BRO1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q929_LEIMA

TriTrypDb:

LmjF.26.1650 , LMJLV39_260022600 , LMJSD75_260021000

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q929

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q929

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.550
CLV_C14_Caspase3-7	39	43	PF00656	0.523
CLV_NRD_NRD_1	183	185	PF00675	0.435
CLV_NRD_NRD_1	64	66	PF00675	0.472
CLV_NRD_NRD_1	71	73	PF00675	0.491
CLV_PCSK_KEX2_1	118	120	PF00082	0.453
CLV_PCSK_KEX2_1	57	59	PF00082	0.506
CLV_PCSK_KEX2_1	64	66	PF00082	0.445
CLV_PCSK_KEX2_1	71	73	PF00082	0.455
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.462
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.568
CLV_PCSK_SKI1_1	115	119	PF00082	0.431
CLV_PCSK_SKI1_1	168	172	PF00082	0.510
CLV_PCSK_SKI1_1	205	209	PF00082	0.635
CLV_PCSK_SKI1_1	220	224	PF00082	0.575
CLV_PCSK_SKI1_1	309	313	PF00082	0.477
CLV_Separin_Metazoa	165	169	PF03568	0.467
DEG_Nend_UBRbox_2	1	3	PF02207	0.652
DOC_CKS1_1	126	131	PF01111	0.463
DOC_PP1_RVXF_1	107	113	PF00149	0.393
DOC_PP4_FxxP_1	126	129	PF00568	0.410
DOC_USP7_MATH_1	159	163	PF00917	0.498
DOC_USP7_MATH_1	166	170	PF00917	0.536
DOC_USP7_UBL2_3	208	212	PF12436	0.686
DOC_WW_Pin1_4	102	107	PF00397	0.512
DOC_WW_Pin1_4	125	130	PF00397	0.454
DOC_WW_Pin1_4	261	266	PF00397	0.471
LIG_14-3-3_CanoR_1	168	174	PF00244	0.496
LIG_14-3-3_CanoR_1	194	198	PF00244	0.540
LIG_Actin_WH2_2	103	120	PF00022	0.494
LIG_Actin_WH2_2	180	196	PF00022	0.522
LIG_BRCT_BRCA1_1	107	111	PF00533	0.453
LIG_BRCT_BRCA1_1	145	149	PF00533	0.530
LIG_Clathr_ClatBox_1	314	318	PF01394	0.603
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.459
LIG_EH1_1	293	301	PF00400	0.461
LIG_FHA_1	126	132	PF00498	0.464
LIG_FHA_1	155	161	PF00498	0.538
LIG_FHA_1	295	301	PF00498	0.460
LIG_FHA_1	310	316	PF00498	0.418
LIG_FHA_1	58	64	PF00498	0.511
LIG_FHA_1	86	92	PF00498	0.518
LIG_FHA_2	17	23	PF00498	0.467
LIG_FHA_2	170	176	PF00498	0.559
LIG_FHA_2	224	230	PF00498	0.601
LIG_FHA_2	37	43	PF00498	0.210
LIG_FHA_2	5	11	PF00498	0.487
LIG_LIR_Apic_2	98	103	PF02991	0.497
LIG_LIR_Gen_1	105	114	PF02991	0.493
LIG_LIR_Nem_3	105	110	PF02991	0.211
LIG_LIR_Nem_3	213	218	PF02991	0.642
LIG_LIR_Nem_3	250	255	PF02991	0.411
LIG_LIR_Nem_3	80	86	PF02991	0.539
LIG_LIR_Nem_3	87	93	PF02991	0.514
LIG_NRBOX	112	118	PF00104	0.385
LIG_PCNA_yPIPBox_3	302	315	PF02747	0.561
LIG_Pex14_1	252	256	PF04695	0.382
LIG_Pex14_2	107	111	PF04695	0.398
LIG_Pex14_2	86	90	PF04695	0.601
LIG_SH2_CRK	100	104	PF00017	0.553
LIG_SH2_CRK	285	289	PF00017	0.389
LIG_SH2_STAP1	156	160	PF00017	0.476
LIG_SH2_STAP1	232	236	PF00017	0.500
LIG_SH2_STAT3	255	258	PF00017	0.445
LIG_SH2_STAT5	132	135	PF00017	0.419
LIG_SH2_STAT5	156	159	PF00017	0.406
LIG_SH2_STAT5	255	258	PF00017	0.516
