Conserved oligomeric Golgi complex subunit 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q946_LEIMA

TriTrypDb:

LmjF.26.1480 , LMJLV39_260020700 , LMJSD75_260019100

Length:

1014

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	10
GO:0016020	membrane	2	10
GO:0017119	Golgi transport complex	3	10
GO:0031090	organelle membrane	3	10
GO:0032991	protein-containing complex	1	10
GO:0098588	bounding membrane of organelle	4	10
GO:0099023	vesicle tethering complex	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q946

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q946

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	2
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.558
CLV_C14_Caspase3-7	641	645	PF00656	0.476
CLV_C14_Caspase3-7	869	873	PF00656	0.592
CLV_NRD_NRD_1	115	117	PF00675	0.607
CLV_NRD_NRD_1	408	410	PF00675	0.431
CLV_NRD_NRD_1	431	433	PF00675	0.553
CLV_NRD_NRD_1	710	712	PF00675	0.487
CLV_NRD_NRD_1	855	857	PF00675	0.511
CLV_NRD_NRD_1	941	943	PF00675	0.379
CLV_PCSK_KEX2_1	212	214	PF00082	0.488
CLV_PCSK_KEX2_1	364	366	PF00082	0.443
CLV_PCSK_KEX2_1	408	410	PF00082	0.437
CLV_PCSK_KEX2_1	431	433	PF00082	0.555
CLV_PCSK_KEX2_1	67	69	PF00082	0.489
CLV_PCSK_KEX2_1	709	711	PF00082	0.427
CLV_PCSK_KEX2_1	855	857	PF00082	0.511
CLV_PCSK_KEX2_1	941	943	PF00082	0.379
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.422
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.356
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.489
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.427
CLV_PCSK_SKI1_1	164	168	PF00082	0.439
CLV_PCSK_SKI1_1	279	283	PF00082	0.474
CLV_PCSK_SKI1_1	302	306	PF00082	0.493
CLV_PCSK_SKI1_1	348	352	PF00082	0.503
CLV_PCSK_SKI1_1	421	425	PF00082	0.566
CLV_PCSK_SKI1_1	592	596	PF00082	0.436
CLV_PCSK_SKI1_1	768	772	PF00082	0.533
CLV_PCSK_SKI1_1	776	780	PF00082	0.520
CLV_PCSK_SKI1_1	958	962	PF00082	0.363
CLV_PCSK_SKI1_1	998	1002	PF00082	0.431
CLV_Separin_Metazoa	405	409	PF03568	0.501
DEG_APCC_DBOX_1	297	305	PF00400	0.426
DEG_APCC_DBOX_1	775	783	PF00400	0.468
DEG_APCC_DBOX_1	957	965	PF00400	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.584
DEG_SCF_FBW7_1	690	697	PF00400	0.472
DEG_SPOP_SBC_1	110	114	PF00917	0.548
DEG_SPOP_SBC_1	457	461	PF00917	0.628
DOC_ANK_TNKS_1	461	468	PF00023	0.609
DOC_CKS1_1	576	581	PF01111	0.587
DOC_CKS1_1	691	696	PF01111	0.482
DOC_CYCLIN_RxL_1	114	123	PF00134	0.576
