Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q945_LEIMA

TriTrypDb:

LmjF.26.1490 , LMJLV39_260020800 , LMJSD75_260019200

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q945

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q945

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.598
CLV_NRD_NRD_1	180	182	PF00675	0.682
CLV_NRD_NRD_1	194	196	PF00675	0.563
CLV_NRD_NRD_1	266	268	PF00675	0.608
CLV_NRD_NRD_1	305	307	PF00675	0.571
CLV_NRD_NRD_1	431	433	PF00675	0.671
CLV_NRD_NRD_1	593	595	PF00675	0.652
CLV_NRD_NRD_1	62	64	PF00675	0.657
CLV_PCSK_KEX2_1	180	182	PF00082	0.682
CLV_PCSK_KEX2_1	194	196	PF00082	0.563
CLV_PCSK_KEX2_1	266	268	PF00082	0.608
CLV_PCSK_KEX2_1	305	307	PF00082	0.571
CLV_PCSK_KEX2_1	431	433	PF00082	0.671
CLV_PCSK_KEX2_1	592	594	PF00082	0.630
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.630
CLV_PCSK_PC7_1	176	182	PF00082	0.574
CLV_PCSK_SKI1_1	147	151	PF00082	0.601
CLV_PCSK_SKI1_1	210	214	PF00082	0.748
CLV_PCSK_SKI1_1	26	30	PF00082	0.426
CLV_PCSK_SKI1_1	366	370	PF00082	0.514
CLV_PCSK_SKI1_1	378	382	PF00082	0.447
CLV_PCSK_SKI1_1	64	68	PF00082	0.643
DEG_APCC_DBOX_1	194	202	PF00400	0.396
DEG_APCC_DBOX_1	363	371	PF00400	0.293
DEG_APCC_DBOX_1	431	439	PF00400	0.439
DEG_Nend_UBRbox_1	1	4	PF02207	0.662
DOC_ANK_TNKS_1	179	186	PF00023	0.392
DOC_CDC14_PxL_1	21	29	PF14671	0.547
DOC_CYCLIN_RxL_1	191	199	PF00134	0.352
DOC_CYCLIN_RxL_1	23	33	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	427	430	PF00134	0.482
DOC_MAPK_gen_1	266	275	PF00069	0.377
DOC_MAPK_gen_1	364	371	PF00069	0.301
DOC_MAPK_gen_1	372	382	PF00069	0.290
DOC_MAPK_gen_1	396	404	PF00069	0.492
DOC_MAPK_gen_1	431	438	PF00069	0.444
DOC_MAPK_gen_1	520	527	PF00069	0.353
DOC_MAPK_MEF2A_6	109	118	PF00069	0.389
DOC_MAPK_MEF2A_6	156	163	PF00069	0.260
DOC_MAPK_MEF2A_6	364	371	PF00069	0.336
DOC_MAPK_MEF2A_6	403	411	PF00069	0.419
DOC_MAPK_MEF2A_6	520	527	PF00069	0.324
DOC_MAPK_MEF2A_6	532	540	PF00069	0.396
DOC_MAPK_MEF2A_6	615	624	PF00069	0.350
DOC_MAPK_NFAT4_5	364	372	PF00069	0.340
DOC_PP1_RVXF_1	24	31	PF00149	0.538
DOC_PP2B_LxvP_1	22	25	PF13499	0.612
DOC_PP2B_LxvP_1	427	430	PF13499	0.523
DOC_USP7_MATH_1	136	140	PF00917	0.441
DOC_USP7_MATH_1	183	187	PF00917	0.430
DOC_USP7_MATH_1	362	366	PF00917	0.387
DOC_USP7_MATH_1	430	434	PF00917	0.419
DOC_USP7_MATH_1	604	608	PF00917	0.447
DOC_WW_Pin1_4	214	219	PF00397	0.476
DOC_WW_Pin1_4	322	327	PF00397	0.441
DOC_WW_Pin1_4	339	344	PF00397	0.366
DOC_WW_Pin1_4	416	421	PF00397	0.529
DOC_WW_Pin1_4	44	49	PF00397	0.441
DOC_WW_Pin1_4	460	465	PF00397	0.368
LIG_14-3-3_CanoR_1	195	201	PF00244	0.344
LIG_14-3-3_CanoR_1	251	257	PF00244	0.417
LIG_14-3-3_CanoR_1	266	273	PF00244	0.506
LIG_14-3-3_CanoR_1	313	319	PF00244	0.392
LIG_14-3-3_CanoR_1	431	436	PF00244	0.432
LIG_14-3-3_CanoR_1	483	488	PF00244	0.431
LIG_14-3-3_CanoR_1	522	528	PF00244	0.375
LIG_14-3-3_CanoR_1	63	73	PF00244	0.430
