Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q948_LEIMA

TriTrypDb:

LmjF.26.1460 , LMJLV39_260020500 , LMJSD75_260018900

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q948

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q948

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.742
CLV_C14_Caspase3-7	94	98	PF00656	0.460
CLV_PCSK_KEX2_1	310	312	PF00082	0.526
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.526
DEG_SPOP_SBC_1	180	184	PF00917	0.432
DOC_PP4_FxxP_1	64	67	PF00568	0.491
DOC_USP7_MATH_1	113	117	PF00917	0.501
DOC_USP7_MATH_1	290	294	PF00917	0.718
DOC_USP7_MATH_1	96	100	PF00917	0.404
DOC_USP7_UBL2_3	304	308	PF12436	0.654
DOC_WW_Pin1_4	151	156	PF00397	0.405
DOC_WW_Pin1_4	296	301	PF00397	0.781
LIG_14-3-3_CanoR_1	18	23	PF00244	0.676
LIG_14-3-3_CanoR_1	241	247	PF00244	0.634
LIG_APCC_ABBA_1	275	280	PF00400	0.710
LIG_BRCT_BRCA1_1	127	131	PF00533	0.402
LIG_BRCT_BRCA1_1	24	28	PF00533	0.573
LIG_BRCT_BRCA1_2	127	133	PF00533	0.383
LIG_FHA_1	164	170	PF00498	0.481
LIG_FHA_1	200	206	PF00498	0.373
LIG_FHA_1	243	249	PF00498	0.566
LIG_FHA_2	154	160	PF00498	0.370
LIG_FHA_2	2	8	PF00498	0.742
LIG_FHA_2	310	316	PF00498	0.680
LIG_HCF-1_HBM_1	134	137	PF13415	0.436
LIG_LIR_Apic_2	61	67	PF02991	0.488
LIG_LIR_Gen_1	148	157	PF02991	0.447
LIG_LIR_Gen_1	202	211	PF02991	0.373
LIG_LIR_Gen_1	312	318	PF02991	0.692
LIG_LIR_Nem_3	148	152	PF02991	0.381
LIG_LIR_Nem_3	202	206	PF02991	0.373
LIG_LIR_Nem_3	25	31	PF02991	0.538
LIG_LIR_Nem_3	312	317	PF02991	0.692
LIG_Pex14_1	314	318	PF04695	0.655
LIG_PTB_Apo_2	185	192	PF02174	0.517
LIG_PTB_Apo_2	84	91	PF02174	0.390
LIG_PTB_Phospho_1	185	191	PF10480	0.519
LIG_PTB_Phospho_1	84	90	PF10480	0.386
LIG_SH2_CRK	149	153	PF00017	0.484
LIG_SH2_GRB2like	53	56	PF00017	0.515
LIG_SH2_PTP2	30	33	PF00017	0.399
LIG_SH2_SRC	53	56	PF00017	0.532
LIG_SH2_STAT5	137	140	PF00017	0.407
LIG_SH2_STAT5	149	152	PF00017	0.477
LIG_SH2_STAT5	191	194	PF00017	0.495
LIG_SH2_STAT5	30	33	PF00017	0.399
LIG_SH2_STAT5	53	56	PF00017	0.515
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.395
MOD_CK1_1	10	16	PF00069	0.752
MOD_CK1_1	104	110	PF00069	0.384
MOD_CK1_1	145	151	PF00069	0.401
MOD_CK2_1	309	315	PF00069	0.702
MOD_GlcNHglycan	144	147	PF01048	0.685
MOD_GlcNHglycan	286	289	PF01048	0.535
MOD_GlcNHglycan	43	46	PF01048	0.738
MOD_GSK3_1	1	8	PF00069	0.771
MOD_GSK3_1	121	128	PF00069	0.446
MOD_GSK3_1	147	154	PF00069	0.511
MOD_GSK3_1	159	166	PF00069	0.510
MOD_GSK3_1	18	25	PF00069	0.606
MOD_GSK3_1	290	297	PF00069	0.702
MOD_GSK3_1	309	316	PF00069	0.659
MOD_GSK3_1	37	44	PF00069	0.238
MOD_GSK3_1	58	65	PF00069	0.472
MOD_N-GLC_1	101	106	PF02516	0.716
MOD_N-GLC_1	119	124	PF02516	0.532
MOD_N-GLC_1	186	191	PF02516	0.722
MOD_N-GLC_1	234	239	PF02516	0.509
MOD_N-GLC_1	48	53	PF02516	0.770
MOD_N-GLC_2	110	112	PF02516	0.588
MOD_N-GLC_2	284	286	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	101	106	PF00069	0.485
MOD_NEK2_1	119	124	PF00069	0.371
MOD_NEK2_1	174	179	PF00069	0.528
MOD_NEK2_1	186	191	PF00069	0.453
MOD_NEK2_1	226	231	PF00069	0.656
MOD_NEK2_1	37	42	PF00069	0.321
MOD_NEK2_2	313	318	PF00069	0.654
MOD_NEK2_2	48	53	PF00069	0.511
MOD_OFUCOSY	38	43	PF10250	0.399
MOD_PIKK_1	169	175	PF00454	0.387
MOD_PIKK_1	22	28	PF00454	0.659
MOD_PIKK_1	290	296	PF00454	0.715
MOD_PKB_1	16	24	PF00069	0.706
MOD_Plk_1	113	119	PF00069	0.349
MOD_Plk_1	158	164	PF00069	0.454
MOD_Plk_1	186	192	PF00069	0.506
MOD_Plk_1	234	240	PF00069	0.709
MOD_Plk_1	48	54	PF00069	0.510
MOD_Plk_1	96	102	PF00069	0.503
MOD_Plk_4	104	110	PF00069	0.374
MOD_Plk_4	165	171	PF00069	0.480
MOD_Plk_4	187	193	PF00069	0.508
MOD_Plk_4	234	240	PF00069	0.627
MOD_Plk_4	313	319	PF00069	0.654
MOD_Plk_4	48	54	PF00069	0.510
MOD_Plk_4	96	102	PF00069	0.449
MOD_ProDKin_1	151	157	PF00069	0.408
MOD_ProDKin_1	296	302	PF00069	0.779
TRG_ENDOCYTIC_2	149	152	PF00928	0.454
TRG_ENDOCYTIC_2	203	206	PF00928	0.334
TRG_ENDOCYTIC_2	278	281	PF00928	0.751
TRG_ENDOCYTIC_2	30	33	PF00928	0.449
TRG_ENDOCYTIC_2	90	93	PF00928	0.490
TRG_ER_diArg_1	15	18	PF00400	0.761

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM62	Leptomonas seymouri	30%	100%
A0A3Q8ICZ0	Leishmania donovani	79%	99%
A4HF01	Leishmania braziliensis	52%	66%
A4I280	Leishmania infantum	79%	99%
E9AYC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%