Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q921_LEIMA

TriTrypDb:

LmjF.26.1720 , LMJLV39_260023300 , LMJSD75_260021700

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q921

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q921

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.504
CLV_C14_Caspase3-7	212	216	PF00656	0.589
CLV_C14_Caspase3-7	51	55	PF00656	0.617
CLV_C14_Caspase3-7	86	90	PF00656	0.672
CLV_MEL_PAP_1	502	508	PF00089	0.624
CLV_NRD_NRD_1	252	254	PF00675	0.401
CLV_NRD_NRD_1	284	286	PF00675	0.429
CLV_NRD_NRD_1	312	314	PF00675	0.385
CLV_NRD_NRD_1	333	335	PF00675	0.448
CLV_NRD_NRD_1	450	452	PF00675	0.605
CLV_NRD_NRD_1	625	627	PF00675	0.746
CLV_NRD_NRD_1	629	631	PF00675	0.816
CLV_NRD_NRD_1	694	696	PF00675	0.691
CLV_PCSK_FUR_1	626	630	PF00082	0.675
CLV_PCSK_KEX2_1	252	254	PF00082	0.401
CLV_PCSK_KEX2_1	284	286	PF00082	0.505
CLV_PCSK_KEX2_1	3	5	PF00082	0.507
CLV_PCSK_KEX2_1	399	401	PF00082	0.608
CLV_PCSK_KEX2_1	450	452	PF00082	0.605
CLV_PCSK_KEX2_1	610	612	PF00082	0.830
CLV_PCSK_KEX2_1	625	627	PF00082	0.709
CLV_PCSK_KEX2_1	628	630	PF00082	0.788
CLV_PCSK_KEX2_1	634	636	PF00082	0.775
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.507
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.608
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.645
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.623
CLV_PCSK_PC7_1	625	631	PF00082	0.676
CLV_PCSK_SKI1_1	231	235	PF00082	0.559
CLV_PCSK_SKI1_1	277	281	PF00082	0.416
CLV_PCSK_SKI1_1	335	339	PF00082	0.623
CLV_PCSK_SKI1_1	41	45	PF00082	0.660
CLV_PCSK_SKI1_1	656	660	PF00082	0.615
CLV_PCSK_SKI1_1	96	100	PF00082	0.655
DEG_SCF_FBW7_1	299	306	PF00400	0.418
DEG_SCF_TRCP1_1	224	230	PF00400	0.530
DEG_SPOP_SBC_1	286	290	PF00917	0.451
DOC_CKS1_1	300	305	PF01111	0.432
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.435
DOC_MAPK_gen_1	10	20	PF00069	0.413
DOC_MAPK_gen_1	284	294	PF00069	0.502
DOC_MAPK_gen_1	334	344	PF00069	0.496
DOC_MAPK_HePTP_8	332	344	PF00069	0.452
DOC_MAPK_MEF2A_6	335	344	PF00069	0.450
DOC_PP1_SILK_1	101	106	PF00149	0.646
DOC_PP2B_LxvP_1	546	549	PF13499	0.650
DOC_USP7_MATH_1	106	110	PF00917	0.503
DOC_USP7_MATH_1	14	18	PF00917	0.409
DOC_USP7_MATH_1	286	290	PF00917	0.451
DOC_USP7_MATH_1	303	307	PF00917	0.382
DOC_USP7_MATH_1	394	398	PF00917	0.672
DOC_USP7_MATH_1	43	47	PF00917	0.729
DOC_USP7_MATH_1	488	492	PF00917	0.555
