AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4Q942_LEIMA

TriTrypDb:

LmjF.26.1520 , LMJLV39_260021200 , LMJSD75_260019600

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q942

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q942

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.391
CLV_NRD_NRD_1	21	23	PF00675	0.338
CLV_NRD_NRD_1	272	274	PF00675	0.284
CLV_PCSK_KEX2_1	272	274	PF00082	0.391
CLV_PCSK_SKI1_1	14	18	PF00082	0.550
CLV_PCSK_SKI1_1	324	328	PF00082	0.375
CLV_PCSK_SKI1_1	58	62	PF00082	0.413
DEG_SPOP_SBC_1	87	91	PF00917	0.333
DOC_ANK_TNKS_1	135	142	PF00023	0.411
DOC_CKS1_1	9	14	PF01111	0.494
DOC_MAPK_gen_1	22	29	PF00069	0.461
DOC_MAPK_gen_1	319	327	PF00069	0.454
DOC_MAPK_MEF2A_6	195	202	PF00069	0.342
DOC_PP2B_LxvP_1	200	203	PF13499	0.357
DOC_PP2B_LxvP_1	293	296	PF13499	0.392
DOC_PP4_FxxP_1	378	381	PF00568	0.274
DOC_USP7_MATH_1	10	14	PF00917	0.447
DOC_USP7_MATH_1	41	45	PF00917	0.369
DOC_USP7_MATH_1	87	91	PF00917	0.364
DOC_WW_Pin1_4	170	175	PF00397	0.435
DOC_WW_Pin1_4	176	181	PF00397	0.348
DOC_WW_Pin1_4	342	347	PF00397	0.334
DOC_WW_Pin1_4	8	13	PF00397	0.430
DOC_WW_Pin1_4	83	88	PF00397	0.258
LIG_14-3-3_CanoR_1	115	121	PF00244	0.421
LIG_14-3-3_CanoR_1	189	193	PF00244	0.489
LIG_14-3-3_CanoR_1	254	263	PF00244	0.407
LIG_14-3-3_CanoR_1	272	278	PF00244	0.404
LIG_Actin_WH2_2	221	239	PF00022	0.370
LIG_APCC_Cbox_2	155	161	PF00515	0.246
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_Clathr_ClatBox_1	197	201	PF01394	0.351
LIG_FHA_1	148	154	PF00498	0.338
LIG_FHA_1	209	215	PF00498	0.343
LIG_FHA_1	256	262	PF00498	0.308
LIG_FHA_1	269	275	PF00498	0.305
LIG_FHA_1	332	338	PF00498	0.370
LIG_FHA_1	371	377	PF00498	0.407
LIG_FHA_1	382	388	PF00498	0.341
LIG_FHA_1	89	95	PF00498	0.251
LIG_FHA_2	74	80	PF00498	0.370
LIG_GBD_Chelix_1	97	105	PF00786	0.357
LIG_LIR_Apic_2	297	302	PF02991	0.391
LIG_LIR_Apic_2	375	381	PF02991	0.391
LIG_LIR_Gen_1	350	361	PF02991	0.396
LIG_LIR_Gen_1	44	53	PF02991	0.347
LIG_LIR_Nem_3	146	152	PF02991	0.284
LIG_LIR_Nem_3	328	332	PF02991	0.250
LIG_LIR_Nem_3	350	356	PF02991	0.297
LIG_LIR_Nem_3	44	48	PF02991	0.323
LIG_LYPXL_yS_3	329	332	PF13949	0.246
LIG_MYND_3	281	285	PF01753	0.274
LIG_PCNA_PIPBox_1	151	160	PF02747	0.246
LIG_SH2_SRC	104	107	PF00017	0.417
LIG_SH2_SRC	157	160	PF00017	0.204
LIG_SH2_STAP1	360	364	PF00017	0.411
LIG_SH2_STAT5	104	107	PF00017	0.341
LIG_SH2_STAT5	152	155	PF00017	0.357
LIG_SH2_STAT5	157	160	PF00017	0.357
LIG_SH2_STAT5	377	380	PF00017	0.442
LIG_SH3_3	129	135	PF00018	0.274
LIG_SH3_3	394	400	PF00018	0.570
LIG_SH3_3	6	12	PF00018	0.424
LIG_SH3_3	66	72	PF00018	0.482
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.390
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.410
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.246
LIG_SUMO_SIM_par_1	196	201	PF11976	0.319
LIG_SUMO_SIM_par_1	217	223	PF11976	0.366
LIG_SUMO_SIM_par_1	383	389	PF11976	0.232
LIG_TRAF2_1	238	241	PF00917	0.321
