Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q950_LEIMA

TriTrypDb:

LmjF.26.1440 , LMJLV39_260020100 , LMJSD75_260018500

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q950

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q950

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.557
CLV_C14_Caspase3-7	157	161	PF00656	0.544
CLV_C14_Caspase3-7	225	229	PF00656	0.306
CLV_C14_Caspase3-7	543	547	PF00656	0.593
CLV_C14_Caspase3-7	679	683	PF00656	0.670
CLV_NRD_NRD_1	134	136	PF00675	0.612
CLV_NRD_NRD_1	17	19	PF00675	0.594
CLV_NRD_NRD_1	483	485	PF00675	0.497
CLV_NRD_NRD_1	586	588	PF00675	0.524
CLV_NRD_NRD_1	691	693	PF00675	0.670
CLV_NRD_NRD_1	751	753	PF00675	0.424
CLV_NRD_NRD_1	82	84	PF00675	0.803
CLV_NRD_NRD_1	92	94	PF00675	0.727
CLV_PCSK_FUR_1	132	136	PF00082	0.667
CLV_PCSK_KEX2_1	132	134	PF00082	0.600
CLV_PCSK_KEX2_1	483	485	PF00082	0.482
CLV_PCSK_KEX2_1	691	693	PF00082	0.670
CLV_PCSK_KEX2_1	753	755	PF00082	0.413
CLV_PCSK_KEX2_1	92	94	PF00082	0.716
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.395
CLV_PCSK_SKI1_1	34	38	PF00082	0.475
CLV_PCSK_SKI1_1	375	379	PF00082	0.556
CLV_PCSK_SKI1_1	427	431	PF00082	0.356
CLV_PCSK_SKI1_1	450	454	PF00082	0.439
CLV_PCSK_SKI1_1	473	477	PF00082	0.403
CLV_PCSK_SKI1_1	486	490	PF00082	0.463
CLV_PCSK_SKI1_1	587	591	PF00082	0.352
CLV_PCSK_SKI1_1	736	740	PF00082	0.314
CLV_Separin_Metazoa	724	728	PF03568	0.399
DEG_APCC_DBOX_1	535	543	PF00400	0.517
DEG_MDM2_SWIB_1	230	238	PF02201	0.396
DEG_SCF_FBW7_2	589	594	PF00400	0.307
DEG_SPOP_SBC_1	347	351	PF00917	0.678
DEG_SPOP_SBC_1	393	397	PF00917	0.617
DOC_CYCLIN_RxL_1	30	38	PF00134	0.482
DOC_MAPK_gen_1	205	215	PF00069	0.392
DOC_MAPK_gen_1	273	282	PF00069	0.634
DOC_MAPK_gen_1	736	744	PF00069	0.401
DOC_MAPK_MEF2A_6	138	146	PF00069	0.607
DOC_MAPK_MEF2A_6	276	284	PF00069	0.587
DOC_MAPK_MEF2A_6	30	39	PF00069	0.513
DOC_MAPK_MEF2A_6	48	57	PF00069	0.408
DOC_MAPK_MEF2A_6	736	744	PF00069	0.441
DOC_PP1_RVXF_1	448	455	PF00149	0.427
DOC_PP2B_LxvP_1	170	173	PF13499	0.703
DOC_PP2B_LxvP_1	453	456	PF13499	0.426
DOC_USP7_MATH_1	158	162	PF00917	0.710
DOC_USP7_MATH_1	187	191	PF00917	0.635
DOC_USP7_MATH_1	255	259	PF00917	0.677
DOC_USP7_MATH_1	347	351	PF00917	0.678
DOC_USP7_MATH_1	371	375	PF00917	0.675
DOC_USP7_MATH_1	392	396	PF00917	0.649
DOC_USP7_MATH_1	419	423	PF00917	0.556
