Guanine nucleotide-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania major

UniProt:

Q4Q957_LEIMA

TriTrypDb:

LmjF.26.1370 , LMJLV39_260019400 , LMJSD75_260017800

Length:

902

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q957

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q957

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.630
CLV_C14_Caspase3-7	228	232	PF00656	0.560
CLV_C14_Caspase3-7	323	327	PF00656	0.734
CLV_C14_Caspase3-7	366	370	PF00656	0.507
CLV_NRD_NRD_1	114	116	PF00675	0.728
CLV_NRD_NRD_1	145	147	PF00675	0.447
CLV_NRD_NRD_1	18	20	PF00675	0.605
CLV_NRD_NRD_1	219	221	PF00675	0.597
CLV_NRD_NRD_1	430	432	PF00675	0.513
CLV_NRD_NRD_1	524	526	PF00675	0.606
CLV_NRD_NRD_1	528	530	PF00675	0.602
CLV_NRD_NRD_1	588	590	PF00675	0.542
CLV_NRD_NRD_1	609	611	PF00675	0.434
CLV_NRD_NRD_1	653	655	PF00675	0.577
CLV_NRD_NRD_1	662	664	PF00675	0.656
CLV_NRD_NRD_1	666	668	PF00675	0.696
CLV_NRD_NRD_1	70	72	PF00675	0.599
CLV_NRD_NRD_1	74	76	PF00675	0.608
CLV_NRD_NRD_1	83	85	PF00675	0.741
CLV_PCSK_FUR_1	68	72	PF00082	0.596
CLV_PCSK_KEX2_1	114	116	PF00082	0.728
CLV_PCSK_KEX2_1	16	18	PF00082	0.599
CLV_PCSK_KEX2_1	191	193	PF00082	0.730
CLV_PCSK_KEX2_1	20	22	PF00082	0.597
CLV_PCSK_KEX2_1	219	221	PF00082	0.684
CLV_PCSK_KEX2_1	524	526	PF00082	0.606
CLV_PCSK_KEX2_1	588	590	PF00082	0.542
CLV_PCSK_KEX2_1	609	611	PF00082	0.434
CLV_PCSK_KEX2_1	661	663	PF00082	0.638
CLV_PCSK_KEX2_1	666	668	PF00082	0.641
CLV_PCSK_KEX2_1	70	72	PF00082	0.597
CLV_PCSK_KEX2_1	73	75	PF00082	0.598
CLV_PCSK_KEX2_1	834	836	PF00082	0.387
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.599
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.674
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.597
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.620
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.387
CLV_PCSK_PC7_1	662	668	PF00082	0.631
CLV_PCSK_PC7_1	70	76	PF00082	0.576
CLV_PCSK_SKI1_1	132	136	PF00082	0.601
CLV_PCSK_SKI1_1	209	213	PF00082	0.565
CLV_PCSK_SKI1_1	360	364	PF00082	0.359
CLV_PCSK_SKI1_1	498	502	PF00082	0.438
CLV_PCSK_SKI1_1	835	839	PF00082	0.441
CLV_PCSK_SKI1_1	863	867	PF00082	0.315
CLV_PCSK_SKI1_1	895	899	PF00082	0.485
DEG_SCF_FBW7_1	737	744	PF00400	0.484
DEG_SCF_TRCP1_1	689	695	PF00400	0.739
DEG_SPOP_SBC_1	236	240	PF00917	0.587
DEG_SPOP_SBC_1	633	637	PF00917	0.645
DOC_MAPK_FxFP_2	171	174	PF00069	0.602
DOC_MAPK_gen_1	428	437	PF00069	0.488
DOC_MAPK_gen_1	539	547	PF00069	0.669
DOC_MAPK_gen_1	588	596	PF00069	0.514
DOC_MAPK_gen_1	833	839	PF00069	0.449
DOC_MAPK_gen_1	840	848	PF00069	0.401
DOC_MAPK_gen_1	882	891	PF00069	0.422
