Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q936_LEIMA

TriTrypDb:

LmjF.26.1580 , LMJLV39_260021900 , LMJSD75_260020300

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q936

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q936

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.563
CLV_C14_Caspase3-7	47	51	PF00656	0.591
CLV_C14_Caspase3-7	561	565	PF00656	0.621
CLV_C14_Caspase3-7	7	11	PF00656	0.739
CLV_NRD_NRD_1	238	240	PF00675	0.462
CLV_NRD_NRD_1	488	490	PF00675	0.630
CLV_NRD_NRD_1	56	58	PF00675	0.542
CLV_NRD_NRD_1	93	95	PF00675	0.553
CLV_PCSK_FUR_1	91	95	PF00082	0.691
CLV_PCSK_KEX2_1	168	170	PF00082	0.627
CLV_PCSK_KEX2_1	237	239	PF00082	0.463
CLV_PCSK_KEX2_1	488	490	PF00082	0.630
CLV_PCSK_KEX2_1	91	93	PF00082	0.572
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.627
CLV_PCSK_PC7_1	87	93	PF00082	0.633
CLV_PCSK_SKI1_1	140	144	PF00082	0.599
CLV_PCSK_SKI1_1	184	188	PF00082	0.693
CLV_PCSK_SKI1_1	382	386	PF00082	0.428
CLV_PCSK_SKI1_1	446	450	PF00082	0.667
CLV_PCSK_SKI1_1	554	558	PF00082	0.494
DEG_Nend_UBRbox_2	1	3	PF02207	0.722
DEG_SPOP_SBC_1	252	256	PF00917	0.713
DEG_SPOP_SBC_1	309	313	PF00917	0.468
DEG_SPOP_SBC_1	34	38	PF00917	0.547
DOC_AGCK_PIF_1	569	574	PF00069	0.559
DOC_CKS1_1	343	348	PF01111	0.360
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.552
DOC_MAPK_gen_1	57	65	PF00069	0.535
DOC_MAPK_MEF2A_6	257	266	PF00069	0.583
DOC_MAPK_MEF2A_6	57	65	PF00069	0.568
DOC_PP1_RVXF_1	552	558	PF00149	0.467
DOC_PP2B_LxvP_1	214	217	PF13499	0.675
DOC_PP4_FxxP_1	46	49	PF00568	0.615
DOC_SPAK_OSR1_1	327	331	PF12202	0.466
DOC_USP7_MATH_1	112	116	PF00917	0.743
DOC_USP7_MATH_1	260	264	PF00917	0.611
DOC_USP7_MATH_1	34	38	PF00917	0.638
DOC_USP7_MATH_1	380	384	PF00917	0.458
DOC_USP7_MATH_1	523	527	PF00917	0.476
DOC_USP7_MATH_1	556	560	PF00917	0.516
DOC_WW_Pin1_4	342	347	PF00397	0.525
DOC_WW_Pin1_4	360	365	PF00397	0.443
DOC_WW_Pin1_4	449	454	PF00397	0.630
DOC_WW_Pin1_4	547	552	PF00397	0.636
DOC_WW_Pin1_4	572	577	PF00397	0.518
LIG_14-3-3_CanoR_1	121	127	PF00244	0.656
LIG_14-3-3_CanoR_1	169	174	PF00244	0.772
LIG_14-3-3_CanoR_1	190	196	PF00244	0.651
LIG_14-3-3_CanoR_1	319	325	PF00244	0.516
LIG_14-3-3_CanoR_1	327	331	PF00244	0.563
LIG_14-3-3_CanoR_1	398	403	PF00244	0.529
LIG_14-3-3_CanoR_1	45	49	PF00244	0.584
LIG_14-3-3_CanoR_1	541	551	PF00244	0.562
LIG_APCC_ABBA_1	136	141	PF00400	0.518
LIG_Clathr_ClatBox_1	531	535	PF01394	0.550
LIG_FHA_1	266	272	PF00498	0.538
LIG_FHA_1	334	340	PF00498	0.510
LIG_FHA_1	431	437	PF00498	0.442
