Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q935_LEIMA

TriTrypDb:

LmjF.26.1590 , LMJLV39_260022000 , LMJSD75_260020400

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4Q935

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q935

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.480
CLV_C14_Caspase3-7	72	76	PF00656	0.507
CLV_MEL_PAP_1	372	378	PF00089	0.339
CLV_NRD_NRD_1	138	140	PF00675	0.470
CLV_NRD_NRD_1	333	335	PF00675	0.285
CLV_NRD_NRD_1	350	352	PF00675	0.180
CLV_NRD_NRD_1	404	406	PF00675	0.227
CLV_NRD_NRD_1	490	492	PF00675	0.245
CLV_PCSK_KEX2_1	137	139	PF00082	0.477
CLV_PCSK_KEX2_1	169	171	PF00082	0.470
CLV_PCSK_KEX2_1	333	335	PF00082	0.288
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.470
CLV_PCSK_SKI1_1	169	173	PF00082	0.497
CLV_PCSK_SKI1_1	393	397	PF00082	0.195
CLV_PCSK_SKI1_1	405	409	PF00082	0.411
CLV_PCSK_SKI1_1	415	419	PF00082	0.435
DEG_APCC_DBOX_1	137	145	PF00400	0.446
DEG_APCC_DBOX_1	414	422	PF00400	0.452
DEG_APCC_DBOX_1	93	101	PF00400	0.520
DEG_MDM2_SWIB_1	362	370	PF02201	0.493
DEG_SCF_FBW7_1	33	40	PF00400	0.539
DEG_SCF_FBW7_1	512	518	PF00400	0.396
DEG_SCF_FBW7_2	155	160	PF00400	0.450
DOC_CKS1_1	28	33	PF01111	0.531
DOC_CKS1_1	512	517	PF01111	0.460
DOC_MAPK_gen_1	180	188	PF00069	0.659
DOC_MAPK_gen_1	281	289	PF00069	0.435
DOC_MAPK_MEF2A_6	558	566	PF00069	0.317
DOC_MAPK_RevD_3	104	117	PF00069	0.528
DOC_PP1_RVXF_1	490	497	PF00149	0.445
DOC_PP4_FxxP_1	41	44	PF00568	0.681
DOC_USP7_MATH_1	104	108	PF00917	0.710
DOC_USP7_MATH_1	37	41	PF00917	0.574
DOC_USP7_MATH_1	433	437	PF00917	0.382
DOC_USP7_MATH_1	44	48	PF00917	0.596
DOC_USP7_MATH_1	480	484	PF00917	0.493
DOC_USP7_MATH_1	515	519	PF00917	0.603
DOC_USP7_MATH_1	83	87	PF00917	0.602
DOC_USP7_UBL2_3	277	281	PF12436	0.596
DOC_WW_Pin1_4	153	158	PF00397	0.527
DOC_WW_Pin1_4	266	271	PF00397	0.640
DOC_WW_Pin1_4	27	32	PF00397	0.574
DOC_WW_Pin1_4	302	307	PF00397	0.421
DOC_WW_Pin1_4	33	38	PF00397	0.569
DOC_WW_Pin1_4	345	350	PF00397	0.493
DOC_WW_Pin1_4	511	516	PF00397	0.458
LIG_14-3-3_CanoR_1	143	152	PF00244	0.465
LIG_14-3-3_CanoR_1	170	175	PF00244	0.531
LIG_14-3-3_CanoR_1	180	188	PF00244	0.597
LIG_14-3-3_CanoR_1	198	205	PF00244	0.552
LIG_14-3-3_CanoR_1	375	383	PF00244	0.220
LIG_14-3-3_CanoR_1	38	42	PF00244	0.590
LIG_14-3-3_CanoR_1	405	414	PF00244	0.436
LIG_14-3-3_CanoR_1	505	515	PF00244	0.414
LIG_14-3-3_CanoR_1	569	577	PF00244	0.431
LIG_14-3-3_CanoR_1	94	98	PF00244	0.556
LIG_14-3-3_CanoR_1	99	109	PF00244	0.586
LIG_14-3-3_CterR_2	592	596	PF00244	0.418
LIG_APCC_ABBA_1	362	367	PF00400	0.395
LIG_BRCT_BRCA1_1	482	486	PF00533	0.395
LIG_deltaCOP1_diTrp_1	520	529	PF00928	0.428
LIG_FHA_1	28	34	PF00498	0.531
