LeishMANIAdb
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J domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
J domain-containing protein
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4Q953_LEIMA
TriTrypDb:
LmjF.26.1410 , LMJLV39_260019800 * , LMJSD75_260018200
Length:
536

Annotations

LeishMANIAdb annotations

These kinetoplastid-specific proteins contain a conserved DnaJ domain at their C-termini and a completely unique structure before and after that.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 9
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4Q953
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q953

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 2
GO:0009987 cellular process 1 2
GO:0061077 chaperone-mediated protein folding 3 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2
GO:0044183 protein folding chaperone 1 2
GO:0051082 unfolded protein binding 3 2
GO:0051087 protein-folding chaperone binding 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 173 177 PF00656 0.423
CLV_C14_Caspase3-7 460 464 PF00656 0.558
CLV_NRD_NRD_1 329 331 PF00675 0.451
CLV_PCSK_FUR_1 247 251 PF00082 0.481
CLV_PCSK_KEX2_1 249 251 PF00082 0.441
CLV_PCSK_KEX2_1 329 331 PF00082 0.451
CLV_PCSK_KEX2_1 342 344 PF00082 0.412
CLV_PCSK_KEX2_1 466 468 PF00082 0.282
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.467
CLV_PCSK_PC1ET2_1 342 344 PF00082 0.483
CLV_PCSK_PC1ET2_1 466 468 PF00082 0.313
CLV_PCSK_SKI1_1 255 259 PF00082 0.341
CLV_PCSK_SKI1_1 324 328 PF00082 0.427
CLV_PCSK_SKI1_1 428 432 PF00082 0.322
DEG_APCC_DBOX_1 301 309 PF00400 0.362
DEG_Nend_Nbox_1 1 3 PF02207 0.698
DEG_SPOP_SBC_1 140 144 PF00917 0.436
DOC_CYCLIN_RxL_1 422 435 PF00134 0.586
DOC_PP1_RVXF_1 115 122 PF00149 0.503
DOC_PP1_RVXF_1 68 74 PF00149 0.388
DOC_PP4_FxxP_1 9 12 PF00568 0.493
DOC_USP7_MATH_1 140 144 PF00917 0.528
DOC_USP7_MATH_1 186 190 PF00917 0.467
DOC_USP7_MATH_1 364 368 PF00917 0.737
DOC_USP7_MATH_1 393 397 PF00917 0.640
DOC_USP7_MATH_1 495 499 PF00917 0.470
DOC_WD40_RPTOR_TOS_1 32 38 PF00400 0.400
DOC_WW_Pin1_4 162 167 PF00397 0.563
DOC_WW_Pin1_4 306 311 PF00397 0.355
LIG_14-3-3_CanoR_1 149 155 PF00244 0.571
LIG_14-3-3_CanoR_1 167 175 PF00244 0.362
LIG_14-3-3_CanoR_1 215 225 PF00244 0.337
LIG_14-3-3_CanoR_1 247 257 PF00244 0.584
LIG_14-3-3_CanoR_1 302 306 PF00244 0.375
LIG_14-3-3_CanoR_1 330 336 PF00244 0.656
LIG_14-3-3_CanoR_1 448 458 PF00244 0.557
LIG_14-3-3_CanoR_1 474 483 PF00244 0.710
LIG_14-3-3_CanoR_1 523 528 PF00244 0.498
LIG_14-3-3_CanoR_1 65 73 PF00244 0.418
LIG_APCC_ABBA_1 83 88 PF00400 0.427
LIG_BRCT_BRCA1_1 213 217 PF00533 0.429
LIG_BRCT_BRCA1_1 28 32 PF00533 0.371
LIG_Clathr_ClatBox_1 21 25 PF01394 0.590
LIG_Clathr_ClatBox_1 31 35 PF01394 0.448
LIG_EH_1 191 195 PF12763 0.347