DOC_USP7_MATH_1	551	555	PF00917	0.660
DOC_USP7_MATH_1	569	573	PF00917	0.493
DOC_USP7_MATH_1	618	622	PF00917	0.772
DOC_USP7_MATH_1	639	643	PF00917	0.639
DOC_USP7_MATH_1	680	684	PF00917	0.701
DOC_USP7_MATH_1	98	102	PF00917	0.549
DOC_USP7_MATH_2	92	98	PF00917	0.578
DOC_USP7_UBL2_3	652	656	PF12436	0.737
DOC_WW_Pin1_4	287	292	PF00397	0.441
DOC_WW_Pin1_4	299	304	PF00397	0.424
DOC_WW_Pin1_4	53	58	PF00397	0.591
DOC_WW_Pin1_4	676	681	PF00397	0.614
LIG_14-3-3_CanoR_1	174	182	PF00244	0.477
LIG_14-3-3_CanoR_1	231	239	PF00244	0.611
LIG_14-3-3_CanoR_1	284	294	PF00244	0.446
LIG_14-3-3_CanoR_1	400	404	PF00244	0.607
LIG_14-3-3_CanoR_1	415	419	PF00244	0.657
LIG_14-3-3_CanoR_1	428	435	PF00244	0.514
LIG_14-3-3_CanoR_1	550	560	PF00244	0.695
LIG_14-3-3_CanoR_1	611	616	PF00244	0.602
LIG_14-3-3_CanoR_1	662	671	PF00244	0.679
LIG_14-3-3_CanoR_1	682	692	PF00244	0.589
LIG_AP_GAE_1	218	224	PF02883	0.621
LIG_APCC_ABBA_1	157	162	PF00400	0.361
LIG_APCC_ABBA_1	315	320	PF00400	0.485
LIG_APCC_ABBAyCdc20_2	314	320	PF00400	0.526
LIG_BIR_III_2	89	93	PF00653	0.667
LIG_BRCT_BRCA1_1	23	27	PF00533	0.500
LIG_BRCT_BRCA1_1	401	405	PF00533	0.634
LIG_BRCT_BRCA1_1	431	435	PF00533	0.612
LIG_eIF4E_1	487	493	PF01652	0.557
LIG_FHA_1	320	326	PF00498	0.418
LIG_FHA_1	509	515	PF00498	0.523
LIG_FHA_1	517	523	PF00498	0.506
LIG_FHA_2	173	179	PF00498	0.567
LIG_FHA_2	319	325	PF00498	0.503
LIG_FHA_2	374	380	PF00498	0.634
LIG_FHA_2	467	473	PF00498	0.560
LIG_FHA_2	585	591	PF00498	0.560
LIG_FHA_2	84	90	PF00498	0.744
LIG_LIR_Gen_1	197	208	PF02991	0.503
LIG_LIR_Gen_1	24	34	PF02991	0.603
LIG_LIR_Gen_1	320	331	PF02991	0.399
LIG_LIR_Gen_1	432	443	PF02991	0.641
LIG_LIR_Gen_1	583	594	PF02991	0.497
LIG_LIR_Nem_3	197	203	PF02991	0.460
LIG_LIR_Nem_3	24	30	PF02991	0.586
LIG_LIR_Nem_3	320	326	PF02991	0.404
LIG_LIR_Nem_3	432	438	PF02991	0.572
LIG_LIR_Nem_3	583	589	PF02991	0.502
LIG_PTB_Apo_2	494	501	PF02174	0.558
LIG_PTB_Phospho_1	494	500	PF10480	0.560
LIG_SH2_CRK	300	304	PF00017	0.466
LIG_SH2_GRB2like	495	498	PF00017	0.609
LIG_SH2_NCK_1	487	491	PF00017	0.650
LIG_SH2_SRC	487	490	PF00017	0.613
LIG_SH2_SRC	495	498	PF00017	0.537
LIG_SH2_STAP1	161	165	PF00017	0.513
LIG_SH2_STAP1	359	363	PF00017	0.544
LIG_SH2_STAT5	169	172	PF00017	0.425
LIG_SH2_STAT5	200	203	PF00017	0.595
LIG_SH2_STAT5	513	516	PF00017	0.504
LIG_SH3_3	124	130	PF00018	0.624
LIG_SH3_3	280	286	PF00018	0.511
LIG_SH3_3	325	331	PF00018	0.472
