Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q928_LEIMA

TriTrypDb:

LmjF.26.1660 , LMJLV39_260022700 , LMJSD75_260021100

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q928

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q928

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.434
CLV_NRD_NRD_1	136	138	PF00675	0.525
CLV_NRD_NRD_1	165	167	PF00675	0.433
CLV_NRD_NRD_1	223	225	PF00675	0.432
CLV_NRD_NRD_1	431	433	PF00675	0.483
CLV_NRD_NRD_1	50	52	PF00675	0.504
CLV_NRD_NRD_1	626	628	PF00675	0.474
CLV_PCSK_FUR_1	221	225	PF00082	0.442
CLV_PCSK_KEX2_1	136	138	PF00082	0.634
CLV_PCSK_KEX2_1	164	166	PF00082	0.550
CLV_PCSK_KEX2_1	223	225	PF00082	0.432
CLV_PCSK_KEX2_1	431	433	PF00082	0.493
CLV_PCSK_KEX2_1	451	453	PF00082	0.433
CLV_PCSK_KEX2_1	470	472	PF00082	0.377
CLV_PCSK_KEX2_1	50	52	PF00082	0.504
CLV_PCSK_KEX2_1	626	628	PF00082	0.442
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.452
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.348
CLV_PCSK_SKI1_1	124	128	PF00082	0.545
CLV_PCSK_SKI1_1	214	218	PF00082	0.354
CLV_PCSK_SKI1_1	369	373	PF00082	0.469
CLV_PCSK_SKI1_1	432	436	PF00082	0.465
CLV_PCSK_SKI1_1	445	449	PF00082	0.450
CLV_PCSK_SKI1_1	619	623	PF00082	0.493
CLV_PCSK_SKI1_1	629	633	PF00082	0.557
CLV_PCSK_SKI1_1	654	658	PF00082	0.512
CLV_PCSK_SKI1_1	667	671	PF00082	0.408
CLV_PCSK_SKI1_1	96	100	PF00082	0.574
DEG_APCC_DBOX_1	123	131	PF00400	0.588
DEG_Nend_UBRbox_4	1	3	PF02207	0.436
DOC_CYCLIN_RxL_1	429	439	PF00134	0.278
DOC_CYCLIN_RxL_1	91	101	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.467
DOC_MAPK_DCC_7	583	592	PF00069	0.470
DOC_MAPK_FxFP_2	27	30	PF00069	0.408
DOC_MAPK_gen_1	253	262	PF00069	0.502
DOC_MAPK_gen_1	367	374	PF00069	0.400
DOC_MAPK_gen_1	450	459	PF00069	0.420
DOC_MAPK_MEF2A_6	583	592	PF00069	0.427
DOC_MAPK_MEF2A_6	629	638	PF00069	0.592
DOC_MAPK_RevD_3	151	166	PF00069	0.475
DOC_PP1_RVXF_1	221	228	PF00149	0.425
DOC_PP1_RVXF_1	599	606	PF00149	0.464
DOC_PP2B_LxvP_1	22	25	PF13499	0.414
DOC_PP4_FxxP_1	27	30	PF00568	0.501
DOC_USP7_MATH_1	249	253	PF00917	0.344
DOC_USP7_MATH_1	334	338	PF00917	0.415
DOC_USP7_MATH_1	479	483	PF00917	0.398
DOC_USP7_MATH_1	565	569	PF00917	0.422
DOC_USP7_MATH_1	61	65	PF00917	0.512
DOC_USP7_MATH_1	611	615	PF00917	0.450
DOC_USP7_MATH_1	675	679	PF00917	0.579
DOC_USP7_UBL2_3	549	553	PF12436	0.624
DOC_WW_Pin1_4	14	19	PF00397	0.456
DOC_WW_Pin1_4	147	152	PF00397	0.606
DOC_WW_Pin1_4	54	59	PF00397	0.505
DOC_WW_Pin1_4	8	13	PF00397	0.457
LIG_14-3-3_CanoR_1	253	258	PF00244	0.490
LIG_14-3-3_CanoR_1	310	316	PF00244	0.371
LIG_14-3-3_CanoR_1	317	322	PF00244	0.384
LIG_14-3-3_CanoR_1	395	403	PF00244	0.421
LIG_14-3-3_CanoR_1	431	435	PF00244	0.421
LIG_14-3-3_CanoR_1	445	454	PF00244	0.347
LIG_14-3-3_CanoR_1	567	572	PF00244	0.381
LIG_14-3-3_CanoR_1	619	625	PF00244	0.480
LIG_14-3-3_CanoR_1	629	634	PF00244	0.540
LIG_14-3-3_CanoR_1	667	674	PF00244	0.504
