Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q917_LEIMA

TriTrypDb:

LmjF.26.1760 , LMJLV39_260023800 , LMJSD75_260022300

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q917

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q917

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.546
CLV_C14_Caspase3-7	224	228	PF00656	0.584
CLV_C14_Caspase3-7	365	369	PF00656	0.468
CLV_C14_Caspase3-7	83	87	PF00656	0.485
CLV_NRD_NRD_1	109	111	PF00675	0.710
CLV_NRD_NRD_1	116	118	PF00675	0.634
CLV_NRD_NRD_1	132	134	PF00675	0.523
CLV_NRD_NRD_1	236	238	PF00675	0.644
CLV_NRD_NRD_1	286	288	PF00675	0.575
CLV_NRD_NRD_1	349	351	PF00675	0.524
CLV_NRD_NRD_1	391	393	PF00675	0.523
CLV_NRD_NRD_1	412	414	PF00675	0.506
CLV_NRD_NRD_1	465	467	PF00675	0.539
CLV_PCSK_FUR_1	286	290	PF00082	0.531
CLV_PCSK_FUR_1	346	350	PF00082	0.527
CLV_PCSK_FUR_1	459	463	PF00082	0.547
CLV_PCSK_KEX2_1	109	111	PF00082	0.710
CLV_PCSK_KEX2_1	115	117	PF00082	0.655
CLV_PCSK_KEX2_1	132	134	PF00082	0.518
CLV_PCSK_KEX2_1	286	288	PF00082	0.575
CLV_PCSK_KEX2_1	348	350	PF00082	0.530
CLV_PCSK_KEX2_1	391	393	PF00082	0.523
CLV_PCSK_KEX2_1	461	463	PF00082	0.557
CLV_PCSK_KEX2_1	464	466	PF00082	0.521
CLV_PCSK_KEX2_1	553	555	PF00082	0.688
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.520
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.557
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.688
CLV_PCSK_SKI1_1	266	270	PF00082	0.608
CLV_PCSK_SKI1_1	304	308	PF00082	0.596
CLV_PCSK_SKI1_1	35	39	PF00082	0.506
CLV_PCSK_SKI1_1	399	403	PF00082	0.412
CLV_PCSK_SKI1_1	465	469	PF00082	0.534
CLV_PCSK_SKI1_1	472	476	PF00082	0.484
CLV_PCSK_SKI1_1	526	530	PF00082	0.606
CLV_PCSK_SKI1_1	570	574	PF00082	0.571
DEG_APCC_DBOX_1	398	406	PF00400	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DOC_CKS1_1	447	452	PF01111	0.528
DOC_CYCLIN_RxL_1	466	479	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	79	82	PF00134	0.470
DOC_MAPK_gen_1	397	404	PF00069	0.452
DOC_MAPK_gen_1	464	476	PF00069	0.546
DOC_MAPK_MEF2A_6	35	44	PF00069	0.509
DOC_MAPK_MEF2A_6	367	376	PF00069	0.521
DOC_MAPK_MEF2A_6	67	75	PF00069	0.451
DOC_MAPK_NFAT4_5	67	75	PF00069	0.451
DOC_MAPK_RevD_3	102	116	PF00069	0.573
DOC_PP1_RVXF_1	509	515	PF00149	0.519
DOC_PP2B_LxvP_1	78	81	PF13499	0.469
DOC_PP4_MxPP_1	530	533	PF00568	0.454
DOC_USP7_MATH_1	258	262	PF00917	0.487
DOC_USP7_MATH_1	271	275	PF00917	0.474
DOC_USP7_MATH_1	559	563	PF00917	0.647
DOC_USP7_UBL2_3	570	574	PF12436	0.646
DOC_WW_Pin1_4	199	204	PF00397	0.674
DOC_WW_Pin1_4	232	237	PF00397	0.687
DOC_WW_Pin1_4	36	41	PF00397	0.502
DOC_WW_Pin1_4	446	451	PF00397	0.533
