Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q918_LEIMA

TriTrypDb:

LmjF.26.1750 , LMJLV39_260023700 , LMJSD75_260022200

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q918

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q918

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.292
CLV_C14_Caspase3-7	389	393	PF00656	0.368
CLV_NRD_NRD_1	154	156	PF00675	0.514
CLV_NRD_NRD_1	256	258	PF00675	0.482
CLV_NRD_NRD_1	428	430	PF00675	0.484
CLV_NRD_NRD_1	496	498	PF00675	0.461
CLV_NRD_NRD_1	77	79	PF00675	0.615
CLV_PCSK_KEX2_1	154	156	PF00082	0.514
CLV_PCSK_KEX2_1	256	258	PF00082	0.358
CLV_PCSK_KEX2_1	428	430	PF00082	0.405
CLV_PCSK_KEX2_1	77	79	PF00082	0.565
CLV_PCSK_PC7_1	252	258	PF00082	0.401
CLV_PCSK_SKI1_1	256	260	PF00082	0.455
CLV_PCSK_SKI1_1	263	267	PF00082	0.414
CLV_PCSK_SKI1_1	307	311	PF00082	0.326
CLV_PCSK_SKI1_1	398	402	PF00082	0.559
CLV_PCSK_SKI1_1	429	433	PF00082	0.417
DEG_APCC_DBOX_1	35	43	PF00400	0.545
DEG_APCC_DBOX_1	428	436	PF00400	0.384
DEG_APCC_DBOX_1	514	522	PF00400	0.515
DEG_SPOP_SBC_1	344	348	PF00917	0.522
DEG_SPOP_SBC_1	87	91	PF00917	0.607
DOC_ANK_TNKS_1	401	408	PF00023	0.469
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.450
DOC_MAPK_DCC_7	136	145	PF00069	0.446
DOC_MAPK_gen_1	136	145	PF00069	0.393
DOC_MAPK_gen_1	260	270	PF00069	0.355
DOC_MAPK_MEF2A_6	136	145	PF00069	0.418
DOC_MAPK_MEF2A_6	263	272	PF00069	0.484
DOC_MAPK_RevD_3	141	155	PF00069	0.487
DOC_PP4_FxxP_1	174	177	PF00568	0.455
DOC_PP4_FxxP_1	22	25	PF00568	0.496
DOC_USP7_MATH_1	122	126	PF00917	0.659
DOC_USP7_MATH_1	134	138	PF00917	0.342
DOC_USP7_MATH_1	15	19	PF00917	0.486
DOC_USP7_MATH_1	225	229	PF00917	0.599
DOC_USP7_MATH_1	344	348	PF00917	0.642
DOC_USP7_MATH_1	350	354	PF00917	0.668
DOC_USP7_MATH_1	405	409	PF00917	0.602
DOC_USP7_MATH_1	439	443	PF00917	0.314
DOC_USP7_MATH_1	448	452	PF00917	0.405
DOC_WW_Pin1_4	110	115	PF00397	0.483
DOC_WW_Pin1_4	412	417	PF00397	0.635
DOC_WW_Pin1_4	88	93	PF00397	0.661
DOC_WW_Pin1_4	97	102	PF00397	0.761
LIG_14-3-3_CanoR_1	128	135	PF00244	0.591
LIG_14-3-3_CanoR_1	327	335	PF00244	0.537
LIG_14-3-3_CanoR_1	36	40	PF00244	0.584
LIG_14-3-3_CanoR_1	489	494	PF00244	0.381
LIG_14-3-3_CanoR_1	515	519	PF00244	0.503
LIG_APCC_ABBA_1	384	389	PF00400	0.419
LIG_BIR_III_2	452	456	PF00653	0.443
LIG_BIR_III_4	164	168	PF00653	0.490
LIG_BRCT_BRCA1_1	417	421	PF00533	0.452
LIG_BRCT_BRCA1_1	479	483	PF00533	0.377
LIG_FHA_1	146	152	PF00498	0.469
LIG_FHA_1	253	259	PF00498	0.494
LIG_FHA_1	286	292	PF00498	0.480
LIG_FHA_2	36	42	PF00498	0.603
LIG_FHA_2	462	468	PF00498	0.443
LIG_LIR_Apic_2	172	177	PF02991	0.426
LIG_LIR_Gen_1	370	380	PF02991	0.418
LIG_LIR_Nem_3	181	186	PF02991	0.498
LIG_LIR_Nem_3	370	375	PF02991	0.387
LIG_MYND_3	518	522	PF01753	0.524
LIG_NRBOX	208	214	PF00104	0.358
LIG_NRBOX	503	509	PF00104	0.432
LIG_PCNA_yPIPBox_3	206	218	PF02747	0.406
LIG_Pex14_2	372	376	PF04695	0.477
LIG_RPA_C_Fungi	150	162	PF08784	0.462