DOC_USP7_MATH_1	456	460	PF00917	0.503
DOC_USP7_MATH_1	545	549	PF00917	0.567
DOC_USP7_MATH_1	558	562	PF00917	0.498
DOC_USP7_MATH_1	628	632	PF00917	0.593
DOC_USP7_MATH_1	634	638	PF00917	0.667
DOC_USP7_MATH_1	674	678	PF00917	0.639
DOC_USP7_MATH_1	78	82	PF00917	0.677
DOC_USP7_UBL2_3	30	34	PF12436	0.525
DOC_WW_Pin1_4	161	166	PF00397	0.644
DOC_WW_Pin1_4	309	314	PF00397	0.611
DOC_WW_Pin1_4	342	347	PF00397	0.591
DOC_WW_Pin1_4	407	412	PF00397	0.635
DOC_WW_Pin1_4	473	478	PF00397	0.522
DOC_WW_Pin1_4	587	592	PF00397	0.482
DOC_WW_Pin1_4	610	615	PF00397	0.436
DOC_WW_Pin1_4	626	631	PF00397	0.456
DOC_WW_Pin1_4	672	677	PF00397	0.732
DOC_WW_Pin1_4	68	73	PF00397	0.587
DOC_WW_Pin1_4	92	97	PF00397	0.727
LIG_14-3-3_CanoR_1	103	108	PF00244	0.730
LIG_14-3-3_CanoR_1	223	227	PF00244	0.383
LIG_14-3-3_CanoR_1	359	366	PF00244	0.607
LIG_14-3-3_CanoR_1	427	432	PF00244	0.355
LIG_14-3-3_CanoR_1	52	56	PF00244	0.483
LIG_14-3-3_CanoR_1	727	731	PF00244	0.535
LIG_Actin_RPEL_3	269	288	PF02755	0.474
LIG_AP2alpha_1	226	230	PF02296	0.303
LIG_BIR_III_2	474	478	PF00653	0.457
LIG_BIR_III_2	673	677	PF00653	0.634
LIG_BIR_III_4	115	119	PF00653	0.646
LIG_BRCT_BRCA1_1	271	275	PF00533	0.629
LIG_BRCT_BRCA1_1	427	431	PF00533	0.356
LIG_Clathr_ClatBox_1	298	302	PF01394	0.480
LIG_Clathr_ClatBox_1	705	709	PF01394	0.597
LIG_CSL_BTD_1	453	456	PF09270	0.426
LIG_deltaCOP1_diTrp_1	463	470	PF00928	0.405
LIG_EVH1_2	740	744	PF00568	0.475
LIG_FHA_1	279	285	PF00498	0.640
LIG_FHA_1	404	410	PF00498	0.607
LIG_FHA_1	412	418	PF00498	0.517
LIG_FHA_1	428	434	PF00498	0.266
LIG_FHA_1	436	442	PF00498	0.396
LIG_FHA_1	494	500	PF00498	0.576
LIG_FHA_1	52	58	PF00498	0.476
LIG_FHA_1	525	531	PF00498	0.561
LIG_FHA_1	667	673	PF00498	0.638
LIG_FHA_2	223	229	PF00498	0.317
LIG_FHA_2	474	480	PF00498	0.424
LIG_FHA_2	530	536	PF00498	0.598
LIG_FHA_2	677	683	PF00498	0.699
LIG_FXI_DFP_1	47	51	PF00024	0.403
LIG_LIR_Apic_2	160	165	PF02991	0.677
LIG_LIR_Apic_2	535	540	PF02991	0.615
LIG_LIR_Gen_1	231	239	PF02991	0.405
LIG_LIR_Gen_1	428	437	PF02991	0.352
LIG_LIR_LC3C_4	235	239	PF02991	0.426
LIG_LIR_Nem_3	231	237	PF02991	0.397
LIG_LIR_Nem_3	613	618	PF02991	0.402
LIG_LIR_Nem_3	68	73	PF02991	0.635
LIG_LIR_Nem_3	743	747	PF02991	0.506
LIG_MYND_1	169	173	PF01753	0.651
LIG_Pex14_1	466	470	PF04695	0.401
LIG_Pex14_2	226	230	PF04695	0.372
LIG_SH2_CRK	70	74	PF00017	0.643
