HEAT repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 287, putative

Species:

Leishmania major

UniProt:

Q4Q913_LEIMA

TriTrypDb:

LmjF.26.1790 , LMJLV39_260024300 , LMJSD75_260022800

Length:

2766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	7
GO:0030684	preribosome	3	2
GO:0030686	90S preribosome	4	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	7
GO:0034455	t-UTP complex	3	2
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7

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Expansion

Sequence features

Q4Q913

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006356	regulation of transcription by RNA polymerase I	7	2
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009889	regulation of biosynthetic process	4	2

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0030515	snoRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1076	1080	PF00656	0.507
CLV_C14_Caspase3-7	1270	1274	PF00656	0.524
CLV_C14_Caspase3-7	1289	1293	PF00656	0.379
CLV_C14_Caspase3-7	1538	1542	PF00656	0.488
CLV_C14_Caspase3-7	1978	1982	PF00656	0.649
CLV_C14_Caspase3-7	218	222	PF00656	0.415
CLV_C14_Caspase3-7	30	34	PF00656	0.461
CLV_C14_Caspase3-7	54	58	PF00656	0.430
CLV_C14_Caspase3-7	936	940	PF00656	0.494
CLV_MEL_PAP_1	969	975	PF00089	0.417

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I130	Leptomonas seymouri	63%	100%
A0A3S7WZZ1	Leishmania donovani	94%	100%
A4HF25	Leishmania braziliensis	80%	100%
A4I2B2	Leishmania infantum	94%	100%
E9AYF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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