Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WWE domain/WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q954_LEIMA

TriTrypDb:

LmjF.26.1400 , LMJLV39_260019700 , LMJSD75_260018100

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

Q4Q954

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q954

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.606
CLV_PCSK_KEX2_1	155	157	PF00082	0.254
CLV_PCSK_KEX2_1	191	193	PF00082	0.450
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.257
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.458
CLV_PCSK_SKI1_1	188	192	PF00082	0.445
CLV_PCSK_SKI1_1	343	347	PF00082	0.298
CLV_PCSK_SKI1_1	517	521	PF00082	0.378
CLV_PCSK_SKI1_1	74	78	PF00082	0.666
DEG_SPOP_SBC_1	26	30	PF00917	0.556
DEG_SPOP_SBC_1	328	332	PF00917	0.610
DOC_ANK_TNKS_1	323	330	PF00023	0.488
DOC_ANK_TNKS_1	357	364	PF00023	0.486
DOC_MAPK_gen_1	154	162	PF00069	0.453
DOC_MAPK_gen_1	186	195	PF00069	0.457
DOC_MAPK_gen_1	64	71	PF00069	0.647
DOC_MAPK_RevD_3	141	156	PF00069	0.558
DOC_PP4_FxxP_1	457	460	PF00568	0.475
DOC_USP7_MATH_1	131	135	PF00917	0.481
DOC_USP7_MATH_1	169	173	PF00917	0.644
DOC_USP7_MATH_1	174	178	PF00917	0.618
DOC_USP7_MATH_1	391	395	PF00917	0.504
DOC_USP7_MATH_1	415	419	PF00917	0.552
DOC_USP7_MATH_1	44	48	PF00917	0.785
DOC_USP7_MATH_1	490	494	PF00917	0.560
DOC_USP7_MATH_1	506	510	PF00917	0.478
DOC_USP7_MATH_2	78	84	PF00917	0.648
DOC_WW_Pin1_4	269	274	PF00397	0.482
DOC_WW_Pin1_4	277	282	PF00397	0.452
DOC_WW_Pin1_4	4	9	PF00397	0.683
DOC_WW_Pin1_4	510	515	PF00397	0.482
LIG_14-3-3_CanoR_1	146	152	PF00244	0.490
LIG_14-3-3_CanoR_1	156	161	PF00244	0.414
LIG_14-3-3_CanoR_1	24	34	PF00244	0.669
LIG_14-3-3_CanoR_1	411	415	PF00244	0.449
LIG_14-3-3_CanoR_1	448	454	PF00244	0.544
LIG_14-3-3_CanoR_1	491	500	PF00244	0.486
LIG_14-3-3_CanoR_1	517	527	PF00244	0.426
LIG_AP2alpha_2	217	219	PF02296	0.447
LIG_BIR_III_4	245	249	PF00653	0.551
LIG_BRCT_BRCA1_1	417	421	PF00533	0.473
LIG_deltaCOP1_diTrp_1	466	476	PF00928	0.539
LIG_eIF4E_1	379	385	PF01652	0.531
LIG_FHA_1	146	152	PF00498	0.461
LIG_FHA_1	157	163	PF00498	0.423
LIG_FHA_1	185	191	PF00498	0.618
LIG_FHA_1	201	207	PF00498	0.562
LIG_FHA_1	278	284	PF00498	0.555
LIG_FHA_1	316	322	PF00498	0.442
LIG_FHA_1	354	360	PF00498	0.437
LIG_FHA_1	373	379	PF00498	0.463
LIG_FHA_1	482	488	PF00498	0.492
LIG_FHA_1	492	498	PF00498	0.482
LIG_FHA_1	66	72	PF00498	0.708
LIG_FHA_2	105	111	PF00498	0.681
LIG_FHA_2	195	201	PF00498	0.566
LIG_FHA_2	321	327	PF00498	0.517
LIG_FHA_2	433	439	PF00498	0.419
LIG_FHA_2	456	462	PF00498	0.530
LIG_LIR_Apic_2	197	201	PF02991	0.675
LIG_LIR_Apic_2	323	328	PF02991	0.556
LIG_LIR_Gen_1	525	531	PF02991	0.507
LIG_LIR_Gen_1	574	581	PF02991	0.542
LIG_LIR_Nem_3	112	117	PF02991	0.472
LIG_LIR_Nem_3	126	130	PF02991	0.436
LIG_LIR_Nem_3	177	182	PF02991	0.507
LIG_LIR_Nem_3	525	530	PF02991	0.441
LIG_LIR_Nem_3	574	578	PF02991	0.518
LIG_LYPXL_yS_3	179	182	PF13949	0.510
LIG_MAD2	498	506	PF02301	0.324
LIG_NRBOX	208	214	PF00104	0.450
LIG_SH2_NCK_1	198	202	PF00017	0.639
LIG_SH2_NCK_1	325	329	PF00017	0.562