LIG_SH2_GRB2like	251	254	PF00017	0.521
LIG_SH2_NCK_1	251	255	PF00017	0.523
LIG_SH2_NCK_1	618	622	PF00017	0.518
LIG_SH2_NCK_1	70	74	PF00017	0.595
LIG_SH2_STAP1	251	255	PF00017	0.523
LIG_SH2_STAP1	593	597	PF00017	0.364
LIG_SH2_STAP1	618	622	PF00017	0.518
LIG_SH2_STAT3	766	769	PF00017	0.477
LIG_SH2_STAT5	424	427	PF00017	0.371
LIG_SH2_STAT5	760	763	PF00017	0.354
LIG_SH3_1	93	99	PF00018	0.655
LIG_SH3_3	170	176	PF00018	0.614
LIG_SH3_3	331	337	PF00018	0.646
LIG_SH3_3	627	633	PF00018	0.667
LIG_SH3_3	651	657	PF00018	0.625
LIG_SH3_3	687	693	PF00018	0.664
LIG_SH3_3	93	99	PF00018	0.665
LIG_SUMO_SIM_anti_2	211	218	PF11976	0.377
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.412
LIG_SUMO_SIM_anti_2	729	734	PF11976	0.399
LIG_SUMO_SIM_par_1	211	218	PF11976	0.377
LIG_SUMO_SIM_par_1	278	283	PF11976	0.539
LIG_SUMO_SIM_par_1	294	303	PF11976	0.407
LIG_SUMO_SIM_par_1	668	673	PF11976	0.615
LIG_SUMO_SIM_par_1	704	709	PF11976	0.539
LIG_SUMO_SIM_par_1	769	775	PF11976	0.307
LIG_WW_2	633	636	PF00397	0.511
MOD_CK1_1	161	167	PF00069	0.746
MOD_CK1_1	229	235	PF00069	0.508
MOD_CK1_1	3	9	PF00069	0.583
MOD_CK1_1	350	356	PF00069	0.691
MOD_CK1_1	395	401	PF00069	0.630
MOD_CK1_1	410	416	PF00069	0.588
MOD_CK1_1	520	526	PF00069	0.668
MOD_CK1_1	652	658	PF00069	0.625
MOD_CK1_1	677	683	PF00069	0.681
MOD_CK1_1	71	77	PF00069	0.646
MOD_CK2_1	3	9	PF00069	0.764
MOD_CK2_1	71	77	PF00069	0.608
MOD_CMANNOS	454	457	PF00535	0.422
MOD_GlcNHglycan	139	142	PF01048	0.667
MOD_GlcNHglycan	152	155	PF01048	0.663
MOD_GlcNHglycan	189	192	PF01048	0.610
MOD_GlcNHglycan	2	5	PF01048	0.582
MOD_GlcNHglycan	231	234	PF01048	0.436
MOD_GlcNHglycan	257	260	PF01048	0.657
MOD_GlcNHglycan	294	297	PF01048	0.398
MOD_GlcNHglycan	305	308	PF01048	0.571
MOD_GlcNHglycan	324	327	PF01048	0.740
MOD_GlcNHglycan	350	353	PF01048	0.718
MOD_GlcNHglycan	390	393	PF01048	0.732
MOD_GlcNHglycan	397	400	PF01048	0.615
MOD_GlcNHglycan	427	430	PF01048	0.357
MOD_GlcNHglycan	496	499	PF01048	0.565
MOD_GlcNHglycan	504	507	PF01048	0.545
MOD_GlcNHglycan	542	545	PF01048	0.604
MOD_GlcNHglycan	546	550	PF01048	0.588
MOD_GSK3_1	103	110	PF00069	0.686
MOD_GSK3_1	146	153	PF00069	0.724
MOD_GSK3_1	161	168	PF00069	0.616
MOD_GSK3_1	222	229	PF00069	0.457
MOD_GSK3_1	342	349	PF00069	0.589
MOD_GSK3_1	371	378	PF00069	0.683
MOD_GSK3_1	388	395	PF00069	0.694
MOD_GSK3_1	399	406	PF00069	0.633