LIG_FHA_1	297	303	PF00498	0.304
LIG_FHA_1	367	373	PF00498	0.420
LIG_FHA_1	423	429	PF00498	0.481
LIG_FHA_1	523	529	PF00498	0.349
LIG_FHA_1	570	576	PF00498	0.490
LIG_FHA_2	262	268	PF00498	0.552
LIG_FHA_2	435	441	PF00498	0.367
LIG_FHA_2	485	491	PF00498	0.387
LIG_LIR_Apic_2	40	44	PF02991	0.682
LIG_LIR_Gen_1	146	157	PF02991	0.527
LIG_LIR_Gen_1	218	227	PF02991	0.538
LIG_LIR_Gen_1	360	370	PF02991	0.517
LIG_LIR_Gen_1	499	508	PF02991	0.374
LIG_LIR_Nem_3	146	152	PF02991	0.524
LIG_LIR_Nem_3	218	224	PF02991	0.540
LIG_LIR_Nem_3	360	365	PF02991	0.517
LIG_LIR_Nem_3	499	504	PF02991	0.406
LIG_LIR_Nem_3	51	57	PF02991	0.447
LIG_LIR_Nem_3	585	590	PF02991	0.353
LIG_NRBOX	108	114	PF00104	0.572
LIG_Pex14_1	474	478	PF04695	0.427
LIG_Pex14_1	496	500	PF04695	0.503
LIG_Pex14_2	362	366	PF04695	0.493
LIG_Pex14_2	390	394	PF04695	0.458
LIG_PTB_Apo_2	187	194	PF02174	0.507
LIG_SH2_CRK	149	153	PF00017	0.576
LIG_SH2_CRK	587	591	PF00017	0.410
LIG_SH2_STAP1	458	462	PF00017	0.293
LIG_SH2_STAP1	57	61	PF00017	0.558
LIG_SH2_STAP1	571	575	PF00017	0.325
LIG_SH2_STAT3	458	461	PF00017	0.291
LIG_SH2_STAT5	167	170	PF00017	0.468
LIG_SH2_STAT5	215	218	PF00017	0.539
LIG_SH2_STAT5	453	456	PF00017	0.354
LIG_SH2_STAT5	500	503	PF00017	0.387
LIG_SH2_STAT5	556	559	PF00017	0.506
LIG_SH2_STAT5	571	574	PF00017	0.411
LIG_SH3_3	416	422	PF00018	0.497
LIG_SH3_3	509	515	PF00018	0.613
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.655
LIG_SUMO_SIM_anti_2	217	226	PF11976	0.440
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.436
LIG_SUMO_SIM_par_1	428	434	PF11976	0.412
LIG_TRAF2_1	264	267	PF00917	0.627
LIG_UBA3_1	108	117	PF00899	0.550
LIG_UBA3_1	275	281	PF00899	0.475
LIG_WRC_WIRS_1	45	50	PF05994	0.505
MOD_CDC14_SPxK_1	348	351	PF00782	0.493
MOD_CDK_SPK_2	153	158	PF00069	0.440
MOD_CDK_SPK_2	266	271	PF00069	0.501
MOD_CDK_SPK_2	33	38	PF00069	0.528
MOD_CDK_SPxK_1	345	351	PF00069	0.493
MOD_CDK_SPxxK_3	27	34	PF00069	0.530
MOD_CDK_SPxxK_3	345	352	PF00069	0.493
MOD_CK1_1	17	23	PF00069	0.563
MOD_CK1_1	197	203	PF00069	0.621
MOD_CK1_1	241	247	PF00069	0.689
MOD_CK1_1	249	255	PF00069	0.700
MOD_CK1_1	259	265	PF00069	0.681
MOD_CK1_1	294	300	PF00069	0.569
MOD_CK1_1	510	516	PF00069	0.418
MOD_CK1_1	88	94	PF00069	0.413
MOD_CK2_1	214	220	PF00069	0.665
MOD_CK2_1	245	251	PF00069	0.548
MOD_CK2_1	261	267	PF00069	0.515
MOD_CK2_1	484	490	PF00069	0.387
MOD_GlcNHglycan	102	105	PF01048	0.629
MOD_GlcNHglycan	122	125	PF01048	0.659
MOD_GlcNHglycan	16	19	PF01048	0.507
MOD_GlcNHglycan	228	231	PF01048	0.651
MOD_GlcNHglycan	396	399	PF01048	0.293
MOD_GlcNHglycan	466	469	PF01048	0.234
MOD_GlcNHglycan	509	512	PF01048	0.376
MOD_GlcNHglycan	517	520	PF01048	0.622