LIG_SH3_3	575	581	PF00018	0.595
LIG_SH3_3	8	14	PF00018	0.431
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.640
LIG_SUMO_SIM_par_1	187	194	PF11976	0.570
LIG_SxIP_EBH_1	662	676	PF03271	0.618
LIG_TRAF2_1	469	472	PF00917	0.554
LIG_TRAF2_1	61	64	PF00917	0.690
LIG_TYR_ITIM	159	164	PF00017	0.411
MOD_CDC14_SPxK_1	679	682	PF00782	0.579
MOD_CDK_SPxK_1	676	682	PF00069	0.583
MOD_CK1_1	21	27	PF00069	0.496
MOD_CK1_1	268	274	PF00069	0.431
MOD_CK1_1	306	312	PF00069	0.362
MOD_CK1_1	373	379	PF00069	0.643
MOD_CK1_1	384	390	PF00069	0.607
MOD_CK1_1	410	416	PF00069	0.611
MOD_CK1_1	431	437	PF00069	0.651
MOD_CK1_1	62	68	PF00069	0.595
MOD_CK1_1	642	648	PF00069	0.831
MOD_CK1_1	683	689	PF00069	0.648
MOD_CK1_1	699	705	PF00069	0.737
MOD_CK2_1	22	28	PF00069	0.439
MOD_CK2_1	318	324	PF00069	0.434
MOD_CK2_1	385	391	PF00069	0.618
MOD_CK2_1	466	472	PF00069	0.563
MOD_CK2_1	512	518	PF00069	0.536
MOD_CK2_1	535	541	PF00069	0.696
MOD_CK2_1	58	64	PF00069	0.648
MOD_Cter_Amidation	448	451	PF01082	0.601
MOD_Cter_Amidation	654	657	PF01082	0.768
MOD_DYRK1A_RPxSP_1	287	291	PF00069	0.440
MOD_GlcNHglycan	106	109	PF01048	0.603
MOD_GlcNHglycan	113	117	PF01048	0.641
MOD_GlcNHglycan	222	227	PF01048	0.716
MOD_GlcNHglycan	262	265	PF01048	0.379
MOD_GlcNHglycan	381	384	PF01048	0.706
MOD_GlcNHglycan	394	397	PF01048	0.551
MOD_GlcNHglycan	45	48	PF01048	0.718
MOD_GlcNHglycan	529	532	PF01048	0.496
MOD_GlcNHglycan	553	556	PF01048	0.717
MOD_GlcNHglycan	637	640	PF01048	0.622
MOD_GlcNHglycan	641	644	PF01048	0.634
MOD_GlcNHglycan	665	668	PF01048	0.732
MOD_GlcNHglycan	674	677	PF01048	0.779
MOD_GlcNHglycan	687	690	PF01048	0.658
MOD_GlcNHglycan	702	705	PF01048	0.595
MOD_GlcNHglycan	96	99	PF01048	0.647
MOD_GSK3_1	14	21	PF00069	0.502
MOD_GSK3_1	169	176	PF00069	0.454
MOD_GSK3_1	190	197	PF00069	0.589
MOD_GSK3_1	227	234	PF00069	0.660
MOD_GSK3_1	299	306	PF00069	0.396
MOD_GSK3_1	381	388	PF00069	0.620
MOD_GSK3_1	410	417	PF00069	0.696
MOD_GSK3_1	429	436	PF00069	0.475
MOD_GSK3_1	455	462	PF00069	0.599
MOD_GSK3_1	49	56	PF00069	0.582
MOD_GSK3_1	508	515	PF00069	0.589
MOD_GSK3_1	58	65	PF00069	0.580
MOD_GSK3_1	620	627	PF00069	0.611
MOD_GSK3_1	635	642	PF00069	0.653
MOD_GSK3_1	672	679	PF00069	0.676
MOD_GSK3_1	680	687	PF00069	0.584
MOD_GSK3_1	696	703	PF00069	0.604
MOD_GSK3_1	76	83	PF00069	0.632
MOD_GSK3_1	94	101	PF00069	0.639
MOD_N-GLC_1	203	208	PF02516	0.480
MOD_N-GLC_1	326	331	PF02516	0.423
MOD_N-GLC_1	428	433	PF02516	0.685
MOD_NEK2_1	152	157	PF00069	0.366
MOD_NEK2_1	203	208	PF00069	0.550
MOD_NEK2_1	260	265	PF00069	0.376
MOD_NEK2_1	381	386	PF00069	0.696
MOD_NEK2_1	392	397	PF00069	0.557
MOD_NEK2_1	414	419	PF00069	0.633
MOD_NEK2_1	584	589	PF00069	0.597
MOD_NEK2_1	599	604	PF00069	0.644
MOD_NEK2_1	624	629	PF00069	0.677
MOD_PIKK_1	59	65	PF00454	0.712
MOD_PIKK_1	644	650	PF00454	0.660
MOD_PKA_1	399	405	PF00069	0.603
MOD_PKA_1	610	616	PF00069	0.638
MOD_PKA_1	630	636	PF00069	0.499
MOD_PKA_2	104	110	PF00069	0.688
MOD_PKA_2	173	179	PF00069	0.508
MOD_PKA_2	286	292	PF00069	0.467
MOD_PKA_2	399	405	PF00069	0.578
MOD_PKA_2	414	420	PF00069	0.625
MOD_PKA_2	429	435	PF00069	0.496
MOD_PKA_2	516	522	PF00069	0.485
MOD_PKA_2	527	533	PF00069	0.579
MOD_PKA_2	551	557	PF00069	0.692
MOD_PKA_2	610	616	PF00069	0.687
MOD_PKA_2	624	630	PF00069	0.642
MOD_PKA_2	639	645	PF00069	0.575
MOD_PKA_2	681	687	PF00069	0.800
MOD_PKA_2	699	705	PF00069	0.586
MOD_PKB_1	628	636	PF00069	0.675
MOD_Plk_1	319	325	PF00069	0.401
MOD_Plk_1	407	413	PF00069	0.699
MOD_Plk_1	488	494	PF00069	0.556
MOD_Plk_4	262	268	PF00069	0.395
MOD_Plk_4	306	312	PF00069	0.450
MOD_Plk_4	336	342	PF00069	0.387
MOD_Plk_4	434	440	PF00069	0.642
MOD_Plk_4	488	494	PF00069	0.556
MOD_Plk_4	556	562	PF00069	0.723
MOD_Plk_4	99	105	PF00069	0.654
MOD_ProDKin_1	287	293	PF00069	0.431
MOD_ProDKin_1	299	305	PF00069	0.418
MOD_ProDKin_1	53	59	PF00069	0.593
MOD_ProDKin_1	676	682	PF00069	0.616
MOD_SUMO_for_1	208	211	PF00179	0.487
MOD_SUMO_for_1	48	51	PF00179	0.603
MOD_SUMO_rev_2	330	340	PF00179	0.423
MOD_SUMO_rev_2	358	364	PF00179	0.507
MOD_SUMO_rev_2	89	98	PF00179	0.734
TRG_DiLeu_BaEn_4	471	477	PF01217	0.574
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.439
TRG_ENDOCYTIC_2	161	164	PF00928	0.463
TRG_ENDOCYTIC_2	200	203	PF00928	0.549
TRG_ER_diArg_1	251	253	PF00400	0.403
TRG_ER_diArg_1	283	285	PF00400	0.486
TRG_ER_diArg_1	32	35	PF00400	0.573
TRG_ER_diArg_1	427	430	PF00400	0.545
TRG_ER_diArg_1	526	529	PF00400	0.467
TRG_ER_diArg_1	549	552	PF00400	0.703
TRG_ER_diArg_1	624	626	PF00400	0.677
TRG_ER_diArg_1	628	630	PF00400	0.698
TRG_NLS_Bipartite_1	634	654	PF00514	0.777
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM04	Leptomonas seymouri	54%	98%
A0A3Q8IDQ2	Leishmania donovani	92%	100%
A4HD56	Leishmania braziliensis	74%	98%
A4I2A4	Leishmania infantum	92%	100%
E9AYF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%