DOC_WW_Pin1_4	45	50	PF00397	0.492
LIG_14-3-3_CanoR_1	103	107	PF00244	0.554
LIG_14-3-3_CanoR_1	152	158	PF00244	0.647
LIG_14-3-3_CanoR_1	17	26	PF00244	0.513
LIG_14-3-3_CanoR_1	179	188	PF00244	0.629
LIG_14-3-3_CanoR_1	237	247	PF00244	0.594
LIG_14-3-3_CanoR_1	266	276	PF00244	0.585
LIG_14-3-3_CanoR_1	286	296	PF00244	0.364
LIG_14-3-3_CanoR_1	331	340	PF00244	0.550
LIG_14-3-3_CanoR_1	399	405	PF00244	0.448
LIG_14-3-3_CanoR_1	466	476	PF00244	0.543
LIG_14-3-3_CanoR_1	50	58	PF00244	0.508
LIG_Actin_RPEL_3	455	474	PF02755	0.502
LIG_APCC_ABBA_1	474	479	PF00400	0.527
LIG_BRCT_BRCA1_1	141	145	PF00533	0.649
LIG_BRCT_BRCA1_1	419	423	PF00533	0.514
LIG_CaM_IQ_9	318	333	PF13499	0.489
LIG_FHA_1	1	7	PF00498	0.494
LIG_FHA_1	168	174	PF00498	0.685
LIG_FHA_1	21	27	PF00498	0.477
LIG_FHA_1	217	223	PF00498	0.637
LIG_FHA_1	401	407	PF00498	0.387
LIG_FHA_1	468	474	PF00498	0.546
LIG_FHA_1	490	496	PF00498	0.559
LIG_FHA_2	205	211	PF00498	0.629
LIG_FHA_2	267	273	PF00498	0.583
LIG_LIR_Gen_1	241	251	PF02991	0.546
LIG_LIR_Gen_1	403	412	PF02991	0.495
LIG_LIR_Nem_3	241	247	PF02991	0.547
LIG_LIR_Nem_3	403	407	PF02991	0.496
LIG_Pex14_2	423	427	PF04695	0.527
LIG_SH2_CRK	244	248	PF00017	0.546
LIG_SH2_PTP2	521	524	PF00017	0.517
LIG_SH2_SRC	225	228	PF00017	0.664
LIG_SH2_STAT3	342	345	PF00017	0.472
LIG_SH2_STAT3	355	358	PF00017	0.389
LIG_SH2_STAT5	342	345	PF00017	0.472
LIG_SH2_STAT5	521	524	PF00017	0.517
LIG_SH3_1	529	535	PF00018	0.591
LIG_SH3_2	233	238	PF14604	0.647
LIG_SH3_3	155	161	PF00018	0.688
LIG_SH3_3	170	176	PF00018	0.517
LIG_SH3_3	191	197	PF00018	0.691
LIG_SH3_3	230	236	PF00018	0.693
LIG_SH3_3	46	52	PF00018	0.501
LIG_SH3_3	529	535	PF00018	0.591
LIG_SH3_3	562	568	PF00018	0.556
LIG_SUMO_SIM_par_1	70	77	PF11976	0.455
LIG_TRAF2_1	428	431	PF00917	0.411
MOD_CDC14_SPxK_1	235	238	PF00782	0.644
MOD_CDK_SPK_2	232	237	PF00069	0.652
MOD_CDK_SPK_2	45	50	PF00069	0.509
MOD_CDK_SPxK_1	232	238	PF00069	0.650
MOD_CDK_SPxxK_3	36	43	PF00069	0.507
MOD_CK1_1	119	125	PF00069	0.710
MOD_CK1_1	128	134	PF00069	0.597
MOD_CK1_1	135	141	PF00069	0.505
MOD_CK1_1	171	177	PF00069	0.620
MOD_CK2_1	266	272	PF00069	0.599
MOD_CK2_1	382	388	PF00069	0.486
MOD_Cter_Amidation	113	116	PF01082	0.591
MOD_GlcNHglycan	140	144	PF01048	0.617
MOD_GlcNHglycan	170	173	PF01048	0.637
MOD_GlcNHglycan	262	265	PF01048	0.607
MOD_GlcNHglycan	269	272	PF01048	0.513
MOD_GlcNHglycan	333	336	PF01048	0.559
MOD_GlcNHglycan	419	422	PF01048	0.513
MOD_GlcNHglycan	53	56	PF01048	0.507
MOD_GlcNHglycan	561	564	PF01048	0.596
MOD_GlcNHglycan	59	62	PF01048	0.495
MOD_GlcNHglycan	97	100	PF01048	0.493
MOD_GSK3_1	118	125	PF00069	0.703
MOD_GSK3_1	128	135	PF00069	0.584