DOC_CYCLIN_RxL_1	418	428	PF00134	0.418
DOC_CYCLIN_RxL_1	592	604	PF00134	0.375
DOC_MAPK_gen_1	154	162	PF00069	0.450
DOC_MAPK_gen_1	902	910	PF00069	0.501
DOC_MAPK_MEF2A_6	902	910	PF00069	0.408
DOC_PP1_RVXF_1	419	426	PF00149	0.412
DOC_PP2B_LxvP_1	24	27	PF13499	0.613
DOC_PP4_FxxP_1	576	579	PF00568	0.595
DOC_USP7_MATH_1	106	110	PF00917	0.633
DOC_USP7_MATH_1	17	21	PF00917	0.637
DOC_USP7_MATH_1	203	207	PF00917	0.553
DOC_USP7_MATH_1	267	271	PF00917	0.644
DOC_USP7_MATH_1	33	37	PF00917	0.675
DOC_USP7_MATH_1	39	43	PF00917	0.634
DOC_USP7_MATH_1	417	421	PF00917	0.428
DOC_USP7_MATH_1	442	446	PF00917	0.674
DOC_USP7_MATH_1	448	452	PF00917	0.677
DOC_USP7_MATH_1	466	470	PF00917	0.720
DOC_USP7_MATH_1	474	478	PF00917	0.584
DOC_USP7_MATH_1	5	9	PF00917	0.720
DOC_USP7_MATH_1	637	641	PF00917	0.571
DOC_USP7_MATH_1	692	696	PF00917	0.481
DOC_USP7_MATH_1	719	723	PF00917	0.434
DOC_USP7_MATH_1	762	766	PF00917	0.525
DOC_USP7_MATH_1	784	788	PF00917	0.567
DOC_USP7_MATH_1	798	802	PF00917	0.606
DOC_USP7_MATH_1	809	813	PF00917	0.705
DOC_USP7_MATH_1	823	827	PF00917	0.555
DOC_USP7_MATH_1	912	916	PF00917	0.623
DOC_USP7_MATH_1	97	101	PF00917	0.744
DOC_WW_Pin1_4	102	107	PF00397	0.510
DOC_WW_Pin1_4	438	443	PF00397	0.541
DOC_WW_Pin1_4	575	580	PF00397	0.613
DOC_WW_Pin1_4	690	695	PF00397	0.441
DOC_WW_Pin1_4	802	807	PF00397	0.637
DOC_WW_Pin1_4	82	87	PF00397	0.526
DOC_WW_Pin1_4	9	14	PF00397	0.703
DOC_WW_Pin1_4	93	98	PF00397	0.614
LIG_14-3-3_CanoR_1	132	140	PF00244	0.438
LIG_14-3-3_CanoR_1	154	162	PF00244	0.490
LIG_14-3-3_CanoR_1	164	172	PF00244	0.410
LIG_14-3-3_CanoR_1	201	208	PF00244	0.607
LIG_14-3-3_CanoR_1	348	354	PF00244	0.499
LIG_14-3-3_CanoR_1	431	435	PF00244	0.554
LIG_14-3-3_CanoR_1	47	52	PF00244	0.476
LIG_14-3-3_CanoR_1	674	683	PF00244	0.460
LIG_14-3-3_CanoR_1	68	78	PF00244	0.488
LIG_14-3-3_CanoR_1	718	724	PF00244	0.414
LIG_14-3-3_CanoR_1	735	743	PF00244	0.438
LIG_14-3-3_CanoR_1	930	938	PF00244	0.561
LIG_14-3-3_CanoR_1	998	1003	PF00244	0.411
LIG_Actin_WH2_2	286	304	PF00022	0.478
LIG_Actin_WH2_2	990	1005	PF00022	0.356
LIG_APCC_ABBAyCdc20_2	116	122	PF00400	0.529
LIG_BRCT_BRCA1_1	572	576	PF00533	0.608
LIG_FHA_1	1	7	PF00498	0.546
LIG_FHA_1	102	108	PF00498	0.693
LIG_FHA_1	157	163	PF00498	0.509
LIG_FHA_1	171	177	PF00498	0.558
LIG_FHA_1	576	582	PF00498	0.670
LIG_FHA_1	651	657	PF00498	0.581
LIG_FHA_1	727	733	PF00498	0.483
LIG_FHA_1	773	779	PF00498	0.482
LIG_FHA_1	949	955	PF00498	0.450