LIG_eIF4E_1 26 32 PF01652 0.451
LIG_eIF4E_1 425 431 PF01652 0.586
LIG_FHA_1 114 120 PF00498 0.432
LIG_FHA_1 217 223 PF00498 0.313
LIG_FHA_1 228 234 PF00498 0.288
LIG_FHA_1 302 308 PF00498 0.340
LIG_FHA_1 489 495 PF00498 0.633
LIG_FHA_1 497 503 PF00498 0.359
LIG_FHA_2 332 338 PF00498 0.602
LIG_FHA_2 458 464 PF00498 0.553
LIG_LIR_Gen_1 404 414 PF02991 0.483
LIG_LIR_Gen_1 456 462 PF02991 0.554
LIG_LIR_Gen_1 519 527 PF02991 0.422
LIG_LIR_Gen_1 61 71 PF02991 0.464
LIG_LIR_LC3C_4 263 266 PF02991 0.285
LIG_LIR_Nem_3 107 113 PF02991 0.424
LIG_LIR_Nem_3 251 257 PF02991 0.559
LIG_LIR_Nem_3 403 409 PF02991 0.466
LIG_LIR_Nem_3 456 461 PF02991 0.554
LIG_LIR_Nem_3 481 486 PF02991 0.643
LIG_LIR_Nem_3 512 517 PF02991 0.549
LIG_LIR_Nem_3 61 66 PF02991 0.466
LIG_LIR_Nem_3 72 76 PF02991 0.410
LIG_LYPXL_S_1 101 105 PF13949 0.590
LIG_LYPXL_S_1 126 130 PF13949 0.692
LIG_LYPXL_yS_3 102 105 PF13949 0.395
LIG_NRBOX 17 23 PF00104 0.378
LIG_NRBOX 279 285 PF00104 0.347
LIG_Pex14_1 46 50 PF04695 0.491
LIG_Pex14_2 130 134 PF04695 0.381
LIG_Pex14_2 217 221 PF04695 0.321
LIG_Pex14_2 50 54 PF04695 0.481
LIG_REV1ctd_RIR_1 47 55 PF16727 0.465
LIG_REV1ctd_RIR_1 480 489 PF16727 0.550
LIG_SH2_CRK 182 186 PF00017 0.483
LIG_SH2_CRK 458 462 PF00017 0.562
LIG_SH2_CRK 63 67 PF00017 0.437
LIG_SH2_PTP2 100 103 PF00017 0.406
LIG_SH2_SRC 100 103 PF00017 0.363
LIG_SH2_SRC 208 211 PF00017 0.374
LIG_SH2_SRC 26 29 PF00017 0.308
LIG_SH2_STAP1 218 222 PF00017 0.372
LIG_SH2_STAP1 260 264 PF00017 0.419
LIG_SH2_STAP1 275 279 PF00017 0.466
LIG_SH2_STAP1 458 462 PF00017 0.562
LIG_SH2_STAP1 63 67 PF00017 0.437
LIG_SH2_STAT3 210 213 PF00017 0.348
LIG_SH2_STAT3 242 245 PF00017 0.606
LIG_SH2_STAT5 100 103 PF00017 0.333
LIG_SH2_STAT5 208 211 PF00017 0.350
LIG_SH2_STAT5 218 221 PF00017 0.378
LIG_SH2_STAT5 242 245 PF00017 0.618
LIG_SH2_STAT5 26 29 PF00017 0.372
LIG_SH2_STAT5 517 520 PF00017 0.415
LIG_SH3_1 182 188 PF00018 0.485
LIG_SH3_2 185 190 PF14604 0.486
LIG_SH3_3 182 188 PF00018 0.485
LIG_SUMO_SIM_anti_2 263 268 PF11976 0.371
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.284
LIG_SUMO_SIM_anti_2 498 504 PF11976 0.422
LIG_SUMO_SIM_par_1 263 268 PF11976 0.395
LIG_SUMO_SIM_par_1 303 309 PF11976 0.411
LIG_SUMO_SIM_par_1 530 536 PF11976 0.555
LIG_TRAF2_1 200 203 PF00917 0.407
LIG_TYR_ITSM 402 409 PF00017 0.402
LIG_WRC_WIRS_1 127 132 PF05994 0.623
LIG_WRC_WIRS_1 218 223 PF05994 0.246
LIG_WRC_WIRS_1 59 64 PF05994 0.594
LIG_WW_3 184 188 PF00397 0.598
MOD_CDK_SPK_2 162 167 PF00069 0.644
MOD_CK1_1 139 145 PF00069 0.721
MOD_CK1_1 148 154 PF00069 0.735
MOD_CK1_1 160 166 PF00069 0.680
MOD_CK1_1 488 494 PF00069 0.571
MOD_CK1_1 61 67 PF00069 0.590
MOD_GlcNHglycan 138 141 PF01048 0.672
MOD_GlcNHglycan 144 147 PF01048 0.711
MOD_GlcNHglycan 159 162 PF01048 0.647
MOD_GlcNHglycan 222 225 PF01048 0.355
