Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q958_LEIMA

TriTrypDb:

LmjF.26.1360 , LMJLV39_260019300 , LMJSD75_260017700

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q958

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q958

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.596
CLV_C14_Caspase3-7	322	326	PF00656	0.538
CLV_C14_Caspase3-7	494	498	PF00656	0.413
CLV_C14_Caspase3-7	539	543	PF00656	0.761
CLV_NRD_NRD_1	31	33	PF00675	0.639
CLV_NRD_NRD_1	328	330	PF00675	0.471
CLV_NRD_NRD_1	354	356	PF00675	0.500
CLV_NRD_NRD_1	421	423	PF00675	0.374
CLV_NRD_NRD_1	68	70	PF00675	0.792
CLV_NRD_NRD_1	7	9	PF00675	0.691
CLV_PCSK_KEX2_1	31	33	PF00082	0.650
CLV_PCSK_KEX2_1	328	330	PF00082	0.544
CLV_PCSK_KEX2_1	354	356	PF00082	0.500
CLV_PCSK_KEX2_1	421	423	PF00082	0.385
CLV_PCSK_KEX2_1	564	566	PF00082	0.563
CLV_PCSK_KEX2_1	67	69	PF00082	0.790
CLV_PCSK_KEX2_1	7	9	PF00082	0.727
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.563
CLV_PCSK_PC7_1	3	9	PF00082	0.685
CLV_PCSK_PC7_1	63	69	PF00082	0.674
CLV_PCSK_SKI1_1	421	425	PF00082	0.453
CLV_PCSK_SKI1_1	53	57	PF00082	0.643
CLV_PCSK_SKI1_1	564	568	PF00082	0.468
DEG_APCC_DBOX_1	420	428	PF00400	0.480
DEG_APCC_DBOX_1	596	604	PF00400	0.435
DEG_Nend_Nbox_1	1	3	PF02207	0.642
DEG_SPOP_SBC_1	141	145	PF00917	0.719
DOC_ANK_TNKS_1	18	25	PF00023	0.455
DOC_ANK_TNKS_1	68	75	PF00023	0.574
DOC_CYCLIN_RxL_1	419	428	PF00134	0.455
DOC_MAPK_gen_1	192	201	PF00069	0.594
DOC_MAPK_MEF2A_6	246	254	PF00069	0.562
DOC_PP4_FxxP_1	366	369	PF00568	0.518
DOC_USP7_MATH_1	140	144	PF00917	0.718
DOC_USP7_MATH_1	152	156	PF00917	0.554
DOC_USP7_MATH_1	176	180	PF00917	0.728
DOC_USP7_MATH_1	283	287	PF00917	0.721
DOC_USP7_MATH_1	479	483	PF00917	0.519
DOC_USP7_MATH_1	505	509	PF00917	0.557
DOC_USP7_MATH_1	546	550	PF00917	0.708
DOC_USP7_UBL2_3	122	126	PF12436	0.545
DOC_USP7_UBL2_3	519	523	PF12436	0.486
DOC_WW_Pin1_4	179	184	PF00397	0.763
DOC_WW_Pin1_4	279	284	PF00397	0.669
DOC_WW_Pin1_4	365	370	PF00397	0.443
DOC_WW_Pin1_4	57	62	PF00397	0.644
LIG_14-3-3_CanoR_1	210	218	PF00244	0.461
LIG_14-3-3_CanoR_1	222	228	PF00244	0.389
LIG_14-3-3_CanoR_1	246	254	PF00244	0.499
LIG_14-3-3_CanoR_1	31	39	PF00244	0.650
LIG_14-3-3_CanoR_1	328	332	PF00244	0.565
LIG_14-3-3_CanoR_1	354	361	PF00244	0.486
LIG_14-3-3_CanoR_1	387	393	PF00244	0.516
LIG_14-3-3_CanoR_1	526	534	PF00244	0.608
LIG_14-3-3_CanoR_1	53	62	PF00244	0.733
LIG_14-3-3_CanoR_1	599	604	PF00244	0.443
LIG_14-3-3_CanoR_1	84	89	PF00244	0.653
LIG_Actin_WH2_2	407	423	PF00022	0.560
LIG_Actin_WH2_2	424	439	PF00022	0.414
LIG_Actin_WH2_2	507	525	PF00022	0.547
LIG_APCC_ABBA_1	550	555	PF00400	0.575
LIG_APCC_ABBAyCdc20_2	404	410	PF00400	0.330
LIG_BIR_III_4	14	18	PF00653	0.524
LIG_BRCT_BRCA1_1	296	300	PF00533	0.586
