RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q941_LEIMA

TriTrypDb:

LmjF.26.1530 , LMJLV39_260021300 , LMJSD75_260019700

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q941

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q941

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	118	122	PF00082	0.314
CLV_PCSK_SKI1_1	166	170	PF00082	0.279
DEG_Nend_UBRbox_2	1	3	PF02207	0.653
DEG_SCF_TRCP1_1	40	45	PF00400	0.624
DOC_CYCLIN_RxL_1	115	122	PF00134	0.514
DOC_MAPK_gen_1	139	148	PF00069	0.497
DOC_WW_Pin1_4	178	183	PF00397	0.519
LIG_14-3-3_CanoR_1	118	127	PF00244	0.547
LIG_FHA_1	199	205	PF00498	0.497
LIG_FHA_2	148	154	PF00498	0.546
LIG_LIR_Nem_3	122	127	PF02991	0.543
LIG_LIR_Nem_3	78	82	PF02991	0.578
LIG_PAM2_1	6	18	PF00658	0.644
LIG_SH2_CRK	165	169	PF00017	0.514
LIG_SH2_CRK	79	83	PF00017	0.575
LIG_SH3_3	11	17	PF00018	0.644
LIG_SH3_3	197	203	PF00018	0.543
LIG_TRAF2_1	150	153	PF00917	0.514
MOD_CK1_1	137	143	PF00069	0.514
MOD_CK1_1	198	204	PF00069	0.506
MOD_CK1_1	38	44	PF00069	0.635
MOD_CK1_1	65	71	PF00069	0.603
MOD_CK2_1	147	153	PF00069	0.514
MOD_CK2_1	188	194	PF00069	0.492
MOD_GlcNHglycan	121	124	PF01048	0.308
MOD_GlcNHglycan	190	193	PF01048	0.496
MOD_GlcNHglycan	40	43	PF01048	0.654
MOD_GlcNHglycan	44	47	PF01048	0.615
MOD_GlcNHglycan	64	67	PF01048	0.620
MOD_GlcNHglycan	8	11	PF01048	0.670
MOD_GSK3_1	153	160	PF00069	0.505
MOD_GSK3_1	178	185	PF00069	0.504
MOD_GSK3_1	31	38	PF00069	0.689
MOD_LATS_1	29	35	PF00433	0.678
MOD_N-GLC_1	137	142	PF02516	0.314
MOD_N-GLC_1	182	187	PF02516	0.478
MOD_N-GLC_1	6	11	PF02516	0.637
MOD_N-GLC_1	62	67	PF02516	0.584
MOD_NEK2_1	85	90	PF00069	0.635
MOD_NEK2_1	96	101	PF00069	0.527
MOD_NEK2_2	157	162	PF00069	0.514
MOD_PIKK_1	19	25	PF00454	0.632
MOD_PIKK_1	209	215	PF00454	0.570
MOD_PIKK_1	35	41	PF00454	0.730
MOD_PKB_1	164	172	PF00069	0.514
MOD_Plk_4	65	71	PF00069	0.603
MOD_ProDKin_1	178	184	PF00069	0.515
TRG_ENDOCYTIC_2	124	127	PF00928	0.543
TRG_ENDOCYTIC_2	165	168	PF00928	0.514
TRG_ENDOCYTIC_2	79	82	PF00928	0.641
TRG_ER_diArg_1	55	58	PF00400	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I044	Leptomonas seymouri	71%	94%
A0A3Q8IC83	Leishmania donovani	96%	99%
A4HF08	Leishmania braziliensis	87%	99%
A4I287	Leishmania infantum	95%	99%
E9AYD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6X2	Leishmania major	32%	100%