DUF4704 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q934_LEIMA

TriTrypDb:

LmjF.26.1600 , LMJLV39_260022100 , LMJSD75_260020500

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q934

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q934

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.564
CLV_C14_Caspase3-7	422	426	PF00656	0.455
CLV_C14_Caspase3-7	463	467	PF00656	0.425
CLV_C14_Caspase3-7	602	606	PF00656	0.586
CLV_C14_Caspase3-7	609	613	PF00656	0.644
CLV_NRD_NRD_1	114	116	PF00675	0.488
CLV_NRD_NRD_1	349	351	PF00675	0.411
CLV_NRD_NRD_1	516	518	PF00675	0.629
CLV_NRD_NRD_1	528	530	PF00675	0.635
CLV_NRD_NRD_1	554	556	PF00675	0.668
CLV_NRD_NRD_1	82	84	PF00675	0.473
CLV_PCSK_FUR_1	525	529	PF00082	0.688
CLV_PCSK_FUR_1	549	553	PF00082	0.604
CLV_PCSK_KEX2_1	516	518	PF00082	0.630
CLV_PCSK_KEX2_1	527	529	PF00082	0.632
CLV_PCSK_KEX2_1	551	553	PF00082	0.769
CLV_PCSK_KEX2_1	554	556	PF00082	0.645
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.760
CLV_PCSK_PC7_1	547	553	PF00082	0.611
CLV_PCSK_SKI1_1	116	120	PF00082	0.451
CLV_PCSK_SKI1_1	159	163	PF00082	0.508
CLV_PCSK_SKI1_1	232	236	PF00082	0.460
CLV_PCSK_SKI1_1	319	323	PF00082	0.444
CLV_PCSK_SKI1_1	350	354	PF00082	0.498
CLV_PCSK_SKI1_1	498	502	PF00082	0.444
CLV_Separin_Metazoa	229	233	PF03568	0.415
DEG_APCC_DBOX_1	158	166	PF00400	0.491
DEG_APCC_DBOX_1	318	326	PF00400	0.442
DEG_APCC_DBOX_1	328	336	PF00400	0.300
DEG_SCF_FBW7_1	132	138	PF00400	0.520
DEG_SPOP_SBC_1	571	575	PF00917	0.553
DEG_SPOP_SBC_1	654	658	PF00917	0.449
DOC_CDC14_PxL_1	649	657	PF14671	0.413
DOC_CKS1_1	132	137	PF01111	0.517
DOC_CYCLIN_RxL_1	226	239	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	269	275	PF00134	0.506
DOC_MAPK_gen_1	176	185	PF00069	0.430
DOC_MAPK_gen_1	481	489	PF00069	0.482
DOC_MAPK_MEF2A_6	361	369	PF00069	0.409
DOC_MAPK_RevD_3	102	116	PF00069	0.466
DOC_PP1_RVXF_1	113	120	PF00149	0.469
DOC_PP1_RVXF_1	230	237	PF00149	0.452
DOC_PP4_FxxP_1	11	14	PF00568	0.443
DOC_PP4_FxxP_1	289	292	PF00568	0.495
DOC_USP7_MATH_1	133	137	PF00917	0.586
DOC_USP7_MATH_1	306	310	PF00917	0.492
DOC_USP7_MATH_1	389	393	PF00917	0.362
DOC_USP7_MATH_1	416	420	PF00917	0.396
DOC_USP7_MATH_1	431	435	PF00917	0.334
DOC_USP7_MATH_1	535	539	PF00917	0.553
DOC_USP7_MATH_1	613	617	PF00917	0.641
DOC_USP7_MATH_1	682	686	PF00917	0.402
DOC_USP7_MATH_1	91	95	PF00917	0.512
DOC_WW_Pin1_4	131	136	PF00397	0.524
DOC_WW_Pin1_4	304	309	PF00397	0.530
DOC_WW_Pin1_4	34	39	PF00397	0.443