LIG_FHA_2	156	162	PF00498	0.433
LIG_FHA_2	200	206	PF00498	0.380
LIG_FHA_2	29	35	PF00498	0.679
LIG_FHA_2	303	309	PF00498	0.515
LIG_FHA_2	431	437	PF00498	0.628
LIG_FHA_2	534	540	PF00498	0.509
LIG_FHA_2	563	569	PF00498	0.727
LIG_FHA_2	639	645	PF00498	0.648
LIG_FHA_2	729	735	PF00498	0.535
LIG_FHA_2	869	875	PF00498	0.499
LIG_FHA_2	950	956	PF00498	0.460
LIG_GBD_Chelix_1	335	343	PF00786	0.437
LIG_LIR_Apic_2	573	579	PF02991	0.601
LIG_LIR_Nem_3	320	325	PF02991	0.527
LIG_LIR_Nem_3	749	755	PF02991	0.364
LIG_MAD2	904	912	PF02301	0.447
LIG_NRBOX	124	130	PF00104	0.519
LIG_PCNA_PIPBox_1	698	707	PF02747	0.379
LIG_PCNA_yPIPBox_3	67	78	PF02747	0.506
LIG_PCNA_yPIPBox_3	698	711	PF02747	0.541
LIG_PCNA_yPIPBox_3	713	727	PF02747	0.421
LIG_Pex14_2	602	606	PF04695	0.457
LIG_PTB_Apo_2	224	231	PF02174	0.479
LIG_PTB_Phospho_1	224	230	PF10480	0.479
LIG_RPA_C_Fungi	390	402	PF08784	0.497
LIG_SH2_CRK	785	789	PF00017	0.498
LIG_SH2_NCK_1	518	522	PF00017	0.370
LIG_SH2_SRC	325	328	PF00017	0.451
LIG_SH2_SRC	704	707	PF00017	0.367
LIG_SH2_STAP1	615	619	PF00017	0.454
LIG_SH2_STAP1	943	947	PF00017	0.501
LIG_SH2_STAT3	315	318	PF00017	0.533
LIG_SH2_STAT3	366	369	PF00017	0.534
LIG_SH2_STAT5	194	197	PF00017	0.432
LIG_SH2_STAT5	214	217	PF00017	0.473
LIG_SH2_STAT5	230	233	PF00017	0.533
LIG_SH2_STAT5	325	328	PF00017	0.541
LIG_SH2_STAT5	704	707	PF00017	0.450
LIG_SH2_STAT5	785	788	PF00017	0.433
LIG_SH2_STAT5	818	821	PF00017	0.609
LIG_SH2_STAT5	956	959	PF00017	0.353
LIG_SH3_3	150	156	PF00018	0.438
LIG_SH3_3	16	22	PF00018	0.706
LIG_SH3_3	179	185	PF00018	0.552
LIG_SH3_3	616	622	PF00018	0.446
LIG_SH3_3	662	668	PF00018	0.478
LIG_SH3_3	748	754	PF00018	0.412
LIG_SUMO_SIM_anti_2	508	514	PF11976	0.457
LIG_SUMO_SIM_par_1	838	845	PF11976	0.407
LIG_TRAF2_1	329	332	PF00917	0.480
LIG_TRAF2_1	433	436	PF00917	0.490
LIG_TRAF2_1	453	456	PF00917	0.626
LIG_TRAF2_1	659	662	PF00917	0.464
LIG_TYR_ITIM	702	707	PF00017	0.371
LIG_UBA3_1	701	709	PF00899	0.462
LIG_WRC_WIRS_1	897	902	PF05994	0.410
MOD_CDC14_SPxK_1	441	444	PF00782	0.573
MOD_CDK_SPxK_1	438	444	PF00069	0.548
MOD_CK1_1	100	106	PF00069	0.699
MOD_CK1_1	109	115	PF00069	0.561
MOD_CK1_1	274	280	PF00069	0.593
MOD_CK1_1	28	34	PF00069	0.637
MOD_CK1_1	451	457	PF00069	0.708
MOD_CK1_1	458	464	PF00069	0.814
MOD_CK1_1	469	475	PF00069	0.610
MOD_CK1_1	477	483	PF00069	0.551
MOD_CK1_1	490	496	PF00069	0.535
MOD_CK1_1	520	526	PF00069	0.345
MOD_CK1_1	553	559	PF00069	0.594