DOC_MAPK_MEF2A_6	428	437	PF00069	0.391
DOC_MAPK_MEF2A_6	882	891	PF00069	0.422
DOC_PP2B_LxvP_1	765	768	PF13499	0.476
DOC_PP4_FxxP_1	171	174	PF00568	0.602
DOC_PP4_FxxP_1	770	773	PF00568	0.416
DOC_PP4_FxxP_1	867	870	PF00568	0.511
DOC_USP7_MATH_1	182	186	PF00917	0.692
DOC_USP7_MATH_1	257	261	PF00917	0.659
DOC_USP7_MATH_1	264	268	PF00917	0.755
DOC_USP7_MATH_1	292	296	PF00917	0.594
DOC_USP7_MATH_1	632	636	PF00917	0.599
DOC_USP7_MATH_1	641	645	PF00917	0.599
DOC_USP7_MATH_1	751	755	PF00917	0.493
DOC_USP7_MATH_1	791	795	PF00917	0.488
DOC_USP7_UBL2_3	16	20	PF12436	0.544
DOC_USP7_UBL2_3	428	432	PF12436	0.418
DOC_USP7_UBL2_3	527	531	PF12436	0.688
DOC_WW_Pin1_4	296	301	PF00397	0.759
DOC_WW_Pin1_4	634	639	PF00397	0.724
DOC_WW_Pin1_4	703	708	PF00397	0.587
DOC_WW_Pin1_4	737	742	PF00397	0.483
LIG_14-3-3_CanoR_1	114	118	PF00244	0.755
LIG_14-3-3_CanoR_1	146	152	PF00244	0.472
LIG_14-3-3_CanoR_1	157	161	PF00244	0.626
LIG_14-3-3_CanoR_1	491	501	PF00244	0.518
LIG_14-3-3_CanoR_1	502	510	PF00244	0.451
LIG_14-3-3_CanoR_1	567	577	PF00244	0.537
LIG_14-3-3_CanoR_1	616	622	PF00244	0.588
LIG_APCC_ABBA_1	361	366	PF00400	0.498
LIG_APCC_ABBAyCdc20_2	360	366	PF00400	0.500
LIG_BIR_III_2	369	373	PF00653	0.433
LIG_BIR_III_4	231	235	PF00653	0.646
LIG_BRCT_BRCA1_1	237	241	PF00533	0.541
LIG_BRCT_BRCA1_1	485	489	PF00533	0.579
LIG_BRCT_BRCA1_1	793	797	PF00533	0.408
LIG_Clathr_ClatBox_1	377	381	PF01394	0.474
LIG_deltaCOP1_diTrp_1	169	173	PF00928	0.598
LIG_deltaCOP1_diTrp_1	390	396	PF00928	0.386
LIG_FHA_1	363	369	PF00498	0.503
LIG_FHA_1	396	402	PF00498	0.377
LIG_FHA_1	540	546	PF00498	0.666
LIG_FHA_1	600	606	PF00498	0.400
LIG_FHA_1	622	628	PF00498	0.698
LIG_FHA_1	640	646	PF00498	0.517
LIG_FHA_1	730	736	PF00498	0.484
LIG_FHA_1	747	753	PF00498	0.484
LIG_FHA_1	780	786	PF00498	0.440
LIG_FHA_2	616	622	PF00498	0.423
LIG_FHA_2	756	762	PF00498	0.484
LIG_GBD_Chelix_1	597	605	PF00786	0.525
LIG_HCF-1_HBM_1	534	537	PF13415	0.571
LIG_LIR_Apic_2	169	174	PF02991	0.598
LIG_LIR_Apic_2	369	374	PF02991	0.434
LIG_LIR_Gen_1	390	399	PF02991	0.381
LIG_LIR_Gen_1	534	545	PF02991	0.540
LIG_LIR_Gen_1	706	715	PF02991	0.455
LIG_LIR_LC3C_4	402	407	PF02991	0.451
LIG_LIR_Nem_3	150	154	PF02991	0.509
LIG_LIR_Nem_3	169	173	PF02991	0.613
LIG_LIR_Nem_3	238	244	PF02991	0.592
LIG_LIR_Nem_3	390	395	PF02991	0.390
LIG_LIR_Nem_3	410	416	PF02991	0.218
LIG_LIR_Nem_3	534	540	PF02991	0.533
LIG_LIR_Nem_3	706	712	PF02991	0.480
LIG_LIR_Nem_3	819	825	PF02991	0.553
LIG_LYPXL_yS_3	413	416	PF13949	0.362
LIG_MAD2	733	741	PF02301	0.484
LIG_MLH1_MIPbox_1	238	242	PF16413	0.612
LIG_NRBOX	52	58	PF00104	0.528
LIG_Pex14_2	167	171	PF04695	0.594