MOD_GlcNHglycan	54	57	PF01048	0.397
MOD_GSK3_1	100	107	PF00069	0.512
MOD_GSK3_1	139	146	PF00069	0.499
MOD_GSK3_1	147	154	PF00069	0.558
MOD_GSK3_1	16	23	PF00069	0.568
MOD_GSK3_1	170	177	PF00069	0.537
MOD_GSK3_1	194	201	PF00069	0.657
MOD_GSK3_1	216	223	PF00069	0.659
MOD_GSK3_1	241	248	PF00069	0.671
MOD_GSK3_1	262	269	PF00069	0.657
MOD_GSK3_1	287	294	PF00069	0.404
MOD_GSK3_1	33	40	PF00069	0.772
MOD_GSK3_1	464	471	PF00069	0.472
MOD_GSK3_1	480	487	PF00069	0.452
MOD_GSK3_1	496	503	PF00069	0.531
MOD_GSK3_1	506	513	PF00069	0.430
MOD_GSK3_1	565	572	PF00069	0.341
MOD_GSK3_1	84	91	PF00069	0.556
MOD_N-GLC_2	291	293	PF02516	0.396
MOD_NEK2_1	275	280	PF00069	0.629
MOD_NEK2_1	394	399	PF00069	0.502
MOD_NEK2_1	407	412	PF00069	0.417
MOD_NEK2_1	484	489	PF00069	0.464
MOD_NEK2_1	507	512	PF00069	0.411
MOD_NEK2_1	523	528	PF00069	0.295
MOD_NEK2_2	500	505	PF00069	0.386
MOD_NEK2_2	571	576	PF00069	0.335
MOD_PIKK_1	262	268	PF00454	0.513
MOD_PIKK_1	291	297	PF00454	0.393
MOD_PIKK_1	431	437	PF00454	0.415
MOD_PK_1	170	176	PF00069	0.580
MOD_PK_1	182	188	PF00069	0.518
MOD_PK_1	85	91	PF00069	0.460
MOD_PKA_1	405	411	PF00069	0.331
MOD_PKA_2	197	203	PF00069	0.580
MOD_PKA_2	37	43	PF00069	0.615
MOD_PKA_2	374	380	PF00069	0.424
MOD_PKA_2	93	99	PF00069	0.488
MOD_PKB_1	137	145	PF00069	0.483
MOD_PKB_1	567	575	PF00069	0.411
MOD_Plk_1	104	110	PF00069	0.461
MOD_Plk_1	366	372	PF00069	0.494
MOD_Plk_1	480	486	PF00069	0.457
MOD_Plk_4	104	110	PF00069	0.530
MOD_Plk_4	220	226	PF00069	0.628
MOD_Plk_4	338	344	PF00069	0.470
MOD_Plk_4	468	474	PF00069	0.434
MOD_Plk_4	480	486	PF00069	0.447
MOD_Plk_4	496	502	PF00069	0.532
MOD_Plk_4	557	563	PF00069	0.441
MOD_Plk_4	571	577	PF00069	0.298
MOD_ProDKin_1	153	159	PF00069	0.531
MOD_ProDKin_1	266	272	PF00069	0.636
MOD_ProDKin_1	27	33	PF00069	0.576
MOD_ProDKin_1	302	308	PF00069	0.422
MOD_ProDKin_1	345	351	PF00069	0.493
MOD_ProDKin_1	511	517	PF00069	0.458
MOD_SUMO_rev_2	237	244	PF00179	0.573
MOD_SUMO_rev_2	348	354	PF00179	0.421
MOD_SUMO_rev_2	389	395	PF00179	0.395
TRG_DiLeu_BaEn_1	220	225	PF01217	0.435
TRG_DiLeu_BaEn_1	331	336	PF01217	0.493
TRG_DiLeu_BaEn_1	533	538	PF01217	0.352
TRG_ENDOCYTIC_2	149	152	PF00928	0.521
TRG_ENDOCYTIC_2	587	590	PF00928	0.417
TRG_ER_diArg_1	137	139	PF00400	0.485
TRG_ER_diArg_1	282	285	PF00400	0.445
TRG_ER_diArg_1	332	334	PF00400	0.453
TRG_ER_diArg_1	566	569	PF00400	0.301
TRG_ER_diArg_1	591	594	PF00400	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G5	Leptomonas seymouri	51%	99%
A0A0S4JNE6	Bodo saltans	32%	92%
A0A1X0NSH5	Trypanosomatidae	37%	100%
A4HF14	Leishmania braziliensis	73%	100%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%