MOD_CK1_1	570	576	PF00069	0.739
MOD_CK1_1	640	646	PF00069	0.667
MOD_CK1_1	651	657	PF00069	0.509
MOD_CK1_1	697	703	PF00069	0.428
MOD_CK1_1	728	734	PF00069	0.495
MOD_CK1_1	801	807	PF00069	0.623
MOD_CK1_1	968	974	PF00069	0.434
MOD_CK2_1	155	161	PF00069	0.433
MOD_CK2_1	199	205	PF00069	0.567
MOD_CK2_1	307	313	PF00069	0.446
MOD_CK2_1	430	436	PF00069	0.478
MOD_CK2_1	562	568	PF00069	0.725
MOD_CK2_1	640	646	PF00069	0.603
MOD_CK2_1	728	734	PF00069	0.507
MOD_CK2_1	868	874	PF00069	0.508
MOD_GlcNHglycan	1004	1007	PF01048	0.624
MOD_GlcNHglycan	108	111	PF01048	0.604
MOD_GlcNHglycan	139	143	PF01048	0.478
MOD_GlcNHglycan	14	17	PF01048	0.587
MOD_GlcNHglycan	148	151	PF01048	0.469
MOD_GlcNHglycan	243	246	PF01048	0.788
MOD_GlcNHglycan	259	263	PF01048	0.749
MOD_GlcNHglycan	273	276	PF01048	0.601
MOD_GlcNHglycan	444	447	PF01048	0.696
MOD_GlcNHglycan	450	453	PF01048	0.737
MOD_GlcNHglycan	471	474	PF01048	0.712
MOD_GlcNHglycan	477	480	PF01048	0.702
MOD_GlcNHglycan	489	492	PF01048	0.672
MOD_GlcNHglycan	544	547	PF01048	0.488
MOD_GlcNHglycan	552	555	PF01048	0.458
MOD_GlcNHglycan	635	638	PF01048	0.581
MOD_GlcNHglycan	738	741	PF01048	0.523
MOD_GlcNHglycan	826	829	PF01048	0.511
MOD_GlcNHglycan	848	851	PF01048	0.515
MOD_GlcNHglycan	862	865	PF01048	0.569
MOD_GlcNHglycan	961	964	PF01048	0.462
MOD_GSK3_1	102	109	PF00069	0.592
MOD_GSK3_1	134	141	PF00069	0.474
MOD_GSK3_1	156	163	PF00069	0.504
MOD_GSK3_1	199	206	PF00069	0.468
MOD_GSK3_1	235	242	PF00069	0.518
MOD_GSK3_1	263	270	PF00069	0.730
MOD_GSK3_1	34	41	PF00069	0.617
MOD_GSK3_1	344	351	PF00069	0.516
MOD_GSK3_1	369	376	PF00069	0.448
MOD_GSK3_1	417	424	PF00069	0.484
MOD_GSK3_1	438	445	PF00069	0.670
MOD_GSK3_1	451	458	PF00069	0.560
MOD_GSK3_1	486	493	PF00069	0.697
MOD_GSK3_1	5	12	PF00069	0.760
MOD_GSK3_1	517	524	PF00069	0.459
MOD_GSK3_1	552	559	PF00069	0.589
MOD_GSK3_1	567	574	PF00069	0.693
MOD_GSK3_1	629	636	PF00069	0.575
MOD_GSK3_1	669	676	PF00069	0.389
MOD_GSK3_1	690	697	PF00069	0.467
MOD_GSK3_1	762	769	PF00069	0.412
MOD_GSK3_1	798	805	PF00069	0.587
MOD_GSK3_1	82	89	PF00069	0.541
MOD_GSK3_1	842	849	PF00069	0.489
MOD_GSK3_1	891	898	PF00069	0.375
MOD_GSK3_1	912	919	PF00069	0.715
MOD_GSK3_1	925	932	PF00069	0.651
MOD_GSK3_1	93	100	PF00069	0.753
MOD_GSK3_1	998	1005	PF00069	0.618
MOD_LATS_1	130	136	PF00433	0.572
MOD_N-GLC_1	239	244	PF02516	0.608
MOD_N-GLC_1	245	250	PF02516	0.605
MOD_N-GLC_1	271	276	PF02516	0.700