LIG_RPA_C_Fungi	605	617	PF08784	0.365
LIG_RPA_C_Insects	651	666	PF08784	0.530
LIG_SH2_CRK	151	155	PF00017	0.551
LIG_SH2_NCK_1	868	872	PF00017	0.424
LIG_SH2_SRC	151	154	PF00017	0.515
LIG_SH2_SRC	709	712	PF00017	0.419
LIG_SH2_SRC	801	804	PF00017	0.397
LIG_SH2_SRC	868	871	PF00017	0.510
LIG_SH2_STAP1	364	368	PF00017	0.458
LIG_SH2_STAP1	385	389	PF00017	0.407
LIG_SH2_STAT3	808	811	PF00017	0.458
LIG_SH2_STAT5	364	367	PF00017	0.340
LIG_SH2_STAT5	425	428	PF00017	0.376
LIG_SH2_STAT5	459	462	PF00017	0.379
LIG_SH2_STAT5	709	712	PF00017	0.419
LIG_SH2_STAT5	801	804	PF00017	0.391
LIG_SH3_3	243	249	PF00018	0.463
LIG_SH3_3	464	470	PF00018	0.468
LIG_SH3_3	701	707	PF00018	0.571
LIG_SH3_3	712	718	PF00018	0.303
LIG_SH3_3	757	763	PF00018	0.324
LIG_SH3_3	769	775	PF00018	0.419
LIG_SH3_3	890	896	PF00018	0.420
LIG_Sin3_3	852	859	PF02671	0.467
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.657
LIG_SUMO_SIM_anti_2	402	410	PF11976	0.352
LIG_SUMO_SIM_anti_2	593	598	PF11976	0.457
LIG_SUMO_SIM_anti_2	754	761	PF11976	0.306
LIG_SUMO_SIM_par_1	397	403	PF11976	0.381
LIG_SUMO_SIM_par_1	404	410	PF11976	0.346
LIG_SUMO_SIM_par_1	732	738	PF11976	0.324
LIG_TRAF2_1	304	307	PF00917	0.576
LIG_TRAF2_1	618	621	PF00917	0.432
LIG_TYR_ITIM	149	154	PF00017	0.514
LIG_UBA3_1	422	429	PF00899	0.379
LIG_UBA3_1	725	733	PF00899	0.324
LIG_WRC_WIRS_1	501	506	PF05994	0.426
MOD_CK1_1	175	181	PF00069	0.641
MOD_CK1_1	237	243	PF00069	0.495
MOD_CK1_1	636	642	PF00069	0.581
MOD_CK1_1	692	698	PF00069	0.689
MOD_CK1_1	98	104	PF00069	0.712
MOD_CK2_1	102	108	PF00069	0.728
MOD_CK2_1	315	321	PF00069	0.673
MOD_CK2_1	380	386	PF00069	0.412
MOD_CK2_1	615	621	PF00069	0.416
MOD_CK2_1	820	826	PF00069	0.423
MOD_Cter_Amidation	5	8	PF01082	0.604
MOD_Cter_Amidation	68	71	PF01082	0.598
MOD_GlcNHglycan	115	118	PF01048	0.675
MOD_GlcNHglycan	123	126	PF01048	0.575
MOD_GlcNHglycan	138	141	PF01048	0.535
MOD_GlcNHglycan	175	178	PF01048	0.708
MOD_GlcNHglycan	184	187	PF01048	0.615
MOD_GlcNHglycan	227	230	PF01048	0.721
MOD_GlcNHglycan	258	262	PF01048	0.634
MOD_GlcNHglycan	294	297	PF01048	0.798
MOD_GlcNHglycan	321	325	PF01048	0.719
MOD_GlcNHglycan	331	335	PF01048	0.651
MOD_GlcNHglycan	4	7	PF01048	0.624
MOD_GlcNHglycan	495	498	PF01048	0.565
MOD_GlcNHglycan	668	671	PF01048	0.637
MOD_GlcNHglycan	688	692	PF01048	0.809
MOD_GlcNHglycan	737	740	PF01048	0.303
MOD_GlcNHglycan	877	880	PF01048	0.415
MOD_GlcNHglycan	92	98	PF01048	0.739
MOD_GSK3_1	113	120	PF00069	0.547
MOD_GSK3_1	156	163	PF00069	0.617
MOD_GSK3_1	169	176	PF00069	0.643
MOD_GSK3_1	275	282	PF00069	0.717
MOD_GSK3_1	292	299	PF00069	0.626
MOD_GSK3_1	320	327	PF00069	0.785
MOD_GSK3_1	330	337	PF00069	0.613