DOC_WW_Pin1_4	488	493	PF00397	0.435
DOC_WW_Pin1_4	572	577	PF00397	0.596
DOC_WW_Pin1_4	73	78	PF00397	0.522
LIG_14-3-3_CanoR_1	159	169	PF00244	0.441
LIG_14-3-3_CanoR_1	176	186	PF00244	0.373
LIG_14-3-3_CanoR_1	418	424	PF00244	0.418
LIG_14-3-3_CanoR_1	432	438	PF00244	0.319
LIG_14-3-3_CanoR_1	449	457	PF00244	0.391
LIG_14-3-3_CanoR_1	534	540	PF00244	0.556
LIG_14-3-3_CanoR_1	83	92	PF00244	0.455
LIG_Actin_WH2_2	334	352	PF00022	0.402
LIG_BRCT_BRCA1_1	18	22	PF00533	0.396
LIG_BRCT_BRCA1_1	269	273	PF00533	0.620
LIG_BRCT_BRCA1_1	7	11	PF00533	0.465
LIG_CtBP_PxDLS_1	621	625	PF00389	0.422
LIG_EH1_1	221	229	PF00400	0.440
LIG_EH1_1	274	282	PF00400	0.391
LIG_eIF4E_1	275	281	PF01652	0.380
LIG_FHA_1	132	138	PF00498	0.520
LIG_FHA_1	191	197	PF00498	0.457
LIG_FHA_1	259	265	PF00498	0.619
LIG_FHA_1	385	391	PF00498	0.352
LIG_FHA_1	575	581	PF00498	0.608
LIG_FHA_1	633	639	PF00498	0.607
LIG_FHA_1	656	662	PF00498	0.375
LIG_FHA_1	69	75	PF00498	0.490
LIG_FHA_2	125	131	PF00498	0.394
LIG_FHA_2	149	155	PF00498	0.649
LIG_FHA_2	236	242	PF00498	0.439
LIG_FHA_2	338	344	PF00498	0.432
LIG_FHA_2	420	426	PF00498	0.524
LIG_FHA_2	431	437	PF00498	0.339
LIG_FHA_2	8	14	PF00498	0.452
LIG_LIR_Apic_2	288	292	PF02991	0.366
LIG_LIR_Apic_2	8	14	PF02991	0.452
LIG_LIR_Gen_1	19	30	PF02991	0.435
LIG_LIR_Gen_1	238	247	PF02991	0.521
LIG_LIR_Gen_1	342	353	PF02991	0.456
LIG_LIR_Gen_1	460	465	PF02991	0.432
LIG_LIR_Gen_1	491	501	PF02991	0.482
LIG_LIR_LC3C_4	688	691	PF02991	0.388
LIG_LIR_Nem_3	19	25	PF02991	0.425
LIG_LIR_Nem_3	199	204	PF02991	0.416
LIG_LIR_Nem_3	235	240	PF02991	0.578
LIG_LIR_Nem_3	294	299	PF02991	0.346
LIG_LIR_Nem_3	342	348	PF02991	0.469
LIG_LIR_Nem_3	460	464	PF02991	0.439
LIG_LIR_Nem_3	491	497	PF02991	0.475
LIG_LIR_Nem_3	669	673	PF02991	0.370
LIG_NRBOX	103	109	PF00104	0.455
LIG_NRBOX	334	340	PF00104	0.425
LIG_PCNA_PIPBox_1	325	334	PF02747	0.285
LIG_SH2_CRK	201	205	PF00017	0.466
LIG_SH2_CRK	345	349	PF00017	0.454
LIG_SH2_CRK	494	498	PF00017	0.486
LIG_SH2_CRK	567	571	PF00017	0.565
LIG_SH2_STAP1	345	349	PF00017	0.454
LIG_SH2_STAT5	296	299	PF00017	0.522
LIG_SH2_STAT5	304	307	PF00017	0.477
LIG_SH2_STAT5	472	475	PF00017	0.421
LIG_SH2_STAT5	640	643	PF00017	0.369
LIG_SH2_STAT5	660	663	PF00017	0.229
LIG_SH2_STAT5	670	673	PF00017	0.371
LIG_SH3_3	359	365	PF00018	0.348
LIG_SH3_3	505	511	PF00018	0.646
LIG_SH3_3	71	77	PF00018	0.485
LIG_Sin3_3	687	694	PF02671	0.440
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.567
LIG_SUMO_SIM_anti_2	191	199	PF11976	0.462
