LIG_LIR_Nem_3	551	557	PF02991	0.316
LIG_LIR_Nem_3	560	564	PF02991	0.332
LIG_LIR_Nem_3	589	593	PF02991	0.354
LIG_LIR_Nem_3	600	606	PF02991	0.292
LIG_NRBOX	418	424	PF00104	0.440
LIG_PDZ_Class_3	625	630	PF00595	0.489
LIG_PDZ_Wminus1_1	628	630	PF00595	0.493
LIG_Pex14_1	590	594	PF04695	0.383
LIG_Pex14_2	557	561	PF04695	0.284
LIG_REV1ctd_RIR_1	254	263	PF16727	0.371
LIG_SH2_CRK	330	334	PF00017	0.458
LIG_SH2_CRK	437	441	PF00017	0.477
LIG_SH2_PTP2	542	545	PF00017	0.440
LIG_SH2_SRC	542	545	PF00017	0.342
LIG_SH2_SRC	603	606	PF00017	0.304
LIG_SH2_STAP1	398	402	PF00017	0.430
LIG_SH2_STAT5	202	205	PF00017	0.463
LIG_SH2_STAT5	277	280	PF00017	0.295
LIG_SH2_STAT5	542	545	PF00017	0.381
LIG_SH3_1	310	316	PF00018	0.515
LIG_SH3_1	443	449	PF00018	0.258
LIG_SH3_2	148	153	PF14604	0.564
LIG_SH3_3	12	18	PF00018	0.511
LIG_SH3_3	145	151	PF00018	0.565
LIG_SH3_3	310	316	PF00018	0.515
LIG_SH3_3	43	49	PF00018	0.616
LIG_SH3_3	443	449	PF00018	0.258
LIG_SH3_3	609	615	PF00018	0.297
LIG_SUMO_SIM_par_1	282	288	PF11976	0.346
LIG_TYR_ITIM	414	419	PF00017	0.425
LIG_TYR_ITIM	465	470	PF00017	0.429
LIG_TYR_ITIM	601	606	PF00017	0.316
LIG_UBA3_1	20	27	PF00899	0.541
LIG_UBA3_1	211	217	PF00899	0.396
LIG_WRC_WIRS_1	558	563	PF05994	0.383
MOD_CDC14_SPxK_1	150	153	PF00782	0.568
MOD_CDK_SPK_2	232	237	PF00069	0.345
MOD_CDK_SPxK_1	147	153	PF00069	0.566
MOD_CDK_SPxK_1	562	568	PF00069	0.408
MOD_CDK_SPxxK_3	147	154	PF00069	0.566
MOD_CDK_SPxxK_3	562	569	PF00069	0.383
MOD_CK1_1	138	144	PF00069	0.740
MOD_CK1_1	158	164	PF00069	0.700
MOD_CK1_1	501	507	PF00069	0.642
MOD_CK1_1	589	595	PF00069	0.284
MOD_CK2_1	259	265	PF00069	0.362
MOD_CMANNOS	587	590	PF00535	0.383
MOD_GlcNHglycan	11	14	PF01048	0.629
MOD_GlcNHglycan	133	136	PF01048	0.580
MOD_GlcNHglycan	137	140	PF01048	0.581
MOD_GlcNHglycan	157	160	PF01048	0.636
MOD_GlcNHglycan	259	262	PF01048	0.408
MOD_GlcNHglycan	320	323	PF01048	0.617
MOD_GlcNHglycan	326	329	PF01048	0.392
MOD_GlcNHglycan	346	349	PF01048	0.454
MOD_GlcNHglycan	368	371	PF01048	0.351
MOD_GlcNHglycan	39	42	PF01048	0.806
MOD_GlcNHglycan	407	410	PF01048	0.456
MOD_GlcNHglycan	424	427	PF01048	0.291
MOD_GlcNHglycan	492	495	PF01048	0.655
MOD_GlcNHglycan	500	503	PF01048	0.619
MOD_GlcNHglycan	504	507	PF01048	0.608
MOD_GlcNHglycan	509	512	PF01048	0.570
MOD_GlcNHglycan	52	55	PF01048	0.559
MOD_GlcNHglycan	549	553	PF01048	0.359
MOD_GSK3_1	131	138	PF00069	0.651
MOD_GSK3_1	139	146	PF00069	0.630
MOD_GSK3_1	177	184	PF00069	0.580
MOD_GSK3_1	255	262	PF00069	0.379
MOD_GSK3_1	314	321	PF00069	0.637
MOD_GSK3_1	334	341	PF00069	0.302
MOD_GSK3_1	366	373	PF00069	0.458
MOD_GSK3_1	444	451	PF00069	0.363