MOD_GSK3_1	139	146	PF00069	0.542
MOD_GSK3_1	167	174	PF00069	0.612
MOD_GSK3_1	186	193	PF00069	0.529
MOD_GSK3_1	20	27	PF00069	0.513
MOD_GSK3_1	227	234	PF00069	0.651
MOD_GSK3_1	267	274	PF00069	0.519
MOD_GSK3_1	378	385	PF00069	0.477
MOD_GSK3_1	489	496	PF00069	0.561
MOD_GSK3_1	520	527	PF00069	0.536
MOD_GSK3_1	57	64	PF00069	0.502
MOD_GSK3_1	80	87	PF00069	0.479
MOD_N-GLC_1	119	124	PF02516	0.663
MOD_N-GLC_1	251	256	PF02516	0.496
MOD_N-GLC_1	84	89	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.492
MOD_NEK2_1	144	149	PF00069	0.621
MOD_NEK2_1	204	209	PF00069	0.670
MOD_NEK2_1	211	216	PF00069	0.601
MOD_NEK2_1	251	256	PF00069	0.586
MOD_NEK2_1	260	265	PF00069	0.496
MOD_NEK2_1	423	428	PF00069	0.527
MOD_NEK2_1	73	78	PF00069	0.460
MOD_NEK2_2	493	498	PF00069	0.543
MOD_PIKK_1	102	108	PF00454	0.638
MOD_PIKK_1	119	125	PF00454	0.572
MOD_PIKK_1	17	23	PF00454	0.511
MOD_PIKK_1	61	67	PF00454	0.476
MOD_PKA_1	116	122	PF00069	0.710
MOD_PKA_1	132	138	PF00069	0.511
MOD_PKA_1	237	243	PF00069	0.610
MOD_PKA_1	287	293	PF00069	0.497
MOD_PKA_2	102	108	PF00069	0.681
MOD_PKA_2	116	122	PF00069	0.562
MOD_PKA_2	132	138	PF00069	0.511
MOD_PKA_2	325	331	PF00069	0.465
MOD_PKB_1	329	337	PF00069	0.558
MOD_Plk_1	139	145	PF00069	0.594
MOD_Plk_1	271	277	PF00069	0.566
MOD_Plk_1	382	388	PF00069	0.386
MOD_Plk_1	524	530	PF00069	0.566
MOD_Plk_1	84	90	PF00069	0.496
MOD_Plk_4	400	406	PF00069	0.495
MOD_Plk_4	493	499	PF00069	0.546
MOD_Plk_4	74	80	PF00069	0.464
MOD_Plk_4	97	103	PF00069	0.500
MOD_ProDKin_1	199	205	PF00069	0.674
MOD_ProDKin_1	232	238	PF00069	0.685
MOD_ProDKin_1	36	42	PF00069	0.504
MOD_ProDKin_1	446	452	PF00069	0.528
MOD_ProDKin_1	45	51	PF00069	0.491
MOD_SUMO_rev_2	291	296	PF00179	0.542
MOD_SUMO_rev_2	430	436	PF00179	0.532
MOD_SUMO_rev_2	542	548	PF00179	0.600
TRG_DiLeu_BaEn_1	292	297	PF01217	0.558
TRG_DiLeu_BaEn_1	302	307	PF01217	0.445
TRG_DiLeu_BaEn_1	411	416	PF01217	0.455
TRG_DiLeu_BaEn_1	439	444	PF01217	0.516
TRG_ENDOCYTIC_2	244	247	PF00928	0.541
TRG_ENDOCYTIC_2	521	524	PF00928	0.517
TRG_ER_diArg_1	108	110	PF00400	0.705
TRG_ER_diArg_1	115	117	PF00400	0.644
TRG_ER_diArg_1	132	134	PF00400	0.504
TRG_ER_diArg_1	286	289	PF00400	0.538
TRG_ER_diArg_1	346	349	PF00400	0.504
TRG_ER_diArg_1	370	373	PF00400	0.478
TRG_ER_diArg_1	464	466	PF00400	0.543
TRG_ER_diArg_1	509	512	PF00400	0.527
TRG_ER_diLys_1	570	574	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	304	309	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC93	Leishmania donovani	92%	100%
A4HD53	Leishmania braziliensis	71%	100%
A4I2A8	Leishmania infantum	92%	100%
E9AYF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%