LIG_SUMO_SIM_par_1	166	172	PF11976	0.542
LIG_SUMO_SIM_par_1	331	337	PF11976	0.381
LIG_SUMO_SIM_par_1	409	417	PF11976	0.362
LIG_SUMO_SIM_par_1	484	491	PF11976	0.438
LIG_SUMO_SIM_par_1	620	625	PF11976	0.434
LIG_TRAF2_1	239	242	PF00917	0.516
LIG_TYR_ITIM	671	676	PF00017	0.456
LIG_TYR_ITSM	197	204	PF00017	0.320
LIG_UBA3_1	280	286	PF00899	0.351
LIG_UBA3_1	366	372	PF00899	0.287
LIG_WW_3	631	635	PF00397	0.454
MOD_CK1_1	131	137	PF00069	0.520
MOD_CK1_1	160	166	PF00069	0.467
MOD_CK1_1	172	178	PF00069	0.604
MOD_CK1_1	258	264	PF00069	0.558
MOD_CK1_1	267	273	PF00069	0.524
MOD_CK1_1	307	313	PF00069	0.583
MOD_CK1_1	392	398	PF00069	0.390
MOD_CK1_1	419	425	PF00069	0.464
MOD_CK1_1	448	454	PF00069	0.385
MOD_CK1_1	490	496	PF00069	0.536
MOD_CK1_1	596	602	PF00069	0.634
MOD_CK1_1	680	686	PF00069	0.404
MOD_CK2_1	124	130	PF00069	0.438
MOD_CK2_1	148	154	PF00069	0.628
MOD_CK2_1	189	195	PF00069	0.472
MOD_CK2_1	235	241	PF00069	0.491
MOD_CK2_1	430	436	PF00069	0.406
MOD_CK2_1	596	602	PF00069	0.669
MOD_CK2_1	67	73	PF00069	0.514
MOD_GlcNHglycan	137	140	PF01048	0.533
MOD_GlcNHglycan	148	151	PF01048	0.557
MOD_GlcNHglycan	171	174	PF01048	0.519
MOD_GlcNHglycan	215	218	PF01048	0.469
MOD_GlcNHglycan	266	269	PF01048	0.496
MOD_GlcNHglycan	433	436	PF01048	0.485
MOD_GlcNHglycan	450	453	PF01048	0.394
MOD_GlcNHglycan	466	469	PF01048	0.558
MOD_GlcNHglycan	5	8	PF01048	0.465
MOD_GlcNHglycan	650	653	PF01048	0.391
MOD_GlcNHglycan	679	682	PF01048	0.407
MOD_GlcNHglycan	85	88	PF01048	0.465
MOD_GSK3_1	124	131	PF00069	0.466
MOD_GSK3_1	135	142	PF00069	0.701
MOD_GSK3_1	148	155	PF00069	0.558
MOD_GSK3_1	196	203	PF00069	0.504
MOD_GSK3_1	232	239	PF00069	0.445
MOD_GSK3_1	258	265	PF00069	0.587
MOD_GSK3_1	3	10	PF00069	0.466
MOD_GSK3_1	306	313	PF00069	0.665
MOD_GSK3_1	392	399	PF00069	0.389
MOD_GSK3_1	43	50	PF00069	0.461
MOD_GSK3_1	460	467	PF00069	0.559
MOD_GSK3_1	475	482	PF00069	0.433
MOD_GSK3_1	512	519	PF00069	0.565
MOD_GSK3_1	537	544	PF00069	0.758
MOD_GSK3_1	570	577	PF00069	0.584
MOD_GSK3_1	593	600	PF00069	0.634
MOD_GSK3_1	69	76	PF00069	0.536
MOD_N-GLC_1	23	28	PF02516	0.437
MOD_N-GLC_1	407	412	PF02516	0.393
MOD_NEK2_1	140	145	PF00069	0.624
MOD_NEK2_1	16	21	PF00069	0.391
MOD_NEK2_1	243	248	PF00069	0.534
MOD_NEK2_1	3	8	PF00069	0.466
MOD_NEK2_1	323	328	PF00069	0.516
MOD_NEK2_1	334	339	PF00069	0.258
MOD_NEK2_1	384	389	PF00069	0.410
MOD_NEK2_1	43	48	PF00069	0.499
MOD_NEK2_1	487	492	PF00069	0.448
MOD_NEK2_1	570	575	PF00069	0.513
MOD_NEK2_1	648	653	PF00069	0.355