LIG_Actin_WH2_2	639	656	PF00022	0.531
LIG_BRCT_BRCA1_1	119	123	PF00533	0.592
LIG_BRCT_BRCA1_1	380	384	PF00533	0.386
LIG_BRCT_BRCA1_1	390	394	PF00533	0.393
LIG_BRCT_BRCA1_1	557	561	PF00533	0.474
LIG_CtBP_PxDLS_1	534	538	PF00389	0.436
LIG_FHA_1	148	154	PF00498	0.567
LIG_FHA_1	425	431	PF00498	0.455
LIG_FHA_1	655	661	PF00498	0.451
LIG_FHA_1	98	104	PF00498	0.528
LIG_FHA_2	200	206	PF00498	0.517
LIG_FHA_2	407	413	PF00498	0.473
LIG_GBD_Chelix_1	239	247	PF00786	0.358
LIG_HP1_1	588	592	PF01393	0.410
LIG_IRF3_LxIS_1	338	344	PF10401	0.395
LIG_LIR_Gen_1	256	262	PF02991	0.411
LIG_LIR_Gen_1	271	279	PF02991	0.236
LIG_LIR_Gen_1	281	290	PF02991	0.329
LIG_LIR_Gen_1	323	333	PF02991	0.460
LIG_LIR_Gen_1	345	354	PF02991	0.407
LIG_LIR_Gen_1	381	392	PF02991	0.308
LIG_LIR_Gen_1	556	566	PF02991	0.539
LIG_LIR_Gen_1	599	610	PF02991	0.440
LIG_LIR_Gen_1	632	643	PF02991	0.284
LIG_LIR_LC3C_4	193	196	PF02991	0.458
LIG_LIR_Nem_3	208	213	PF02991	0.389
LIG_LIR_Nem_3	256	260	PF02991	0.468
LIG_LIR_Nem_3	271	275	PF02991	0.321
LIG_LIR_Nem_3	281	285	PF02991	0.414
LIG_LIR_Nem_3	323	328	PF02991	0.487
LIG_LIR_Nem_3	345	351	PF02991	0.411
LIG_LIR_Nem_3	381	387	PF02991	0.297
LIG_LIR_Nem_3	466	472	PF02991	0.463
LIG_LIR_Nem_3	556	562	PF02991	0.561
LIG_LIR_Nem_3	599	605	PF02991	0.422
LIG_LIR_Nem_3	632	638	PF02991	0.360
LIG_LIR_Nem_3	647	653	PF02991	0.571
LIG_LIR_Nem_3	93	98	PF02991	0.432
LIG_NRBOX	212	218	PF00104	0.475
LIG_Pex14_2	27	31	PF04695	0.419
LIG_REV1ctd_RIR_1	466	475	PF16727	0.384
LIG_RPA_C_Fungi	248	260	PF08784	0.324
LIG_SH2_CRK	210	214	PF00017	0.438
LIG_SH2_CRK	282	286	PF00017	0.464
LIG_SH2_SRC	573	576	PF00017	0.428
LIG_SH2_STAP1	282	286	PF00017	0.419
LIG_SH2_STAT5	304	307	PF00017	0.349
LIG_SH2_STAT5	573	576	PF00017	0.511
LIG_SH3_3	122	128	PF00018	0.581
LIG_SH3_3	135	141	PF00018	0.629
LIG_SH3_3	148	154	PF00018	0.591
LIG_SH3_3	15	21	PF00018	0.451
LIG_SH3_3	46	52	PF00018	0.492
LIG_SH3_3	582	588	PF00018	0.497
LIG_SH3_3	643	649	PF00018	0.452
LIG_SUMO_SIM_anti_2	335	340	PF11976	0.386
LIG_SUMO_SIM_par_1	588	594	PF11976	0.348
MOD_CK1_1	117	123	PF00069	0.479
MOD_CK1_1	271	277	PF00069	0.296
MOD_CK1_1	278	284	PF00069	0.382
MOD_CK1_1	433	439	PF00069	0.493
MOD_CK1_1	513	519	PF00069	0.461
MOD_CK1_1	57	63	PF00069	0.734
MOD_CK1_1	606	612	PF00069	0.411
MOD_CK1_1	64	70	PF00069	0.590
MOD_CK1_1	8	14	PF00069	0.539
MOD_CK2_1	406	412	PF00069	0.487
MOD_CK2_1	524	530	PF00069	0.440
MOD_CK2_1	642	648	PF00069	0.523
MOD_Cter_Amidation	162	165	PF01082	0.466
MOD_GlcNHglycan	119	122	PF01048	0.521
MOD_GlcNHglycan	144	147	PF01048	0.534
MOD_GlcNHglycan	257	260	PF01048	0.431
MOD_GlcNHglycan	306	309	PF01048	0.497
MOD_GlcNHglycan	486	489	PF01048	0.449
MOD_GlcNHglycan	526	529	PF01048	0.479
MOD_GlcNHglycan	569	572	PF01048	0.481
MOD_GlcNHglycan	578	582	PF01048	0.440
MOD_GlcNHglycan	59	62	PF01048	0.516
MOD_GlcNHglycan	612	616	PF01048	0.436
MOD_GlcNHglycan	63	66	PF01048	0.507
MOD_GSK3_1	142	149	PF00069	0.562