LIG_SH2_CRK	83	87	PF00017	0.595
LIG_SH2_NCK_1	469	473	PF00017	0.490
LIG_SH2_NCK_1	83	87	PF00017	0.595
LIG_SH2_PTP2	142	145	PF00017	0.475
LIG_SH2_STAP1	28	32	PF00017	0.552
LIG_SH2_STAT5	142	145	PF00017	0.364
LIG_SH2_STAT5	198	201	PF00017	0.398
LIG_SH2_STAT5	449	452	PF00017	0.562
LIG_SH2_STAT5	491	494	PF00017	0.385
LIG_SH3_1	98	104	PF00018	0.629
LIG_SH3_3	196	202	PF00018	0.508
LIG_SH3_3	410	416	PF00018	0.700
LIG_SH3_3	98	104	PF00018	0.708
LIG_SUMO_SIM_par_1	363	368	PF11976	0.403
LIG_SUMO_SIM_par_1	59	66	PF11976	0.442
LIG_TRAF2_1	104	107	PF00917	0.701
LIG_TYR_ITIM	140	145	PF00017	0.369
MOD_CK1_1	127	133	PF00069	0.648
MOD_CK1_1	415	421	PF00069	0.723
MOD_CK1_1	442	448	PF00069	0.386
MOD_CK1_1	461	467	PF00069	0.394
MOD_CK2_1	277	283	PF00069	0.404
MOD_CK2_1	343	349	PF00069	0.552
MOD_CK2_1	461	467	PF00069	0.512
MOD_CK2_1	88	94	PF00069	0.694
MOD_GlcNHglycan	124	127	PF01048	0.684
MOD_GlcNHglycan	136	139	PF01048	0.480
MOD_GlcNHglycan	17	20	PF01048	0.462
MOD_GlcNHglycan	242	246	PF01048	0.580
MOD_GlcNHglycan	30	33	PF01048	0.474
MOD_GlcNHglycan	406	410	PF01048	0.687
MOD_GlcNHglycan	44	47	PF01048	0.417
MOD_GlcNHglycan	493	496	PF01048	0.563
MOD_GSK3_1	110	117	PF00069	0.817
MOD_GSK3_1	124	131	PF00069	0.514
MOD_GSK3_1	273	280	PF00069	0.436
MOD_GSK3_1	345	352	PF00069	0.599
MOD_GSK3_1	453	460	PF00069	0.569
MOD_GSK3_1	82	89	PF00069	0.612
MOD_GSK3_1	93	100	PF00069	0.771
MOD_N-GLC_1	56	61	PF02516	0.412
MOD_N-GLC_2	360	362	PF02516	0.405
MOD_NEK2_1	250	255	PF00069	0.503
MOD_NEK2_1	277	282	PF00069	0.441
MOD_NEK2_1	458	463	PF00069	0.449
MOD_NEK2_1	483	488	PF00069	0.384
MOD_NEK2_1	51	56	PF00069	0.502
MOD_NEK2_2	93	98	PF00069	0.612
MOD_OFUCOSY	362	369	PF10250	0.398
MOD_PK_1	82	88	PF00069	0.505
MOD_PKA_2	127	133	PF00069	0.594
MOD_PKA_2	179	185	PF00069	0.498
MOD_PKA_2	35	41	PF00069	0.584
MOD_PKA_2	514	520	PF00069	0.471
MOD_Plk_1	93	99	PF00069	0.639
MOD_Plk_4	483	489	PF00069	0.476
MOD_ProDKin_1	110	116	PF00069	0.480
MOD_ProDKin_1	412	418	PF00069	0.631
MOD_ProDKin_1	88	94	PF00069	0.669
MOD_ProDKin_1	97	103	PF00069	0.762
MOD_SUMO_for_1	470	473	PF00179	0.496
MOD_SUMO_rev_2	392	400	PF00179	0.379
MOD_SUMO_rev_2	494	499	PF00179	0.487
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.536
TRG_ENDOCYTIC_2	142	145	PF00928	0.364
TRG_ENDOCYTIC_2	210	213	PF00928	0.368
TRG_ENDOCYTIC_2	83	86	PF00928	0.583
TRG_ER_diArg_1	153	155	PF00400	0.510
TRG_ER_diArg_1	256	258	PF00400	0.416
TRG_ER_diArg_1	427	429	PF00400	0.445
TRG_ER_diArg_1	77	79	PF00400	0.409
TRG_NES_CRM1_1	301	314	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU4	Leptomonas seymouri	55%	100%
A0A1X0P8W2	Trypanosomatidae	34%	100%
A0A3S7X019	Leishmania donovani	94%	100%
A0A422N4R1	Trypanosoma rangeli	30%	100%
A4HD54	Leishmania braziliensis	80%	100%
A4I2A7	Leishmania infantum	94%	100%
C9ZXD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AYF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BF90	Trypanosoma cruzi	34%	100%