LIG_TYR_ITIM	327	332	PF00017	0.246
LIG_UBA3_1	218	226	PF00899	0.411
LIG_WRC_WIRS_1	42	47	PF05994	0.274
MOD_CDK_SPxK_1	8	14	PF00069	0.458
MOD_CK1_1	114	120	PF00069	0.274
MOD_CK1_1	125	131	PF00069	0.269
MOD_CK1_1	143	149	PF00069	0.364
MOD_CK1_1	160	166	PF00069	0.324
MOD_CK1_1	170	176	PF00069	0.253
MOD_CK1_1	178	184	PF00069	0.388
MOD_CK1_1	187	193	PF00069	0.379
MOD_CK1_1	208	214	PF00069	0.403
MOD_CK1_1	231	237	PF00069	0.289
MOD_CK1_1	287	293	PF00069	0.425
MOD_CK1_1	309	315	PF00069	0.444
MOD_CK1_1	331	337	PF00069	0.324
MOD_CK1_1	86	92	PF00069	0.327
MOD_CK2_1	235	241	PF00069	0.315
MOD_GlcNHglycan	230	233	PF01048	0.296
MOD_GlcNHglycan	237	240	PF01048	0.285
MOD_GlcNHglycan	289	292	PF01048	0.397
MOD_GlcNHglycan	308	311	PF01048	0.349
MOD_GlcNHglycan	38	41	PF01048	0.443
MOD_GSK3_1	143	150	PF00069	0.358
MOD_GSK3_1	157	164	PF00069	0.320
MOD_GSK3_1	172	179	PF00069	0.307
MOD_GSK3_1	183	190	PF00069	0.389
MOD_GSK3_1	208	215	PF00069	0.291
MOD_GSK3_1	231	238	PF00069	0.316
MOD_GSK3_1	60	67	PF00069	0.279
MOD_GSK3_1	83	90	PF00069	0.334
MOD_N-GLC_1	182	187	PF02516	0.356
MOD_N-GLC_1	208	213	PF02516	0.292
MOD_N-GLC_1	228	233	PF02516	0.155
MOD_NEK2_1	147	152	PF00069	0.312
MOD_NEK2_1	256	261	PF00069	0.308
MOD_NEK2_1	284	289	PF00069	0.351
MOD_NEK2_1	36	41	PF00069	0.321
MOD_NEK2_1	73	78	PF00069	0.380
MOD_NEK2_2	372	377	PF00069	0.391
MOD_PIKK_1	147	153	PF00454	0.489
MOD_PK_1	365	371	PF00069	0.442
MOD_PKA_2	114	120	PF00069	0.274
MOD_PKA_2	167	173	PF00069	0.302
MOD_PKA_2	188	194	PF00069	0.488
MOD_Plk_1	228	234	PF00069	0.269
MOD_Plk_1	284	290	PF00069	0.344
MOD_Plk_1	64	70	PF00069	0.444
MOD_Plk_1	99	105	PF00069	0.341
MOD_Plk_4	295	301	PF00069	0.386
MOD_Plk_4	336	342	PF00069	0.253
MOD_Plk_4	372	378	PF00069	0.366
MOD_Plk_4	41	47	PF00069	0.365
MOD_ProDKin_1	170	176	PF00069	0.435
MOD_ProDKin_1	342	348	PF00069	0.334
MOD_ProDKin_1	8	14	PF00069	0.436
MOD_ProDKin_1	83	89	PF00069	0.258
MOD_SUMO_rev_2	187	197	PF00179	0.270
TRG_DiLeu_BaEn_1	383	388	PF01217	0.319
TRG_ENDOCYTIC_2	329	332	PF00928	0.249
TRG_ENDOCYTIC_2	353	356	PF00928	0.352
TRG_ER_diArg_1	251	254	PF00400	0.321
TRG_ER_diArg_1	272	274	PF00400	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L5	Leptomonas seymouri	26%	99%
A0A0N1I6V6	Leptomonas seymouri	57%	100%
A0A1X0NNK2	Trypanosomatidae	25%	100%
A0A1X0NS30	Trypanosomatidae	33%	100%
A0A3Q8I9M0	Leishmania donovani	25%	100%
A0A3Q8IDU3	Leishmania donovani	94%	100%
A0A3R7LZE9	Trypanosoma rangeli	26%	100%
A4H7A0	Leishmania braziliensis	26%	98%
A4HF07	Leishmania braziliensis	81%	100%
A4HVP2	Leishmania infantum	25%	100%
A4I286	Leishmania infantum	95%	100%
C9ZRQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A6K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9APD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AYD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QG40	Leishmania major	25%	100%
V5ARR6	Trypanosoma cruzi	26%	94%