MOD_GSK3_1	407	414	PF00069	0.576
MOD_GSK3_1	520	527	PF00069	0.663
MOD_GSK3_1	634	641	PF00069	0.688
MOD_GSK3_1	645	652	PF00069	0.598
MOD_GSK3_1	668	675	PF00069	0.773
MOD_GSK3_1	678	685	PF00069	0.665
MOD_N-GLC_1	103	108	PF02516	0.604
MOD_N-GLC_1	682	687	PF02516	0.620
MOD_N-GLC_2	290	292	PF02516	0.362
MOD_N-GLC_2	554	556	PF02516	0.577
MOD_NEK2_1	403	408	PF00069	0.624
MOD_NEK2_1	417	422	PF00069	0.525
MOD_NEK2_1	491	496	PF00069	0.481
MOD_NEK2_1	56	61	PF00069	0.504
MOD_NEK2_1	746	751	PF00069	0.451
MOD_NEK2_2	51	56	PF00069	0.479
MOD_NEK2_2	597	602	PF00069	0.366
MOD_NMyristoyl	1	7	PF02799	0.586
MOD_PIKK_1	103	109	PF00454	0.674
MOD_PIKK_1	260	266	PF00454	0.595
MOD_PIKK_1	380	386	PF00454	0.740
MOD_PIKK_1	435	441	PF00454	0.385
MOD_PKA_2	222	228	PF00069	0.375
MOD_PKA_2	388	394	PF00069	0.676
MOD_PKA_2	51	57	PF00069	0.474
MOD_PKA_2	517	523	PF00069	0.680
MOD_PKA_2	726	732	PF00069	0.418
MOD_Plk_2-3	222	228	PF00069	0.312
MOD_Plk_2-3	668	674	PF00069	0.615
MOD_Plk_4	158	164	PF00069	0.565
MOD_Plk_4	399	405	PF00069	0.609
MOD_Plk_4	51	57	PF00069	0.474
MOD_Plk_4	604	610	PF00069	0.454
MOD_Plk_4	638	644	PF00069	0.593
MOD_Plk_4	649	655	PF00069	0.518
MOD_ProDKin_1	161	167	PF00069	0.646
MOD_ProDKin_1	309	315	PF00069	0.613
MOD_ProDKin_1	342	348	PF00069	0.591
MOD_ProDKin_1	407	413	PF00069	0.634
MOD_ProDKin_1	473	479	PF00069	0.517
MOD_ProDKin_1	587	593	PF00069	0.475
MOD_ProDKin_1	610	616	PF00069	0.436
MOD_ProDKin_1	626	632	PF00069	0.459
MOD_ProDKin_1	672	678	PF00069	0.732
MOD_ProDKin_1	68	74	PF00069	0.590
MOD_ProDKin_1	92	98	PF00069	0.727
MOD_SUMO_rev_2	583	590	PF00179	0.457
TRG_DiLeu_BaEn_1	649	654	PF01217	0.608
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.702
TRG_ENDOCYTIC_2	70	73	PF00928	0.640
TRG_ER_diArg_1	102	105	PF00400	0.797
TRG_ER_diArg_1	132	135	PF00400	0.600
TRG_ER_diArg_1	483	486	PF00400	0.380
TRG_ER_diArg_1	690	692	PF00400	0.668
TRG_ER_diArg_1	751	754	PF00400	0.477
TRG_ER_diArg_1	91	93	PF00400	0.689
TRG_ER_diLys_1	778	782	PF00400	0.562
TRG_NLS_MonoExtN_4	15	22	PF00514	0.587
TRG_NLS_MonoExtN_4	270	277	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P8	Leptomonas seymouri	40%	99%
A0A3Q8IFV9	Leishmania donovani	89%	100%
A4HEZ9	Leishmania braziliensis	63%	99%
A4I278	Leishmania infantum	89%	100%
E9AYC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%