LIG_BRCT_BRCA1_1	367	371	PF00533	0.385
LIG_BRCT_MDC1_1	601	605	PF00533	0.470
LIG_CaM_IQ_9	39	55	PF13499	0.636
LIG_FHA_1	158	164	PF00498	0.730
LIG_FHA_1	224	230	PF00498	0.397
LIG_FHA_1	287	293	PF00498	0.550
LIG_FHA_1	296	302	PF00498	0.415
LIG_FHA_1	31	37	PF00498	0.696
LIG_FHA_1	436	442	PF00498	0.582
LIG_FHA_1	445	451	PF00498	0.545
LIG_FHA_1	457	463	PF00498	0.622
LIG_FHA_2	134	140	PF00498	0.607
LIG_FHA_2	231	237	PF00498	0.451
LIG_FHA_2	328	334	PF00498	0.589
LIG_FHA_2	389	395	PF00498	0.493
LIG_FHA_2	468	474	PF00498	0.607
LIG_GBD_Chelix_1	510	518	PF00786	0.531
LIG_LIR_Gen_1	197	206	PF02991	0.490
LIG_LIR_Gen_1	368	379	PF02991	0.353
LIG_LIR_Gen_1	410	419	PF02991	0.497
LIG_LIR_Gen_1	512	522	PF02991	0.392
LIG_LIR_Nem_3	197	201	PF02991	0.511
LIG_LIR_Nem_3	368	374	PF02991	0.365
LIG_LIR_Nem_3	410	414	PF02991	0.448
LIG_LIR_Nem_3	512	518	PF02991	0.369
LIG_LYPXL_SIV_4	119	127	PF13949	0.504
LIG_NRBOX	513	519	PF00104	0.534
LIG_NRBOX	599	605	PF00104	0.468
LIG_Pex14_1	2	6	PF04695	0.679
LIG_SH2_STAT5	111	114	PF00017	0.446
LIG_SH2_STAT5	120	123	PF00017	0.377
LIG_SH2_STAT5	227	230	PF00017	0.389
LIG_SH2_STAT5	365	368	PF00017	0.447
LIG_SH2_STAT5	384	387	PF00017	0.314
LIG_SH2_STAT5	484	487	PF00017	0.464
LIG_SH2_STAT5	88	91	PF00017	0.505
LIG_SH3_3	585	591	PF00018	0.543
LIG_SUMO_SIM_par_1	157	164	PF11976	0.535
LIG_SUMO_SIM_par_1	422	428	PF11976	0.383
LIG_TRAF2_1	330	333	PF00917	0.553
LIG_TRAF2_1	545	548	PF00917	0.692
LIG_UBA3_1	251	260	PF00899	0.533
LIG_UBA3_1	514	523	PF00899	0.415
MOD_CDC14_SPxK_1	60	63	PF00782	0.525
MOD_CDK_SPxK_1	57	63	PF00069	0.523
MOD_CK1_1	157	163	PF00069	0.725
MOD_CK1_1	179	185	PF00069	0.745
MOD_CK1_1	214	220	PF00069	0.464
MOD_CK1_1	273	279	PF00069	0.731
MOD_CK1_1	286	292	PF00069	0.512
MOD_CK1_1	294	300	PF00069	0.475
MOD_CK1_1	388	394	PF00069	0.526
MOD_CK1_1	45	51	PF00069	0.748
MOD_CK1_1	530	536	PF00069	0.693
MOD_CK1_1	57	63	PF00069	0.661
MOD_CK2_1	152	158	PF00069	0.732
MOD_CK2_1	327	333	PF00069	0.562
MOD_CK2_1	354	360	PF00069	0.481
MOD_CK2_1	467	473	PF00069	0.577
MOD_CK2_1	542	548	PF00069	0.691
MOD_GlcNHglycan	117	120	PF01048	0.465
MOD_GlcNHglycan	146	149	PF01048	0.699
MOD_GlcNHglycan	162	166	PF01048	0.652
MOD_GlcNHglycan	173	176	PF01048	0.722
MOD_GlcNHglycan	184	187	PF01048	0.776
MOD_GlcNHglycan	213	216	PF01048	0.463
MOD_GlcNHglycan	273	276	PF01048	0.690
MOD_GlcNHglycan	279	282	PF01048	0.706
MOD_GlcNHglycan	285	288	PF01048	0.636
MOD_GlcNHglycan	293	296	PF01048	0.428
MOD_GlcNHglycan	502	506	PF01048	0.571
MOD_GlcNHglycan	507	510	PF01048	0.473
MOD_GlcNHglycan	544	547	PF01048	0.678
MOD_GlcNHglycan	74	77	PF01048	0.657
MOD_GSK3_1	140	147	PF00069	0.670
MOD_GSK3_1	157	164	PF00069	0.605
MOD_GSK3_1	273	280	PF00069	0.707