LIG_14-3-3_CanoR_1	80	88	PF00244	0.406
LIG_APCC_ABBA_1	579	584	PF00400	0.443
LIG_BIR_III_4	211	215	PF00653	0.506
LIG_BIR_III_4	328	332	PF00653	0.436
LIG_BRCT_BRCA1_1	32	36	PF00533	0.425
LIG_CaM_NSCaTE_8	88	95	PF13499	0.381
LIG_Clathr_ClatBox_1	537	541	PF01394	0.407
LIG_CtBP_PxDLS_1	257	261	PF00389	0.431
LIG_FHA_1	110	116	PF00498	0.361
LIG_FHA_1	243	249	PF00498	0.369
LIG_FHA_1	406	412	PF00498	0.558
LIG_FHA_1	442	448	PF00498	0.399
LIG_FHA_1	491	497	PF00498	0.379
LIG_FHA_1	519	525	PF00498	0.346
LIG_FHA_1	65	71	PF00498	0.417
LIG_FHA_2	408	414	PF00498	0.597
LIG_FHA_2	421	427	PF00498	0.435
LIG_FHA_2	444	450	PF00498	0.431
LIG_FHA_2	483	489	PF00498	0.447
LIG_IBAR_NPY_1	152	154	PF08397	0.287
LIG_LIR_Apic_2	317	321	PF02991	0.404
LIG_LIR_Gen_1	157	163	PF02991	0.289
LIG_LIR_Gen_1	342	348	PF02991	0.372
LIG_LIR_Gen_1	377	386	PF02991	0.373
LIG_LIR_Nem_3	143	149	PF02991	0.374
LIG_LIR_Nem_3	157	161	PF02991	0.273
LIG_LIR_Nem_3	223	227	PF02991	0.324
LIG_LIR_Nem_3	312	318	PF02991	0.299
LIG_LIR_Nem_3	342	347	PF02991	0.331
LIG_LIR_Nem_3	355	360	PF02991	0.294
LIG_LIR_Nem_3	377	382	PF02991	0.367
LIG_LIR_Nem_3	488	494	PF02991	0.329
LIG_LYPXL_yS_3	588	591	PF13949	0.456
LIG_NRBOX	366	372	PF00104	0.314
LIG_PTB_Apo_2	117	124	PF02174	0.359
LIG_PTB_Apo_2	149	156	PF02174	0.328
LIG_PTB_Phospho_1	117	123	PF10480	0.359
LIG_PTB_Phospho_1	149	155	PF10480	0.326
LIG_SH2_CRK	146	150	PF00017	0.392
LIG_SH2_NCK_1	123	127	PF00017	0.346
LIG_SH2_SRC	123	126	PF00017	0.370
LIG_SH2_SRC	187	190	PF00017	0.285
LIG_SH2_STAP1	550	554	PF00017	0.353
LIG_SH2_STAT5	197	200	PF00017	0.415
LIG_SH2_STAT5	318	321	PF00017	0.362
LIG_SH3_3	401	407	PF00018	0.561
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.258
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.373
LIG_SUMO_SIM_par_1	205	211	PF11976	0.475
LIG_SUMO_SIM_par_1	244	249	PF11976	0.309
LIG_SUMO_SIM_par_1	407	414	PF11976	0.425
LIG_SUMO_SIM_par_1	433	441	PF11976	0.375
LIG_SUMO_SIM_par_1	523	529	PF11976	0.373
LIG_SUMO_SIM_par_1	536	541	PF11976	0.382
LIG_TRAF2_1	464	467	PF00917	0.402
LIG_TRAF2_1	513	516	PF00917	0.420
LIG_TYR_ITIM	634	639	PF00017	0.519
LIG_UBA3_1	21	26	PF00899	0.551
LIG_UBA3_1	367	375	PF00899	0.321
LIG_WRC_WIRS_1	221	226	PF05994	0.343
LIG_WRC_WIRS_1	27	32	PF05994	0.412
LIG_WW_3	428	432	PF00397	0.464
MOD_CK1_1	242	248	PF00069	0.361
MOD_CK1_1	268	274	PF00069	0.448
MOD_CK1_1	4	10	PF00069	0.673
MOD_CK1_1	441	447	PF00069	0.330
MOD_CK1_1	546	552	PF00069	0.416
MOD_CK1_1	57	63	PF00069	0.489
MOD_CK1_1	91	97	PF00069	0.346
MOD_CK2_1	420	426	PF00069	0.461
MOD_CK2_1	431	437	PF00069	0.468
MOD_CK2_1	443	449	PF00069	0.392
MOD_CK2_1	460	466	PF00069	0.515
MOD_CK2_1	482	488	PF00069	0.453
MOD_CK2_1	510	516	PF00069	0.444
MOD_Cter_Amidation	178	181	PF01082	0.581
MOD_Cter_Amidation	303	306	PF01082	0.563
MOD_GlcNHglycan	14	17	PF01048	0.504
MOD_GlcNHglycan	169	172	PF01048	0.604
MOD_GlcNHglycan	277	280	PF01048	0.580