LIG_FHA_1	500	506	PF00498	0.655
LIG_FHA_1	527	533	PF00498	0.500
LIG_FHA_1	544	550	PF00498	0.399
LIG_FHA_2	130	136	PF00498	0.555
LIG_FHA_2	265	271	PF00498	0.582
LIG_FHA_2	37	43	PF00498	0.716
LIG_FHA_2	45	51	PF00498	0.527
LIG_LIR_Apic_2	172	176	PF02991	0.759
LIG_LIR_Apic_2	43	49	PF02991	0.628
LIG_LIR_Gen_1	179	189	PF02991	0.585
LIG_LIR_Gen_1	207	217	PF02991	0.616
LIG_LIR_Gen_1	67	75	PF02991	0.528
LIG_LIR_Nem_3	133	139	PF02991	0.455
LIG_LIR_Nem_3	207	212	PF02991	0.554
LIG_LIR_Nem_3	383	388	PF02991	0.552
LIG_LIR_Nem_3	567	572	PF02991	0.468
LIG_LIR_Nem_3	573	577	PF02991	0.490
LIG_LIR_Nem_3	67	72	PF02991	0.466
LIG_PDZ_Class_2	581	586	PF00595	0.597
LIG_Pex14_1	244	248	PF04695	0.504
LIG_Pex14_1	324	328	PF04695	0.661
LIG_Pex14_2	187	191	PF04695	0.754
LIG_Pex14_2	385	389	PF04695	0.568
LIG_REV1ctd_RIR_1	134	143	PF16727	0.605
LIG_SH2_CRK	471	475	PF00017	0.433
LIG_SH2_PTP2	317	320	PF00017	0.427
LIG_SH2_PTP2	62	65	PF00017	0.556
LIG_SH2_PTP2	69	72	PF00017	0.478
LIG_SH2_SRC	226	229	PF00017	0.509
LIG_SH2_SRC	69	72	PF00017	0.528
LIG_SH2_STAP1	226	230	PF00017	0.493
LIG_SH2_STAP1	248	252	PF00017	0.668
LIG_SH2_STAP1	578	582	PF00017	0.574
LIG_SH2_STAT3	464	467	PF00017	0.494
LIG_SH2_STAT3	577	580	PF00017	0.508
LIG_SH2_STAT5	245	248	PF00017	0.479
LIG_SH2_STAT5	281	284	PF00017	0.474
LIG_SH2_STAT5	317	320	PF00017	0.514
LIG_SH2_STAT5	322	325	PF00017	0.551
LIG_SH2_STAT5	572	575	PF00017	0.488
LIG_SH2_STAT5	578	581	PF00017	0.507
LIG_SH2_STAT5	62	65	PF00017	0.543
LIG_SH2_STAT5	69	72	PF00017	0.431
LIG_SH3_3	151	157	PF00018	0.781
LIG_SH3_3	209	215	PF00018	0.521
LIG_SH3_3	361	367	PF00018	0.769
LIG_SH3_3	416	422	PF00018	0.629
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.559
LIG_SUMO_SIM_par_1	267	273	PF11976	0.536
LIG_SUMO_SIM_par_1	306	313	PF11976	0.520
LIG_SUMO_SIM_par_1	520	526	PF11976	0.472
LIG_TYR_ITIM	469	474	PF00017	0.500
LIG_WRC_WIRS_1	399	404	PF05994	0.515
LIG_WRC_WIRS_1	571	576	PF05994	0.499
MOD_CDK_SPK_2	449	454	PF00069	0.630
MOD_CDK_SPxxK_3	547	554	PF00069	0.626
MOD_CK1_1	115	121	PF00069	0.641
MOD_CK1_1	129	135	PF00069	0.492
MOD_CK1_1	250	256	PF00069	0.623
MOD_CK1_1	35	41	PF00069	0.669
MOD_CK1_1	350	356	PF00069	0.525
MOD_CK1_1	4	10	PF00069	0.603
MOD_CK1_1	458	464	PF00069	0.559
MOD_CK1_1	525	531	PF00069	0.499
MOD_CK1_1	550	556	PF00069	0.463
MOD_CK2_1	197	203	PF00069	0.655
MOD_CK2_1	36	42	PF00069	0.694
MOD_GlcNHglycan	114	117	PF01048	0.681
MOD_GlcNHglycan	249	253	PF01048	0.597
MOD_GlcNHglycan	369	372	PF01048	0.695
MOD_GlcNHglycan	509	512	PF01048	0.542