MOD_GSK3_1	395	402	PF00069	0.559
MOD_GSK3_1	632	639	PF00069	0.558
MOD_GSK3_1	729	736	PF00069	0.324
MOD_GSK3_1	737	744	PF00069	0.324
MOD_GSK3_1	751	758	PF00069	0.324
MOD_GSK3_1	95	102	PF00069	0.772
MOD_NEK2_1	113	118	PF00069	0.751
MOD_NEK2_1	225	230	PF00069	0.591
MOD_NEK2_1	380	385	PF00069	0.423
MOD_NEK2_1	604	609	PF00069	0.506
MOD_NEK2_1	875	880	PF00069	0.424
MOD_NEK2_1	889	894	PF00069	0.403
MOD_NEK2_2	130	135	PF00069	0.595
MOD_NEK2_2	445	450	PF00069	0.397
MOD_PIKK_1	275	281	PF00454	0.740
MOD_PIKK_1	315	321	PF00454	0.569
MOD_PK_1	733	739	PF00069	0.324
MOD_PKA_1	654	660	PF00069	0.522
MOD_PKA_1	666	672	PF00069	0.524
MOD_PKA_2	113	119	PF00069	0.755
MOD_PKA_2	156	162	PF00069	0.602
MOD_PKA_2	314	320	PF00069	0.668
MOD_PKA_2	615	621	PF00069	0.528
MOD_PKA_2	666	672	PF00069	0.564
MOD_PKA_2	729	735	PF00069	0.333
MOD_Plk_1	264	270	PF00069	0.701
MOD_Plk_1	330	336	PF00069	0.605
MOD_Plk_1	380	386	PF00069	0.445
MOD_Plk_1	77	83	PF00069	0.534
MOD_Plk_2-3	352	358	PF00069	0.389
MOD_Plk_2-3	381	387	PF00069	0.446
MOD_Plk_2-3	755	761	PF00069	0.303
MOD_Plk_4	117	123	PF00069	0.747
MOD_Plk_4	237	243	PF00069	0.517
MOD_Plk_4	264	270	PF00069	0.687
MOD_Plk_4	421	427	PF00069	0.462
MOD_Plk_4	705	711	PF00069	0.502
MOD_Plk_4	721	727	PF00069	0.324
MOD_Plk_4	755	761	PF00069	0.324
MOD_Plk_4	889	895	PF00069	0.388
MOD_ProDKin_1	296	302	PF00069	0.758
MOD_ProDKin_1	634	640	PF00069	0.727
MOD_ProDKin_1	703	709	PF00069	0.570
MOD_ProDKin_1	737	743	PF00069	0.322
MOD_SUMO_rev_2	90	96	PF00179	0.629
TRG_DiLeu_BaEn_1	208	213	PF01217	0.576
TRG_DiLeu_BaEn_1	755	760	PF01217	0.303
TRG_DiLeu_BaEn_4	24	30	PF01217	0.450
TRG_DiLeu_BaEn_4	561	567	PF01217	0.595
TRG_ENDOCYTIC_2	151	154	PF00928	0.537
TRG_ENDOCYTIC_2	413	416	PF00928	0.362
TRG_ENDOCYTIC_2	457	460	PF00928	0.404
TRG_ENDOCYTIC_2	537	540	PF00928	0.549
TRG_ENDOCYTIC_2	591	594	PF00928	0.478
TRG_ENDOCYTIC_2	709	712	PF00928	0.419
TRG_ENDOCYTIC_2	801	804	PF00928	0.404
TRG_ER_diArg_1	113	115	PF00400	0.756
TRG_ER_diArg_1	219	221	PF00400	0.684
TRG_ER_diArg_1	609	611	PF00400	0.434
TRG_ER_diArg_1	68	71	PF00400	0.585
TRG_ER_diArg_1	73	75	PF00400	0.596
TRG_ER_diArg_1	884	887	PF00400	0.429
TRG_NLS_MonoExtC_3	15	20	PF00514	0.540
TRG_NLS_MonoExtC_3	427	432	PF00514	0.337
TRG_NLS_MonoExtC_3	528	534	PF00514	0.612
TRG_NLS_MonoExtN_4	527	533	PF00514	0.675
TRG_NLS_MonoExtN_4	658	665	PF00514	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA6	Leptomonas seymouri	60%	100%
A0A3S7WZV4	Leishmania donovani	92%	100%
A4HEZ2	Leishmania braziliensis	76%	100%
A4I266	Leishmania infantum	92%	100%
E9AYB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%