MOD_GlcNHglycan	382	385	PF01048	0.488
MOD_GlcNHglycan	440	443	PF01048	0.533
MOD_GlcNHglycan	606	609	PF01048	0.673
MOD_GSK3_1	105	112	PF00069	0.476
MOD_GSK3_1	183	190	PF00069	0.429
MOD_GSK3_1	210	217	PF00069	0.500
MOD_GSK3_1	26	33	PF00069	0.497
MOD_GSK3_1	335	342	PF00069	0.309
MOD_GSK3_1	405	412	PF00069	0.526
MOD_GSK3_1	416	423	PF00069	0.520
MOD_GSK3_1	437	444	PF00069	0.285
MOD_GSK3_1	479	486	PF00069	0.465
MOD_GSK3_1	536	543	PF00069	0.355
MOD_GSK3_1	64	71	PF00069	0.365
MOD_GSK3_1	79	86	PF00069	0.411
MOD_GSK3_1	88	95	PF00069	0.327
MOD_N-GLC_1	105	110	PF02516	0.650
MOD_N-GLC_1	483	488	PF02516	0.607
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	196	201	PF00069	0.400
MOD_NEK2_1	239	244	PF00069	0.370
MOD_NEK2_1	275	280	PF00069	0.484
MOD_NEK2_1	30	35	PF00069	0.357
MOD_NEK2_1	311	316	PF00069	0.381
MOD_NEK2_1	411	416	PF00069	0.530
MOD_NEK2_1	443	448	PF00069	0.342
MOD_NEK2_1	479	484	PF00069	0.415
MOD_NEK2_1	518	523	PF00069	0.366
MOD_PIKK_1	249	255	PF00454	0.398
MOD_PIKK_1	54	60	PF00454	0.538
MOD_PKA_1	431	437	PF00069	0.405
MOD_PKA_2	136	142	PF00069	0.417
MOD_PKA_2	167	173	PF00069	0.404
MOD_PKA_2	265	271	PF00069	0.481
MOD_PKA_2	275	281	PF00069	0.496
MOD_PKA_2	395	401	PF00069	0.502
MOD_PKA_2	430	436	PF00069	0.442
MOD_PKA_2	482	488	PF00069	0.436
MOD_PKA_2	79	85	PF00069	0.441
MOD_Plk_1	311	317	PF00069	0.385
MOD_Plk_1	483	489	PF00069	0.402
MOD_Plk_1	540	546	PF00069	0.376
MOD_Plk_1	83	89	PF00069	0.348
MOD_Plk_4	196	202	PF00069	0.276
MOD_Plk_4	30	36	PF00069	0.393
MOD_Plk_4	314	320	PF00069	0.391
MOD_Plk_4	335	341	PF00069	0.292
MOD_Plk_4	431	437	PF00069	0.436
MOD_Plk_4	83	89	PF00069	0.345
MOD_ProDKin_1	214	220	PF00069	0.468
MOD_ProDKin_1	322	328	PF00069	0.437
MOD_ProDKin_1	339	345	PF00069	0.368
MOD_ProDKin_1	416	422	PF00069	0.531
MOD_ProDKin_1	44	50	PF00069	0.441
MOD_ProDKin_1	460	466	PF00069	0.373
MOD_SUMO_rev_2	139	149	PF00179	0.405
TRG_DiLeu_BaEn_2	376	382	PF01217	0.325
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.337
TRG_ENDOCYTIC_2	123	126	PF00928	0.335
TRG_ENDOCYTIC_2	146	149	PF00928	0.354
TRG_ENDOCYTIC_2	155	158	PF00928	0.278
TRG_ENDOCYTIC_2	588	591	PF00928	0.503
TRG_ENDOCYTIC_2	636	639	PF00928	0.619
TRG_ER_diArg_1	193	195	PF00400	0.400
TRG_ER_diArg_1	265	267	PF00400	0.461
TRG_ER_diArg_1	273	276	PF00400	0.489
TRG_ER_diArg_1	364	367	PF00400	0.350
TRG_ER_diArg_1	430	432	PF00400	0.473
TRG_ER_diArg_1	520	523	PF00400	0.363
TRG_ER_diArg_1	593	595	PF00400	0.452
TRG_ER_diLys_1	651	655	PF00400	0.661
TRG_NLS_MonoExtC_3	371	377	PF00514	0.347
TRG_NLS_MonoExtN_4	589	596	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M6	Leptomonas seymouri	58%	100%
A0A0S4JKY7	Bodo saltans	28%	100%
A0A1X0P7Z9	Trypanosomatidae	25%	100%
A0A3S5H7G3	Leishmania donovani	92%	100%
A4HF04	Leishmania braziliensis	77%	100%
A4I283	Leishmania infantum	92%	100%
E9AYC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B6M4	Trypanosoma cruzi	26%	100%