MOD_GSK3_1	1	8	PF00069	0.652
MOD_GSK3_1	122	129	PF00069	0.645
MOD_GSK3_1	247	254	PF00069	0.575
MOD_GSK3_1	260	267	PF00069	0.566
MOD_GSK3_1	32	39	PF00069	0.699
MOD_GSK3_1	338	345	PF00069	0.480
MOD_GSK3_1	367	374	PF00069	0.724
MOD_GSK3_1	398	405	PF00069	0.546
MOD_GSK3_1	40	47	PF00069	0.637
MOD_GSK3_1	455	462	PF00069	0.509
MOD_GSK3_1	496	503	PF00069	0.541
MOD_GSK3_1	507	514	PF00069	0.577
MOD_GSK3_1	522	529	PF00069	0.375
MOD_GSK3_1	543	550	PF00069	0.521
MOD_GSK3_1	572	579	PF00069	0.469
MOD_N-GLC_1	371	376	PF02516	0.611
MOD_N-GLC_1	430	435	PF02516	0.452
MOD_N-GLC_1	449	454	PF02516	0.505
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	177	182	PF00069	0.635
MOD_NEK2_1	308	313	PF00069	0.546
MOD_NEK2_1	320	325	PF00069	0.389
MOD_NEK2_1	347	352	PF00069	0.506
MOD_NEK2_1	500	505	PF00069	0.569
MOD_NEK2_1	522	527	PF00069	0.470
MOD_NEK2_1	542	547	PF00069	0.312
MOD_NEK2_2	333	338	PF00069	0.540
MOD_NEK2_2	380	385	PF00069	0.477
MOD_PIKK_1	543	549	PF00454	0.567
MOD_PIKK_1	576	582	PF00454	0.504
MOD_PK_1	338	344	PF00069	0.607
MOD_PKA_2	126	132	PF00069	0.533
MOD_PKA_2	191	197	PF00069	0.655
MOD_PKA_2	32	38	PF00069	0.748
MOD_PKA_2	326	332	PF00069	0.467
MOD_PKA_2	44	50	PF00069	0.505
MOD_PKB_1	396	404	PF00069	0.605
MOD_Plk_1	226	232	PF00069	0.487
MOD_Plk_1	371	377	PF00069	0.668
MOD_Plk_1	405	411	PF00069	0.471
MOD_Plk_1	458	464	PF00069	0.522
MOD_Plk_2-3	50	56	PF00069	0.580
MOD_Plk_4	338	344	PF00069	0.593
MOD_Plk_4	459	465	PF00069	0.488
MOD_Plk_4	496	502	PF00069	0.610
MOD_ProDKin_1	342	348	PF00069	0.533
MOD_ProDKin_1	360	366	PF00069	0.443
MOD_ProDKin_1	449	455	PF00069	0.620
MOD_ProDKin_1	547	553	PF00069	0.627
MOD_ProDKin_1	572	578	PF00069	0.519
MOD_SUMO_for_1	337	340	PF00179	0.609
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.681
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.314
TRG_ENDOCYTIC_2	317	320	PF00928	0.427
TRG_ENDOCYTIC_2	471	474	PF00928	0.450
TRG_ENDOCYTIC_2	62	65	PF00928	0.510
TRG_ENDOCYTIC_2	69	72	PF00928	0.419
TRG_ER_diArg_1	236	239	PF00400	0.320
TRG_ER_diArg_1	324	327	PF00400	0.418
TRG_ER_diArg_1	396	399	PF00400	0.584
TRG_ER_diArg_1	487	489	PF00400	0.634
TRG_ER_diArg_1	90	93	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.769
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II93	Leptomonas seymouri	43%	100%
A0A3S7WZW7	Leishmania donovani	93%	100%
A4HF13	Leishmania braziliensis	80%	100%
A4I292	Leishmania infantum	94%	100%
C9ZRP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AYD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%