MOD_GSK3_1	498	505	PF00069	0.478
MOD_GSK3_1	50	57	PF00069	0.656
MOD_GSK3_1	507	514	PF00069	0.487
MOD_GSK3_1	572	579	PF00069	0.272
MOD_N-GLC_1	178	183	PF02516	0.503
MOD_N-GLC_1	292	297	PF02516	0.435
MOD_N-GLC_1	432	437	PF02516	0.306
MOD_NEK2_1	1	6	PF00069	0.656
MOD_NEK2_1	193	198	PF00069	0.540
MOD_NEK2_1	255	260	PF00069	0.381
MOD_NEK2_1	334	339	PF00069	0.336
MOD_NEK2_1	422	427	PF00069	0.422
MOD_NEK2_1	557	562	PF00069	0.350
MOD_NEK2_1	586	591	PF00069	0.284
MOD_NEK2_1	9	14	PF00069	0.660
MOD_PKA_2	371	377	PF00069	0.424
MOD_PKA_2	405	411	PF00069	0.442
MOD_PKA_2	463	469	PF00069	0.323
MOD_PKA_2	526	532	PF00069	0.397
MOD_PKA_2	570	576	PF00069	0.355
MOD_PKB_1	175	183	PF00069	0.535
MOD_Plk_1	178	184	PF00069	0.500
MOD_Plk_1	267	273	PF00069	0.247
MOD_Plk_1	292	298	PF00069	0.438
MOD_Plk_4	1	7	PF00069	0.601
MOD_Plk_4	16	22	PF00069	0.579
MOD_Plk_4	259	265	PF00069	0.387
MOD_Plk_4	281	287	PF00069	0.379
MOD_Plk_4	357	363	PF00069	0.413
MOD_Plk_4	527	533	PF00069	0.401
MOD_Plk_4	557	563	PF00069	0.481
MOD_Plk_4	589	595	PF00069	0.254
MOD_ProDKin_1	147	153	PF00069	0.703
MOD_ProDKin_1	232	238	PF00069	0.340
MOD_ProDKin_1	309	315	PF00069	0.687
MOD_ProDKin_1	376	382	PF00069	0.434
MOD_ProDKin_1	562	568	PF00069	0.333
MOD_ProDKin_1	572	578	PF00069	0.289
MOD_SUMO_for_1	121	124	PF00179	0.254
TRG_DiLeu_BaEn_1	207	212	PF01217	0.407
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.334
TRG_ENDOCYTIC_2	202	205	PF00928	0.448
TRG_ENDOCYTIC_2	330	333	PF00928	0.458
TRG_ENDOCYTIC_2	391	394	PF00928	0.334
TRG_ENDOCYTIC_2	416	419	PF00928	0.350
TRG_ENDOCYTIC_2	437	440	PF00928	0.477
TRG_ENDOCYTIC_2	467	470	PF00928	0.304
TRG_ENDOCYTIC_2	534	537	PF00928	0.380
TRG_ENDOCYTIC_2	542	545	PF00928	0.344
TRG_ENDOCYTIC_2	603	606	PF00928	0.295
TRG_ER_diArg_1	172	175	PF00400	0.684
TRG_ER_diArg_1	21	24	PF00400	0.548
TRG_ER_diArg_1	442	444	PF00400	0.439
TRG_ER_diArg_1	472	474	PF00400	0.292
TRG_ER_diArg_1	584	586	PF00400	0.324
TRG_ER_diArg_1	6	8	PF00400	0.518
TRG_NLS_Bipartite_1	136	157	PF00514	0.571
TRG_NLS_MonoExtC_3	495	500	PF00514	0.674
TRG_NLS_MonoExtN_4	151	157	PF00514	0.713
TRG_NLS_MonoExtN_4	340	346	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ3	Leptomonas seymouri	60%	97%
A0A0S4KIC5	Bodo saltans	32%	100%
A0A1X0NS61	Trypanosomatidae	44%	100%
A0A3Q8IDV4	Leishmania donovani	94%	100%
A4HEY9	Leishmania braziliensis	81%	100%
A4I263	Leishmania infantum	94%	100%
C9ZRT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AYB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AYB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q959	Leishmania major	30%	100%
V5AUB9	Trypanosoma cruzi	26%	100%