MOD_GSK3_1	291	298	PF00069	0.422
MOD_GSK3_1	30	37	PF00069	0.696
MOD_GSK3_1	38	45	PF00069	0.648
MOD_GSK3_1	497	504	PF00069	0.576
MOD_GSK3_1	542	549	PF00069	0.685
MOD_GSK3_1	575	582	PF00069	0.496
MOD_GSK3_1	586	593	PF00069	0.527
MOD_GSK3_1	595	602	PF00069	0.434
MOD_N-GLC_1	115	120	PF02516	0.537
MOD_N-GLC_1	270	275	PF02516	0.636
MOD_NEK2_1	1	6	PF00069	0.634
MOD_NEK2_1	127	132	PF00069	0.535
MOD_NEK2_1	230	235	PF00069	0.443
MOD_NEK2_1	293	298	PF00069	0.522
MOD_NEK2_1	327	332	PF00069	0.493
MOD_NEK2_1	385	390	PF00069	0.485
MOD_NEK2_1	39	44	PF00069	0.692
MOD_NEK2_1	501	506	PF00069	0.620
MOD_NEK2_1	517	522	PF00069	0.359
MOD_NEK2_1	524	529	PF00069	0.545
MOD_NEK2_1	54	59	PF00069	0.602
MOD_NEK2_1	559	564	PF00069	0.412
MOD_NEK2_1	579	584	PF00069	0.537
MOD_PIKK_1	163	169	PF00454	0.727
MOD_PIKK_1	187	193	PF00454	0.771
MOD_PIKK_1	39	45	PF00454	0.616
MOD_PIKK_1	479	485	PF00454	0.503
MOD_PIKK_1	527	533	PF00454	0.607
MOD_PIKK_1	590	596	PF00454	0.488
MOD_PIKK_1	99	105	PF00454	0.427
MOD_PK_1	246	252	PF00069	0.500
MOD_PK_1	449	455	PF00069	0.564
MOD_PKA_1	354	360	PF00069	0.481
MOD_PKA_2	245	251	PF00069	0.551
MOD_PKA_2	30	36	PF00069	0.695
MOD_PKA_2	327	333	PF00069	0.469
MOD_PKA_2	354	360	PF00069	0.472
MOD_PKA_2	467	473	PF00069	0.618
MOD_PKA_2	527	533	PF00069	0.591
MOD_PKB_1	597	605	PF00069	0.446
MOD_Plk_1	115	121	PF00069	0.505
MOD_Plk_1	152	158	PF00069	0.689
MOD_Plk_1	546	552	PF00069	0.633
MOD_Plk_2-3	497	503	PF00069	0.596
MOD_Plk_4	230	236	PF00069	0.508
MOD_Plk_4	246	252	PF00069	0.418
MOD_Plk_4	449	455	PF00069	0.605
MOD_Plk_4	579	585	PF00069	0.492
MOD_Plk_4	599	605	PF00069	0.430
MOD_Plk_4	84	90	PF00069	0.602
MOD_ProDKin_1	179	185	PF00069	0.763
MOD_ProDKin_1	279	285	PF00069	0.663
MOD_ProDKin_1	365	371	PF00069	0.437
MOD_ProDKin_1	57	63	PF00069	0.648
MOD_SUMO_rev_2	549	559	PF00179	0.648
TRG_DiLeu_BaEn_1	473	478	PF01217	0.585
TRG_DiLeu_BaEn_4	319	325	PF01217	0.507
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.722
TRG_ENDOCYTIC_2	227	230	PF00928	0.385
TRG_ER_diArg_1	220	223	PF00400	0.536
TRG_ER_diArg_1	327	329	PF00400	0.545
TRG_ER_diArg_1	353	355	PF00400	0.565
TRG_ER_diArg_1	420	422	PF00400	0.407
TRG_ER_diArg_1	526	529	PF00400	0.573
TRG_ER_diArg_1	597	600	PF00400	0.425
TRG_ER_diArg_1	6	8	PF00400	0.670
TRG_ER_diArg_1	66	69	PF00400	0.784
TRG_NES_CRM1_1	341	352	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P9	Leptomonas seymouri	65%	100%
A0A0S4KJS0	Bodo saltans	32%	100%
A0A1X0NTU8	Trypanosomatidae	43%	100%
A0A3Q8IDS9	Leishmania donovani	93%	100%
A4HEZ1	Leishmania braziliensis	79%	100%
A4I265	Leishmania infantum	94%	100%
C9ZRT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AYB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B9R8	Trypanosoma cruzi	43%	100%