MOD_NEK2_1	655	660	PF00069	0.382
MOD_NEK2_1	67	72	PF00069	0.507
MOD_NEK2_1	85	90	PF00069	0.304
MOD_NEK2_2	200	205	PF00069	0.329
MOD_NEK2_2	379	384	PF00069	0.459
MOD_PIKK_1	160	166	PF00454	0.476
MOD_PIKK_1	255	261	PF00454	0.623
MOD_PIKK_1	582	588	PF00454	0.638
MOD_PIKK_1	96	102	PF00454	0.494
MOD_PK_1	516	522	PF00069	0.626
MOD_PKA_1	516	522	PF00069	0.599
MOD_PKA_1	83	89	PF00069	0.468
MOD_PKA_2	431	437	PF00069	0.460
MOD_PKA_2	448	454	PF00069	0.384
MOD_PKA_2	516	522	PF00069	0.599
MOD_PKB_1	545	553	PF00069	0.689
MOD_Plk_1	157	163	PF00069	0.649
MOD_Plk_1	190	196	PF00069	0.399
MOD_Plk_1	232	238	PF00069	0.423
MOD_Plk_1	379	385	PF00069	0.398
MOD_Plk_1	406	412	PF00069	0.419
MOD_Plk_1	416	422	PF00069	0.525
MOD_Plk_1	622	628	PF00069	0.468
MOD_Plk_2-3	597	603	PF00069	0.721
MOD_Plk_4	124	130	PF00069	0.404
MOD_Plk_4	200	206	PF00069	0.341
MOD_Plk_4	232	238	PF00069	0.432
MOD_Plk_4	291	297	PF00069	0.565
MOD_Plk_4	323	329	PF00069	0.455
MOD_Plk_4	334	340	PF00069	0.271
MOD_Plk_4	379	385	PF00069	0.469
MOD_Plk_4	407	413	PF00069	0.356
MOD_Plk_4	43	49	PF00069	0.505
MOD_Plk_4	460	466	PF00069	0.480
MOD_ProDKin_1	131	137	PF00069	0.528
MOD_ProDKin_1	304	310	PF00069	0.541
MOD_ProDKin_1	34	40	PF00069	0.432
MOD_ProDKin_1	488	494	PF00069	0.430
MOD_ProDKin_1	572	578	PF00069	0.602
MOD_ProDKin_1	73	79	PF00069	0.524
MOD_SUMO_for_1	695	698	PF00179	0.409
TRG_DiLeu_BaEn_1	318	323	PF01217	0.431
TRG_DiLeu_BaEn_2	156	162	PF01217	0.511
TRG_DiLeu_BaEn_2	379	385	PF01217	0.398
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.395
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.580
TRG_ENDOCYTIC_2	201	204	PF00928	0.399
TRG_ENDOCYTIC_2	240	243	PF00928	0.633
TRG_ENDOCYTIC_2	287	290	PF00928	0.434
TRG_ENDOCYTIC_2	296	299	PF00928	0.362
TRG_ENDOCYTIC_2	345	348	PF00928	0.467
TRG_ENDOCYTIC_2	494	497	PF00928	0.477
TRG_ENDOCYTIC_2	567	570	PF00928	0.568
TRG_ENDOCYTIC_2	673	676	PF00928	0.464
TRG_ER_diArg_1	483	486	PF00400	0.474
TRG_ER_diArg_1	524	527	PF00400	0.680
TRG_ER_diArg_1	528	531	PF00400	0.639
TRG_ER_diArg_1	552	555	PF00400	0.670
TRG_NES_CRM1_1	220	233	PF08389	0.400
TRG_NLS_MonoCore_2	550	555	PF00514	0.613
TRG_NLS_MonoExtC_3	550	555	PF00514	0.613
TRG_NLS_MonoExtN_4	549	555	PF00514	0.798

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I134	Leptomonas seymouri	41%	100%
A0A3S7WZX2	Leishmania donovani	92%	100%
A4HF15	Leishmania braziliensis	77%	100%
A4I293	Leishmania infantum	93%	100%
E9AYD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%