LIG_SH2_STAT5	34	37	PF00017	0.398
LIG_SH3_1	100	106	PF00018	0.581
LIG_SH3_1	313	319	PF00018	0.623
LIG_SH3_3	100	106	PF00018	0.566
LIG_SH3_3	262	268	PF00018	0.564
LIG_SH3_3	313	319	PF00018	0.632
LIG_SH3_3	88	94	PF00018	0.554
LIG_SH3_4	208	215	PF00018	0.664
LIG_SH3_5	96	100	PF00018	0.607
LIG_Sin3_3	11	18	PF02671	0.432
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.525
LIG_SUMO_SIM_par_1	295	301	PF11976	0.432
LIG_TRAF2_1	226	229	PF00917	0.609
LIG_UBA3_1	113	118	PF00899	0.405
LIG_ULM_U2AF65_1	71	76	PF00076	0.596
LIG_WRC_WIRS_1	83	88	PF05994	0.645
MOD_CDK_SPxxK_3	102	109	PF00069	0.524
MOD_CK1_1	105	111	PF00069	0.464
MOD_CK1_1	169	175	PF00069	0.614
MOD_CK1_1	264	270	PF00069	0.524
MOD_CK1_1	4	10	PF00069	0.358
MOD_CK1_1	73	79	PF00069	0.568
MOD_CK1_1	85	91	PF00069	0.519
MOD_CK2_1	159	165	PF00069	0.460
MOD_CK2_1	223	229	PF00069	0.572
MOD_CK2_1	238	244	PF00069	0.475
MOD_CK2_1	4	10	PF00069	0.493
MOD_GlcNHglycan	157	160	PF01048	0.502
MOD_GlcNHglycan	161	164	PF01048	0.520
MOD_GlcNHglycan	22	26	PF01048	0.449
MOD_GlcNHglycan	240	243	PF01048	0.482
MOD_GlcNHglycan	285	288	PF01048	0.413
MOD_GlcNHglycan	322	325	PF01048	0.728
MOD_GSK3_1	127	134	PF00069	0.512
MOD_GSK3_1	155	162	PF00069	0.476
MOD_GSK3_1	192	199	PF00069	0.517
MOD_GSK3_1	223	230	PF00069	0.584
MOD_GSK3_1	234	241	PF00069	0.202
MOD_GSK3_1	320	327	PF00069	0.590
MOD_GSK3_1	73	80	PF00069	0.536
MOD_NEK2_1	117	122	PF00069	0.361
MOD_NEK2_1	21	26	PF00069	0.523
MOD_NEK2_1	52	57	PF00069	0.558
MOD_NEK2_1	70	75	PF00069	0.440
MOD_NEK2_2	143	148	PF00069	0.515
MOD_PIKK_1	85	91	PF00454	0.595
MOD_PKA_1	57	63	PF00069	0.514
MOD_PKA_2	193	199	PF00069	0.538
MOD_PKA_2	57	63	PF00069	0.512
MOD_PKA_2	70	76	PF00069	0.490
MOD_Plk_1	1	7	PF00069	0.553
MOD_Plk_1	294	300	PF00069	0.489
MOD_Plk_1	77	83	PF00069	0.602
MOD_Plk_4	127	133	PF00069	0.525
MOD_Plk_4	210	216	PF00069	0.664
MOD_Plk_4	294	300	PF00069	0.453
MOD_Plk_4	4	10	PF00069	0.398
MOD_Plk_4	78	84	PF00069	0.635
MOD_ProDKin_1	102	108	PF00069	0.507
MOD_ProDKin_1	125	131	PF00069	0.455
MOD_ProDKin_1	261	267	PF00069	0.467
MOD_SUMO_for_1	319	322	PF00179	0.595
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.382
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.526
TRG_ENDOCYTIC_2	285	288	PF00928	0.414
TRG_ER_diArg_1	63	65	PF00400	0.449
TRG_ER_diArg_1	70	72	PF00400	0.469
TRG_NES_CRM1_1	283	295	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG5	Leptomonas seymouri	79%	99%
A0A0S4JUF0	Bodo saltans	36%	99%
A0A1X0NS29	Trypanosomatidae	45%	100%
A0A3R7KFL2	Trypanosoma rangeli	43%	100%
A0A3S7WZW5	Leishmania donovani	97%	100%
A4HF20	Leishmania braziliensis	89%	100%
A4I299	Leishmania infantum	96%	100%
E9AYE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5AKX8	Trypanosoma cruzi	47%	99%