MOD_GSK3_1	249	256	PF00069	0.484
MOD_GSK3_1	271	278	PF00069	0.323
MOD_GSK3_1	312	319	PF00069	0.494
MOD_GSK3_1	373	380	PF00069	0.279
MOD_GSK3_1	426	433	PF00069	0.488
MOD_GSK3_1	480	487	PF00069	0.480
MOD_GSK3_1	57	64	PF00069	0.510
MOD_GSK3_1	573	580	PF00069	0.476
MOD_GSK3_1	654	661	PF00069	0.565
MOD_GSK3_1	78	85	PF00069	0.486
MOD_GSK3_1	8	15	PF00069	0.448
MOD_N-GLC_1	341	346	PF02516	0.429
MOD_N-GLC_1	513	518	PF02516	0.537
MOD_N-GLC_1	549	554	PF02516	0.589
MOD_N-GLC_1	603	608	PF02516	0.461
MOD_NEK2_1	181	186	PF00069	0.494
MOD_NEK2_1	217	222	PF00069	0.449
MOD_NEK2_1	260	265	PF00069	0.383
MOD_NEK2_1	275	280	PF00069	0.215
MOD_NEK2_1	3	8	PF00069	0.548
MOD_NEK2_1	316	321	PF00069	0.429
MOD_NEK2_1	33	38	PF00069	0.398
MOD_NEK2_1	341	346	PF00069	0.381
MOD_NEK2_1	357	362	PF00069	0.281
MOD_NEK2_1	372	377	PF00069	0.256
MOD_NEK2_1	378	383	PF00069	0.350
MOD_NEK2_1	424	429	PF00069	0.429
MOD_NEK2_1	434	439	PF00069	0.489
MOD_NEK2_1	45	50	PF00069	0.475
MOD_NEK2_1	484	489	PF00069	0.405
MOD_NEK2_1	510	515	PF00069	0.356
MOD_NEK2_1	540	545	PF00069	0.441
MOD_NEK2_1	577	582	PF00069	0.398
MOD_NEK2_1	605	610	PF00069	0.356
MOD_NEK2_2	596	601	PF00069	0.475
MOD_PIKK_1	659	665	PF00454	0.525
MOD_PKA_2	260	266	PF00069	0.260
MOD_PKA_2	309	315	PF00069	0.383
MOD_PKA_2	316	322	PF00069	0.382
MOD_PKA_2	430	436	PF00069	0.422
MOD_PKB_1	164	172	PF00069	0.521
MOD_PKB_1	253	261	PF00069	0.440
MOD_PKB_1	617	625	PF00069	0.475
MOD_PKB_1	627	635	PF00069	0.517
MOD_Plk_1	413	419	PF00069	0.454
MOD_Plk_1	513	519	PF00069	0.378
MOD_Plk_1	606	612	PF00069	0.493
MOD_Plk_1	670	676	PF00069	0.648
MOD_Plk_4	114	120	PF00069	0.607
MOD_Plk_4	33	39	PF00069	0.657
MOD_Plk_4	334	340	PF00069	0.377
MOD_Plk_4	480	486	PF00069	0.397
MOD_Plk_4	555	561	PF00069	0.514
MOD_Plk_4	620	626	PF00069	0.427
MOD_ProDKin_1	147	153	PF00069	0.597
MOD_ProDKin_1	17	23	PF00069	0.428
MOD_ProDKin_1	54	60	PF00069	0.507
MOD_ProDKin_1	8	14	PF00069	0.459
MOD_SUMO_for_1	90	93	PF00179	0.505
TRG_DiLeu_BaEn_1	242	247	PF01217	0.470
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.401
TRG_DiLeu_BaLyEn_6	582	587	PF01217	0.381
TRG_DiLeu_BaLyEn_6	664	669	PF01217	0.456
TRG_ENDOCYTIC_2	210	213	PF00928	0.376
TRG_ENDOCYTIC_2	282	285	PF00928	0.441
TRG_ENDOCYTIC_2	422	425	PF00928	0.477
TRG_ER_diArg_1	135	137	PF00400	0.616
TRG_ER_diArg_1	164	166	PF00400	0.544
TRG_ER_diArg_1	221	224	PF00400	0.558
TRG_ER_diArg_1	366	369	PF00400	0.429
TRG_ER_diArg_1	430	432	PF00400	0.456
TRG_ER_diArg_1	49	51	PF00400	0.503
TRG_ER_diArg_1	617	620	PF00400	0.466
TRG_ER_diArg_1	625	627	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P389	Leptomonas seymouri	68%	100%
A0A1X0NSQ4	Trypanosomatidae	32%	100%
A0A3Q8IPA0	Leishmania donovani	96%	100%
A0A422N1Z7	Trypanosoma rangeli	35%	100%
A4HF21	Leishmania braziliensis	91%	100%
A4I2A0	Leishmania infantum	95%	100%
C9ZRP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B197	Trypanosoma cruzi	33%	100%