MOD_GlcNHglycan 395 398 PF01048 0.643
MOD_GlcNHglycan 451 454 PF01048 0.402
MOD_GlcNHglycan 51 54 PF01048 0.580
MOD_GlcNHglycan 511 514 PF01048 0.638
MOD_GSK3_1 136 143 PF00069 0.692
MOD_GSK3_1 144 151 PF00069 0.718
MOD_GSK3_1 153 160 PF00069 0.663
MOD_GSK3_1 216 223 PF00069 0.367
MOD_GSK3_1 227 234 PF00069 0.283
MOD_GSK3_1 265 272 PF00069 0.406
MOD_GSK3_1 286 293 PF00069 0.480
MOD_GSK3_1 45 52 PF00069 0.588
MOD_GSK3_1 457 464 PF00069 0.480
MOD_GSK3_1 54 61 PF00069 0.620
MOD_GSK3_1 65 72 PF00069 0.443
MOD_NEK2_1 113 118 PF00069 0.518
MOD_NEK2_1 138 143 PF00069 0.610
MOD_NEK2_1 217 222 PF00069 0.419
MOD_NEK2_1 27 32 PF00069 0.491
MOD_NEK2_1 363 368 PF00069 0.659
MOD_NEK2_1 410 415 PF00069 0.460
MOD_NEK2_1 49 54 PF00069 0.579
MOD_NEK2_2 227 232 PF00069 0.373
MOD_NEK2_2 45 50 PF00069 0.572
MOD_PIKK_1 167 173 PF00454 0.718
MOD_PKA_1 249 255 PF00069 0.561
MOD_PKA_2 148 154 PF00069 0.725
MOD_PKA_2 186 192 PF00069 0.628
MOD_PKA_2 249 255 PF00069 0.592
MOD_PKA_2 301 307 PF00069 0.437
MOD_PKA_2 522 528 PF00069 0.596
MOD_PKA_2 69 75 PF00069 0.345
MOD_Plk_1 227 233 PF00069 0.415
MOD_Plk_4 126 132 PF00069 0.589
MOD_Plk_4 217 223 PF00069 0.429
MOD_Plk_4 227 233 PF00069 0.373
MOD_Plk_4 238 244 PF00069 0.527
MOD_Plk_4 269 275 PF00069 0.379
MOD_Plk_4 27 33 PF00069 0.523
MOD_Plk_4 301 307 PF00069 0.410
MOD_Plk_4 313 319 PF00069 0.369
MOD_Plk_4 457 463 PF00069 0.420
MOD_Plk_4 496 502 PF00069 0.414
MOD_Plk_4 516 522 PF00069 0.555
MOD_Plk_4 55 61 PF00069 0.604
MOD_Plk_4 78 84 PF00069 0.400
MOD_ProDKin_1 162 168 PF00069 0.726
MOD_ProDKin_1 306 312 PF00069 0.355
MOD_SUMO_rev_2 336 344 PF00179 0.612
MOD_SUMO_rev_2 416 424 PF00179 0.341
MOD_SUMO_rev_2 87 91 PF00179 0.344
TRG_DiLeu_BaEn_1 17 22 PF01217 0.447
TRG_DiLeu_BaEn_1 301 306 PF01217 0.355
TRG_DiLeu_BaLyEn_6 114 119 PF01217 0.653
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.551
TRG_DiLeu_BaLyEn_6 71 76 PF01217 0.536
TRG_ENDOCYTIC_2 102 105 PF00928 0.525
TRG_ENDOCYTIC_2 110 113 PF00928 0.504
TRG_ENDOCYTIC_2 127 130 PF00928 0.616
TRG_ENDOCYTIC_2 218 221 PF00928 0.373
TRG_ENDOCYTIC_2 406 409 PF00928 0.338
TRG_ENDOCYTIC_2 458 461 PF00928 0.335
TRG_ENDOCYTIC_2 470 473 PF00928 0.475
TRG_ENDOCYTIC_2 517 520 PF00928 0.534
TRG_ENDOCYTIC_2 63 66 PF00928 0.554
TRG_NES_CRM1_1 25 38 PF08389 0.581
TRG_Pf-PMV_PEXEL_1 167 171 PF00026 0.493
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4K7 Leptomonas seymouri 58% 100%
A0A1X0NST5 Trypanosomatidae 31% 100%
A0A3Q8ICU0 Leishmania donovani 92% 100%
A0A3R7KCJ4 Trypanosoma rangeli 31% 100%
A4HEZ6 Leishmania braziliensis 80% 100%
A4I270 Leishmania infantum 93% 100%
C9ZRS7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AYC0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5DAA3 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS