ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q919_LEIMA

TriTrypDb:

LmjF.26.1740 , LMJLV39_260023600 , LMJSD75_260022000 , LMJSD75_260022100

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q919

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q919

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.784
CLV_C14_Caspase3-7	594	598	PF00656	0.622
CLV_NRD_NRD_1	223	225	PF00675	0.583
CLV_NRD_NRD_1	434	436	PF00675	0.611
CLV_NRD_NRD_1	632	634	PF00675	0.632
CLV_PCSK_KEX2_1	434	436	PF00082	0.611
CLV_PCSK_KEX2_1	631	633	PF00082	0.653
CLV_PCSK_SKI1_1	12	16	PF00082	0.690
CLV_PCSK_SKI1_1	504	508	PF00082	0.568
CLV_Separin_Metazoa	620	624	PF03568	0.630
DOC_CDC14_PxL_1	397	405	PF14671	0.591
DOC_CKS1_1	289	294	PF01111	0.733
DOC_CKS1_1	582	587	PF01111	0.756
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.717
DOC_CYCLIN_yCln2_LP_2	582	588	PF00134	0.751
DOC_MAPK_gen_1	224	232	PF00069	0.587
DOC_MAPK_gen_1	459	468	PF00069	0.588
DOC_MAPK_gen_1	611	621	PF00069	0.636
DOC_MAPK_gen_1	631	639	PF00069	0.325
DOC_MAPK_gen_1	649	659	PF00069	0.354
DOC_MAPK_MEF2A_6	140	147	PF00069	0.756
DOC_MAPK_MEF2A_6	652	661	PF00069	0.629
DOC_PP1_RVXF_1	300	307	PF00149	0.595
DOC_PP1_SILK_1	500	505	PF00149	0.560
DOC_PP2B_LxvP_1	312	315	PF13499	0.797
DOC_PP4_FxxP_1	59	62	PF00568	0.836
DOC_USP7_MATH_1	119	123	PF00917	0.843
DOC_USP7_MATH_1	213	217	PF00917	0.546
DOC_USP7_MATH_1	320	324	PF00917	0.747
DOC_USP7_MATH_1	488	492	PF00917	0.692
DOC_USP7_UBL2_3	658	662	PF12436	0.463
DOC_WW_Pin1_4	196	201	PF00397	0.761
DOC_WW_Pin1_4	241	246	PF00397	0.574
DOC_WW_Pin1_4	278	283	PF00397	0.695
DOC_WW_Pin1_4	288	293	PF00397	0.574
DOC_WW_Pin1_4	310	315	PF00397	0.795
DOC_WW_Pin1_4	386	391	PF00397	0.694
DOC_WW_Pin1_4	576	581	PF00397	0.810
DOC_WW_Pin1_4	597	602	PF00397	0.593
LIG_14-3-3_CanoR_1	234	242	PF00244	0.789
LIG_14-3-3_CanoR_1	277	282	PF00244	0.687
LIG_14-3-3_CanoR_1	330	337	PF00244	0.673
LIG_14-3-3_CanoR_1	402	410	PF00244	0.548
LIG_14-3-3_CanoR_1	434	438	PF00244	0.590
LIG_14-3-3_CanoR_1	459	464	PF00244	0.599
LIG_14-3-3_CanoR_1	536	542	PF00244	0.435
LIG_BIR_III_4	523	527	PF00653	0.620
LIG_CSL_BTD_1	582	585	PF09270	0.777
LIG_deltaCOP1_diTrp_1	419	427	PF00928	0.586
LIG_FHA_1	413	419	PF00498	0.448
LIG_FHA_1	537	543	PF00498	0.573
LIG_FHA_1	565	571	PF00498	0.792
LIG_FHA_1	598	604	PF00498	0.585
LIG_FHA_2	150	156	PF00498	0.712
LIG_FHA_2	582	588	PF00498	0.751
LIG_LIR_Apic_2	58	62	PF02991	0.836
LIG_LIR_Gen_1	152	160	PF02991	0.743
LIG_LIR_Gen_1	393	401	PF02991	0.452
LIG_LIR_Gen_1	452	463	PF02991	0.579
LIG_LIR_Gen_1	587	597	PF02991	0.646
LIG_LIR_Nem_3	130	136	PF02991	0.635
LIG_LIR_Nem_3	146	150	PF02991	0.630
LIG_LIR_Nem_3	152	157	PF02991	0.727
LIG_LIR_Nem_3	220	226	PF02991	0.700
LIG_LIR_Nem_3	393	397	PF02991	0.672
LIG_LIR_Nem_3	452	458	PF02991	0.563
LIG_LIR_Nem_3	587	593	PF02991	0.658
LIG_NRBOX	368	374	PF00104	0.571
LIG_Pex14_2	274	278	PF04695	0.648
LIG_Rb_LxCxE_1	170	187	PF01857	0.724
LIG_SH2_CRK	223	227	PF00017	0.741
LIG_SH2_CRK	248	252	PF00017	0.548
LIG_SH2_GRB2like	365	368	PF00017	0.371
LIG_SH2_NCK_1	328	332	PF00017	0.715
LIG_SH2_STAT5	133	136	PF00017	0.775
LIG_SH2_STAT5	248	251	PF00017	0.645
LIG_SH2_STAT5	262	265	PF00017	0.419
LIG_SH2_STAT5	352	355	PF00017	0.545
LIG_SH2_STAT5	365	368	PF00017	0.343
LIG_SH2_STAT5	399	402	PF00017	0.598
LIG_SH2_STAT5	656	659	PF00017	0.630
LIG_SH3_3	239	245	PF00018	0.762
LIG_SH3_3	294	300	PF00018	0.765
LIG_SH3_3	384	390	PF00018	0.661
LIG_SH3_3	574	580	PF00018	0.738
LIG_SH3_3	582	588	PF00018	0.700
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.614
LIG_SUMO_SIM_par_1	293	299	PF11976	0.765
LIG_SUMO_SIM_par_1	556	561	PF11976	0.612
LIG_TRAF2_1	296	299	PF00917	0.776
LIG_TRAF2_1	428	431	PF00917	0.595
LIG_TRAF2_1	643	646	PF00917	0.645
LIG_TRAF2_1	78	81	PF00917	0.641
LIG_UBA3_1	180	184	PF00899	0.708
LIG_UBA3_1	653	662	PF00899	0.630
MOD_CK1_1	112	118	PF00069	0.756
MOD_CK1_1	122	128	PF00069	0.659
MOD_CK1_1	310	316	PF00069	0.794
MOD_CK1_1	486	492	PF00069	0.713
MOD_CK1_1	648	654	PF00069	0.647
MOD_CK1_1	83	89	PF00069	0.764
MOD_CK1_1	97	103	PF00069	0.599
MOD_CK2_1	143	149	PF00069	0.751
MOD_CK2_1	23	29	PF00069	0.646
MOD_CK2_1	318	324	PF00069	0.771
MOD_CK2_1	476	482	PF00069	0.546
MOD_CK2_1	635	641	PF00069	0.645
MOD_GlcNHglycan	219	222	PF01048	0.693
MOD_GlcNHglycan	253	256	PF01048	0.599
MOD_GlcNHglycan	271	274	PF01048	0.363
MOD_GlcNHglycan	309	312	PF01048	0.717
MOD_GlcNHglycan	574	577	PF01048	0.624
MOD_GlcNHglycan	85	88	PF01048	0.698
MOD_GSK3_1	119	126	PF00069	0.801
MOD_GSK3_1	213	220	PF00069	0.638
MOD_GSK3_1	310	317	PF00069	0.793
MOD_GSK3_1	386	393	PF00069	0.631
MOD_GSK3_1	449	456	PF00069	0.590
MOD_GSK3_1	472	479	PF00069	0.518
MOD_GSK3_1	558	565	PF00069	0.690
MOD_GSK3_1	572	579	PF00069	0.593
MOD_GSK3_1	593	600	PF00069	0.611
MOD_GSK3_1	97	104	PF00069	0.659
MOD_NEK2_1	102	107	PF00069	0.827
MOD_NEK2_1	189	194	PF00069	0.659
MOD_NEK2_1	23	28	PF00069	0.481
MOD_NEK2_1	412	417	PF00069	0.569
MOD_NEK2_1	457	462	PF00069	0.489
MOD_NEK2_1	483	488	PF00069	0.763
MOD_NEK2_1	5	10	PF00069	0.732
MOD_NEK2_1	558	563	PF00069	0.667
MOD_NEK2_1	607	612	PF00069	0.682
MOD_NMyristoyl	1	7	PF02799	0.529
MOD_PIKK_1	103	109	PF00454	0.613
MOD_PIKK_1	149	155	PF00454	0.712
MOD_PIKK_1	167	173	PF00454	0.472
MOD_PIKK_1	486	492	PF00454	0.581
MOD_PIKK_1	94	100	PF00454	0.590
MOD_PK_1	123	129	PF00069	0.810
MOD_PKA_2	401	407	PF00069	0.559
MOD_PKA_2	433	439	PF00069	0.595
MOD_PKA_2	648	654	PF00069	0.647
MOD_Plk_1	80	86	PF00069	0.798
MOD_Plk_4	23	29	PF00069	0.760
MOD_Plk_4	246	252	PF00069	0.653
MOD_Plk_4	314	320	PF00069	0.597
MOD_Plk_4	374	380	PF00069	0.574
MOD_Plk_4	488	494	PF00069	0.673
MOD_Plk_4	537	543	PF00069	0.573
MOD_Plk_4	586	592	PF00069	0.671
MOD_Plk_4	635	641	PF00069	0.645
MOD_ProDKin_1	196	202	PF00069	0.760
MOD_ProDKin_1	241	247	PF00069	0.566
MOD_ProDKin_1	278	284	PF00069	0.704
MOD_ProDKin_1	288	294	PF00069	0.578
MOD_ProDKin_1	310	316	PF00069	0.794
MOD_ProDKin_1	386	392	PF00069	0.699
MOD_ProDKin_1	576	582	PF00069	0.808
MOD_ProDKin_1	597	603	PF00069	0.591
MOD_SUMO_for_1	183	186	PF00179	0.705
MOD_SUMO_rev_2	86	96	PF00179	0.818
TRG_ENDOCYTIC_2	133	136	PF00928	0.775
TRG_ENDOCYTIC_2	223	226	PF00928	0.730
TRG_ENDOCYTIC_2	248	251	PF00928	0.645
TRG_ENDOCYTIC_2	656	659	PF00928	0.630
TRG_ER_diArg_1	458	461	PF00400	0.590
TRG_ER_diArg_1	630	633	PF00400	0.641
TRG_NLS_MonoExtN_4	609	615	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDV3	Leishmania donovani	90%	100%
A4I2A6	Leishmania infantum	90%	100%