LIG_SH2_SRC	360	363	PF00017	0.523
LIG_SH2_STAP1	158	162	PF00017	0.493
LIG_SH2_STAP1	341	345	PF00017	0.496
LIG_SH2_STAT3	512	515	PF00017	0.520
LIG_SH2_STAT5	158	161	PF00017	0.514
LIG_SH2_STAT5	198	201	PF00017	0.638
LIG_SH2_STAT5	275	278	PF00017	0.476
LIG_SH2_STAT5	512	515	PF00017	0.497
LIG_SH3_1	424	430	PF00018	0.530
LIG_SH3_3	290	296	PF00018	0.582
LIG_SH3_3	424	430	PF00018	0.452
LIG_SH3_3	98	104	PF00018	0.669
LIG_Sin3_3	290	297	PF02671	0.503
LIG_SUMO_SIM_par_1	93	99	PF11976	0.561
LIG_TRFH_1	421	425	PF08558	0.450
MOD_CDK_SPxxK_3	4	11	PF00069	0.676
MOD_CDK_SPxxK_3	510	517	PF00069	0.483
MOD_CK1_1	15	21	PF00069	0.679
MOD_CK1_1	315	321	PF00069	0.538
MOD_CK1_1	332	338	PF00069	0.516
MOD_CK1_1	523	529	PF00069	0.437
MOD_CK1_1	566	572	PF00069	0.446
MOD_CK1_1	7	13	PF00069	0.650
MOD_CK2_1	104	110	PF00069	0.759
MOD_CK2_1	320	326	PF00069	0.504
MOD_CK2_1	432	438	PF00069	0.484
MOD_GlcNHglycan	133	136	PF01048	0.314
MOD_GlcNHglycan	171	174	PF01048	0.608
MOD_GlcNHglycan	304	307	PF01048	0.469
MOD_GlcNHglycan	46	49	PF01048	0.752
MOD_GSK3_1	12	19	PF00069	0.747
MOD_GSK3_1	196	203	PF00069	0.594
MOD_GSK3_1	269	276	PF00069	0.435
MOD_GSK3_1	312	319	PF00069	0.484
MOD_GSK3_1	328	335	PF00069	0.524
MOD_GSK3_1	506	513	PF00069	0.452
MOD_GSK3_1	526	533	PF00069	0.382
MOD_GSK3_1	556	563	PF00069	0.517
MOD_N-GLC_1	339	344	PF02516	0.499
MOD_N-GLC_1	472	477	PF02516	0.370
MOD_N-GLC_1	534	539	PF02516	0.501
MOD_NEK2_1	145	150	PF00069	0.507
MOD_NEK2_1	263	268	PF00069	0.445
MOD_NEK2_1	301	306	PF00069	0.390
MOD_NEK2_1	449	454	PF00069	0.430
MOD_NEK2_1	481	486	PF00069	0.471
MOD_NEK2_1	530	535	PF00069	0.451
MOD_NEK2_2	506	511	PF00069	0.474
MOD_PIKK_1	80	86	PF00454	0.722
MOD_PKA_1	154	160	PF00069	0.539
MOD_PKA_2	145	151	PF00069	0.529
MOD_PKA_2	410	416	PF00069	0.465
MOD_PKA_2	490	496	PF00069	0.496
MOD_Plk_1	312	318	PF00069	0.495
MOD_Plk_1	460	466	PF00069	0.506
MOD_Plk_1	472	478	PF00069	0.455
MOD_Plk_1	534	540	PF00069	0.495
MOD_Plk_1	566	572	PF00069	0.464
MOD_Plk_4	109	115	PF00069	0.643
MOD_Plk_4	147	153	PF00069	0.505
MOD_Plk_4	317	323	PF00069	0.577
MOD_Plk_4	332	338	PF00069	0.475
MOD_Plk_4	523	529	PF00069	0.515
MOD_Plk_4	545	551	PF00069	0.457
MOD_Plk_4	556	562	PF00069	0.474
MOD_Plk_4	90	96	PF00069	0.737
MOD_ProDKin_1	269	275	PF00069	0.479
MOD_ProDKin_1	277	283	PF00069	0.457
MOD_ProDKin_1	4	10	PF00069	0.682
MOD_ProDKin_1	510	516	PF00069	0.480
MOD_SUMO_rev_2	200	209	PF00179	0.670
MOD_SUMO_rev_2	438	442	PF00179	0.493
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.725
TRG_ENDOCYTIC_2	179	182	PF00928	0.510
TRG_ER_diArg_1	550	553	PF00400	0.377
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB1	Leptomonas seymouri	63%	100%
A0A0S4KLR3	Bodo saltans	26%	100%
A0A1X0NS60	Trypanosomatidae	32%	100%
A0A3S7WZV3	Leishmania donovani	93%	100%
A0A422NIT0	Trypanosoma rangeli	37%	100%
A4HEZ5	Leishmania braziliensis	74%	99%
A4I269	Leishmania infantum	93%	100%
C4Q0P6	Schistosoma mansoni	23%	100%
C9ZRS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AYB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5BEB9	Trypanosoma cruzi	34%	100%