MOD_NEK2_1	1002	1007	PF00069	0.468
MOD_NEK2_1	160	165	PF00069	0.428
MOD_NEK2_1	349	354	PF00069	0.492
MOD_NEK2_1	425	430	PF00069	0.422
MOD_NEK2_1	517	522	PF00069	0.376
MOD_NEK2_1	601	606	PF00069	0.313
MOD_NEK2_1	846	851	PF00069	0.478
MOD_PIKK_1	134	140	PF00454	0.496
MOD_PIKK_1	369	375	PF00454	0.411
MOD_PIKK_1	451	457	PF00454	0.533
MOD_PIKK_1	694	700	PF00454	0.517
MOD_PIKK_1	816	822	PF00454	0.663
MOD_PIKK_1	916	922	PF00454	0.681
MOD_PIKK_1	925	931	PF00454	0.694
MOD_PKA_2	1002	1008	PF00069	0.462
MOD_PKA_2	156	162	PF00069	0.565
MOD_PKA_2	255	261	PF00069	0.794
MOD_PKA_2	344	350	PF00069	0.490
MOD_PKA_2	430	436	PF00069	0.546
MOD_PKA_2	673	679	PF00069	0.474
MOD_PKA_2	929	935	PF00069	0.590
MOD_Plk_1	160	166	PF00069	0.506
MOD_Plk_1	302	308	PF00069	0.525
MOD_Plk_1	421	427	PF00069	0.512
MOD_Plk_1	648	654	PF00069	0.546
MOD_Plk_1	965	971	PF00069	0.574
MOD_Plk_4	148	154	PF00069	0.542
MOD_Plk_4	349	355	PF00069	0.601
MOD_Plk_4	421	427	PF00069	0.377
MOD_Plk_4	47	53	PF00069	0.477
MOD_Plk_4	601	607	PF00069	0.360
MOD_Plk_4	651	657	PF00069	0.470
MOD_Plk_4	697	703	PF00069	0.383
MOD_Plk_4	766	772	PF00069	0.434
MOD_Plk_4	888	894	PF00069	0.464
MOD_Plk_4	896	902	PF00069	0.474
MOD_ProDKin_1	102	108	PF00069	0.509
MOD_ProDKin_1	438	444	PF00069	0.548
MOD_ProDKin_1	575	581	PF00069	0.607
MOD_ProDKin_1	690	696	PF00069	0.433
MOD_ProDKin_1	802	808	PF00069	0.637
MOD_ProDKin_1	82	88	PF00069	0.529
MOD_ProDKin_1	9	15	PF00069	0.705
MOD_ProDKin_1	93	99	PF00069	0.609
MOD_SUMO_for_1	755	758	PF00179	0.484
MOD_SUMO_rev_2	204	208	PF00179	0.552
MOD_SUMO_rev_2	299	304	PF00179	0.468
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.486
TRG_ENDOCYTIC_2	518	521	PF00928	0.409
TRG_ENDOCYTIC_2	704	707	PF00928	0.367
TRG_ENDOCYTIC_2	785	788	PF00928	0.485
TRG_ER_diArg_1	407	409	PF00400	0.411
TRG_ER_diArg_1	430	432	PF00400	0.546
TRG_ER_diArg_1	710	713	PF00400	0.487
TRG_ER_diArg_1	941	943	PF00400	0.379
TRG_NLS_MonoExtC_3	708	713	PF00514	0.417
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	878	882	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B9	Leptomonas seymouri	54%	99%
A0A1X0NS38	Trypanosomatidae	25%	100%
A0A3Q8IP82	Leishmania donovani	91%	100%
A0A422NIU2	Trypanosoma rangeli	26%	100%
A4HF03	Leishmania braziliensis	74%	100%
A4I282	Leishmania infantum	91%	100%
C9ZRR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AYC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%